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Science 15 July 1994:
Vol. 265. no. 5170, pp. 407 - 409
DOI: 10.1126/science.8023164
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Articles

Science, Vol 265, Issue 5170, 407-409
Copyright © 1994 by American Association for the Advancement of Science

articles

Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs

PL Foster and JM Trimarchi

Department of Environmental Health, Boston University School of Public Health, MA 02118.

Spontaneous mutations are thought to occur primarily in growing cells. However, spontaneous mutations also arise in nutritionally deprived cells, and in some cases this process appears to be adaptive. Here it is reported that when a Lac- strain of Escherichia coli is under selection for lactose use, the spectrum of Lac+ mutations that arises is different, and simpler, than that arising without selection. Mutations appearing during selection were mainly one-base deletions in runs of iterated bases. Similar mutations occurring in repetitive DNA elements are associated with a variety of human hereditary diseases and are increased in cells that cannot correct heteroduplex DNA.


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