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Science 5 August 1994:
Vol. 265. no. 5173, pp. 785 - 789
DOI: 10.1126/science.7914031
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Articles

Science, Vol 265, Issue 5173, 785-789
Copyright © 1994 by American Association for the Advancement of Science

articles

Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans

R Quiring, U Walldorf, U Kloter, and WJ Gehring

Department of Cell Biology, University of Basel, Switzerland.

A Drosophila gene that contains both a paired box and a homeobox and has extensive sequence homology to the mouse Pax-6 (Small eye) gene was isolated and mapped to chromosome IV in a region close to the eyeless locus. Two spontaneous mutations, ey2 and eyR, contain transposable element insertions into the cloned gene and affect gene expression, particularly in the eye primordia. This indicates that the cloned gene encodes ey. The finding that ey of Drosophila, Small eye of the mouse, and human Aniridia are encoded by homologous genes suggests that eye morphogenesis is under similar genetic control in both vertebrates and insects, in spite of the large differences in eye morphology and mode of development.


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FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development.
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The retinal determination gene, dachshund, is required for mushroom body cell differentiation.
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The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye.
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J Curtiss and M Mlodzik (2000)
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   Abstract »    Full Text »
Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.
J. I. Kim, T. Li, I.-C. Ho, M. J. Grusby, and L. H. Glimcher (1999)
PNAS 96, 3781-3785
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Science. ISSN 0036-8075 (print), 1095-9203 (online)