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Science 5 August 1994: Vol. 265. no. 5173, pp. 781 - 784 DOI: 10.1126/science.8047883
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Articles
Science, Vol 265, Issue 5173, 781-784
Copyright © 1994 by American Association for the Advancement of Science
Gene therapy for vascular smooth muscle cell proliferation after arterial injury
T Ohno,
D Gordon,
H San,
VJ Pompili,
MJ Imperiale,
GJ Nabel,
and
EG Nabel
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109.
Accumulation of vascular smooth muscle cells as a consequence of arterial injury is a major feature of vascular proliferative disorders. Molecular approaches to the inhibition of smooth muscle cell proliferation in these settings could potentially limit intimal expansion. This problem was approached by introducing adenoviral vectors encoding the herpesvirus thymidine kinase (tk) into porcine arteries that had been injured by a balloon on a catheter. These smooth muscle cells were shown to be infectable with adenoviral vectors, and introduction of the tk gene rendered them sensitive to the nucleoside analog ganciclovir. When this vector was introduced into porcine arteries immediately after a balloon injury, intimal hyperplasia decreased after a course of ganciclovir treatment. No major local or systemic toxicities were observed. These data suggest that transient expression of an enzyme that catalyzes the formation of a cytotoxic drug locally may limit smooth muscle cell proliferation in response to balloon injury.
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- M. D. Rekhter, R. D. Simari, C. W. Work, G. J. Nabel, E. G. Nabel, and D. Gordon (1998)
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82, 295-305
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- F. C. Tanner, Z.-Y. Yang, E. Duckers, D. Gordon, G. J. Nabel, and E. G. Nabel (1998)
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- M. Sata, H. Perlman, D. A. Muruve, M. Silver, M. Ikebe, T. A. Libermann, P. Oettgen, and K. Walsh (1998)
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35, 505-513
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| PDF »
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35, 536-546
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96, 621-627
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| Abstract »
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- O. Tahlil, M. Brami, L. J Feldman, D. Branellec, and Ph.G. Steg (1997)
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| Full Text »
- Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells : Association With the Activated Phenotype.
- A. B. Firulli, J. M. Miano, W. Bi, A. D. Johnson, W. Casscells, E. N. Olson, and J. J. Schwarz (1996)
Circ. Res.
78, 196-204
| Abstract »
| Full Text »
- The SM 22 promoter directs tissue-specific expression in arterial but not in venous or visceral smooth muscle cells in transgenic mice.
- H Moessler, M Mericskay, Z Li, S Nagl, D Paulin, and J. Small (1996)
Development
122, 2415-2425
| Abstract »
| PDF »
- Adenovirus-Mediated Gene Transfer to Normal and Atherosclerotic Arteries : A Novel Approach.
- C. D. Rios, H. Ooboshi, D. Piegors, B. L. Davidson, and D. D. Heistad (1995)
Arterioscler. Thromb. Vasc. Biol.
15, 2241-2245
| Abstract »
| Full Text »
- Quantitative Analysis of Repeat Adenovirus-Mediated Gene Transfer Into Injured Canine Femoral Arteries.
- H. Ueno, J.-J. Li, H. Tomita, H. Yamamoto, Y. Pan, Y. Kanegae, I. Saito, and A. Takeshita (1995)
Arterioscler. Thromb. Vasc. Biol.
15, 2246-2253
| Abstract »
| Full Text »
- Immunohistochemical Detection of Ki-67 in Replicative Smooth Muscle Cells of Rabbit Carotid Arteries After Balloon Denudation.
- M. Aoyagi, M. Yamamoto, H. Wakimoto, H. Azuma, K. Hirakawa, and K. Yamamoto (1995)
Stroke
26, 2328-2332
| Abstract »
| Full Text »
- Efficiency of In Vivo Gene Transfection Into Transplanted Rat Heart by Coronary Infusion of HVJ Liposome.
- Y. Sawa, K. Suzuki, H.-Z. Bai, R. Shirakura, R. Morishita, Y. Kaneda, and H. Matsuda (1995)
Circulation
92, 479-482
| Abstract »
| Full Text »
- Antisense Therapy for Angioplasty Restenosis : Some Critical Considerations.
- M. R. Bennett and S. M. Schwartz (1995)
Circulation
92, 1981-1993
| Full Text »
- Gene Therapy -- Promise, Pitfalls, and Prognosis.
- J. M. Leiden (1995)
N. Engl. J. Med.
333, 871-873
| Full Text »
- Adenovirus-Mediated Gene Transfer In Vivo to Cerebral Blood Vessels and Perivascular Tissue.
- H. Ooboshi, M. J. Welsh, C. D. Rios, B. L. Davidson, and D. D. Heistad (1995)
Circ. Res.
77, 7-13
| Abstract »
| Full Text »
- Apoptosis in Human Atherosclerosis and Restenosis.
- J. M. Isner, M. Kearney, S. Bortman, and J. Passeri (1995)
Circulation
91, 2703-2711
| Abstract »
| Full Text »
- Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product.
- M. Chang, E Barr, J Seltzer, Y. Jiang, G. Nabel, E. Nabel, M. Parmacek, and J. Leiden (1995)
Science
267, 518-522
| Abstract »
| PDF »
- Genetic Models of Human Vascular Disease.
- V. J. Dzau, G. H. Gibbons, B. K. Kobilka, R. M. Lawn, and R. E. Pratt (1995)
Circulation
91, 521-531
| Abstract »
| Full Text »
- Gene Therapy for Cardiovascular Disease.
- E. G. Nabel (1995)
Circulation
91, 541-548
| Full Text »
- Can Gene Therapy Prevent Vascular Restenosis?.
- (1994)
Journal Watch Dermatology
1994, 13
| Full Text »
- CAN GENE THERAPY PREVENT VASCULAR RESTENOSIS?.
- (1994)
Journal Watch (General)
1994, 7
| Full Text »
- Improved Adenoviral Vector for Vascular Gene Therapy : Beneficial Effects on Vascular Function and Inflammation.
- H. S. Qian, K. Channon, V. Neplioueva, Q. Wang, M. Finer, L. Tsui, S. E. George, and J. McArthur (2001)
Circ. Res.
88, 911-917
| Abstract »
| Full Text »
| PDF »
|
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