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Science 26 August 1994:
Vol. 265. no. 5176, pp. 1231 - 1234
DOI: 10.1126/science.8066462
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Articles

Science, Vol 265, Issue 5176, 1231-1234
Copyright © 1994 by American Association for the Advancement of Science

articles

cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y

K Akiyama, K Yokota, S Kagawa, N Shimbara, T Tamura, H Akioka, HG Nothwang, C Noda, K Tanaka, and A Ichihara

Department of Urology, School of Medicine, University of Tokushima, Japan.

Proteasomes are the proteolytic complex responsible for major histocompatibility complex (MHC) class I-restricted antigen presentation. Interferon gamma treatment increases expression MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of two proteasome subunits, named X and Y, which alters the proteolytic specificity of proteasomes. Molecular cloning of complementary DNAs encoding X and Y showed that their proteins are proteasomal subunits with high amino acid similarity to LMP7 and LMP2, respectively. Thus, interferon gamma may induce subunit replacements of X and Y by LMP7 and LMP2, respectively, producing proteasomes perhaps more appropriate for the immunological processing of endogenous antigens.


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