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Science 29 July 1994: Vol. 265. no. 5172, pp. 682 - 684 DOI: 10.1126/science.8036519
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Articles
Science, Vol 265, Issue 5172, 682-684
Copyright © 1994 by American Association for the Advancement of Science
Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog
G Cacalano,
J Lee,
K Kikly,
AM Ryan,
S Pitts-Meek,
B Hultgren,
WI Wood,
and
MW Moore
Department of Cell Genetics, Genentech, South San Francisco, CA 94080.
Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors was cloned and then deleted from the mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting from an increase in B cells, and splenomegaly, resulting from an increase in metamyelocytes, band, and mature neutrophils. Thus, this receptor may participate in the expansion and development of neutrophils and B cells. This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease.
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Blood
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- Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1+ Lymphocyte-Associated Th2-Type Immune Response in the Intestine.
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