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Science 29 July 1994:
Vol. 265. no. 5172, pp. 682 - 684
DOI: 10.1126/science.8036519

Articles

Science, Vol 265, Issue 5172, 682-684
Copyright © 1994 by American Association for the Advancement of Science


articles

Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog

G Cacalano, J Lee, K Kikly, AM Ryan, S Pitts-Meek, B Hultgren, WI Wood, and MW Moore

Department of Cell Genetics, Genentech, South San Francisco, CA 94080.

Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors was cloned and then deleted from the mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting from an increase in B cells, and splenomegaly, resulting from an increase in metamyelocytes, band, and mature neutrophils. Thus, this receptor may participate in the expansion and development of neutrophils and B cells. This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease.


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M. Yang, H. Sang, A. Rahman, D. Wu, A. B. Malik, and R. D. Ye (2001)
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Reduced Leukocyte Migration, but Normal Rolling and Arrest, in Interleukin-8 Receptor Homologue Knockout Mice.
M. D. Becker, L. M. O’Rourke, W. S. Blackman, S. R. Planck, and J. T. Rosenbaum (2000)
Invest. Ophthalmol. Vis. Sci. 41, 1812-1817
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International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors.
P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power (2000)
Pharmacol. Rev. 52, 145-176
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Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Galpha 15 Knockout Mice.
I. Davignon, M. D. Catalina, D. Smith, J. Montgomery, J. Swantek, J. Croy, M. Siegelman, and T. M. Wilkie (2000)
Mol. Cell. Biol. 20, 797-804
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Bacterial Clearance and Survival Are Dependent on CXC Chemokine Receptor-2 Ligands in a Murine Model of Pulmonary Nocardia asteroides Infection.
T. A. Moore, M. W. Newstead, R. M. Strieter, B. Mehrad, B. L. Beaman, and T. J. Standiford (2000)
J. Immunol. 164, 908-915
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NH2- and COOH-Terminal Truncations of Murine Granulocyte Chemotactic Protein-2 Augment the In Vitro and In Vivo Neutrophil Chemotactic Potency.
A. Wuyts, A. D'Haese, V. Cremers, P. Menten, J.-P. Lenaerts, A. De Loof, H. Heremans, P. Proost, and J. Van Damme (1999)
J. Immunol. 163, 6155-6163
   Abstract »    Full Text »    PDF »
Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines.
C. M. HOGABOAM, C. L. BONE-LARSON, M. L. STEINHAUSER, N. W. LUKACS, L. M. COLLETTI, K. J. SIMPSON, R. M. STRIETER, and S. L. KUNKEL (1999)
FASEB J 13, 1565-1574
   Abstract »    Full Text »
Cutting Edge: CXCR4-Lo: Molecular Cloning and Functional Expression of a Novel Human CXCR4 Splice Variant.
S. K. Gupta and K. Pillarisetti (1999)
J. Immunol. 163, 2368-2372
   Abstract »    Full Text »    PDF »
Inhibition of Murine Neutrophil Recruitment In Vivo by CXC Chemokine Receptor Antagonists.
S. R. McColl and I. Clark-Lewis (1999)
J. Immunol. 163, 2829-2835
   Abstract »    Full Text »    PDF »
Commentary: Role of the Pathologist in the Identification and Characterization of Therapeutic Molecules.
A. M. Ryan (1999)
Toxicol Pathol 27, 474-476
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Neutralization of Macrophage Inflammatory Protein 2 (MIP-2) and MIP-1alpha Attenuates Neutrophil Recruitment in the Central Nervous System during Experimental Bacterial Meningitis.
A. Diab, H. Abdalla, H. L. Li, F. D. Shi, J. Zhu, B. Hojberg, L. Lindquist, B. Wretlind, M. Bakhiet, and H. Link (1999)
Infect. Immun. 67, 2590-2601
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Distinct CXC Chemokines Mediate Tumorigenicity of Prostate Cancer Cells.
B. B. Moore, D. A. Arenberg, K. Stoy, T. Morgan, C. L. Addison, S. B. Morris, M. Glass, C. Wilke, Y. Y. Xue, S. Sitterding, et al. (1999)
Am. J. Pathol. 154, 1503-1512
   Abstract »    Full Text »    PDF »
A Cell's Sense of Direction.
C. A. Parent and P. N. Devreotes (1999)
Science 284, 765-770
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IL-12 Administered During Chlamydia psittaci Lung Infection in Mice Confers Immediate and Long-Term Protection and Reduces Macrophage Inflammatory Protein-2 Level and Neutrophil Infiltration in Lung Tissue.
J. Huang, M.-D. Wang, S. Lenz, D. Gao, and B. Kaltenboeck (1999)
J. Immunol. 162, 2217-2226
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Involvement of Mitogen-Activated Protein Kinase Pathways in Interleukin-8 Production by Human Monocytes and Polymorphonuclear Cells Stimulated with Lipopolysaccharide or Mycoplasma fermentans Membrane Lipoproteins.
C. Marie, S. Roman-Roman, and G. Rawadi (1999)
Infect. Immun. 67, 688-693
   Abstract »    Full Text »    PDF »
PU.1 Regulates the CXCR1 Promoter.
N. C. Wilkinson and J. Navarro (1999)
J. Biol. Chem. 274, 438-443
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Antigen-Induced Eosinophilic Lung Inflammation Develops in Mice Deficient in Chemokine Eotaxin.
Y. Yang, J. Loy, R.-P. Ryseck, D. Carrasco, and R. Bravo (1998)
Blood 92, 3912-3923
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Rapid Secretion of Prestored Interleukin 8 from Weibel-Palade Bodies of Microvascular Endothelial Cells.
J. O. Utgaard, F. L. Jahnsen, A. Bakka, P. Brandtzaeg, and G. Haraldsen (1998)
J. Exp. Med. 188, 1751-1756
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Inhibition of Leukocyte Emigration Induced During the Systemic Inflammatory Reaction In Vivo Is Not Due to IL-8.
B. Schleiffenbaum, J. Fehr, B. Odermatt, and R. Sperb (1998)
J. Immunol. 161, 3631-3638
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Induction of Acute Inflammation In Vivo by Staphylococcal Superantigens. II. Critical Role for Chemokines, ICAM-1, and TNF-{alpha}.
P. A. Tessier, P. H. Naccache, K. R. Diener, R. P. Gladue, K. S. Neote, I. Clark-Lewis, and S. R. McColl (1998)
J. Immunol. 161, 1204-1211
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Physiologic Regulation of Postovulatory Neutrophil Migration into Vagina in Mice by a C-X-C Chemokine(s).
Y. Sonoda, N. Mukaida, J.-b. Wang, M. Shimada-Hiratsuka, M. Naito, T. Kasahara, A. Harada, M. Inoue, and K. Matsushima (1998)
J. Immunol. 160, 6159-6165
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