Related Content
Search Google Scholar for:
|
|
Science 5 August 1994:
Vol. 265. no. 5173, pp. 803 - 806
DOI: 10.1126/science.8047887
|
|
Articles
Science, Vol 265, Issue 5173, 803-806
Copyright © 1994 by American Association for the Advancement of Science
Induction of mesoderm in Xenopus laevis embryos by translation initiation factor 4E
PS Klein
and
DA Melton
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
The microinjection of messenger RNA encoding the eukaryotic translation initiation factor 4E (eIF-4E) into early embryos of Xenopus laevis leads to the induction of mesoderm in ectodermal explants. This induction occurs without a stimulation of overall protein synthesis and is blocked by the co-expression of a dominant negative mutant of the proto-oncogene ras or a truncated activin type II receptor. Although other translation factors have been studied in vertebrate and invertebrate embryos, none have been shown to play a direct role in development. The results here suggest a mechanism for relaying and amplifying signals for mesoderm induction.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Embryonic-stage-dependent changes in the level of eIF4E-binding proteins during early development of sea urchin embryos.
- P. Salaun, S. Boulben, O. Mulner-Lorillon, R. Belle, N. Sonenberg, J. Morales, and P. Cormier (2005)
J. Cell Sci.
118, 1385-1394
| Abstract »
| Full Text »
| PDF »
- Amino Acid Transport Regulates Blastocyst Implantation.
- P. M. Martin, A. E. Sutherland, and L. J. Van Winkle (2003)
Biol Reprod
69, 1101-1108
| Abstract »
| Full Text »
| PDF »
- Translation Factor eIF4E Rescues Cells from Myc-dependent Apoptosis by Inhibiting Cytochrome c Release.
- S. Li, T. Takasu, D. M. Perlman, M. S. Peterson, D. Burrichter, S. Avdulov, P. B. Bitterman, and V. A. Polunovsky (2003)
J. Biol. Chem.
278, 3015-3022
| Abstract »
| Full Text »
| PDF »
- Direct Interaction of the Spinal Muscular Atrophy Disease Protein SMN with the Small Nucleolar RNA-associated Protein Fibrillarin.
- K. W. Jones, K. Gorzynski, C. M. Hales, U. Fischer, F. Badbanchi, R. M. Terns, and M. P. Terns (2001)
J. Biol. Chem.
276, 38645-38651
| Abstract »
| Full Text »
| PDF »
- Transient Expression of a Translation Initiation Factor Is Conservatively Associated with Embryonic Gene Activation in Murine and Bovine Embryos.
- P. A. De Sousa,, A. J. Watson,, and R. M. Schultz (1998)
Biol Reprod
59, 969-977
| Abstract »
| Full Text »
- Cloning and Characterization of 4EHP, a Novel Mammalian eIF4E-related Cap-binding Protein.
- E. Rom, H. C. Kim, A.-C. Gingras, J. Marcotrigiano, D. Favre, H. Olsen, S. K. Burley, and N. Sonenberg (1998)
J. Biol. Chem.
273, 13104-13109
| Abstract »
| Full Text »
| PDF »
- Epidermal induction and inhibition of neural fate by translation initiation factor 4AIII.
- D. Weinstein, E Honore, and A Hemmati-Brivanlou (1997)
Development
124, 4235-4242
| Abstract »
| PDF »
- The role in neural patterning of translation initiation factor eIF4AII; induction of neural fold genes.
- R Morgan and M. Sargent (1997)
Development
124, 2751-2760
| Abstract »
| PDF »
- Alternatively Spliced Transcripts from the Drosophila eIF4E Gene Produce Two Different Cap-binding Proteins.
- C. A. Lavoie, P. E.D. Lachance, N. Sonenberg, and P. Lasko (1996)
J. Biol. Chem.
271, 16393-16398
| Abstract »
| Full Text »
| PDF »
- A common function for mRNA 5' and 3' ends in translation initiation in yeast..
- S Z Tarun and A B Sachs (1995)
Genes & Dev.
9, 2997-3007
| Abstract »
| PDF »
- Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209.
- B. Joshi, A.-L. Cai, B. D. Keiper, W. B. Minich, R. Mendez, C. M. Beach, J. Stepinski, R. Stolarski, E. Darzynkiewicz, and R. E. Rhoads (1995)
J. Biol. Chem.
270, 14597-14603
| Abstract »
| Full Text »
| PDF »
- Vertebrate embryonic induction: mesodermal and neural patterning.
- D. Kessler and D. Melton (1994)
Science
266, 596-604
| Abstract »
| PDF »
|
|
