Science 22 July 1994: Vol. 265. no. 5171, pp. 528 - 530 DOI: 10.1126/science.7518614

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Articles

High antigen levels are the cause of T cell exhaustion during chronic viral infection.

S. N. Mueller and R. Ahmed (2009)
PNAS 106, 8623-8628
 |  Abstract »  |  Full Text »  |  PDF »

Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes.

G Ahlen, E Derk, M Weiland, J Jiao, N Rahbin, S Aleman, D L Peterson, K Pokrovskaja, D Grander, L Frelin, et al. (2009)
Gut 58, 560-569
 |  Abstract »  |  Full Text »  |  PDF »

Notch Regulates Cytolytic Effector Function in CD8+ T Cells.

O. H. Cho, H. M. Shin, L. Miele, T. E. Golde, A. Fauq, L. M. Minter, and B. A. Osborne (2009)
J. Immunol. 182, 3380-3389
 |  Abstract »  |  Full Text »  |  PDF »

Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection.

W. Hou, H. S. Kang, and B. S. Kim (2009)
J. Exp. Med. 206, 313-328
 |  Abstract »  |  Full Text »  |  PDF »

Role of TNF-{alpha} Produced by Nonantigen-Specific Cells in a Fulminant Hepatitis Mouse Model.

H. Ito, K. Ando, T. Ishikawa, K. Saito, M. Takemura, M. Imawari, H. Moriwaki, and M. Seishima (2009)
J. Immunol. 182, 391-397
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Serpins in T cell immunity.

M. Bots and J. P. Medema (2008)
J. Leukoc. Biol. 84, 1238-1247
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Idiotype-Specific T Cells in Myeloma Cell Growth and Survival: Th1 and CTL Cells Are Tumoricidal while Th2 Cells Promote Tumor Growth.

S. Hong, J. Qian, J. Yang, H. Li, L. W. Kwak, and Q. Yi (2008)
Cancer Res. 68, 8456-8464
 |  Abstract »  |  Full Text »  |  PDF »

Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing.

P. B. Watchmaker, J. A. Urban, E. Berk, Y. Nakamura, R. B. Mailliard, S. C. Watkins, S. M. van Ham, and P. Kalinski (2008)
J. Immunol. 180, 3857-3865
 |  Abstract »  |  Full Text »  |  PDF »

Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes.

V. Mateo, M. Menager, G. de Saint-Basile, M.-C. Stolzenberg, B. Roquelaure, N. Andre, B. Florkin, F. le Deist, C. Picard, A. Fischer, et al. (2007)
Blood 110, 4285-4292
 |  Abstract »  |  Full Text »  |  PDF »

Fas Ligand Interactions Contribute to CD8+ T-Cell-Mediated Control of West Nile Virus Infection in the Central Nervous System.

B. Shrestha and M. S. Diamond (2007)
J. Virol. 81, 11749-11757
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic {beta}-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice.

S. Kim, H. S. Kim, K. W. Chung, S. H. Oh, J. W. Yun, S.-H. Im, M.-K. Lee, K.-W. Kim, and M.-S. Lee (2007)
Diabetes 56, 2561-2568
 |  Abstract »  |  Full Text »  |  PDF »

Anti-IE1 CD4+ T-cell clones kill peptide-pulsed, but not human cytomegalovirus-infected, target cells.

S. Delmas, P. Brousset, D. Clement, E. Le Roy, and J.-L. Davignon (2007)
J. Gen. Virol. 88, 2441-2449
 |  Abstract »  |  Full Text »  |  PDF »

Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma.

J. Qian, J. Xie, S. Hong, J. Yang, L. Zhang, X. Han, M. Wang, F. Zhan, J. D. Shaughnessy Jr, J. Epstein, et al. (2007)
Blood 110, 1587-1594
 |  Abstract »  |  Full Text »  |  PDF »

CD8+ T Cells Circumvent Immune Privilege in the Eye and Mediate Intraocular Tumor Rejection by a TNF-{alpha}-Dependent Mechanism.

D. S. Dace, P. W. Chen, and J. Y. Niederkorn (2007)
J. Immunol. 178, 6115-6122
 |  Abstract »  |  Full Text »  |  PDF »

On the TRAIL Toward Death Receptor-Based Cancer Therapeutics.

T. F. Gajewski (2007)
J. Clin. Oncol. 25, 1305-1307
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Differential Survival of Cytotoxic T Cells and Memory Cell Precursors.

M. Zhang, S. Byrne, N. Liu, Y. Wang, A. Oxenius, and P. G. Ashton-Rickardt (2007)
J. Immunol. 178, 3483-3491
 |  Abstract »  |  Full Text »  |  PDF »

Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo.

C. Chiu, A. G. Heaps, V. Cerundolo, A. J. McMichael, C. R. Bangham, and M. F. C. Callan (2007)
Blood 109, 1086-1094
 |  Abstract »  |  Full Text »  |  PDF »

Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8+ cells and prolongs cardiac allograft survival.

K. Oshima, G. Cui, T. Tung, O. Okotie, H. Laks, and L. Sen (2007)
Am J Physiol Heart Circ Physiol 292, H277-H284
 |  Abstract »  |  Full Text »  |  PDF »

Delayed Expansion and Contraction of CD8+ T Cell Response during Infection with Virulent Salmonella typhimurium.

R. A. Luu, K. Gurnani, R. Dudani, R. Kammara, H. van Faassen, J.-C. Sirard, L. Krishnan, and S. Sad (2006)
J. Immunol. 177, 1516-1525
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cells Can Protect APC from CTL-Mediated Elimination..

S. N. Mueller, C. M. Jones, A. T. Stock, M. Suter, W. R. Heath, and F. R. Carbone (2006)
J. Immunol. 176, 7379-7384
 |  Abstract »  |  Full Text »  |  PDF »

Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation..

C. S. Mitsiades, V. Poulaki, G. Fanourakis, E. Sozopoulos, D. McMillin, Z. Wen, G. Voutsinas, S. Tseleni-Balafouta, and N. Mitsiades (2006)
Clin. Cancer Res. 12, 3705-3712
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory cells in the airways in COPD.

R O'Donnell, D Breen, S Wilson, and R Djukanovic (2006)
Thorax 61, 448-454
 |  Abstract »  |  Full Text »  |  PDF »

Immunosensitization of Tumor Cells to Dendritic Cell-Activated Immune Responses with the Proteasome Inhibitor Bortezomib (PS-341, Velcade)..

L. Y. Schumacher, D. D. Vo, H. J. Garban, B. Comin-Anduix, S. K. Owens, V. B. Dissette, J. A. Glaspy, W. H. McBride, B. Bonavida, J. S. Economou, et al. (2006)
J. Immunol. 176, 4757-4765
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Interferon-{gamma} Signaling in Oligodendroglia Delays Coronavirus Clearance without Altering Demyelination.

J. M. Gonzalez, C. C. Bergmann, C. Ramakrishna, D. R. Hinton, R. Atkinson, J. Hoskin, W. B. Macklin, and S. A. Stohlman (2006)
Am. J. Pathol. 168, 796-804
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Vaccine-Induced Memory CD8+ T Cells Cannot Prevent Central Nervous System Virus Reactivation..

C. Ramakrishna, R. A. Atkinson, S. A. Stohlman, and C. C. Bergmann (2006)
J. Immunol. 176, 3062-3069
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of Cancers to Immunologic Cytotoxicity and Adoptive Immunotherapy via X-Linked Inhibitor of Apoptosis Protein Expression and Coexisting Defects in Mitochondrial Death Signaling.

R. Ravi, E. J. Fuchs, A. Jain, V. Pham, K. Yoshimura, T. Prouser, S. Jalla, X. Zhou, E. Garrett-Mayer, S. H. Kaufmann, et al. (2006)
Cancer Res. 66, 1730-1739
 |  Abstract »  |  Full Text »  |  PDF »

Relation between viral fitness and immune escape within the hepatitis C virus protease.

J Soderholm, G Ahlen, A Kaul, L Frelin, M Alheim, C Barnfield, P Liljestrom, O Weiland, D R Milich, R Bartenschlager, et al. (2006)
Gut 55, 266-274
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Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help.

L. O. Atherly, M. A. Brehm, R. M. Welsh, and L. J. Berg (2006)
J. Immunol. 176, 1571-1581
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TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque.

K. Sato, A. Niessner, S. L. Kopecky, R. L. Frye, J. J. Goronzy, and C. M. Weyand (2006)
J. Exp. Med. 203, 239-250
 |  Abstract »  |  Full Text »  |  PDF »

Human T Cells Armed with Her2/neu Bispecific Antibodies Divide, Are Cytotoxic, and Secrete Cytokines with Repeated Stimulation.

R. C. Grabert, L. P. Cousens, J. A. Smith, S. Olson, J. Gall, W. B. Young, P. A. Davol, and L. G. Lum (2006)
Clin. Cancer Res. 12, 569-576
 |  Abstract »  |  Full Text »  |  PDF »

CD8+ T Cells Require Perforin To Clear West Nile Virus from Infected Neurons.

B. Shrestha, M. A. Samuel, and M. S. Diamond (2006)
J. Virol. 80, 119-129
 |  Abstract »  |  Full Text »  |  PDF »

Clinical relevance of Fas expression in oesophageal squamous cell carcinoma.

K W Chan, P Y Lee, A K Y Lam, S Law, J Wong, and G Srivastava (2006)
J. Clin. Pathol. 59, 101-104
 |  Abstract »  |  Full Text »  |  PDF »

Fas receptor signaling is requisite for B cell differentiation.

Valerie Pasqualetto, Florence Vasseur, Flora Zavala, Elke Schneider, and Sophie Ezine (2005)
J. Leukoc. Biol. 78, 1106-1117
 |  Abstract »  |  Full Text »  |  PDF »

Nitric Oxide Sensitizes Tumor Cells to Dendritic Cell-Mediated Apoptosis, Uptake, and Cross-Presentation.

J. Huang, T. Tatsumi, E. Pizzoferrato, N. Vujanovic, and W. J. Storkus (2005)
Cancer Res. 65, 8461-8470
 |  Abstract »  |  Full Text »  |  PDF »

Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis.

F. J. Branco and N. W. Fraser (2005)
J. Virol. 79, 9019-9025
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis: a mechanism of acute and chronic liver injury.

M E Guicciardi and G J Gores (2005)
Gut 54, 1024-1033
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Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Immune Response to Influenza Virus Infection in Mice.

E. Ishikawa, M. Nakazawa, M. Yoshinari, and M. Minami (2005)
J. Virol. 79, 7658-7663
 |  Abstract »  |  Full Text »  |  PDF »

Low Levels of Her2/neu Expressed by Ewing's Family Tumor Cell Lines Can Redirect Cytokine-Induced Killer Cells.

M. R. Verneris, A. Arshi, M. Edinger, M. Kornacker, Y. Natkunam, M. Karami, Y.-a. Cao, N. Marina, C. H. Contag, and R. S. Negrin (2005)
Clin. Cancer Res. 11, 4561-4570
 |  Abstract »  |  Full Text »  |  PDF »

Immune Selection and Emergence of Aggressive Tumor Variants as Negative Consequences of Fas-Mediated Cytotoxicity and Altered IFN-{gamma}-Regulated Gene Expression.

K. Liu, S. A. Caldwell, and S. I. Abrams (2005)
Cancer Res. 65, 4376-4388
 |  Abstract »  |  Full Text »  |  PDF »

Human 60-kDa Heat Shock Protein Is a Target Autoantigen of T Cells Derived from Atherosclerotic Plaques.

M. Benagiano, M. M. D'Elios, A. Amedei, A. Azzurri, R. van der Zee, A. Ciervo, G. Rombola, S. Romagnani, A. Cassone, and G. Del Prete (2005)
J. Immunol. 174, 6509-6517
 |  Abstract »  |  Full Text »  |  PDF »

Reducing the Stimulation of CD8+ T Cells during Infection with Intracellular Bacteria Promotes Differentiation Primarily into a Central (CD62LhighCD44high) Subset.

H. van Faassen, M. Saldanha, D. Gilbertson, R. Dudani, L. Krishnan, and S. Sad (2005)
J. Immunol. 174, 5341-5350
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Impaired Cytolytic Activity in Calreticulin-Deficient CTLs.

S. Sipione, C. Ewen, I. Shostak, M. Michalak, and R. C. Bleackley (2005)
J. Immunol. 174, 3212-3219
 |  Abstract »  |  Full Text »  |  PDF »

Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease.

Y. Maeda, R. B. Levy, P. Reddy, C. Liu, S. G. Clouthier, T. Teshima, and J. L. M. Ferrara (2005)
Blood 105, 2023-2027
 |  Abstract »  |  Full Text »  |  PDF »

Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines.

T. Matsuda, A. Almasan, M. Tomita, J.-n. Uchihara, M. Masuda, K. Ohshiro, N. Takasu, H. Yagita, T. Ohta, and N. Mori (2005)
J. Virol. 79, 1367-1378
 |  Abstract »  |  Full Text »  |  PDF »

Human Retinoblastoma Cells Are Resistant to Apoptosis Induced by Death Receptors: Role of Caspase-8 Gene Silencing.

V. Poulaki, C. S. Mitsiades, C. McMullan, G. Fanourakis, J. Negri, A. Goudopoulou, I. X. Halikias, G. Voutsinas, S. Tseleni-Balafouta, J. W. Miller, et al. (2005)
Invest. Ophthalmol. Vis. Sci. 46, 358-366
 |  Abstract »  |  Full Text »  |  PDF »

Vaccine-Stimulated, Adoptively Transferred CD8+ T Cells Traffic Indiscriminately and Ubiquitously while Mediating Specific Tumor Destruction.

D. C. Palmer, S. Balasubramaniam, K.-i. Hanada, C. Wrzesinski, Z. Yu, S. Farid, M. R. Theoret, L. N. Hwang, C. A. Klebanoff, L. Gattinoni, et al. (2004)
J. Immunol. 173, 7209-7216
 |  Abstract »  |  Full Text »  |  PDF »

The perforin mediated apoptotic pathway in lung injury and fibrosis.

H Miyazaki, K Kuwano, K Yoshida, T Maeyama, M Yoshimi, M Fujita, N Hagimoto, R Yoshida, and Y Nakanishi (2004)
J. Clin. Pathol. 57, 1292-1298
 |  Abstract »  |  Full Text »  |  PDF »

Perforin and Fas Act Together in the Induction of Apoptosis, and Both Are Critical in the Clearance of Lymphocytic Choriomeningitis Virus Infection.

M. Rode, S. Balkow, V. Sobek, R. Brehm, P. Martin, A. Kersten, T. Dumrese, T. Stehle, A. Mullbacher, R. Wallich, et al. (2004)
J. Virol. 78, 12395-12405
 |  Abstract »  |  Full Text »  |  PDF »

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.

J. Pardo, A. Bosque, R. Brehm, R. Wallich, J. Naval, A. Mullbacher, A. Anel, and M. M. Simon (2004)
J. Cell Biol. 167, 457-468
 |  Abstract »  |  Full Text »  |  PDF »

Recent Advances in the Treatment of Graft-Versus-Host Disease.

T. Iwasaki (2004)
Clin. Med. Res. 2, 243-252
 |  Abstract »  |  Full Text »  |  PDF »

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL.

H. Qin, J. D. Trudeau, G. S. D. Reid, I-F. Lee, J. P. Dutz, P. Santamaria, C. B. Verchere, and R. Tan (2004)
Int. Immunol. 16, 1657-1662
 |  Abstract »  |  Full Text »  |  PDF »

A Role for the Granzyme B Inhibitor Serine Protease Inhibitor 6 in CD8+ Memory Cell Homeostasis.

T. Phillips, J. T. Opferman, R. Shah, N. Liu, C. J. Froelich, and P. G. Ashton-Rickardt (2004)
J. Immunol. 173, 3801-3809
 |  Abstract »  |  Full Text »  |  PDF »

High Frequency of Functionally Active Melan-A-Specific T Cells in a Patient with Progressive Immunoproteasome-Deficient Melanoma.

N. Meidenbauer, A. Zippelius, M. J. Pittet, M. Laumer, S. Vogl, J. Heymann, M. Rehli, B. Seliger, S. Schwarz, F.-A. L. Gal, et al. (2004)
Cancer Res. 64, 6319-6326
 |  Abstract »  |  Full Text »  |  PDF »

NK Cells Use Perforin Rather than Granulysin for Anticryptococcal Activity.

L. L. Ma, C. L. C. Wang, G. G. Neely, S. Epelman, A. M. Krensky, and C. H. Mody (2004)
J. Immunol. 173, 3357-3365
 |  Abstract »  |  Full Text »  |  PDF »

Graft-versus-host disease after allogeneic hematopoietic stem cell transplantation induces a CD8+ T cell-mediated graft-versus-tumor effect that is independent of the recognition of alloantigenic tumor targets.

M. Stelljes, R. Strothotte, H.-G. Pauels, C. Poremba, M. Milse, C. Specht, J. Albring, G. Bisping, C. Scheffold, T. Kammertoens, et al. (2004)
Blood 104, 1210-1216
 |  Abstract »  |  Full Text »  |  PDF »

NK Cells Stimulate Proliferation of T and NK Cells through 2B4/CD48 Interactions.

E. Assarsson, T. Kambayashi, J. D. Schatzle, S. O. Cramer, A. von Bonin, P. E. Jensen, H.-G. Ljunggren, and B. J. Chambers (2004)
J. Immunol. 173, 174-180
 |  Abstract »  |  Full Text »  |  PDF »

Fatal Disseminated Mouse Adenovirus Type 1 Infection in Mice Lacking B Cells or Bruton's Tyrosine Kinase.

M. L. Moore, E. L. McKissic, C. C. Brown, J. E. Wilkinson, and K. R. Spindler (2004)
J. Virol. 78, 5584-5590
 |  Abstract »  |  Full Text »  |  PDF »

Antiviral Cytokines Induce Hepatic Expression of the Granzyme B Inhibitors, Proteinase Inhibitor 9 and Serine Proteinase Inhibitor 6.

M. B. Barrie, H. W. Stout, M. S. Abougergi, B. C. Miller, and D. L. Thiele (2004)
J. Immunol. 172, 6453-6459
 |  Abstract »  |  Full Text »  |  PDF »

Structural and biomolecular changes in aorta and pulmonary trunk of patients with aortic aneurysm and valve disease: implications for the Ross procedure.

F.-X. Schmid, K. Bielenberg, S. Holmer, K. Lehle, B. Djavidani, C. Prasser, C. Wiesenack, and D. Birnbaum (2004)
Eur. J. Cardiothorac. Surg. 25, 748-753
 |  Abstract »  |  Full Text »  |  PDF »

A New Recombinant Single Chain Trispecific Antibody Recruits T Lymphocytes to Kill CEA (Carcinoma Embryonic Antigen) Positive Tumor Cells In Vitro Efficiently.

X.-B. Wang, B.-F. Zhao, Q. Zhao, J.-H. Piao, J. Liu, Q. Lin, and H.-L. Huang (2004)
J. Biochem. 135, 555-565
 |  Abstract »  |  Full Text »  |  PDF »

Survivin Enhances Fas Ligand Expression via Up-Regulation of Specificity Protein 1-Mediated Gene Transcription in Colon Cancer Cells.

K. Asanuma, N. Tsuji, T. Endoh, A. Yagihashi, and N. Watanabe (2004)
J. Immunol. 172, 3922-3929
 |  Abstract »  |  Full Text »  |  PDF »

Cytotoxic T Lymphocytes Derived from Patients with Chronic Hepatitis C Virus Infection Kill Bystander Cells via Fas-FasL Interaction.

C. Gremion, B. Grabscheid, B. Wolk, D. Moradpour, J. Reichen, W. Pichler, and A. Cerny (2004)
J. Virol. 78, 2152-2157
 |  Abstract »  |  Full Text »  |  PDF »

Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.

G. Panyi, G. Vamosi, Z. Bacso, M. Bagdany, A. Bodnar, Z. Varga, R. Gaspar, L. Matyus, and S. Damjanovich (2004)
PNAS 101, 1285-1290
 |  Abstract »  |  Full Text »  |  PDF »

Mycobacterium tuberculosis Growth at the Cavity Surface: a Microenvironment with Failed Immunity.

G. Kaplan, F. A. Post, A. L. Moreira, H. Wainwright, B. N. Kreiswirth, M. Tanverdi, B. Mathema, S. V. Ramaswamy, G. Walther, L. M. Steyn, et al. (2003)
Infect. Immun. 71, 7099-7108
 |  Abstract »  |  Full Text »  |  PDF »

Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.

J. Pardo, M. Buferne, M.-J. Martinez-Lorenzo, J. Naval, A.-M. Schmitt-Verhulst, C. Boyer, and A. Anel (2003)
Int. Immunol. 15, 1441-1450
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold.

M. Faroudi, C. Utzny, M. Salio, V. Cerundolo, M. Guiraud, S. Muller, and S. Valitutti (2003)
PNAS 100, 14145-14150
 |  Abstract »  |  Full Text »  |  PDF »

Distinct time pattern of complement activation and cytotoxic T cell response in Guillain-Barre syndrome.

J. Wanschitz, H. Maier, H. Lassmann, H. Budka, and T. Berger (2003)
Brain 126, 2034-2042
 |  Abstract »  |  Full Text »  |  PDF »

Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing.

C. Wulfing, B. Purtic, J. Klem, and J. D. Schatzle (2003)
PNAS 100, 7767-7772
 |  Abstract »  |  Full Text »  |  PDF »

T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions.

M. Benagiano, A. Azzurri, A. Ciervo, A. Amedei, C. Tamburini, M. Ferrari, J. L. Telford, C. T. Baldari, S. Romagnani, A. Cassone, et al. (2003)
PNAS 100, 6658-6663
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Terminally Differentiated Tumor-specific CD8+ T Cells at Tumor Site in Spite of Antitumor Immunity to Self-Antigens in Human Metastatic Melanoma.

R. Mortarini, A. Piris, A. Maurichi, A. Molla, I. Bersani, A. Bono, C. Bartoli, M. Santinami, C. Lombardo, F. Ravagnani, et al. (2003)
Cancer Res. 63, 2535-2545
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95L-, TNFR1-, and TRAIL-dependent killing.

M. Komatsu, M. Mammolenti, M. Jones, R. Jurecic, T. J. Sayers, and R. B. Levy (2003)
Blood 101, 3991-3999
 |  Abstract »  |  Full Text »  |  PDF »

TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells.

K. Uno, T. Inukai, N. Kayagaki, K. Goi, H. Sato, A. Nemoto, K. Takahashi, K. Kagami, N. Yamaguchi, H. Yagita, et al. (2003)
Blood 101, 3658-3667
 |  Abstract »  |  Full Text »  |  PDF »

Ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve: involvement and clinical relevance of smooth muscle cell apoptosis and expression of cell death-initiating proteins.

F.-X. Schmid, K. Bielenberg, A. Schneider, A. Haussler, A. Keyser, and D. Birnbaum (2003)
Eur. J. Cardiothorac. Surg. 23, 537-543
 |  Abstract »  |  Full Text »  |  PDF »

Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects.

P. Reddy, T. Teshima, G. Hildebrandt, D. L. Williams, C. Liu, K. R. Cooke, and J. L.M. Ferrara (2003)
Blood 101, 2877-2885
 |  Abstract »  |  Full Text »  |  PDF »

Loss of the Perforin Cytotoxic Pathway Predisposes Mice to Experimental Cytomegalovirus Retinitis.

R. D. Dix, E. R. Podack, and S. W. Cousins (2003)
J. Virol. 77, 3402-3408
 |  Abstract »  |  Full Text »  |  PDF »

Perforin-Mediated Effector Function Within the Central Nervous System Requires IFN-{gamma}-Mediated MHC Up-Regulation.

C. C. Bergmann, B. Parra, D. R. Hinton, R. Chandran, M. Morrison, and S. A. Stohlman (2003)
J. Immunol. 170, 3204-3213
 |  Abstract »  |  Full Text »  |  PDF »

High Expression of Fas Ligand by Synovial Fluid-Derived {gamma}{delta} T Cells in Lyme Arthritis.

K. Roessner, J. Wolfe, C. Shi, L. H. Sigal, S. Huber, and R. C. Budd (2003)
J. Immunol. 170, 2702-2710
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Lack of Tumor Necrosis Factor Alpha Induces Impaired Proliferation of Hepatitis B Virus-Specific Cytotoxic T Lymphocytes.

S. Kasahara, K. Ando, K. Saito, K. Sekikawa, H. Ito, T. Ishikawa, H. Ohnishi, M. Seishima, S. Kakumu, and H. Moriwaki (2003)
J. Virol. 77, 2469-2476
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Perforin Down-Regulates CD4 and CD8 T Cell-Mediated Immune Responses to a Transplanted Organ.

A. Bose, Y. Inoue, K. E. Kokko, and F. G. Lakkis (2003)
J. Immunol. 170, 1611-1614
 |  Abstract »  |  Full Text »  |  PDF »

Essential Roles of Perforin in Antigen-Specific Cytotoxicity Mediated by Human CD4+ T Lymphocytes: Analysis Using the Combination of Hereditary Perforin-Deficient Effector Cells and Fas-Deficient Target Cells.

F. Yanai, E. Ishii, K. Kojima, A. Hasegawa, T. Azuma, S. Hirose, N. Suga, A. Mitsudome, M. Zaitsu, Y. Ishida, et al. (2003)
J. Immunol. 170, 2205-2213
 |  Abstract »  |  Full Text »  |  PDF »

Perforin-Dependent Brain-Infiltrating Cytotoxic CD8+ T Lymphocytes Mediate Experimental Cerebral Malaria Pathogenesis.

J. Nitcheu, O. Bonduelle, C. Combadiere, M. Tefit, D. Seilhean, D. Mazier, and B. Combadiere (2003)
J. Immunol. 170, 2221-2228
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Characterization of Lung {gamma}{delta} T Cells Following Intranasal Infection with Mycobacterium bovis Bacillus Calmette-Guerin.

F. Dieli, J. Ivanyi, P. Marsh, A. Williams, I. Naylor, G. Sireci, N. Caccamo, C. Di Sano, and A. Salerno (2003)
J. Immunol. 170, 463-469
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Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8+ Cytotoxic T Lymphocytes.

L. Musey, Y. Ding, J. Cao, J. Lee, C. Galloway, A. Yuen, K. R. Jerome, and M. J. McElrath (2002)
J. Virol. 77, 291-300
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Mouse Vascular Endothelium Activates CD8+ T Lymphocytes in a B7-Dependent Fashion.

D. Kreisel, A. S. Krupnick, K. R. Balsara, M. Riha, A. E. Gelman, S. H. Popma, W. Y. Szeto, L. A. Turka, and B. R. Rosengard (2002)
J. Immunol. 169, 6154-6161
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Autoreactive CD8+ Cytotoxic T Cells during Theiler's Murine Encephalomyelitis Virus Infection: Implications for Autoimmunity.

I. Tsunoda, L.-Q. Kuang, and R. S. Fujinami (2002)
J. Virol. 76, 12834-12844
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an Interferon-{gamma}-inducible Carcinoembryonic Antigen (CEA) CD8+ T-Cell Epitope, Which Mediates Tumor Killing in CEA Transgenic Mice.

J. Schmitz, E. Reali, J. W. Hodge, A. Patel, G. Davis, J. Schlom, and J. W. Greiner (2002)
Cancer Res. 62, 5058-5064
 |  Abstract »  |  Full Text »  |  PDF »

Macrophages as Effector Cells in Interleukin 12-induced T Cell-dependent Tumor Rejection.

K. Tsung, J. P. Dolan, Y. L. Tsung, and J. A. Norton (2002)
Cancer Res. 62, 5069-5075
 |  Abstract »  |  Full Text »  |  PDF »

Tumor-Infiltrating CD4+ T Lymphocytes Express APO2 Ligand (APO2L)/TRAIL upon Specific Stimulation with Autologous Lung Carcinoma Cells: Role of IFN-{alpha} on APO2L/TRAIL Expression and -Mediated Cytotoxicity.

G. Dorothee, I. Vergnon, J. Menez, H. Echchakir, D. Grunenwald, M. Kubin, S. Chouaib, and F. Mami-Chouaib (2002)
J. Immunol. 169, 809-817
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-Dependent Release of IFN-{gamma} by Cytotoxic T Cells Up-Regulates Fas on Target Cells and Facilitates Exocytosis-Independent Specific Target Cell Lysis.

A. Mullbacher, M. Lobigs, R. T. Hla, T. Tran, T. Stehle, and M. M. Simon (2002)
J. Immunol. 169, 145-150
 |  Abstract »  |  Full Text »  |  PDF »

Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes.

M. Nakayama, M. Nagata, H. Yasuda, K. Arisawa, R. Kotani, K. Yamada, S. A. Chowdhury, S. Chakrabarty, Z. Z. Jin, H. Yagita, et al. (2002)
Diabetes 51, 1391-1397
 |  Abstract »  |  Full Text »  |  PDF »

Tumor lysate-specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy.

Y.-J. Wen, R. Min, G. Tricot, B. Barlogie, and Q. Yi (2002)
Blood 99, 3280-3285
 |  Abstract »  |  Full Text »  |  PDF »

Protective Cross-Reactive Cellular Immunity to Lethal A/Goose/Guangdong/1/96-Like H5N1 Influenza Virus Is Correlated with the Proportion of Pulmonary CD8+ T Cells Expressing Gamma Interferon.

S. H. Seo, M. Peiris, and R. G. Webster (2002)
J. Virol. 76, 4886-4890
 |  Abstract »  |  Full Text »  |  PDF »

Lack of both Fas Ligand and Perforin Protects from Flavivirus-Mediated Encephalitis in Mice.

R. M. Licon Luna, E. Lee, A. Mullbacher, R. V. Blanden, R. Langman, and M. Lobigs (2002)
J. Virol. 76, 3202-3211
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection.

S. Zhou, R. Ou, L. Huang, and D. Moskophidis (2002)
J. Virol. 76, 829-840
 |  Abstract »  |  Full Text »  |  PDF »

Tissue inhibitor of metalloproteinases 1 is an autocrine and paracrine survival factor, with additional immune-regulatory functions, expressed by Hodgkin/Reed-Sternberg cells.

E. Oelmann, H. Herbst, M. Zuhlsdorf, O. Albrecht, A. Nolte, C. Schmitmann, O. Manzke, V. Diehl, H. Stein, and W. E. Berdel (2002)
Blood 99, 258-267
 |  Abstract »  |  Full Text »  |  PDF »

CD8+ T Cells in Cutaneous T-Cell Lymphoma: Expression of Cytotoxic Proteins, Fas Ligand, and Killing Inhibitory Receptors and Their Relationship With Clinical Behavior.

M. H. Vermeer, R. van Doorn, D. Dukers, M. W. Bekkenk, C. J.L.M. Meijer, and R. Willemze (2001)
J. Clin. Oncol. 19, 4322-4329
 |  Abstract »  |  Full Text »

The Activatory Receptor 2B4 Is Expressed In Vivo by Human CD8+ Effector {alpha}{beta} T Cells.

D. E. Speiser, M. Colonna, M. Ayyoub, M. Cella, M. J. Pittet, P. Batard, D. Valmori, P. Guillaume, D. Lienard, J.-C. Cerottini, et al. (2001)
J. Immunol. 167, 6165-6170
 |  Abstract »  |  Full Text »  |  PDF »

TCR/Self-Antigen Interactions Drive Double-Negative T Cell Peripheral Expansion and Differentiation into Suppressor Cells.

J. J. Priatel, O. Utting, and H.-S. Teh (2001)
J. Immunol. 167, 6188-6194
 |  Abstract »  |  Full Text »  |  PDF »

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