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Science 19 August 1994:
Vol. 265. no. 5175, pp. 1107 - 1110
DOI: 10.1126/science.8066451
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Articles

Science, Vol 265, Issue 5175, 1107-1110
Copyright © 1994 by American Association for the Advancement of Science

articles

Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF

H Mitsumoto, K Ikeda, B Klinkosz, JM Cedarbaum, V Wong, and RM Lindsay

Department of Neurology, Cleveland Clinic Foundation, OH 44195.

Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) each promote the survival and differentiation of developing motor neurons, but do so through distinct cellular signaling pathways. Administration of either factor alone has been shown to slow, but not to arrest, progression of motor neuron dysfunction in wobbler mice, an animal model of motor neuron disease. Because CNTF and BDNF are known to synergize in vitro and in ovo, the efficacy of CNTF and BDNF cotreatment was tested in the same animal mode. Subcutaneous injection of the two factors on alternate days was found to arrest disease progression in wobbler mice for 1 month, as measured by several behavioral, physiological, and histological criteria.


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