Science 19 August 1994: Vol. 265. no. 5175, pp. 1095 - 1098 DOI: 10.1126/science.8066448

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Articles

Establishment of Experimental Eosinophilic Vasculitis by IgE-Mediated Cutaneous Reverse Passive Arthus Reaction.

T. Ishii, T. Fujita, T. Matsushita, K. Yanaba, M. Hasegawa, H. Nakashima, F. Ogawa, K. Shimizu, K. Takehara, T. F. Tedder, et al. (2009)
Am. J. Pathol. 174, 2225-2233
 |  Abstract »  |  Full Text »  |  PDF »

Profile of Jeffrey Ravetch.

P. Downey (2009)
PNAS 106, 7689-7691
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Inflammation induces hemorrhage in thrombocytopenia.

T. Goerge, B. Ho-Tin-Noe, C. Carbo, C. Benarafa, E. Remold-O'Donnell, B.-Q. Zhao, S. M. Cifuni, and D. D. Wagner (2008)
Blood 111, 4958-4964
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Vav Proteins in Post-Recruitment Neutrophil Cytotoxicity in IgG but Not Complement C3-Dependent Injury.

A. Utomo, J. Hirahashi, D. Mekala, K. Asano, M. Glogauer, X. Cullere, and T. N. Mayadas (2008)
J. Immunol. 180, 6279-6287
 |  Abstract »  |  Full Text »  |  PDF »

Fc{gamma} Receptor Regulation of Citrobacter rodentium Infection.

A. Masuda, M. Yoshida, H. Shiomi, S. Ikezawa, T. Takagawa, H. Tanaka, R. Chinzei, T. Ishida, Y. Morita, H. Kutsumi, et al. (2008)
Infect. Immun. 76, 1728-1737
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Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fc{gamma} receptors and can be effectively blocked by decoy Fc{gamma} receptors.

R. Shashidharamurthy, R. A. Hennigar, S. Fuchs, P. Palaniswami, M. Sherman, and P. Selvaraj (2008)
Blood 111, 894-904
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Immune Complex-Mediated Hypersensitivity with Recombinant Soluble Human Fc{gamma}RIA (CD64A).

J. L. Ellsworth, M. Maurer, B. Harder, N. Hamacher, M. Lantry, K. B. Lewis, S. Rene, K. Byrnes-Blake, S. Underwood, K. S. Waggie, et al. (2008)
J. Immunol. 180, 580-589
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Abrogation of Lupus Nephritis in Activation-Induced Deaminase-Deficient MRL/lpr Mice.

C. Jiang, J. Foley, N. Clayton, G. Kissling, M. Jokinen, R. Herbert, and M. Diaz (2007)
J. Immunol. 178, 7422-7431
 |  Abstract »  |  Full Text »  |  PDF »

Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction.

H. Orito, M. Fujimoto, N. Ishiura, K. Yanaba, T. Matsushita, M. Hasegawa, F. Ogawa, K. Takehara, and S. Sato (2007)
J. Leukoc. Biol. 81, 1197-1204
 |  Abstract »  |  Full Text »  |  PDF »

FcR-Bearing Myeloid Cells Are Responsible for Triggering Murine Lupus Nephritis.

A. Bergtold, A. Gavhane, V. D'Agati, M. Madaio, and R. Clynes (2006)
J. Immunol. 177, 7287-7295
 |  Abstract »  |  Full Text »  |  PDF »

Role of FcRs in Animal Model of Autoimmune Bullous Pemphigoid..

M. Zhao, M. E. Trimbeger, N. Li, L. A. Diaz, S. D. Shapiro, and Z. Liu (2006)
J. Immunol. 177, 3398-3405
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Immune complexes alter cerebral microvessel permeability: roles of complement and leukocyte adhesion.

K. J. Lister and M. J. Hickey (2006)
Am J Physiol Heart Circ Physiol 291, H694-H704
 |  Abstract »  |  Full Text »  |  PDF »

Coupling of C3bi to IgG inhibits the tyrosine phosphorylation signaling cascade downstream Syk and reduces cytokine induction in monocytes.

A. G. Trinidad, M. L. de la Puerta, N. Fernandez, Y. Bayon, M. S. Crespo, and A. Alonso (2006)
J. Leukoc. Biol. 79, 1073-1082
 |  Abstract »  |  Full Text »  |  PDF »

Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors.

Y. Kaneko, F. Nimmerjahn, M. P. Madaio, and J. V. Ravetch (2006)
J. Exp. Med. 203, 789-797
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine-mediated regulation of activating and inhibitory Fc{gamma} receptors in human monocytes.

Y. Liu, E. Masuda, M. C. Blank, K. A. Kirou, X. Gao, M.-S. Park, and L. Pricop (2005)
J. Leukoc. Biol. 77, 767-776
 |  Abstract »  |  Full Text »  |  PDF »

Signal-Specific Activation and Regulation of Human Neutrophil Fc{gamma} Receptors.

S. Nagarajan, N. H. Fifadara, and P. Selvaraj (2005)
J. Immunol. 174, 5423-5432
 |  Abstract »  |  Full Text »  |  PDF »

C5a Initiates the Inflammatory Cascade in Immune Complex Peritonitis.

J. Godau, T. Heller, H. Hawlisch, M. Trappe, E. Howells, J. Best, J. Zwirner, J. S. Verbeek, P. M. Hogarth, C. Gerard, et al. (2004)
J. Immunol. 173, 3437-3445
 |  Abstract »  |  Full Text »  |  PDF »

P-selectin glycoprotein ligand-1 is required for the development of cutaneous vasculitis induced by immune complex deposition.

K. Yanaba, K. Komura, M. Horikawa, Y. Matsushita, K. Takehara, and S. Sato (2004)
J. Leukoc. Biol. 76, 374-382
 |  Abstract »  |  Full Text »  |  PDF »

Fc receptor-mediated accumulation of macrophages in crescentic glomerulonephritis induced by anti-glomerular basement membrane antibody administration in WKY rats.

P. Kovalenko, H. Fujinaka, Y. Yoshida, H. Kawamura, Z. Qu, A. G. A. El-Shemi, H. Li, A. Matsuki, V. Bilim, E. Yaoita, et al. (2004)
Int. Immunol. 16, 625-634
 |  Abstract »  |  Full Text »  |  PDF »

Dual Role of Fc{gamma} Receptor in Transient Focal Cerebral Ischemia in Mice.

M. Komine-Kobayashi, N. Chou, H. Mochizuki, A. Nakao, Y. Mizuno, and T. Urabe (2004)
Stroke 35, 958-963
 |  Abstract »  |  Full Text »  |  PDF »

Fc{epsilon}RI{gamma}-ITAM Is Differentially Required for Mast Cell Function In Vivo.

D. Sakurai, S. Yamasaki, K. Arase, S. Y. Park, H. Arase, A. Konno, and T. Saito (2004)
J. Immunol. 172, 2374-2381
 |  Abstract »  |  Full Text »  |  PDF »

Release of Arachidonic Acid by Stimulation of Opsonic Receptors in Human Monocytes: THE Fc{gamma}R AND THE COMPLEMENT RECEPTOR 3 PATHWAYS.

N. Fernandez, M. Renedo, S. Alonso, and M. S. Crespo (2003)
J. Biol. Chem. 278, 52179-52187
 |  Abstract »  |  Full Text »  |  PDF »

Relative Contributions of Selectins and Intercellular Adhesion Molecule-1 to Tissue Injury Induced by Immune Complex Deposition.

K. Yanaba, Y. Kaburagi, K. Takehara, D. A. Steeber, T. F. Tedder, and S. Sato (2003)
Am. J. Pathol. 162, 1463-1473
 |  Abstract »  |  Full Text »  |  PDF »

Targeting of platelet integrin {alpha}IIb{beta}3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory Fc{gamma}R.

B. Nieswandt, W. Bergmeier, V. Schulte, T. Takai, U. Baumann, R. E. Schmidt, H. Zirngibl, W. Bloch, and J. E. Gessner (2003)
Int. Immunol. 15, 341-349
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Fc{gamma}R Signaling in the K/B x N Serum Transfer Model of Arthritis.

M. Corr and B. Crain (2002)
J. Immunol. 169, 6604-6609
 |  Abstract »  |  Full Text »  |  PDF »

Fc{gamma}R-Mediated Phagocytosis Stimulates Localized Pinocytosis in Human Neutrophils.

R. J. Botelho, H. Tapper, W. Furuya, D. Mojdami, and S. Grinstein (2002)
J. Immunol. 169, 4423-4429
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Constitutive versus Activation-dependent Cross-Presentation of Immune Complexes by CD8+ and CD8- Dendritic Cells In Vivo.

J. M.M. den Haan and M. J. Bevan (2002)
J. Exp. Med. 196, 817-827
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Activation of Monocytic Cells Through Fc{gamma} Receptors Induces the Expression of Macrophage-Inflammatory Protein (MIP)-1{alpha}, MIP-1{beta}, and RANTES.

N. Fernandez, M. Renedo, C. Garcia-Rodriguez, and M. Sanchez Crespo (2002)
J. Immunol. 169, 3321-3328
 |  Abstract »  |  Full Text »  |  PDF »

The Cutaneous Reverse Arthus Reaction Requires Intercellular Adhesion Molecule 1 and L-Selectin Expression.

Y. Kaburagi, M. Hasegawa, T. Nagaoka, Y. Shimada, Y. Hamaguchi, K. Komura, E. Saito, K. Yanaba, K. Takehara, T. Kadono, et al. (2002)
J. Immunol. 168, 2970-2978
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Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody.

S. A. da Silveira, S. Kikuchi, L. Fossati-Jimack, T. Moll, T. Saito, J. S. Verbeek, M. Botto, M. J. Walport, M. Carroll, and S. Izui (2002)
J. Exp. Med. 195, 665-672
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A Dominant Role for Fc{{gamma}} Receptors in Antibody-Dependent Corneal Inflammation.

L. R. Hall, E. Diaconu, and E. Pearlman (2001)
J. Immunol. 167, 919-925
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Tissue Site-Specific Requirements of Mast Cells and Complement Components C3/C5a Receptor in IgG Immune Complex-Induced Injury of Skin and Lung.

U. Baumann, N. Chouchakova, B. Gewecke, J. Kohl, M. C. Carroll, R. E. Schmidt, and J. E. Gessner (2001)
J. Immunol. 167, 1022-1027
 |  Abstract »  |  Full Text »  |  PDF »

Fc{{gamma}}RIII-Mediated Production of TNF-{{alpha}} Induces Immune Complex Alveolitis Independently of CXC Chemokine Generation.

N. Chouchakova, J. Skokowa, U. Baumann, T. Tschernig, K. M. H. Philippens, B. Nieswandt, R. E. Schmidt, and J. E. Gessner (2001)
J. Immunol. 166, 5193-5200
 |  Abstract »  |  Full Text »  |  PDF »

Lymphocytes induce monocyte chemoattractant protein-1 production by renal cells after Fc{gamma} receptor cross-linking: role of IL-1{beta}.

B. H. Rovin, L. Lu, and C. B. Marsh (2001)
J. Leukoc. Biol. 69, 435-439
 |  Abstract »  |  Full Text »

MHC Class I-Related Neonatal Fc Receptor for IgG Is Functionally Expressed in Monocytes, Intestinal Macrophages, and Dendritic Cells.

X. Zhu, G. Meng, B. L. Dickinson, X. Li, E. Mizoguchi, L. Miao, Y. Wang, C. Robert, B. Wu, P. D. Smith, et al. (2001)
J. Immunol. 166, 3266-3276
 |  Abstract »  |  Full Text »  |  PDF »

Lyn Is Essential for Fc{{gamma}} Receptor III-mediated Systemic Anaphylaxis but Not for the Arthus Reaction.

T. Yuasa, M. Ono, T. Watanabe, and T. Takai (2001)
J. Exp. Med. 193, 563-572
 |  Abstract »  |  Full Text »  |  PDF »

Immune Inhibitory Receptors.

J. V. Ravetch and L. L. Lanier (2000)
Science 290, 84-89
 |  Abstract »  |  Full Text »

Differential Mitogen-Activated Protein Kinase Stimulation by Fc{gamma} Receptor IIa and Fc{gamma} Receptor IIIb Determines the Activation Phenotype of Human Neutrophils.

P. Y. Coxon, M. J. Rane, D. W. Powell, J. B. Klein, and K. R. McLeish (2000)
J. Immunol. 164, 6530-6537
 |  Abstract »  |  Full Text »  |  PDF »

Induction and Suppression of Collagen-induced Arthritis Is Dependent on Distinct Fc{gamma} Receptors.

S. Kleinau, P. Martinsson, and B. Heyman (2000)
J. Exp. Med. 191, 1611-1616
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Complement in Antibody-Mediated Inflammation: C5-Deficient DBA/1 Mice Are Resistant to Collagen-Induced Arthritis.

Y. Wang, J. Kristan, L. Hao, C. S. Lenkoski, Y. Shen, and L. A. Matis (2000)
J. Immunol. 164, 4340-4347
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Fc{gamma}R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I{kappa}B-{alpha} degradation and formation of p50/p65 NF-{kappa}B/Rel complexes.

A. Alonso, Y. Bayon, M. Renedo, and M. S. Crespo (2000)
Int. Immunol. 12, 547-554
 |  Abstract »  |  Full Text »  |  PDF »

Role of CC Chemokines (Macrophage Inflammatory Protein-1{beta}, Monocyte Chemoattractant Protein-1, RANTES) in Acute Lung Injury in Rats.

N. M. Bless, M. Huber-Lang, R.-F. Guo, R. L. Warner, H. Schmal, B. J. Czermak, T. P. Shanley, L. D. Crouch, A. B. Lentsch, V. Sarma, et al. (2000)
J. Immunol. 164, 2650-2659
 |  Abstract »  |  Full Text »  |  PDF »

Administration of IgG Fc Fragments Prevents Glomerular Injury in Experimental Immune Complex Nephritis.

C. Gomez-Guerrero, N. Duque, M. T. Casado, C. Pastor, J. Blanco, F. Mampaso, F. Vivanco, and J. Egido (2000)
J. Immunol. 164, 2092-2101
 |  Abstract »  |  Full Text »  |  PDF »

A Codominant Role of Fc{gamma}RI/III and C5aR in the Reverse Arthus Reaction.

U. Baumann, J. Kohl, T. Tschernig, K. Schwerter-Strumpf, J. S. Verbeek, R. E. Schmidt, and J. E. Gessner (2000)
J. Immunol. 164, 1065-1070
 |  Abstract »  |  Full Text »  |  PDF »

The Arthus Reaction in Rodents: Species-Specific Requirement of Complement.

A. J. Szalai, S. B. Digerness, A. Agrawal, J. F. Kearney, R. P. Bucy, S. Niwas, J. M. Kilpatrick, Y. S. Babu, and J. E. Volanakis (2000)
J. Immunol. 164, 463-468
 |  Abstract »  |  Full Text »  |  PDF »

Stimulatory Function of Paired Immunoglobulin-like Receptor-A in Mast Cell Line by Associating with Subunits Common to Fc Receptors.

M. Ono, T. Yuasa, C. Ra, and T. Takai (1999)
J. Biol. Chem. 274, 30288-30296
 |  Abstract »  |  Full Text »  |  PDF »

IL-1 and TNF Receptor-Deficient Mice Show Decreased Inflammation in an Immune Complex Model of Uveitis.

B. E. Brito, L. M. O’Rourke, Y. Pan, J. Anglin, S. R. Planck, and J. T. Rosenbaum (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2583-2589
 |  Abstract »  |  Full Text »  |  PDF »

IgG-Mediated Enhancement of Antibody Responses Is Low in Fc Receptor {gamma} Chain-Deficient Mice and Increased in Fc{gamma}RII-Deficient Mice.

S. Wernersson, M. C. I. Karlsson, J. Dahlstrom, R. Mattsson, J. S. Verbeek, and B. Heyman (1999)
J. Immunol. 163, 618-622
 |  Abstract »  |  Full Text »  |  PDF »

Selection of a C5a Receptor Antagonist from Phage Libraries Attenuating the Inflammatory Response in Immune Complex Disease and Ischemia/Reperfusion Injury.

T. Heller, M. Hennecke, U. Baumann, J. E. Gessner, A. Meyer zu Vilsendorf, M. Baensch, F. Boulay, A. Kola, A. Klos, W. Bautsch, et al. (1999)
J. Immunol. 163, 985-994
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Fc Receptor Type I for IgG on Macrophages and Complement Mediate the Inflammatory Response in Immune Complex Peritonitis.

T. Heller, J. E. Gessner, R. E. Schmidt, A. Klos, W. Bautsch, and J. Kohl (1999)
J. Immunol. 162, 5657-5661
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: C1q Protects Against the Development of Glomerulonephritis Independently of C3 Activation.

D. A. Mitchell, P. R. Taylor, H. T. Cook, J. Moss, A. E. Bygrave, M. J. Walport, and M. Botto (1999)
J. Immunol. 162, 5676-5679
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Monocyte Survival In Vitro by Deposited IgG: Role of Macrophage Colony-Stimulating Factor.

C. B. Marsh, R. P. Pomerantz, J. M. Parker, A. V. Winnard, E. L. Mazzaferri Jr., N. Moldovan, T. W. Kelley, E. Beck, and M. D. Wewers (1999)
J. Immunol. 162, 6217-6225
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Enhancement of Chemokine Generation and Lung Injury by C5a or the Membrane Attack Complex of Complement.

B. J. Czermak, A. B. Lentsch, N. M. Bless, H. Schmal, H. P. Friedl, and P. A. Ward (1999)
Am. J. Pathol. 154, 1513-1524
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro and In Vivo Dependency of Chemokine Generation on C5a and TNF-{alpha}.

B. J. Czermak, V. Sarma, N. M. Bless, H. Schmal, H. P. Friedl, and P. A. Ward (1999)
J. Immunol. 162, 2321-2325
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Immune Complex-induced Inflammation In Vivo by the Coordinate Expression of Activation and Inhibitory Fc Receptors.

R. Clynes, J. S. Maizes, R. Guinamard, M. Ono, T. Takai, and J. V. Ravetch (1999)
J. Exp. Med. 189, 179-186
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of Fcgamma Receptor IIB Renders H-2b Mice Susceptible to Collagen-induced Arthritis.

T. Yuasa, S. Kubo, T. Yoshino, A. Ujike, K. Matsumura, M. Ono, J. V. Ravetch, and T. Takai (1999)
J. Exp. Med. 189, 187-194
 |  Abstract »  |  Full Text »  |  PDF »

Fcgamma RIII (CD16)-Deficient Mice Show IgG Isotype-Dependent Protection to Experimental Autoimmune Hemolytic Anemia.

D. Meyer, C. Schiller, J. Westermann, S. Izui, W. L. W. Hazenbos, J. S. Verbeek, R. E. Schmidt, and J. E. Gessner (1998)
Blood 92, 3997-4002
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Inflammatory Response to a Prototypic B Cell Superantigen: Elicitation of an Arthus Reaction by Staphylococcal Protein A.

L. M. Kozlowski, W. Li, M. Goldschmidt, and A. I. Levinson (1998)
J. Immunol. 160, 5246-5252
 |  Abstract »  |  Full Text »  |  PDF »

The Fcgamma Receptor-Mediated Respiratory Burst of Rolling Neutrophils to Cytokine-Activated, Immune Complex-Bearing Endothelial Cells Depends on L-Selectin But Not on E-Selectin.

D. Frohlich, O. Spertini, and R. Moser (1998)
Blood 91, 2558-2564
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cell-mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell-dependent Mechanism Requiring Fc Receptor Signaling.

D. Jankovic, A. W. Cheever, M. C. Kullberg, T. A. Wynn, G. Yap, P. Caspar, F. A. Lewis, R. Clynes, J. V. Ravetch, and A. Sher (1998)
J. Exp. Med. 187, 619-629
 |  Abstract »  |  Full Text »  |  PDF »

Antibody-mediated Modulation of Cryptococcus neoformans Infection Is Dependent on Distinct Fc Receptor Functions and IgG Subclasses.

R. Yuan, R. Clynes, J. Oh, J. V. Ravetch, and M. D. Scharff (1998)
J. Exp. Med. 187, 641-648
 |  Abstract »  |  Full Text »  |  PDF »

Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis.

R. Clynes, C. Dumitru, and J. V. Ravetch (1998)
Science 279, 1052-1054
 |  Abstract »  |  Full Text »

Fc receptors are required in passive and active immunity to melanoma.

R. Clynes, Y. Takechi, Y. Moroi, A. Houghton, and J. V. Ravetch (1998)
PNAS 95, 652-656
 |  Abstract »  |  Full Text »  |  PDF »

Fcgamma RIII-Mediated Regulation of Hematopoiesis in Murine Bone Marrow Cells by Interleukin-3 and CD95 (Fas/Apo-1).

H. Yoshikawa, T. Sakihama, Y. Nakajima, and K. Tasaka (1997)
Blood 90, 1911-1919
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Inflammatory Responses in the Reverse Arthus Reaction Through Genetic Deletion of the C5a Receptor.

U. E. Hopken, B. Lu, N. P. Gerard, and C. Gerard (1997)
J. Exp. Med. 186, 749-756
 |  Abstract »  |  Full Text »  |  PDF »

Immunoglobulin G-mediated Inflammatory Responses Develop Normally in Complement-deficient Mice.

D. Sylvestre, R. Clynes, M. Ma, H. Warren, M. C. Carroll, and J. V. Ravetch (1996)
J. Exp. Med. 184, 2385-2392
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Major Tyrosine Kinase Substrate in Signaling Complexes Formed after Engagement of Fc[IMAGE] Receptors.

A. Marcilla, O. M. Rivero-Lezcano, A. Agarwal, and K. C. Robbins (1995)
J. Biol. Chem. 270, 9115-9120
 |  Abstract »  |  Full Text »  |  PDF »

New Insights into Immune Complex Diseases.

(1994)
Journal Watch Dermatology 1994, 11
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