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Science 15 July 1994: Vol. 265. no. 5170, pp. 391 - 394 DOI: 10.1126/science.8023160
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Articles
Science, Vol 265, Issue 5170, 391-394
Copyright © 1994 by American Association for the Advancement of Science
Potential role of human cytomegalovirus and p53 interaction in coronary restenosis
E Speir,
R Modali,
ES Huang,
MB Leon,
F Shawl,
T Finkel,
and
SE Epstein
Cardiology Branch, National Institutes of Health, Bethesda, MD 20892.
A subset of patients who have undergone coronary angioplasty develop restenosis, a vessel renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 human restenosis lesions examined, 23 (38 percent) were found to have accumulated high amounts of the tumor suppressor protein p53, and this correlated with the presence of human cytomegalovirus (HCMV) in the lesions. SMCs grown from the lesions expressed HCMV protein IE84 and high amounts of p53. HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression. IE84 also bound to p53 and abolished its ability to transcriptionally activate a reporter gene. Thus, HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.
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Circulation
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- Cytomegalovirus, Chlamydia pneumoniae, and Helicobacter pylori IgG antibodies and restenosis after stent implantation: an angiographic and intravascular ultrasound study.
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- Chronic Infections and the Risk of Carotid Atherosclerosis : Prospective Results From a Large Population Study.
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Circulation
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- Human Cytomegalovirus with IE-2 (UL122) Deleted Fails To Express Early Lytic Genes.
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- Adult human heart microvascular endothelial cells are permissive for non-lytic infection by human cytomegalovirus.
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Cardiovasc Res
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- Antioxidant Effect of Estrogen on Cytomegalovirus-Induced Gene Expression in Coronary Artery Smooth Muscle Cells.
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Circulation
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- Competition for p300 Regulates Transcription by Estrogen Receptors and Nuclear Factor-{kappa}B in Human Coronary Smooth Muscle Cells.
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- Activation of Transcription of the Human Cytomegalovirus Early UL4 Promoter by the Ets Transcription Factor Binding Element.
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- Valganciclovir Results in Improved Oral Absorption of Ganciclovir in Liver Transplant Recipients.
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- The Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein Interacts
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