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Science 15 July 1994:
Vol. 265. no. 5170, pp. 410 - 412
DOI: 10.1126/science.8023165
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Articles

Science, Vol 265, Issue 5170, 410-412
Copyright © 1994 by American Association for the Advancement of Science

articles

Growth-promoting effects of glycine-extended progastrin

C Seva, CJ Dickinson, and T Yamada

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109.

Peptide alpha amidation is required to produce some hormones, such as gastrin, from their glycine-extended precursors. This terminal posttranslational processing reaction is thought to be essential for the biological activation of many peptide hormones; only amidated gastrin exerts a physiological effect that results in gastric acid secretion. However, both amidated gastrin and glycine-extended gastrin stimulate proliferation of exocrine pancreatic cell line AR4-2J through selective receptors for the substrate and the product, respectively, of peptide alpha amidation. Thus, the amidation reaction may function as a determinant of the specific biological actions of products derived from prohormones.


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