Science 5 August 1994: Vol. 265. no. 5173, pp. 806 - 808 DOI: 10.1126/science.8047888

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Articles

Pulmonary Inflammation Triggered by Ricin Toxin Requires Macrophages and IL-1 Signaling.

M. L. Lindauer, J. Wong, Y. Iwakura, and B. E. Magun (2009)
J. Immunol. 183, 1419-1426
 |  Abstract »  |  Full Text »  |  PDF »

siRNA screening reveals JNK2 as an evolutionary conserved regulator of triglyceride homeostasis.

V. Grimard, J. Massier, D. Richter, D. Schwudke, Y. Kalaidzidis, E. Fava, A. Hermetter, and C. Thiele (2008)
J. Lipid Res. 49, 2427-2440
 |  Abstract »  |  Full Text »  |  PDF »

Abrogation of Hyperosmotic Impairment of Insulin Signaling by a Novel Class of 1,2-Dithiole-3-thiones through the Inhibition of S6K1 Activation.

E. J. Bae, Y. M. Yang, and S. G. Kim (2008)
Mol. Pharmacol. 73, 1502-1512
 |  Abstract »  |  Full Text »  |  PDF »

Prolactin-induced production of cytokines in macrophages in vitro involves JAK/STAT and JNK MAPK pathways.

A. Tripathi and A. Sodhi (2008)
Int. Immunol. 20, 327-336
 |  Abstract »  |  Full Text »  |  PDF »

Expressed in the Yeast Saccharomyces cerevisiae, Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase.

A. W. Truman, S. H. Millson, J. M. Nuttall, V. King, M. Mollapour, C. Prodromou, L. H. Pearl, and P. W. Piper (2006)
Eukaryot. Cell 5, 1914-1924
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen-Mediated Regulation of p38 Mitogen-Activated Protein Kinase in Human Endometrium.

Y. Seval, H. Cakmak, U. A. Kayisli, and A. Arici (2006)
J. Clin. Endocrinol. Metab. 91, 2349-2357
 |  Abstract »  |  Full Text »  |  PDF »

Selective Role of Intracellular Chloride in the Regulation of the Intrinsic but Not Extrinsic Pathway of Apoptosis in Jurkat T-cells.

G. Heimlich and J. A. Cidlowski (2006)
J. Biol. Chem. 281, 2232-2241
 |  Abstract »  |  Full Text »  |  PDF »

Hypertonic Induction of COX-2 in Collecting Duct Cells by Reactive Oxygen Species of Mitochondrial Origin.

T. Yang, A. Zhang, M. Honeggar, D. E. Kohan, D. Mizel, K. Sanders, J. R. Hoidal, J. P. Briggs, and J. B. Schnermann (2005)
J. Biol. Chem. 280, 34966-34973
 |  Abstract »  |  Full Text »  |  PDF »

Feasibility of Using Hyperosmolar Mannitol as a Liquid Tumor Embolization Agent.

L. Feng, B. A. Kienitz, C. Matsumoto, J. Bruce, M. Sisti, H. Duong, and J. Pile-Spellman (2005)
AJNR Am. J. Neuroradiol. 26, 1405-1412
 |  Abstract »  |  Full Text »  |  PDF »

The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans.

D. M. Arana, C. Nombela, R. Alonso-Monge, and J. Pla (2005)
Microbiology 151, 1033-1049
 |  Abstract »  |  Full Text »  |  PDF »

Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.

J. Copp, S. Wiley, M. W. Ward, and P. van der Geer (2005)
Am J Physiol Cell Physiol 288, C403-C415
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Matrix Metalloproteinases by Hyperosmolarity via a JNK Pathway in Human Corneal Epithelial Cells.

D.-Q. Li, Z. Chen, X. J. Song, L. Luo, and S. C. Pflugfelder (2004)
Invest. Ophthalmol. Vis. Sci. 45, 4302-4311
 |  Abstract »  |  Full Text »  |  PDF »

Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction.

A. Herrlich, V. Leitch, and L. S. King (2004)
PNAS 101, 15799-15804
 |  Abstract »  |  Full Text »  |  PDF »

Signaling by Higher Inositol Polyphosphates: SYNTHESIS OF BISDIPHOSPHOINOSITOL TETRAKISPHOSPHATE ("InsP8") IS SELECTIVELY ACTIVATED BY HYPEROSMOTIC STRESS.

X. Pesesse, K. Choi, T. Zhang, and S. B. Shears (2004)
J. Biol. Chem. 279, 43378-43381
 |  Abstract »  |  Full Text »  |  PDF »

Evidence That {Delta}Np73 Promotes Neuronal Survival by p53-Dependent and p53-Independent Mechanisms.

A. F. Lee, D. K. Ho, P. Zanassi, G. S. Walsh, D. R. Kaplan, and F. D. Miller (2004)
J. Neurosci. 24, 9174-9184
 |  Abstract »  |  Full Text »  |  PDF »

Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells.

H. Zhao, R. Hyde, and H. S Hundal (2004)
J. Physiol. 560, 123-136
 |  Abstract »  |  Full Text »  |  PDF »

ORF36 Protein Kinase of Kaposi's Sarcoma Herpesvirus Activates the c-Jun N-terminal Kinase Signaling Pathway.

M. S. Hamza, R. A. Reyes, Y. Izumiya, R. Wisdom, H.-J. Kung, and P. A. Luciw (2004)
J. Biol. Chem. 279, 38325-38330
 |  Abstract »  |  Full Text »  |  PDF »

MAP kinases as structural adaptors and enzymatic activators in transcription complexes.

J. W. Edmunds and L. C. Mahadevan (2004)
J. Cell Sci. 117, 3715-3723
 |  Abstract »  |  Full Text »  |  PDF »

Response of human cells to desiccation: comparison with hyperosmotic stress response.

Z. Huang and A. Tunnacliffe (2004)
J. Physiol. 558, 181-191
 |  Abstract »  |  Full Text »  |  PDF »

Annexin 2 Binding to Phosphatidylinositol 4,5-Bisphosphate on Endocytic Vesicles Is Regulated by the Stress Response Pathway.

M. J. Hayes, C. J. Merrifield, D. Shao, J. Ayala-Sanmartin, C. D. Schorey, T. P. Levine, J. Proust, J. Curran, M. Bailly, and S. E. Moss (2004)
J. Biol. Chem. 279, 14157-14164
 |  Abstract »  |  Full Text »  |  PDF »

p38 Mitogen-Activated Protein Kinase Activation and Cell Localization in Human Glomerulonephritis: Correlation with Renal Injury.

C. Stambe, D. J. Nikolic-Paterson, P. A. Hill, J. Dowling, and R. C. Atkins (2004)
J. Am. Soc. Nephrol. 15, 326-336
 |  Abstract »  |  Full Text »  |  PDF »

Copper-inducible transcription: regulation by metal- and oxidative stressresponsive pathways.

M. D. Mattie and J. H. Freedman (2004)
Am J Physiol Cell Physiol 286, C293-C301
 |  Abstract »  |  Full Text »

UV-Induced Signaling Pathways Associated with Corneal Epithelial Cell Apoptosis.

L. Lu, L. Wang, and B. Shell (2003)
Invest. Ophthalmol. Vis. Sci. 44, 5102-5109
 |  Abstract »  |  Full Text »  |  PDF »

Subcellular Localization of Activating Transcription Factor 2 in Melanoma Specimens Predicts Patient Survival.

A. J. Berger, H. M. Kluger, N. Li, E. Kielhorn, R. Halaban, Z.'e. Ronai, and D. L. Rimm (2003)
Cancer Res. 63, 8103-8107
 |  Abstract »  |  Full Text »  |  PDF »

Hyperosmolar Mannitol Stimulates Expression of Aquaporins 4 and 9 through a p38 Mitogen-activated Protein Kinase-dependent Pathway in Rat Astrocytes.

H. Arima, N. Yamamoto, K. Sobue, F. Umenishi, T. Tada, H. Katsuya, and K. Asai (2003)
J. Biol. Chem. 278, 44525-44534
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities.

S.-G. Cho, J. W. Kim, Y. H. Lee, H. S. Hwang, M.-S. Kim, K. Ryoo, M. J. Kim, K. T. Noh, E. K. Kim, J.-H. Cho, et al. (2003)
J. Cell Biol. 163, 71-81
 |  Abstract »  |  Full Text »  |  PDF »

Hyperosmotic-induced Protein Kinase N 1 Activation in a Vesicular Compartment Is Dependent upon Rac1 and 3-Phosphoinositide-dependent Kinase 1.

N. E. Torbett, A. Casamassima, and P. J. Parker (2003)
J. Biol. Chem. 278, 32344-32351
 |  Abstract »  |  Full Text »  |  PDF »

Combination of Two Activating Mutations in One HOG1 Gene Forms Hyperactive Enzymes That Induce Growth Arrest.

G. Yaakov, M. Bell, S. Hohmann, and D. Engelberg (2003)
Mol. Cell. Biol. 23, 4826-4840
 |  Abstract »  |  Full Text »  |  PDF »

The Osmoregulatory and the Amino Acid-regulated Responses of System A Are Mediated by Different Signal Transduction Pathways.

M. Lopez-Fontanals, S. Rodriguez-Mulero, F. J. Casado, B. Derijard, and M. Pastor-Anglada (2003)
J. Gen. Physiol. 122, 5-16
 |  Abstract »  |  Full Text »  |  PDF »

The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation in Candidaalbicans.

R. Alonso-Monge, F. Navarro-Garcia, E. Roman, A. I. Negredo, B. Eisman, C. Nombela, and J. Pla (2003)
Eukaryot. Cell 2, 351-361
 |  Abstract »  |  Full Text »  |  PDF »

The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro.

C. Pepper, A. Thomas, T. Hoy, D. Milligan, P. Bentley, and C. Fegan (2003)
Blood 101, 2454-2459
 |  Abstract »  |  Full Text »  |  PDF »

Prolactin Regulation of Neonatal Ovine Uterine Gland Morphogenesis.

K. D. Carpenter, C. A. Gray, S. Noel, A. Gertler, F. W. Bazer, and T. E. Spencer (2003)
Endocrinology 144, 110-120
 |  Abstract »  |  Full Text »  |  PDF »

The Srk1 Protein Kinase Is a Target for the Sty1 Stress-activated MAPK in Fission Yeast.

D. A. Smith, W. M. Toone, D. Chen, J. Bahler, N. Jones, B. A. Morgan, and J. Quinn (2002)
J. Biol. Chem. 277, 33411-33421
 |  Abstract »  |  Full Text »  |  PDF »

Invited Review: Cell Volume Control and Signal Transduction in Apoptosis.

M. Gomez-Angelats and J. A. Cidlowski (2002)
Toxicol Pathol 30, 541-551
 |  Abstract »  |  PDF »

Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Intracellular signaling in contracting skeletal muscle.

K. Sakamoto and L. J. Goodyear (2002)
J Appl Physiol 93, 369-383
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis.

G. S. Kerby, V. Cottin, F. J. Accurso, F. Hoffmann, E. D. Chan, V. A. Fadok, and D. W. H. Riches (2002)
Am J Physiol Lung Cell Mol Physiol 283, L188-L197
 |  Abstract »  |  Full Text »  |  PDF »

Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes.

E. Burkert, O. Radmark, B. Samuelsson, D. Steinhilber, and O. Werz (2002)
J. Leukoc. Biol. 71, 477-486
 |  Abstract »  |  Full Text »  |  PDF »

Integrins Play a Critical Role in Mechanical Stress-Induced p38 MAPK Activation.

R. Aikawa, T. Nagai, S. Kudoh, Y. Zou, M. Tanaka, M. Tamura, H. Akazawa, H. Takano, R. Nagai, and I. Komuro (2002)
Hypertension 39, 233-238
 |  Abstract »  |  Full Text »  |  PDF »

Human Neutrophil Lactoferrin trans-Activates the Matrix Metalloproteinase 1 Gene through Stress-activated MAPK Signaling Modules.

S.-M. Oh, D. H. Hahm, I.-H. Kim, and S.-Y. Choi (2001)
J. Biol. Chem. 276, 42575-42579
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of multiple MAPK pathways by mechanical overload in the perfused amphibian heart.

I.-K. S. Aggeli, C. Gaitanaki, A. Lazou, and I. Beis (2001)
Am J Physiol Regulatory Integrative Comp Physiol 281, R1689-R1698
 |  Abstract »  |  Full Text »  |  PDF »

Hematopoietic Protein Tyrosine Phosphatase Suppresses Extracellular Stimulus-Regulated Kinase Activation.

M. Gronda, S. Arab, B. Iafrate, H. Suzuki, and B. W. Zanke (2001)
Mol. Cell. Biol. 21, 6851-6858
 |  Abstract »  |  Full Text »  |  PDF »

Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle.

M. Yu, E. Blomstrand, A. V Chibalin, A. Krook, and J. R Zierath (2001)
J. Physiol. 536, 273-282
 |  Abstract »  |  Full Text »  |  PDF »

LDL-Activated p38 in Endothelial Cells Is Mediated by Ras.

Y. Zhu, H. Liao, N. Wang, K.-S. Ma, L. K. Verna, J. Y.-J. Shyy, S. Chien, and M. B. Stemerman (2001)
Arterioscler. Thromb. Vasc. Biol. 21, 1159-1164
 |  Abstract »  |  Full Text »  |  PDF »

Peroxide Sensors for the Fission Yeast Stress-activated Mitogen-activated Protein Kinase Pathway.

V. Buck, J. Quinn, T. S. Pino, H. Martin, J. Saldanha, K. Makino, B. A. Morgan, and J. B.A. Millar (2001)
Mol. Biol. Cell 12, 407-419
 |  Abstract »  |  Full Text »

beta -Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3.

P. H. McDonald, C.-W. Chow, W. E. Miller, S. A. Laporte, M. E. Field, F.-T. Lin, R. J. Davis, and R. J. Lefkowitz (2000)
Science 290, 1574-1577
 |  Abstract »  |  Full Text »

Control of the eukaryotic cell cycle by MAP kinase signaling pathways.

M. G. WILKINSON and J. B. A. MILLAR (2000)
FASEB J 14, 2147-2157
 |  Abstract »  |  Full Text »

Prolactin Stimulates Activation of c-jun N-Terminal Kinase (JNK).

K. L. Schwertfeger, S. Hunter, L. E. Heasley, V. Levresse, R. P. Leon, J. DeGregori, and S. M. Anderson (2000)
Mol. Endocrinol. 14, 1592-1602
 |  Abstract »  |  Full Text »

Osmotic and glutamate receptor regulation of c-Jun NH2-terminal protein kinase in neuroendocrine cells.

R. Meeker and A. Fernandes (2000)
Am J Physiol Endocrinol Metab 279, E475-E486
 |  Abstract »  |  Full Text »  |  PDF »

Marathon running transiently increases c-Jun NH2-terminal kinase and p38{gamma} activities in human skeletal muscle.

M. D Boppart, S. Asp, J. F P Wojtaszewski, R. A Fielding, T. Mohr, and L. J Goodyear (2000)
J. Physiol. 526, 663-669
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAP Kinase Mediates Bax Translocation in Nitric Oxide-induced Apoptosis in Neurons.

S. Ghatan, S. Larner, Y. Kinoshita, M. Hetman, L. Patel, Z. Xia, R. J. Youle, and R. S. Morrison (2000)
J. Cell Biol. 150, 335-348
 |  Abstract »  |  Full Text »  |  PDF »

TAK1 Participates in c-Jun N-Terminal Kinase Signaling during Drosophila Development.

Y. Takatsu, M. Nakamura, M. Stapleton, M. C. Danos, K. Matsumoto, M. B. O'Connor, H. Shibuya, and N. Ueno (2000)
Mol. Cell. Biol. 20, 3015-3026
 |  Abstract »  |  Full Text »

Microbiological High Throughput Screening: An Opportunity for the Lead Discovery Process.

M.-H. Beydon, A. Fournier, L. Drugeault, and J. Becquart (2000)
J Biomol Screen 5, 13-21
 |  Abstract »  |  PDF »

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways.

M. S. Iordanov, J. M. Paranjape, A. Zhou, J. Wong, B. R. G. Williams, E. F. Meurs, R. H. Silverman, and B. E. Magun (2000)
Mol. Cell. Biol. 20, 617-627
 |  Abstract »  |  Full Text »

Redox Regulation of Glutathione S-Transferase Induction by Benzyl Isothiocyanate: Correlation of Enzyme Induction with the Formation of Reactive Oxygen Intermediates.

Y. Nakamura, H. Ohigashi, S. Masuda, A. Murakami, Y. Morimitsu, Y. Kawamoto, T. Osawa, M. Imagawa, and K. Uchida (2000)
Cancer Res. 60, 219-225
 |  Abstract »  |  Full Text »

Novel Membrane-Targeted ERK1 and ERK2 Chimeras Which Act as Dominant Negative, Isotype-Specific Mitogen-Activated Protein Kinase Inhibitors of Ras-Raf-Mediated Transcriptional Activation of c-fos in NIH 3T3 Cells.

F. Hochholdinger, G. Baier, A. Nogalo, B. Bauer, H. H. Grunicke, and F. Uberall (1999)
Mol. Cell. Biol. 19, 8052-8065
 |  Abstract »  |  Full Text »  |  PDF »

Cell Shrinkage Triggers the Activation of Mitogen-activated Protein Kinases by Hypertonicity in the Rat Kidney Medullary Thick Ascending Limb of the Henle's Loop. REQUIREMENT OF p38 KINASE FOR THE REGULATORY VOLUME INCREASE RESPONSE.

F. Roger, P.-Y. Martin, M. Rousselot, H. Favre, and E. Feraille (1999)
J. Biol. Chem. 274, 34103-34110
 |  Abstract »  |  Full Text »  |  PDF »

Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor.

E. Tassi, Z. Biesova, P. P. Di Fiore, J. S. Gutkind, and W. T. Wong (1999)
J. Biol. Chem. 274, 33287-33295
 |  Abstract »  |  Full Text »  |  PDF »

Eccentric exercise markedly increases c-Jun NH2-terminal kinase activity in human skeletal muscle.

M. D. Boppart, D. Aronson, L. Gibson, R. Roubenoff, L. W. Abad, J. Bean, L. J. Goodyear, and R. A. Fielding (1999)
J Appl Physiol 87, 1668-1673
 |  Abstract »  |  Full Text »  |  PDF »

JNK Activation Is Required for JB6 Cell Transformation Induced by Tumor Necrosis Factor-alpha but Not by 12-O-Tetradecanoylphorbol-13-Acetate.

C. Huang, J. Li, W.-Y. Ma, and Z. Dong (1999)
J. Biol. Chem. 274, 29672-29676
 |  Abstract »  |  Full Text »  |  PDF »

JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl cotransporter in vitro.

J. D. Klein, S. T. Lamitina, and W. C. O'Neill (1999)
Am J Physiol Cell Physiol 277, C425-C431
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of Activation of JNK and p38 for Environmental Stress-Induced Erythroid Differentiation and Apoptosis and of Inhibition of ERK for Apoptosis.

Y. Nagata and K. Todokoro (1999)
Blood 94, 853-863
 |  Abstract »  |  Full Text »  |  PDF »

The Drosophila Ral GTPase Regulates Developmental Cell Shape Changes through the Jun NH2-terminal Kinase Pathway.

K. Sawamoto, P. Winge, S. Koyama, Y. Hirota, C. Yamada, S. Miyao, S. Yoshikawa, M.-h. Jin, A. Kikuchi, and H. Okano (1999)
J. Cell Biol. 146, 361-372
 |  Abstract »  |  Full Text »  |  PDF »

Antiproliferative Effect of IL-1 Is Mediated by p38 Mitogen-Activated Protein Kinase in Human Melanoma Cell A375.

S. Itoh, T. Hattori, H. Hayashi, Y. Mizutani, M. Todo, T. Takii, D. Yang, J. C. Lee, S. Matsufuji, Y. Murakami, et al. (1999)
J. Immunol. 162, 7434-7440
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Hematopoietic Progenitor Kinase-1 by Erythropoietin.

Y. Nagata, F. Kiefer, T. Watanabe, and K. Todokoro (1999)
Blood 93, 3347-3354
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Mechanism of Ion Homeostasis and Salt Tolerance in Yeast: the Hal4 and Hal5 Protein Kinases Modulate the Trk1-Trk2 Potassium Transporter.

J. M. Mulet, M. P. Leube, S. J. Kron, G. Rios, G. R. Fink, and R. Serrano (1999)
Mol. Cell. Biol. 19, 3328-3337
 |  Abstract »  |  Full Text »  |  PDF »

Isolation of a Mammalian Homologue of a Fission Yeast Differentiation Regulator.

H. Yamamoto, K. Tsukahara, Y. Kanaoka, S. Jinno, and H. Okayama (1999)
Mol. Cell. Biol. 19, 3829-3841
 |  Abstract »  |  Full Text »  |  PDF »

Phorbol Ester-induced Mononuclear Cell Differentiation Is Blocked by the Mitogen-activated Protein Kinase Kinase (MEK) Inhibitor PD98059.

H. He, X. Wang, M. Gorospe, N. J. Holbrook, and M. A. Trush (1999)
Cell Growth Differ. 10, 307-315
 |  Abstract »  |  Full Text »

Physiological significance of volume-regulatory transporters.

W. C. O'Neill (1999)
Am J Physiol Cell Physiol 276, C995-C1011
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning and Expression of a Stress-responsive Mitogen-activated Protein Kinase-related Kinase from Tetrahymena Cells.

S. Nakashima, S. Wang, N. Hisamoto, H. Sakai, M. Andoh, K. Matsumoto, and Y. Nozawa (1999)
J. Biol. Chem. 274, 9976-9983
 |  Abstract »  |  Full Text »  |  PDF »

p38 Mitogen-Activated Protein Kinase Mediates Signal Integration of TCR/CD28 Costimulation in Primary Murine T Cells.

J. Zhang, K. V. Salojin, J.-X. Gao, M. J. Cameron, I. Bergerot, and T. L. Delovitch (1999)
J. Immunol. 162, 3819-3829
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Signaling Pathways Mediate Touch and Osmosensory Responses in a Polymodal Sensory Neuron.

A. C. Hart, J. Kass, J. E. Shapiro, and J. M. Kaplan (1999)
J. Neurosci. 19, 1952-1958
 |  Abstract »  |  Full Text »  |  PDF »

Murine p38-delta Mitogen-activated Protein Kinase, a Developmentally Regulated Protein Kinase That Is Activated by Stress and Proinflammatory Cytokines.

M. C.-T. Hu, Y.-p. Wang, A. Mikhail, W. R. Qiu, and T.-H. Tan (1999)
J. Biol. Chem. 274, 7095-7102
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the p38 Mitogen-Activated Protein Kinase Pathway by Gonadotropin-Releasing Hormone.

M. S. Roberson, T. Zhang, H. L. Li, and J. M. Mulvaney (1999)
Endocrinology 140, 1310-1318
 |  Abstract »  |  Full Text »

An Ultraviolet-activated K+ Channel Mediates Apoptosis Of Myeloblastic Leukemia Cells.

L. Wang, D. Xu, W. Dai, and L. Lu (1999)
J. Biol. Chem. 274, 3678-3685
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Hematopoietic Progenitor Kinase 1 with Adapter Proteins Crk and CrkL Leads to Synergistic Activation of c-Jun N-Terminal Kinase.

P. Ling, Z. Yao, C. F. Meyer, X. S. Wang, W. Oehrl, S. M. Feller, and T.-H. Tan (1999)
Mol. Cell. Biol. 19, 1359-1368
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Rat Aldose Reductase Gene Transcription Is Mediated through the cis-Element, Osmotic Response Element (ORE): Increased Synthesis and/or Activation by Phosphorylation of ORE-Binding Protein Is a Key Step.

K. Aida, M. Tawata, Y. Ikegishi, and T. Onaya (1999)
Endocrinology 140, 609-617
 |  Abstract »  |  Full Text »

Hyperosmolarity-induced Interleukin-8 Expression in Human Bronchial Epithelial Cells through p38 Mitogen-activated Protein Kinase.

S. HASHIMOTO, K. MATSUMOTO, Y. GON, T. NAKAYAMA, I. TAKESHITA, and T. HORIE (1999)
Am. J. Respir. Crit. Care Med. 159, 634-640
 |  Abstract »  |  Full Text »

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation. 4-HYDROXY-2-NONENAL IS A POTENTIAL INDUCER OF INTRACELLULAR PEROXIDE PRODUCTION.

K. Uchida, M. Shiraishi, Y. Naito, Y. Torii, Y. Nakamura, and T. Osawa (1999)
J. Biol. Chem. 274, 2234-2242
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human.

C. WIDMANN, S. GIBSON, M. B. JARPE, and G. L. JOHNSON (1999)
Physiol Rev 79, 143-180
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the Interaction between c-Jun and c-Jun N-terminal Kinase in Vivo.

G. H. W. May, K. E. Allen, W. Clark, M. Funk, and D. A. F. Gillespie (1998)
J. Biol. Chem. 273, 33429-33435
 |  Abstract »  |  Full Text »  |  PDF »

Mannitol at Clinical Concentrations Activates Multiple Signaling Pathways and Induces Apoptosis in Endothelial Cells • Editorial Comment.

A. M. Malek, G. G. Goss, L. Jiang, S. Izumo, S. L. Alper, and C. Y. Hsu (1998)
Stroke 29, 2631-2640
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Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH2-terminal Kinase (JNK/SAPK).

L.-F. Lee, G. Li, D. J. Templeton, and J. P.-Y. Ting (1998)
J. Biol. Chem. 273, 28253-28260
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Hypotonicity activates transcription through ERK-dependent and -independent pathways in renal cells.

Z. Zhang, X.-Y. Yang, and D. M. Cohen (1998)
Am J Physiol Cell Physiol 275, C1104-C1112
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Hypertonicity activates MAP kinases and inhibits HCO-3 absorption via distinct pathways in thick ascending limb.

B. A. Watts III, J. F. Di Mari, R. J. Davis, and D. W. Good (1998)
Am J Physiol Renal Physiol 275, F478-F486
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Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation.

Y. Nagata, N. Takahashi, R. J. Davis, and K. Todokoro (1998)
Blood 92, 1859-1869
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Activation of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway by Osmotic Shock.

P. Gatsios, L. Terstegen, F. Schliess, D. Haussinger, I. M. Kerr, P. C. Heinrich, and L. Graeve (1998)
J. Biol. Chem. 273, 22962-22968
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MEKK1/JNK signaling stabilizes and activates p53.

S. Y. Fuchs, V. Adler, M. R. Pincus, and Z.'e. Ronai (1998)
PNAS 95, 10541-10546
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JNK targets p53 ubiquitination and degradation in nonstressed cells.

S. Y. Fuchs, V. Adler, T. Buschmann, Z. Yin, X. Wu, S. N. Jones, and Z.'e. Ronai (1998)
Genes & Dev. 12, 2658-2663
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An RNA Binding Protein Negatively Controlling Differentiation in Fission Yeast.

K. Tsukahara, H. Yamamoto, and H. Okayama (1998)
Mol. Cell. Biol. 18, 4488-4498
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Extracellular-regulated protein kinase cascades are activated in response to injury in human skeletal muscle.

D. Aronson, J. F. P. Wojtaszewski, A. Thorell, J. Nygren, D. Zangen, E. A. Richter, O. Ljungqvist, R. A. Fielding, and L. J. Goodyear (1998)
Am J Physiol Cell Physiol 275, C555-C561
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The Fission Yeast Mitotic Regulator win1+ Encodes an MAP Kinase Kinase Kinase That Phosphorylates and Activates Wis1 MAP Kinase Kinase in Response to High Osmolarity.

I. Samejima, S. Mackie, E. Warbrick, R. Weisman, and P. A. Fantes (1998)
Mol. Biol. Cell 9, 2325-2335
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p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts.

J. Milanini, F. Vinals, J. Pouyssegur, and G. Pages (1998)
J. Biol. Chem. 273, 18165-18172
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Ultraviolet Radiation Triggers the Ribotoxic Stress Response in Mammalian Cells.

M. S. Iordanov, D. Pribnow, J. L. Magun, T.-H. Dinh, J. A. Pearson, and B. E. Magun (1998)
J. Biol. Chem. 273, 15794-15803
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Bidirectional Regulation of p38 Kinase and c-Jun N-terminal Protein Kinase by Insulin-like Growth Factor-I.

H.-L. Cheng and E. L. Feldman (1998)
J. Biol. Chem. 273, 14560-14565
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Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi.

F. Banuett (1998)
Microbiol. Mol. Biol. Rev. 62, 249-274
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A combination of NaCl and urea enhances survival of IMCD cells to hyperosmolality.

B. C. Santos, A. Chevaile, M.-J. Hebert, J. Zagajeski, and S. R. Gullans (1998)
Am J Physiol Renal Physiol 274, F1167-F1173
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Hyperosmolality Causes Growth Arrest of Murine Kidney Cells. INDUCTION OF GADD45 AND GADD153 BY OSMOSENSING VIA STRESS-ACTIVATED PROTEIN KINASE 2.

D. Kultz, S. Madhany, and M. B. Burg (1998)
J. Biol. Chem. 273, 13645-13651
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SAPKs and transcription factors do the nucleocytoplasmic tango.

M. G. Wilkinson and J. B.A. Millar (1998)
Genes & Dev. 12, 1391-1397
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Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli.

I. N. Foltz, R. E. Gerl, J. S. Wieler, M. Luckach, R. A. Salmon, and J. W. Schrader (1998)
J. Biol. Chem. 273, 9344-9351
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