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Science 19 August 1994:
Vol. 265. no. 5175, pp. 1101 - 1103
DOI: 10.1126/science.7520603
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Articles

Science, Vol 265, Issue 5175, 1101-1103
Copyright © 1994 by American Association for the Advancement of Science

articles

Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA

M Kloc and LD Etkin

Department of Molecular Genetics, University of Texas, M.D. Anderson Cancer Center, Houston 77030.

The Xlsirts are a family of transcribed repeat sequence genes that do not code for protein. Xlsirt RNAs become localized to the vegetal cortex of Xenopus oocytes early in oogenesis, before the localization of the messenger RNA Vg1, which encodes a transforming growth factor-beta-like molecule involved in mesoderm formation, and coincident with the localization of Xcat2 transcripts, which encode a nanos-like molecule. Destruction of the localized Xlsirts by injection of antisense oligodeoxynucleotides into stage 4 oocytes resulted in the release of Vg1 transcripts but not Xcat2 transcripts from the vegetal cortex. Xlsirt RNAs, which may be a structural component of the vegetal cortex, are a crucial part of a genetic pathway necessary for the proper localization of Vg1 that leads to subsequent normal pattern formation.


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