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Science 5 August 1994:
Vol. 265. no. 5173, pp. 781 - 784
DOI: 10.1126/science.8047883

Articles

Science, Vol 265, Issue 5173, 781-784
Copyright © 1994 by American Association for the Advancement of Science


articles

Gene therapy for vascular smooth muscle cell proliferation after arterial injury

T Ohno, D Gordon, H San, VJ Pompili, MJ Imperiale, GJ Nabel, and EG Nabel

Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109.

Accumulation of vascular smooth muscle cells as a consequence of arterial injury is a major feature of vascular proliferative disorders. Molecular approaches to the inhibition of smooth muscle cell proliferation in these settings could potentially limit intimal expansion. This problem was approached by introducing adenoviral vectors encoding the herpesvirus thymidine kinase (tk) into porcine arteries that had been injured by a balloon on a catheter. These smooth muscle cells were shown to be infectable with adenoviral vectors, and introduction of the tk gene rendered them sensitive to the nucleoside analog ganciclovir. When this vector was introduced into porcine arteries immediately after a balloon injury, intimal hyperplasia decreased after a course of ganciclovir treatment. No major local or systemic toxicities were observed. These data suggest that transient expression of an enzyme that catalyzes the formation of a cytotoxic drug locally may limit smooth muscle cell proliferation in response to balloon injury.


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Y. Sawa, K. Suzuki, H.-Z. Bai, R. Shirakura, R. Morishita, Y. Kaneda, and H. Matsuda (1995)
Circulation 92, 479-482
   Abstract »    Full Text »
Antisense Therapy for Angioplasty Restenosis : Some Critical Considerations.
M. R. Bennett and S. M. Schwartz (1995)
Circulation 92, 1981-1993
   Full Text »
Gene Therapy -- Promise, Pitfalls, and Prognosis.
J. M. Leiden (1995)
N. Engl. J. Med. 333, 871-873
   Full Text »
Adenovirus-Mediated Gene Transfer In Vivo to Cerebral Blood Vessels and Perivascular Tissue.
H. Ooboshi, M. J. Welsh, C. D. Rios, B. L. Davidson, and D. D. Heistad (1995)
Circ. Res. 77, 7-13
   Abstract »    Full Text »
Apoptosis in Human Atherosclerosis and Restenosis.
J. M. Isner, M. Kearney, S. Bortman, and J. Passeri (1995)
Circulation 91, 2703-2711
   Abstract »    Full Text »
Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product.
M. Chang, E Barr, J Seltzer, Y. Jiang, G. Nabel, E. Nabel, M. Parmacek, and J. Leiden (1995)
Science 267, 518-522
   Abstract »    PDF »
Genetic Models of Human Vascular Disease.
V. J. Dzau, G. H. Gibbons, B. K. Kobilka, R. M. Lawn, and R. E. Pratt (1995)
Circulation 91, 521-531
   Abstract »    Full Text »
Gene Therapy for Cardiovascular Disease.
E. G. Nabel (1995)
Circulation 91, 541-548
   Full Text »
Can Gene Therapy Prevent Vascular Restenosis?.
(1994)
Journal Watch Dermatology 1994, 13
   Full Text »
CAN GENE THERAPY PREVENT VASCULAR RESTENOSIS?.
(1994)
Journal Watch (General) 1994, 7
   Full Text »
Improved Adenoviral Vector for Vascular Gene Therapy : Beneficial Effects on Vascular Function and Inflammation.
H. S. Qian, K. Channon, V. Neplioueva, Q. Wang, M. Finer, L. Tsui, S. E. George, and J. McArthur (2001)
Circ. Res. 88, 911-917
   Abstract »    Full Text »    PDF »



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