Science 22 July 1994: Vol. 265. no. 5171, pp. 531 - 533 DOI: 10.1126/science.8036496

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Articles

Pressure-Induced Vascular Oxidative Stress Is Mediated Through Activation of Integrin-Linked Kinase 1/{beta}PIX/Rac-1 Pathway.

C. Vecchione, D. Carnevale, A. Di Pardo, M. T. Gentile, A. Damato, G. Cocozza, G. Antenucci, G. Mascio, U. Bettarini, A. Landolfi, et al. (2009)
Hypertension 54, 1028-1034
 |  Abstract »  |  Full Text »  |  PDF »

Green Tea Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Rats by Modulating Reactive Oxygen Species Production and the Src/Epidermal Growth Factor Receptor/Akt Signaling Pathway.

I. Papparella, G. Ceolotto, D. Montemurro, M. Antonello, S. Garbisa, G. Rossi, and A. Semplicini (2008)
J. Nutr. 138, 1596-1601
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67phox and p40phox That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils.

N. J. D. McLaughlin, A. Banerjee, S. Y. Khan, J. L. Lieber, M. R. Kelher, F. Gamboni-Robertson, F. R. Sheppard, E. E. Moore, G. W. Mierau, D. J. Elzi, et al. (2008)
J. Immunol. 180, 8192-8203
 |  Abstract »  |  Full Text »  |  PDF »

The Rho5 GTPase is necessary for oxidant-induced cell death in budding yeast.

K. Singh, P. J. Kang, and H.-O. Park (2008)
PNAS 105, 1522-1527
 |  Abstract »  |  Full Text »  |  PDF »

Rac2 GTPase activation by angiotensin II is modulated by Ca2+/calcineurin and mitogen-activated protein kinases in human neutrophils.

R. El Bekay, G. Alba, M E. Reyes, P. Chacon, A. Vega, J. Martin-Nieto, J. Jimenez, E. Ramos, J. Olivan, E. Pintado, et al. (2007)
J. Mol. Endocrinol. 39, 351-363
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Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.

M. A. Nardi, Y. Gor, S. J. Feinmark, F. Xu, and S. Karpatkin (2007)
Blood 110, 1989-1996
 |  Abstract »  |  Full Text »  |  PDF »

Generation of reactive oxygen species by fungal NADPH oxidases is required for rice blast disease.

M. J. Egan, Z.-Y. Wang, M. A. Jones, N. Smirnoff, and N. J. Talbot (2007)
PNAS 104, 11772-11777
 |  Abstract »  |  Full Text »  |  PDF »

NADPH oxidase-dependent reactive oxygen species formation required for root hair growth depends on ROP GTPase.

M. A. Jones, M. J. Raymond, Z. Yang, and N. Smirnoff (2007)
J. Exp. Bot. 58, 1261-1270
 |  Abstract »  |  Full Text »  |  PDF »

The Granulocyte Receptor Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 (CEACAM3) Directly Associates with Vav to Promote Phagocytosis of Human Pathogens.

T. Schmitter, S. Pils, V. Sakk, R. Frank, K.-D. Fischer, and C. R. Hauck (2007)
J. Immunol. 178, 3797-3805
 |  Abstract »  |  Full Text »  |  PDF »

Cooperation of DEF6 with Activated Rac in Regulating Cell Morphology.

T. Oka, S. Ihara, and Y. Fukui (2007)
J. Biol. Chem. 282, 2011-2018
 |  Abstract »  |  Full Text »  |  PDF »

The phosphoinositide-binding protein p40phox activates the NADPH oxidase during Fc{gamma}IIA receptor-induced phagocytosis.

C.-I. Suh, N. D. Stull, X. J. Li, W. Tian, M. O. Price, S. Grinstein, M. B. Yaffe, S. Atkinson, and M. C. Dinauer (2006)
J. Exp. Med. 203, 1915-1925
 |  Abstract »  |  Full Text »  |  PDF »

Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.

L. Moldovan, K. Mythreye, P. J. Goldschmidt-Clermont, and L. L. Satterwhite (2006)
Cardiovasc Res 71, 236-246
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of Rac1 in the development of cardiac hypertrophy.

M. Satoh, H. Ogita, K. Takeshita, Y. Mukai, D. J. Kwiatkowski, and J. K. Liao (2006)
PNAS 103, 7432-7437
 |  Abstract »  |  Full Text »  |  PDF »

Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships.

A. Mizrahi, Y. Berdichevsky, Y. Ugolev, S. Molshanski-Mor, Y. Nakash, I. Dahan, N. Alloul, Y. Gorzalczany, R. Sarfstein, M. Hirshberg, et al. (2006)
J. Leukoc. Biol. 79, 881-895
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91phox.

J. Anrather, G. Racchumi, and C. Iadecola (2006)
J. Biol. Chem. 281, 5657-5667
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of NADPH Oxidases: The Role of Rac Proteins.

P. L. Hordijk (2006)
Circ. Res. 98, 453-462
 |  Abstract »  |  Full Text »  |  PDF »

Selective Rac-1 Inhibition Protects From Diabetes-Induced Vascular Injury.

C. Vecchione, A. Aretini, G. Marino, U. Bettarini, R. Poulet, A. Maffei, M. Sbroggio, L. Pastore, M. T. Gentile, A. Notte, et al. (2006)
Circ. Res. 98, 218-225
 |  Abstract »  |  Full Text »  |  PDF »

Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes.

Q. Li, M. M. Harraz, W. Zhou, L. N. Zhang, W. Ding, Y. Zhang, T. Eggleston, C. Yeaman, B. Banfi, and J. F. Engelhardt (2006)
Mol. Cell. Biol. 26, 140-154
 |  Abstract »  |  Full Text »  |  PDF »

Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid.

C. Kim and M. C. Dinauer (2006)
J. Leukoc. Biol. 79, 223-234
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role of STAT1 in Caspase-Independent Cell Death of Activated Macrophages through the p38 Mitogen-Activated Protein Kinase/STAT1/Reactive Oxygen Species Pathway.

H. S. Kim and M.-S. Lee (2005)
Mol. Cell. Biol. 25, 6821-6833
 |  Abstract »  |  Full Text »  |  PDF »

Superoxide Production in Galleria mellonella Hemocytes: Identification of Proteins Homologous to the NADPH Oxidase Complex of Human Neutrophils.

D. Bergin, E. P. Reeves, J. Renwick, F. B. Wientjes, and K. Kavanagh (2005)
Infect. Immun. 73, 4161-4170
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor {alpha} Stimulation of Rac1 Activity: ROLE OF ISOPRENYLCYSTEINE CARBOXYLMETHYLTRANSFERASE.

C. Papaharalambus, W. Sajjad, A. Syed, C. Zhang, M. O. Bergo, R. W. Alexander, and M. Ahmad (2005)
J. Biol. Chem. 280, 18790-18796
 |  Abstract »  |  Full Text »  |  PDF »

Rac2 Regulates Neutrophil Chemotaxis, Superoxide Production, and Myeloid Colony Formation through Multiple Distinct Effector Pathways.

D. Carstanjen, A. Yamauchi, A. Koornneef, H. Zang, M.-D. Filippi, C. Harris, J. Towe, S. Atkinson, Y. Zheng, M. C. Dinauer, et al. (2005)
J. Immunol. 174, 4613-4620
 |  Abstract »  |  Full Text »  |  PDF »

Effects of p47phox C Terminus Phosphorylations on Binding Interactions with p40phox and p67phox: STRUCTURAL AND FUNCTIONAL COMPARISON OF p40phox and p67phox SH3 DOMAINS.

C. Massenet, S. Chenavas, C. Cohen-Addad, M.-C. Dagher, G. Brandolin, E. Pebay-Peyroula, and F. Fieschi (2005)
J. Biol. Chem. 280, 13752-13761
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitory Effects of AT1 Receptor Blocker, Olmesartan, and Estrogen on Atherosclerosis Via Anti-Oxidative Stress.

M. Tsuda, M. Iwai, J.-M. Li, H.-S. Li, L.-J. Min, A. Ide, M. Okumura, J. Suzuki, M. Mogi, H. Suzuki, et al. (2005)
Hypertension 45, 545-551
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Phagocyte NADPH Oxidase by Rac Guanine Nucleotide Exchange Factors in Conjunction with ATP and Nucleoside Diphosphate Kinase.

A. Mizrahi, S. Molshanski-Mor, C. Weinbaum, Y. Zheng, M. Hirshberg, and E. Pick (2005)
J. Biol. Chem. 280, 3802-3811
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a novel tumor necrosis factor {alpha}-responsive region in the NCF2 promoter.

K. A. Gauss, P. L. Bunger, T. C. Larson, C. J. Young, L. K. Nelson-Overton, D. W. Siemsen, and M. T. Quinn (2005)
J. Leukoc. Biol. 77, 267-278
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells.

T. Kawahara, M. Kohjima, Y. Kuwano, H. Mino, S. Teshima-Kondo, R. Takeya, S. Tsunawaki, A. Wada, H. Sumimoto, and K. Rokutan (2005)
Am J Physiol Cell Physiol 288, C450-C457
 |  Abstract »  |  Full Text »  |  PDF »

Fungal Metabolite Gliotoxin Targets Flavocytochrome b558 in the Activation of the Human Neutrophil NADPH Oxidase.

S. Nishida, L. S. Yoshida, T. Shimoyama, H. Nunoi, T. Kobayashi, and S. Tsunawaki (2005)
Infect. Immun. 73, 235-244
 |  Abstract »  |  Full Text »  |  PDF »

Vascular NADPH oxidases: molecular mechanisms of activation.

R. P. Brandes and J. Kreuzer (2005)
Cardiovasc Res 65, 16-27
 |  Abstract »  |  Full Text »  |  PDF »

Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles.

A. Yamauchi, C. Kim, S. Li, C. C. Marchal, J. Towe, S. J. Atkinson, and M. C. Dinauer (2004)
J. Immunol. 173, 5971-5979
 |  Abstract »  |  Full Text »  |  PDF »

Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases.

M. T. Quinn and K. A. Gauss (2004)
J. Leukoc. Biol. 76, 760-781
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of Anionic Amphiphiles on the Recruitment of Rac in Neutrophils.

K. Nigorikawa, N. Okamura, and O. Hazeki (2004)
J. Biochem. 136, 463-470
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B and AP-1 Connection: Mechanism of NF-{kappa}B-Dependent Regulation of AP-1 Activity.

S. Fujioka, J. Niu, C. Schmidt, G. M. Sclabas, B. Peng, T. Uwagawa, Z. Li, D. B. Evans, J. L. Abbruzzese, and P. J. Chiao (2004)
Mol. Cell. Biol. 24, 7806-7819
 |  Abstract »  |  Full Text »  |  PDF »

Reactive Oxygen Species Activation of Plant Ca2+ Channels. A Signaling Mechanism in Polar Growth, Hormone Transduction, Stress Signaling, and Hypothetically Mechanotransduction.

I. C. Mori and J. I. Schroeder (2004)
Plant Physiology 135, 702-708
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GTPases and reactive oxygen species: switches for killing and signaling.

E. Werner (2004)
J. Cell Sci. 117, 143-153
 |  Abstract »  |  Full Text »  |  PDF »

Interaction between a Ras and a Rho GTPase Couples Selection of a Growth Site to the Development of Cell Polarity in Yeast.

K. G. Kozminski, L. Beven, E. Angerman, A. H. Y. Tong, C. Boone, and H.-O. Park (2003)
Mol. Biol. Cell 14, 4958-4970
 |  Abstract »  |  Full Text »  |  PDF »

Human Monocytes Use Rac1, Not Rac2, in the NADPH Oxidase Complex.

X. Zhao, K. A. Carnevale, and M. K. Cathcart (2003)
J. Biol. Chem. 278, 40788-40792
 |  Abstract »  |  Full Text »  |  PDF »

Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch.

D. Gregg, F. M. Rauscher, and P. J. Goldschmidt-Clermont (2003)
Am J Physiol Cell Physiol 285, C723-C734
 |  Abstract »  |  Full Text »  |  PDF »

Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment.

C. Maack, T. Kartes, H. Kilter, H.-J. Schafers, G. Nickenig, M. Bohm, and U. Laufs (2003)
Circulation 108, 1567-1574
 |  Abstract »  |  Full Text »  |  PDF »

Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions.

M. Glogauer, C. C. Marchal, F. Zhu, A. Worku, B. E. Clausen, I. Foerster, P. Marks, G. P. Downey, M. Dinauer, and D. J. Kwiatkowski (2003)
J. Immunol. 170, 5652-5657
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of Rac-1 GTPase by Estrogen.

U. Laufs, O. Adam, K. Strehlow, S. Wassmann, C. Konkol, K. Laufs, W. Schmidt, M. Bohm, and G. Nickenig (2003)
J. Biol. Chem. 278, 5956-5962
 |  Abstract »  |  Full Text »  |  PDF »

Chemoattractant-Stimulated Rac Activation in Wild-Type and Rac2-Deficient Murine Neutrophils: Preferential Activation of Rac2 and Rac2 Gene Dosage Effect on Neutrophil Functions.

S. Li, A. Yamauchi, C. C. Marchal, J. K. Molitoris, L. A. Quilliam, and M. C. Dinauer (2002)
J. Immunol. 169, 5043-5051
 |  Abstract »  |  Full Text »  |  PDF »

Current molecular models for NADPH oxidase regulation by Rac GTPase.

G. M. Bokoch and B. A. Diebold (2002)
Blood 100, 2692-2695
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells.

M.-J. Rabiet, M. Tardif, L. Braun, and F. Boulay (2002)
Blood 100, 1835-1844
 |  Abstract »  |  Full Text »  |  PDF »

Rac Activation Induces NADPH Oxidase Activity in Transgenic COSphox Cells, and the Level of Superoxide Production Is Exchange Factor-dependent.

M. O. Price, S. J. Atkinson, U. G. Knaus, and M. C. Dinauer (2002)
J. Biol. Chem. 277, 19220-19228
 |  Abstract »  |  Full Text »  |  PDF »

Role of Ras in metal-induced EGF receptor signaling and NF-kappa B activation in human airway epithelial cells.

W. Wu, I. Jaspers, W. Zhang, L. M. Graves, and J. M. Samet (2002)
Am J Physiol Lung Cell Mol Physiol 282, L1040-L1048
 |  Abstract »  |  Full Text »  |  PDF »

Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system.

M. O. Price, L. C. McPhail, J. D. Lambeth, C.-H. Han, U. G. Knaus, and M. C. Dinauer (2002)
Blood 99, 2653-2661
 |  Abstract »  |  Full Text »  |  PDF »

Architecture of the p40-p47-p67phox Complex in the Resting State of the NADPH Oxidase. A CENTRAL ROLE FOR p67phox.

K. Lapouge, S. J. M. Smith, Y. Groemping, and K. Rittinger (2002)
J. Biol. Chem. 277, 10121-10128
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and sequencing of rabbit leukocyte NADPH oxidase genes reveals a unique p67phox homolog.

K. A. Gauss, P. L. Mascolo, D. W. Siemsen, L. K. Nelson, P. L. Bunger, P. J. Pagano, and M. T. Quinn (2002)
J. Leukoc. Biol. 71, 319-328
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency of Small Gtpase Rac2 Affects T Cell Activation.

H. Yu, D. Leitenberg, B. Li, and R. A. Flavell (2001)
J. Exp. Med. 194, 915-926
 |  Abstract »  |  Full Text »  |  PDF »

The Insert Region of Rac1 Is Essential for Membrane Ruffling but Not Cellular Transformation.

A. E. Karnoub, C. J. Der, and S. L. Campbell (2001)
Mol. Cell. Biol. 21, 2847-2857
 |  Abstract »  |  Full Text »  |  PDF »

Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways.

C. Kim and M. C. Dinauer (2001)
J. Immunol. 166, 1223-1232
 |  Abstract »  |  Full Text »  |  PDF »

MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells.

T. Kawashima, K. Hirose, T. Satoh, A. Kaneko, Y. Ikeda, Y. Kaziro, T. Nosaka, and T. Kitamura (2000)
Blood 96, 2116-2124
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-derived Growth Factor-induced H2O2 Production Requires the Activation of Phosphatidylinositol 3-Kinase.

Y. S. Bae, J.-Y. Sung, O.-S. Kim, Y. J. Kim, K. C. Hur, A. Kazlauskas, and S. G. Rhee (2000)
J. Biol. Chem. 275, 10527-10531
 |  Abstract »  |  Full Text »  |  PDF »

Tetratricopeptide Repeat (TPR) Motifs of p67phox Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase.

H. Koga, H. Terasawa, H. Nunoi, K. Takeshige, F. Inagaki, and H. Sumimoto (1999)
J. Biol. Chem. 274, 25051-25060
 |  Abstract »  |  Full Text »  |  PDF »

The p67phox Activation Domain Regulates Electron Flow from NADPH to Flavin in Flavocytochrome b558.

Y. Nisimoto, S. Motalebi, C.-H. Han, and J. D. Lambeth (1999)
J. Biol. Chem. 274, 22999-23005
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of p21rac Activation in Human Neutrophils.

N. Geijsen, S. van Delft, J. A.M. Raaijmakers, J.-W. J. Lammers, J. G. Collard, L. Koenderman, and P. J. Coffer (1999)
Blood 94, 1121-1130
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Phagocyte NADPH Oxidase Protein p47phox. PHOSPHORYLATION CONTROLS SH3 DOMAIN-DEPENDENT BINDING TO p22phox.

J. Huang and M. E. Kleinberg (1999)
J. Biol. Chem. 274, 19731-19737
 |  Abstract »  |  Full Text »  |  PDF »

Mechanotransduction of Rat Aortic Vascular Smooth Muscle Cells Requires RhoA and Intact Actin Filaments.

K. Numaguchi, S. Eguchi, T. Yamakawa, E. D. Motley, and T. Inagami (1999)
Circ. Res. 85, 5-11
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoinositide 3-Kinase-dependent and -independent Activation of the Small GTPase Rac2 in Human Neutrophils.

T. Akasaki, H. Koga, and H. Sumimoto (1999)
J. Biol. Chem. 274, 18055-18059
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases.

V. Benard, B. P. Bohl, and G. M. Bokoch (1999)
J. Biol. Chem. 274, 13198-13204
 |  Abstract »  |  Full Text »  |  PDF »

Mutagenesis of an Arginine- and Lysine-rich Domain in the gp91phox Subunit of the Phagocyte NADPH-oxidase Flavocytochrome b558.

K. J. Biberstine-Kinkade, L. Yu, and M. C. Dinauer (1999)
J. Biol. Chem. 274, 10451-10457
 |  Abstract »  |  Full Text »  |  PDF »

Reactive Oxygen Intermediate-Dependent NF-kappa B Activation by Interleukin-1beta Requires 5-Lipoxygenase or NADPH Oxidase Activity.

G. Bonizzi, J. Piette, S. Schoonbroodt, R. Greimers, L. Havard, M.-P. Merville, and V. Bours (1999)
Mol. Cell. Biol. 19, 1950-1960
 |  Abstract »  |  Full Text »  |  PDF »

NADPH Oxidase: An Update.

B. M. Babior (1999)
Blood 93, 1464-1476
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The Involvement of Hydrogen Peroxide in the Differentiation of Secondary Walls in Cotton Fibers.

T. S. Potikha, C. C. Collins, D. I. Johnson, D. P. Delmer, and A. Levine (1999)
Plant Physiology 119, 849-858
 |  Abstract »  |  Full Text »

Regulation of the Neutrophil Respiratory Burst Oxidase. IDENTIFICATION OF AN ACTIVATION DOMAIN IN p67phox.

C.-H. Han, J. L. R. Freeman, T. Lee, S. A. Motalebi, and J. D. Lambeth (1998)
J. Biol. Chem. 273, 16663-16668
 |  Abstract »  |  Full Text »  |  PDF »

Cryptic Rac-binding and p21Cdc42HS/Rac-activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67phox.

S. Ahmed, E. Prigmore, S. Govind, C. Veryard, R. Kozma, F. B. Wientjes, A. W. Segal, and L. Lim (1998)
J. Biol. Chem. 273, 15693-15701
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins.

A. E. Aplin, A. Howe, S. K. Alahari, and R. L. Juliano (1998)
Pharmacol. Rev. 50, 197-264
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Rac1 with GTPase-activating Proteins and Putative Effectors. A COMPARISON WITH Cdc42 AND RhoA.

B. Zhang, J. Chernoff, and Y. Zheng (1998)
J. Biol. Chem. 273, 8776-8782
 |  Abstract »  |  Full Text »  |  PDF »

Anionic Amphiphile-independent Activation of the Phagocyte NADPH Oxidase in a Cell-free System by p47phox and p67phox, Both in C Terminally Truncated Forms. IMPLICATION FOR REGULATORY Src HOMOLOGY 3 DOMAIN-MEDIATED INTERACTIONS.

K. Hata, T. Ito, K. Takeshige, and H. Sumimoto (1998)
J. Biol. Chem. 273, 4232-4236
 |  Abstract »  |  Full Text »  |  PDF »

The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.

J Faix, C Clougherty, A Konzok, U Mintert, J Murphy, R Albrecht, B Muhlbauer, and J Kuhlmann (1998)
J. Cell Sci. 111, 3059-3071
 |  Abstract »  |  PDF »

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.

S. Weed, Y Du, and J. Parsons (1998)
J. Cell Sci. 111, 2433-2443
 |  Abstract »  |  PDF »

p140Sra-1 (Specifically Rac1-associated Protein) Is a Novel Specific Target for Rac1 Small GTPase.

K. Kobayashi, S. Kuroda, M. Fukata, T. Nakamura, T. Nagase, N. Nomura, Y. Matsuura, N. Yoshida-Kubomura, A. Iwamatsu, and K. Kaibuchi (1998)
J. Biol. Chem. 273, 291-295
 |  Abstract »  |  Full Text »  |  PDF »

Rho GTPases and signaling networks.

L. Van Aelst and C. D'Souza-Schorey (1997)
Genes & Dev. 11, 2295-2322
 |  Full Text »  |  PDF »

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins.

D. J.G. Mackay, F. Esch, H. Furthmayr, and A. Hall (1997)
J. Cell Biol. 138, 927-938
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of RAC3, a Novel Member of the Rho Family.

L. Haataja, J. Groffen, and N. Heisterkamp (1997)
J. Biol. Chem. 272, 20384-20388
 |  Abstract »  |  Full Text »  |  PDF »

Rac Binding to p67phox. STRUCTURAL BASIS FOR INTERACTIONS OF THE Rac1 EFFECTOR REGION AND INSERT REGION WITH COMPONENTS OF THE RESPIRATORY BURST OXIDASE.

Y. Nisimoto, J. L. R. Freeman, S. A. Motalebi, M. Hirshberg, and J. D. Lambeth (1997)
J. Biol. Chem. 272, 18834-18841
 |  Abstract »  |  Full Text »  |  PDF »

Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils.

A Grogan, E Reeves, N Keep, F Wientjes, N. Totty, A. Burlingame, J. Hsuan, and A. Segal (1997)
J. Cell Sci. 110, 3071-3081
 |  Abstract »  |  PDF »

The Cytosolic Component p47phox Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production.

V. Koshkin, O. Lotan, and E. Pick (1996)
J. Biol. Chem. 271, 30326-30329
 |  Abstract »  |  Full Text »  |  PDF »

The Renaturable 69-and 63-kDa Protein Kinases That Undergo Rapid Activation in Chemoattractant-stimulated Guinea Pig Neutrophils Are p21-Activated Kinases.

J. Ding, U. G. Knaus, J. P. Lian, G. M. Bokoch, and J. A. Badwey (1996)
J. Biol. Chem. 271, 24869-24873
 |  Abstract »  |  Full Text »  |  PDF »

Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1.

S. Kuroda, M. Fukata, K. Kobayashi, M. Nakafuku, N. Nomura, A. Iwamatsu, and K. Kaibuchi (1996)
J. Biol. Chem. 271, 23363-23367
 |  Abstract »  |  Full Text »  |  PDF »

NADPH Oxidase Activity Is Independent of p47phox in Vitro.

J. L. Freeman and J. D. Lambeth (1996)
J. Biol. Chem. 271, 22578-22582
 |  Abstract »  |  Full Text »  |  PDF »

Rac ``Insert Region'' Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65.

J. L. Freeman, A. Abo, and J. D. Lambeth (1996)
J. Biol. Chem. 271, 19794-19801
 |  Abstract »  |  Full Text »  |  PDF »

The Ras-related GTPase Rac1 Binds Tubulin.

A. Best, S. Ahmed, R. Kozma, and L. Lim (1996)
J. Biol. Chem. 271, 3756-3762
 |  Abstract »  |  Full Text »  |  PDF »

The Rac Target NADPH Oxidase p67[IMAGE] Interacts Preferentially with Rac2 Rather Than Rac1.

O. Dorseuil, L. Reibel, G. M. Bokoch, J. Camonis, and G. Gacon (1996)
J. Biol. Chem. 271, 83-88
 |  Abstract »  |  Full Text »  |  PDF »

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases.

P. D. Burbelo, D. Drechsel, and A. Hall (1995)
J. Biol. Chem. 270, 29071-29074
 |  Abstract »  |  Full Text »  |  PDF »

``Peptide Walking'' Is a Novel Method for Mapping Functional Domains in Proteins.

G. Joseph and E. Pick (1995)
J. Biol. Chem. 270, 29079-29082
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Molecular Cloning of a p21[IMAGE]-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets.

M. Teo, E. Manser, and L. Lim (1995)
J. Biol. Chem. 270, 26690-26697
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Effector-specifying Domain of Rac Involved in NADPH Oxidase Activation.

C. H. Kwong, A. G. Adams, and T. L. Leto (1995)
J. Biol. Chem. 270, 19868-19872
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors.

U. Knaus, S Morris, H. Dong, J Chernoff, and G. Bokoch (1995)
Science 269, 221-223
 |  Abstract »  |  PDF »

A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils.

E. Prigmore, S. Ahmed, A. Best, R. Kozma, E. Manser, A. W. Segal, and L. Lim (1995)
J. Biol. Chem. 270, 10717-10722
 |  Abstract »  |  Full Text »  |  PDF »

Mapping the Domains of Interaction of p40[IMAGE] with Both p47[IMAGE] and p67[IMAGE] of the Neutrophil Oxidase Complex Using the Two-hybrid System.

A. Fuchs, M.-C. Dagher, and P. V. Vignais (1995)
J. Biol. Chem. 270, 5695-5697
 |  Abstract »  |  Full Text »  |  PDF »

The Small G-protein Rac Mediates Depolarization-induced Superoxide Formation in Human Endothelial Cells.

H.-Y. Sohn, M. Keller, T. Gloe, H. Morawietz, U. Rueckschloss, and U. Pohl (2000)
J. Biol. Chem. 275, 18745-18750
 |  Abstract »  |  Full Text »  |  PDF »

Targeting of Rac1 to the Phagocyte Membrane Is Sufficient for the Induction of NADPH Oxidase Assembly.

Y. Gorzalczany, N. Sigal, M. Itan, O. Lotan, and E. Pick (2000)
J. Biol. Chem. 275, 40073-40081
 |  Abstract »  |  Full Text »  |  PDF »

The Active N-terminal Region of p67phox. STRUCTURE AT 1.8 A RESOLUTION AND BIOCHEMICAL CHARACTERIZATIONS OF THE A128V MUTANT IMPLICATED IN CHRONIC GRANULOMATOUS DISEASE.

S. Grizot, F. Fieschi, M.-C. Dagher, and E. Pebay-Peyroula (2001)
J. Biol. Chem. 276, 21627-21631
 |  Abstract »  |  Full Text »  |  PDF »

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.

D. R. Ambruso, C. Knall, A. N. Abell, J. Panepinto, A. Kurkchubasche, G. Thurman, C. Gonzalez-Aller, A. Hiester, M. deBoer, R. J. Harbeck, et al. (2000)
PNAS 97, 4654-4659
 |  Abstract »  |  Full Text »  |  PDF »

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