Science 19 August 1994: Vol. 265. no. 5175, pp. 1093 - 1095 DOI: 10.1126/science.8066447

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Articles

Purification and Characterization of Mouse Lacrimal Gland Epithelial Cells and Reconstruction of an Acinarlike Structure in Three-Dimensional Culture.

Y. Ueda, Y. Karasawa, Y. Satoh, S. Nishikawa, J. Imaki, and M. Ito (2009)
Invest. Ophthalmol. Vis. Sci. 50, 1978-1987
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PET-Based Biodistribution and Radiation Dosimetry of Epidermal Growth Factor Receptor-Selective Tracer 11C-PD153035 in Humans.

N. Liu, M. Li, X. Li, X. Meng, G. Yang, S. Zhao, Y. Yang, L. Ma, Z. Fu, and J. Yu (2009)
J. Nucl. Med. 50, 303-308
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Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.

T. B. Deb, C. M. Coticchia, R. Barndt, H. Zuo, R. B. Dickson, and M. D. Johnson (2008)
Am J Physiol Cell Physiol 295, C365-C377
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Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover.

N. K. Prasad, M. Tandon, S. Badve, P. W. Snyder, and H. Nakshatri (2008)
Carcinogenesis 29, 25-34
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Epidermal Growth Factor Receptor Phosphorylates Protein Kinase C {delta} at Tyr332 to form a Trimeric Complex with p66Shc in the H2O2-stimulated Cells.

M. Morita, H. Matsuzaki, T. Yamamoto, Y. Fukami, and U. Kikkawa (2008)
J. Biochem. 143, 31-38
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Activation of Epidermal Akt by Diverse Mouse Skin Tumor Promoters.

J. Lu, O. Rho, E. Wilker, L. Beltran, and J. DiGiovanni (2007)
Mol. Cancer Res. 5, 1342-1352
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EGFR Activation Results in Enhanced Cyclooxygenase-2 Expression through p38 Mitogen-Activated Protein Kinase-Dependent Activation of the Sp1/Sp3 Transcription Factors in Human Gliomas.

K. Xu and H.-K. G. Shu (2007)
Cancer Res. 67, 6121-6129
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Epidermal Growth Factor Receptor Is Not Required for Human Cytomegalovirus Entry or Signaling.

M. K. Isaacson, A. L. Feire, and T. Compton (2007)
J. Virol. 81, 6241-6247
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Testosterone Activates Mitogen-Activated Protein Kinase via Src Kinase and the Epidermal Growth Factor Receptor in Sertoli Cells.

J. Cheng, S. C. Watkins, and W. H. Walker (2007)
Endocrinology 148, 2066-2074
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Tethered Epidermal Growth Factor Provides a Survival Advantage to Mesenchymal Stem Cells.

V. H. Fan, A. Au, K. Tamama, R. Littrell, L. B. Richardson, J. W. Wright, A. Wells, and L. G. Griffith (2007)
Stem Cells 25, 1241-1251
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Control of tight junctional sealing: role of epidermal growth factor.

D. Flores-Benitez, A. Ruiz-Cabrera, C. Flores-Maldonado, L. Shoshani, M. Cereijido, and R. G. Contreras (2007)
Am J Physiol Renal Physiol 292, F828-F836
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Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib.

J. An and M. B. Rettig (2007)
Mol. Cancer Ther. 6, 61-69
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Maximal beta3-Adrenergic Regulation of Lipolysis Involves Src and Epidermal Growth Factor Receptor-dependent ERK1/2 Activation.

J. Robidoux, N. Kumar, K. W. Daniel, F. Moukdar, M. Cyr, A. V. Medvedev, and S. Collins (2006)
J. Biol. Chem. 281, 37794-37802
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Podocytes are sensitive to fluid shear stress in vitro.

C. Friedrich, N. Endlich, W. Kriz, and K. Endlich (2006)
Am J Physiol Renal Physiol 291, F856-F865
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FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract.

D. Zhang, J. Kosman, N. Carmean, R. Grady, and J. A. Bassuk (2006)
Am J Physiol Renal Physiol 291, F481-F494
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Tannic Acid, a potent inhibitor of epidermal growth factor receptor tyrosine kinase..

E. B. Yang, L. Wei, K. Zhang, Y. Z. Chen, and W. N. Chen (2006)
J. Biochem. 139, 495-502
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Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits..

L. E. Johannessen, N. M. Pedersen, K. W. Pedersen, I. H. Madshus, and E. Stang (2006)
Mol. Cell. Biol. 26, 389-401
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Mechanism of von Hippel-Lindau Protein-Mediated Suppression of Nuclear Factor kappa B Activity.

J. An and M. B. Rettig (2005)
Mol. Cell. Biol. 25, 7546-7556
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Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptors.

D. S. Lidke, K. A. Lidke, B. Rieger, T. M. Jovin, and D. J. Arndt-Jovin (2005)
J. Cell Biol. 170, 619-626
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Cdc2-mediated Inhibition of Epidermal Growth Factor Activation of the Extracellular Signal-regulated Kinase Pathway during Mitosis.

S. Dangi and P. Shapiro (2005)
J. Biol. Chem. 280, 24524-24531
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Inhibitors of growth factor signalling.

A E Wakeling (2005)
Endocr. Relat. Cancer 12, S183-S187
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Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.

Z. Ren and C. M. Baumgarten (2005)
Am J Physiol Heart Circ Physiol 288, H2628-H2636
 |  Abstract »  |  Full Text »  |  PDF »

Phase 1 Clinical and Pharmacokinetics Evaluation of Oral CI-1033 in Patients with Refractory Cancer.

J. Nemunaitis, I. Eiseman, C. Cunningham, N. Senzer, A. Williams, P. F. Lenehan, S. C. Olson, P. Bycott, M. Schlicht, R. Zentgraff, et al. (2005)
Clin. Cancer Res. 11, 3846-3853
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Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment.

C. D. Woodworth, E. Michael, D. Marker, S. Allen, L. Smith, and M. Nees (2005)
Mol. Cancer Ther. 4, 650-658
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SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION: INSIGHTS INTO THE MOLECULAR BASIS OF ORAL CANCER.

H. Siavash, N.G. Nikitakis, and J.J. Sauk (2004)
Critical Reviews in Oral Biology & Medicine 15, 298-307
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Induced Autocrine Signaling through the Epidermal Growth Factor Receptor Contributes to the Response of Mammary Epithelial Cells to Tumor Necrosis Factor {alpha}.

W.-N. U. Chen, R. L. Woodbury, L. E. Kathmann, L. K. Opresko, R. C. Zangar, H. S. Wiley, and B. D. Thrall (2004)
J. Biol. Chem. 279, 18488-18496
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Gs Protein-coupled Receptor Agonists Induce Transactivation of the Epidermal Growth Factor Receptor in T84 Cells: IMPLICATIONS FOR EPITHELIAL SECRETORY RESPONSES.

L. S. Bertelsen, K. E. Barrett, and S. J. Keely (2004)
J. Biol. Chem. 279, 6271-6279
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Intersectin Activates Ras but Stimulates Transcription through an Independent Pathway Involving JNK.

R. P. Mohney, M. Das, T. G. Bivona, R. Hanes, A. G. Adams, M. R. Philips, and J. P. O'Bryan (2003)
J. Biol. Chem. 278, 47038-47045
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Hypoxia Inducible Factor Activates the Transforming Growth Factor-{alpha}/Epidermal Growth Factor Receptor Growth Stimulatory Pathway in VHL-/- Renal Cell Carcinoma Cells.

L. Gunaratnam, M. Morley, A. Franovic, N. de Paulsen, K. Mekhail, D. A. E. Parolin, E. Nakamura, I. A. J. Lorimer, and S. Lee (2003)
J. Biol. Chem. 278, 44966-44974
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Resistance to Small Molecule Inhibitors of Epidermal Growth Factor Receptor in Malignant Gliomas.

B. Li, C.-M. Chang, M. Yuan, W. G. McKenna, and H.-K. G. Shu (2003)
Cancer Res. 63, 7443-7450
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Ectodomain Cleavage of ErbB-4: CHARACTERIZATION OF THE CLEAVAGE SITE AND m80 FRAGMENT.

Q.-C. Cheng, O. Tikhomirov, W. Zhou, and G. Carpenter (2003)
J. Biol. Chem. 278, 38421-38427
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Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck.

S. Xi, Q. Zhang, K. F. Dyer, E. C. Lerner, T. E. Smithgall, W. E. Gooding, J. Kamens, and J. R. Grandis (2003)
J. Biol. Chem. 278, 31574-31583
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Profiling receptor tyrosine kinase activation by using Ab microarrays.

U. B. Nielsen, M. H. Cardone, A. J. Sinskey, G. MacBeath, and P. K. Sorger (2003)
PNAS 100, 9330-9335
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Regulation of TGF-{alpha}-induced activation of AP-1 in the aging gastric mucosa.

Z.-Q. Xiao, J. Li, and A. P. N. Majumdar (2003)
Am J Physiol Gastrointest Liver Physiol 285, G396-G403
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Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitors.

S. Blencke, A. Ullrich, and H. Daub (2003)
J. Biol. Chem. 278, 15435-15440
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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.

P. L. Leong, G. A. Andrews, D. E. Johnson, K. F. Dyer, S. Xi, J. C. Mai, P. D. Robbins, S. Gadiparthi, N. A. Burke, S. F. Watkins, et al. (2003)
PNAS 100, 4138-4143
 |  Abstract »  |  Full Text »  |  PDF »

Role of EGFR Transactivation in Angiotensin II Signaling to Extracellular Regulated Kinase in Preglomerular Smooth Muscle Cells.

B. T. Andresen, J. J. Linnoila, E. K. Jackson, and G. G. Romero (2003)
Hypertension 41, 781-786
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptome Analysis of HER2 Reveals a Molecular Connection to Fatty Acid Synthesis.

C. Kumar-Sinha, K. W. Ignatoski, M. E. Lippman, S. P. Ethier, and A. M. Chinnaiyan (2003)
Cancer Res. 63, 132-139
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The Mitogenic Potential of Heparin-Binding Epidermal Growth Factor in the Human Endometrium Is Mediated by the Epidermal Growth Factor Receptor and Is Modulated by Tumor Necrosis Factor-{alpha}.

K. Chobotova, M.-E. Muchmore, J. Carver, H.-J Yoo, S. Manek, W. J. Gullick, D. H. Barlow, and H. J. Mardon (2002)
J. Clin. Endocrinol. Metab. 87, 5769-5777
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PARs in the stars: proteinase-activated receptors and astrocyte function. Focus on "Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways".

M. D. Hollenberg (2002)
Am J Physiol Cell Physiol 283, C1347-C1350
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Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways.

H. Wang, J. J. Ubl, R. Stricker, and G. Reiser (2002)
Am J Physiol Cell Physiol 283, C1351-C1364
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Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium.

T. Uesaka, H. Lu, O. Katoh, and H. Watanabe (2002)
Am J Physiol Gastrointest Liver Physiol 283, G840-G847
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Targeting the Epidermal Growth Factor Receptor for Cancer Therapy.

J. Mendelsohn (2002)
J. Clin. Oncol. 20, 1s-13
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Effect of Tyrosine Kinase Inhibitors on Clathrin-coated Pit Recruitment and Internalization of Epidermal Growth Factor Receptor.

T. Sorkina, F. Huang, L. Beguinot, and A. Sorkin (2002)
J. Biol. Chem. 277, 27433-27441
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Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines.

L. Li and P. E. Shaw (2002)
J. Biol. Chem. 277, 17397-17405
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Epidermal Growth Factor Receptor With Tyrosine Kinase Inhibitors: Small Molecules, Big Hopes.

J. Baselga (2002)
J. Clin. Oncol. 20, 2217-2219
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Mechanotransduction in the Lung: Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells.

E. Correa-Meyer, L. Pesce, C. Guerrero, and J. I. Sznajder (2002)
Am J Physiol Lung Cell Mol Physiol 282, L883-L891
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Role of Ras in metal-induced EGF receptor signaling and NF-kappa B activation in human airway epithelial cells.

W. Wu, I. Jaspers, W. Zhang, L. M. Graves, and J. M. Samet (2002)
Am J Physiol Lung Cell Mol Physiol 282, L1040-L1048
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Regulation of Mesangial Cell Hexokinase Activity and Expression by Heparin-binding Epidermal Growth Factor-like Growth Factor. EPIDERMAL GROWTH FACTORS AND PHORBOL ESTERS INCREASE GLUCOSE METABOLISM VIA A COMMON MECHANISM INVOLVING CLASSIC MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY ACTIVATION AND INDUCTION OF HEXOKINASE II EXPRESSION.

R. B. Robey, J. Ma, A. V. P. Santos, O. A. Noboa, P. E. Coy, and J. M. Bryson (2002)
J. Biol. Chem. 277, 14370-14378
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Lymnaea Epidermal Growth Factor Promotes Axonal Regeneration in CNS Organ Culture.

W. C. Wildering, P. M. Hermann, and A. G. M. Bulloch (2001)
J. Neurosci. 21, 9345-9354
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Epidermal Growth Factor Receptor Signaling and the Invasive Phenotype of Ovarian Carcinoma Cells.

O. Alper, E. S. Bergmann-Leitner, T. A. Bennett, N. F. Hacker, K. Stromberg, and W. G. Stetler-Stevenson (2001)
J Natl Cancer Inst 93, 1375-1384
 |  Abstract »  |  Full Text »  |  PDF »

Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity.

O. Bartsch, B. Bartlick, and R. Ivell (2001)
Mol. Hum. Reprod. 7, 799-809
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EGF receptor function is required in late G1 for cell cycle progression induced by bombesin and bradykinin.

C. Santiskulvong, J. Sinnett-Smith, and E. Rozengurt (2001)
Am J Physiol Cell Physiol 281, C886-C898
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase.

A. McFall, A. Ulku, Q. T. Lambert, A. Kusa, K. Rogers-Graham, and C. J. Der (2001)
Mol. Cell. Biol. 21, 5488-5499
 |  Abstract »  |  Full Text »  |  PDF »

Signaling-inactive Epidermal Growth Factor Receptor/Ligand Complexes in Intact Carcinoma Cells by Quinazoline Tyrosine Kinase Inhibitors.

R. B. Lichtner, A. Menrad, A. Sommer, U. Klar, and M. R. Schneider (2001)
Cancer Res. 61, 5790-5795
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Focal Adhesion Kinase (FAK) Inhibits Epidermal Growth Factor Receptor-dependent Migration and Induces Aggregation of NH2-Terminal FAK in the Nuclei of Apoptotic Glioblastoma Cells.

G. Jones, J. Machado Jr., and A. Merlo (2001)
Cancer Res. 61, 4978-4981
 |  Abstract »  |  Full Text »  |  PDF »

Heterogeneity of signal transduction at the subcellular level: microsphere-based focal EGF receptor activation and stimulation of Shc translocation.

R. Brock and T. M. Jovin (2001)
J. Cell Sci. 114, 2437-2447
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic stretch activates p38 SAPK2-, ErbB2-, and AT1-dependent signaling in bladder smooth muscle cells.

H. T. Nguyen, R. M. Adam, S. H. Bride, J. M. Park, C. A. Peters, and M. R. Freeman (2000)
Am J Physiol Cell Physiol 279, C1155-C1167
 |  Abstract »  |  Full Text »  |  PDF »

Thyrotropin-Releasing Hormone Stimulates Phosphorylation of the Epidermal Growth Factor Receptor in GH3 Pituitary Cells.

Y.-H. Wang, S. F. Jue, and R. A. Maurer (2000)
Mol. Endocrinol. 14, 1328-1337
 |  Abstract »  |  Full Text »

Neurotrophic Actions of a Novel Molluscan Epidermal Growth Factor.

P. M. Hermann, R. E. van Kesteren, W. C. Wildering, S. D. Painter, J. M. Reno, J. S. Smith, S. B. Kumar, W. P. M. Geraerts, L. H. Ericsson, A. B. Smit, et al. (2000)
J. Neurosci. 20, 6355-6364
 |  Abstract »  |  Full Text »  |  PDF »

Clinical Use of Tyrosine Kinase Inhibitors: Therapy for Chronic Myelogenous Leukemia and Other Cancers.

N. J. Donato and M. Talpaz (2000)
Clin. Cancer Res. 6, 2965-2966
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Antitumor Effect and Potentiation of Cytotoxic Drugs Activity in Human Cancer Cells by ZD-1839 (Iressa), an Epidermal Growth Factor Receptor-selective Tyrosine Kinase Inhibitor.

F. Ciardiello, R. Caputo, R. Bianco, V. Damiano, G. Pomatico, S. De Placido, A. R. Bianco, and G. Tortora (2000)
Clin. Cancer Res. 6, 2053-2063
 |  Abstract »  |  Full Text »

Reversible G1 Arrest Induced by Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Requires Up-regulation of p27KIP1 Independent of MAPK Activity.

D. Busse, R. S. Doughty, T. T. Ramsey, W. E. Russell, J. O. Price, W. M. Flanagan, L. K. Shawver, and C. L. Arteaga (2000)
J. Biol. Chem. 275, 6987-6995
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Ferritin mRNA Translation in Primary Erythroid Progenitors: Shift to Iron-Dependent Regulation by the v-ErbA Oncoprotein.

W. Mikulits, M. Schranzhofer, A. Bauer, H. Dolznig, L. Lobmayr, A. A. Infante, H. Beug, and E. W. Mullner (1999)
Blood 94, 4321-4332
 |  Abstract »  |  Full Text »  |  PDF »

Specificity of {{alpha}}-Cyano-{{beta}}-Hydroxy-{{beta}}-Methyl-N-[4-(Trifluoromethoxy)Phenyl]-Propenamide as an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase.

S. Ghosh, Y. Zheng, X. Jun, S. Mahajan, C. Mao, E. A. Sudbeck, and F. M. Uckun (1999)
Clin. Cancer Res. 5, 4264-4272
 |  Abstract »  |  Full Text »  |  PDF »

Catalytically Active TYK2 Is Essential for Interferon-beta -mediated Phosphorylation of STAT3 and Interferon-alpha Receptor-1 (IFNAR-1) but Not for Activation of Phosphoinositol 3-Kinase.

M. R. S. Rani, D. W. Leaman, Y. Han, S. Leung, E. Croze, E. N. Fish, A. Wolfman, and R. M. Ransohoff (1999)
J. Biol. Chem. 274, 32507-32511
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals.

W. Wu, L. M. Graves, I. Jaspers, R. B. Devlin, W. Reed, and J. M. Samet (1999)
Am J Physiol Lung Cell Mol Physiol 277, L924-L931
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis.

C. L. Zanella, C. R. Timblin, A. Cummins, M. Jung, J. Goldberg, R. Raabe, T. R. Tritton, and B. T. Mossman (1999)
Am J Physiol Lung Cell Mol Physiol 277, L684-L693
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of beta 1-Integrin Function by Epidermal Growth Factor and Heregulin-beta Has Distinct Requirements for erbB2 but a Similar Dependence on Phosphoinositide 3-OH Kinase.

M. A. Adelsman, J. B. McCarthy, and Y. Shimizu (1999)
Mol. Biol. Cell 10, 2861-2878
 |  Abstract »  |  Full Text »

A Role for Phospholipase C-{{gamma}}-mediated Signaling in Tumor Cell Invasion.

J. Kassis, J. Moellinger, H. Lo, N. M. Greenberg, H.-G. Kim, and A. Wells (1999)
Clin. Cancer Res. 5, 2251-2260
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Antitumor Activity of Choline Kinase Inhibitors: A Novel Target for Anticancer Drug Discovery.

R. Hernandez-Alcoceba, F. Fernandez, and J. C. Lacal (1999)
Cancer Res. 59, 3112-3118
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Paclitaxel-, 5-Fluoro-2'-deoxyuridine-, and Epidermal Growth Factor (EGF)-induced Apoptosis. EVIDENCE FOR EGF-INDUCED ANOIKIS.

T. J. Kottke, A. L. Blajeski, L. M. Martins, P. W. Mesner Jr., N. E. Davidson, W. C. Earnshaw, D. K. Armstrong, and S. H. Kaufmann (1999)
J. Biol. Chem. 274, 15927-15936
 |  Abstract »  |  Full Text »  |  PDF »

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.

J. Dong, L. K. Opresko, P. J. Dempsey, D. A. Lauffenburger, R. J. Coffey, and H. S. Wiley (1999)
PNAS 96, 6235-6240
 |  Abstract »  |  Full Text »  |  PDF »

Keratinocyte Collagenase-1 Expression Requires an Epidermal Growth Factor Receptor Autocrine Mechanism.

B. K. Pilcher, J. Dumin, M. J. Schwartz, B. A. Mast, G. S. Schultz, W. C. Parks, and H. G. Welgus (1999)
J. Biol. Chem. 274, 10372-10381
 |  Abstract »  |  Full Text »  |  PDF »

Elevation of the Epidermal Growth Factor Receptor and Dependent Signaling in Human Papillomavirus-infected Laryngeal Papillomas.

D. Johnston, H. Hall, T. P. DiLorenzo, and B. M. Steinberg (1999)
Cancer Res. 59, 968-974
 |  Abstract »  |  Full Text »  |  PDF »

Differential Immediate Early Gene Expression in Conditional Hepatitis B Virus pX-transforming Versus Nontransforming Hepatocyte Cell Lines.

C. Tarn, M. L. Bilodeau, R. L. Hullinger, and O. M. Andrisani (1999)
J. Biol. Chem. 274, 2327-2336
 |  Abstract »  |  Full Text »  |  PDF »

Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy.

P Nagy, A Jenei, A. Kirsch, J Szollosi, S Damjanovich, and T. Jovin (1999)
J. Cell Sci. 112, 1733-1741
 |  Abstract »  |  PDF »

Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields.

K. Fang, E Ionides, G Oster, R Nuccitelli, and R. Isseroff (1999)
J. Cell Sci. 112, 1967-1978
 |  Abstract »  |  PDF »

SU5416 Is a Potent and Selective Inhibitor of the Vascular Endothelial Growth Factor Receptor (Flk-1/KDR) That Inhibits Tyrosine Kinase Catalysis, Tumor Vascularization, and Growth of Multiple Tumor Types.

T. A. T. Fong, L. K. Shawver, L. Sun, C. Tang, H. App, T. J. Powell, Y. H. Kim, R. Schreck, X. Wang, W. Risau, et al. (1999)
Cancer Res. 59, 99-106
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic Ha-Ras-dependent Mitogen-activated Protein Kinase Activity Requires Signaling Through the Epidermal Growth Factor Receptor.

M. Hamilton and A. Wolfman (1998)
J. Biol. Chem. 273, 28155-28162
 |  Abstract »  |  Full Text »  |  PDF »

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.

D. W. Fry, A. J. Bridges, W. A. Denny, A. Doherty, K. D. Greis, J. L. Hicks, K. E. Hook, P. R. Keller, W. R. Leopold, J. A. Loo, et al. (1998)
PNAS 95, 12022-12027
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Biological Characterization and Antiangiogenic Effects of PD 166866, a Selective Inhibitor of the FGF-1 Receptor Tyrosine Kinase.

R. L. Panek, G. H. Lu, T. K. Dahring, B. L. Batley, C. Connolly, J. M. Hamby, and K. J. Brown (1998)
J. Pharmacol. Exp. Ther. 286, 569-577
 |  Abstract »  |  Full Text »

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway.

J. M. Cunnick, J. F. Dorsey, T. Standley, J. Turkson, A. J. Kraker, D. W. Fry, R. Jove, and J. Wu (1998)
J. Biol. Chem. 273, 14468-14475
 |  Abstract »  |  Full Text »  |  PDF »

Gene Trapping Identifies Inhibitors of Oncogenic Transformation. THE TISSUE INHIBITOR OF METALLOPROTEINASES-3 (TIMP3) AND COLLAGEN TYPE I alpha 2 (COL1A2) ARE EPIDERMAL GROWTH FACTOR-REGULATED GROWTH REPRESSORS.

T. Andreu, T. Beckers, E. Thoenes, P. Hilgard, and H. von Melchner (1998)
J. Biol. Chem. 273, 13848-13854
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Granulocyte-Macrophage Colony-stimulating Factor Receptor Expressed in Primary Avian Hematopoietic Progenitors: Lineage-specific Regulation of Proliferation and Differentiation.

O. Wessely, E.-M. Deiner, K. C. Lim, G. Mellitzer, P. Steinlein, and H. Beug (1998)
J. Cell Biol. 141, 1041-1051
 |  Abstract »  |  Full Text »  |  PDF »

Parallel Contractile Signal Transduction Pathways Activated by Receptors for Thrombin and Epidermal Growth Factor-Urogastrone in Guinea Pig Gastric Smooth Muscle: Blockade by Inhibitors of Mitogen-Activated Protein Kinase-Kinase and Phosphatidyl Inositol 3'-Kinase.

X.-L. Zheng, B. Renaux, and M. D. Hollenberg (1998)
J. Pharmacol. Exp. Ther. 285, 325-334
 |  Abstract »  |  Full Text »

Thrombin Aivation of the 9E3/CEF4 Chemokine Involves Tyrosine Kinases Including c-src and the Epidermal Growth Factor Receptor.

S. M. Vaingankar and M. Martins-Green (1998)
J. Biol. Chem. 273, 5226-5234
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor.

R. L. Panek, G. H. Lu, S. R. Klutchko, B. L. Batley, T. K. Dahring, J. M. Hamby, H. Hallak, A. M. Doherty, and J. A. Keiser (1997)
J. Pharmacol. Exp. Ther. 283, 1433-1444
 |  Abstract »  |  Full Text »

A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells.

L. M. Gangarosa, N. Sizemore, R. Graves-Deal, S. M. Oldham, C. J. Der, and R. J. Coffey (1997)
J. Biol. Chem. 272, 18926-18931
 |  Abstract »  |  Full Text »  |  PDF »

Contractile Action of Ethanol in Guinea Pig Gastric Smooth Muscle: Inhibition by Tyrosine Kinase Inhibitors and Comparison with the Contractile Action of Epidermal Growth Factor-Urogastrone.

X.-L. Zheng, S. Mokashi, and M. D. Hollenberg (1997)
J. Pharmacol. Exp. Ther. 282, 485-495
 |  Abstract »  |  Full Text »

An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors.

H. Sakurai, E. J. Barros, T. Tsukamoto, J. Barasch, and S. K. Nigam (1997)
PNAS 94, 6279-6284
 |  Abstract »  |  Full Text »  |  PDF »

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T. K. Dahring, G. H. Lu, J. M. Hamby, B. L. Batley, A. J. Kraker, and R. L. Panek (1997)
J. Pharmacol. Exp. Ther. 281, 1446-1456
 |  Abstract »

Protein-tyrosine Phosphatase-mediated Decrease of Epidermal Growth Factor and Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation in High Cell Density Cultures.

M. Sörby and A. Ostman (1996)
J. Biol. Chem. 271, 10963-10966
 |  Abstract »  |  Full Text »  |  PDF »

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X. Yan (1996)
J. Biol. Chem. 271, 1845-1848
 |  Abstract »  |  Full Text »  |  PDF »

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo.

D. R. Alessi, A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel (1995)
J. Biol. Chem. 270, 27489-27494
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine kinase inhibition: an approach to drug development.

A Levitzki and A Gazit (1995)
Science 267, 1782-1788
 |  Abstract »  |  PDF »

Epidermal Growth Factor Induction of Apolipoprotein A-I Is Mediated by the Ras-MAP Kinase Cascade and Sp1.

X.-L. Zheng, S. Matsubara, C. Diao, M. D. Hollenberg, and N. C. W. Wong (2001)
J. Biol. Chem. 276, 13822-13829
 |  Abstract »  |  Full Text »  |  PDF »

From Consensus Sequence Peptide to High Affinity Ligand, a "Library Scan" Strategy.

R.-H. Yeh, T. R. Lee, and D. S. Lawrence (2001)
J. Biol. Chem. 276, 12235-12240
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis B Virus X Protein Differentially Activates RAS-RAF-MAPK and JNK Pathways in X-transforming Versus Non-transforming AML12 Hepatocytes.

C. Tarn, S. Lee, Y. Hu, C. Ashendel, and O. M. Andrisani (2001)
J. Biol. Chem. 276, 34671-34680
 |  Abstract »  |  Full Text »  |  PDF »

Human Homeobox HOXA7 Regulates Keratinocyte Transglutaminase Type 1 and Inhibits Differentiation.

P. T. La Celle and R. R. Polakowska (2001)
J. Biol. Chem. 276, 32844-32853
 |  Abstract »  |  Full Text »  |  PDF »

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