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Science 12 August 1994:
Vol. 265. no. 5174, pp. 962 - 966
DOI: 10.1126/science.8052856
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Articles

Science, Vol 265, Issue 5174, 962-966
Copyright © 1994 by American Association for the Advancement of Science

articles

Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells

B O'Rourke, BM Ramza, and E Marban

Johns Hopkins University, Department of Medicine, Baltimore, MD 21205.

Periodic changes in membrane ionic current linked to intrinsic oscillations of energy metabolism were identified in guinea pig cardiomyocytes. Metabolic stress initiated cyclical activation of adenosine triphosphate-sensitive potassium current and concomitant suppression of depolarization-evoked intracellular calcium transients. The oscillations in membrane current and excitation-contraction coupling were linked to oscillations in the oxidation state of pyridine nucleotides but were not driven by pacemaker currents or alterations in the concentration of cytosolic calcium. Interventions that altered the rate of glucose metabolism modulated the oscillations, suggesting that the rhythms originated at the level of glycolysis. The energy-driven oscillations in potassium currents produced cyclical changes in the cardiac action potential and thus may contribute to the genesis of arrhythmias during metabolic compromise.


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