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Science 29 July 1994:
Vol. 265. no. 5172, pp. 615 - 621
DOI: 10.1126/science.8036511
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Articles

Science, Vol 265, Issue 5172, 615-621
Copyright © 1994 by American Association for the Advancement of Science

articles

Conserved structures and diversity of functions of RNA-binding proteins

CG Burd and G Dreyfuss

Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104-6148.

In eukaryotic cells, a multitude of RNA-binding proteins play key roles in the posttranscriptional regulation of gene expression. Characterization of these proteins has led to the identification of several RNA-binding motifs, and recent experiments have begun to illustrate how several of them bind RNA. The significance of these interactions is reflected in the recent discoveries that several human and other vertebrate genetic disorders are caused by aberrant expression of RNA-binding proteins. The major RNA-binding motifs are described and examples of how they may function are given.


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Mol. Cell. Biol. 23, 8405-8415
   Abstract »    Full Text »    PDF »
A Proteomic Analysis of Arginine-methylated Protein Complexes.
F.-M. Boisvert, J. Cote, M.-C. Boulanger, and S. Richard (2003)
Mol. Cell. Proteomics 2, 1319-1330
   Abstract »    Full Text »    PDF »
RNA-protein interactions promote asymmetric sorting of the ASH1 mRNA ribonucleoprotein complex.
G. B. GONSALVEZ, K. A. LEHMANN, D. K. HO, E. S. STANITSA, J. R. WILLIAMSON, and R. M. LONG (2003)
RNA 9, 1383-1399
   Abstract »    Full Text »    PDF »
Origin of Higher Affinity to RNA of the N-terminal RNA-binding Domain than That of the C-terminal One of a Mouse Neural Protein, Musashi1, as Revealed by Comparison of Their Structures, Modes of Interaction, Surface Electrostatic Potentials, and Backbone Dynamics.
Y. Miyanoiri, H. Kobayashi, T. Imai, M. Watanabe, T. Nagata, S. Uesugi, H. Okano, and M. Katahira (2003)
J. Biol. Chem. 278, 41309-41315
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dsRBM1 and a proline-rich domain of RNA helicase A can form a composite binder to recognize a specific dsDNA.
M.-L. Hung, P. Chao, and K.-Y. Chang (2003)
Nucleic Acids Res. 31, 5741-5753
   Abstract »    Full Text »    PDF »
LRP130, a Pentatricopeptide Motif Protein with a Noncanonical RNA-Binding Domain, Is Bound In Vivo to Mitochondrial and Nuclear RNAs.
S. Mili and S. Pinol-Roma (2003)
Mol. Cell. Biol. 23, 4972-4982
   Abstract »    Full Text »    PDF »
Splits ends is a tissue/promoter specific regulator of Wingless signaling.
H. V. Lin, D. B. Doroquez, S. Cho, F. Chen, I. Rebay, and K. M. Cadigan (2003)
Development 130, 3125-3135
   Abstract »    Full Text »    PDF »
RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiae.
C. BERSET, A. ZURBRIGGEN, S. DJAFARZADEH, M. ALTMANN, and H. TRACHSEL (2003)
RNA 9, 871-880
   Abstract »    Full Text »    PDF »


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