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Science 15 July 1994:
Vol. 265. no. 5170, pp. 391 - 394
DOI: 10.1126/science.8023160

Articles

Science, Vol 265, Issue 5170, 391-394
Copyright © 1994 by American Association for the Advancement of Science


articles

Potential role of human cytomegalovirus and p53 interaction in coronary restenosis

E Speir, R Modali, ES Huang, MB Leon, F Shawl, T Finkel, and SE Epstein

Cardiology Branch, National Institutes of Health, Bethesda, MD 20892.

A subset of patients who have undergone coronary angioplasty develop restenosis, a vessel renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 human restenosis lesions examined, 23 (38 percent) were found to have accumulated high amounts of the tumor suppressor protein p53, and this correlated with the presence of human cytomegalovirus (HCMV) in the lesions. SMCs grown from the lesions expressed HCMV protein IE84 and high amounts of p53. HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression. IE84 also bound to p53 and abolished its ability to transcriptionally activate a reporter gene. Thus, HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.


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Human Cytomegalovirus Inhibits Cytokine-Induced Macrophage Differentiation.
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J. Virol. 78, 4498-4507
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CMV Escapes!.
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Enhanced Cytomegalovirus Infection in Atherosclerotic Human Blood Vessels.
P. L. Nerheim, J. L. Meier, M. A. Vasef, W.-G. Li, L. Hu, J. B. Rice, D. Gavrila, W. E. Richenbacher, and N. L. Weintraub (2004)
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Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration Is Mediated by Focal Adhesion Kinase and Src.
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J. Biol. Chem. 278, 50456-50465
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Human Cytomegalovirus Inhibits Differentiation of Monocytes into Dendritic Cells with the Consequence of Depressed Immunological Functions.
S. Gredmark and C. Soderberg-Naucler (2003)
J. Virol. 77, 10943-10956
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Cell Cycle Regulation by Kaposi's Sarcoma-Associated Herpesvirus K-bZIP: Direct Interaction with Cyclin-CDK2 and Induction of G1 Growth Arrest.
Y. Izumiya, S.-F. Lin, T. J. Ellison, A. M. Levy, G. L. Mayeur, C. Izumiya, and H.-J. Kung (2003)
J. Virol. 77, 9652-9661
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Absence of p53 Leads to Accelerated Neointimal Hyperplasia After Vascular Injury.
M. Sata, K. Tanaka, N. Ishizaka, Y. Hirata, and R. Nagai (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 1548-1552
   Abstract »    Full Text »    PDF »
Acute Cytomegalovirus Infection and Transient Carotid Intimal-Medial Thickening in a Young, Otherwise Healthy Woman.
Y. Hirabayashi, T. Ishii, T. Kodera, H. Fujii, Y. Munakata, and T. Sasaki (2003)
J. Clin. Microbiol. 41, 3978-3980
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Paradoxical Upregulation of Tumor Suppressor Protein p53 in Serum-Stimulated Vascular Smooth Muscle Cells: A Novel Negative-Feedback Regulatory Mechanism.
Z. H. Mnjoyan, R. Dutta, D. Zhang, B.-B. Teng, and K. Fujise (2003)
Circulation 108, 464-471
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Endothelium-Dependent Effects of Statins.
S. Wolfrum, K. S. Jensen, and J. K. Liao (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 729-736
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Resveratrol Increases Serine15-Phosphorylated but Transcriptionally Impaired p53 and Induces a Reversible DNA Replication Block in Serum-Activated Vascular Smooth Muscle Cells.
U. G. B. Haider, D. Sorescu, K. K. Griendling, A. M. Vollmar, and V. M. Dirsch (2003)
Mol. Pharmacol. 63, 925-932
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Human Cytomegalovirus pp71 Stimulates Cell Cycle Progression by Inducing the Proteasome-Dependent Degradation of the Retinoblastoma Family of Tumor Suppressors.
R. F. Kalejta, J. T. Bechtel, and T. Shenk (2003)
Mol. Cell. Biol. 23, 1885-1895
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Cytomegalovirus-Mediated Upregulation of Chemokine Expression Correlates with the Acceleration of Chronic Rejection in Rat Heart Transplants.
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J. Virol. 77, 2182-2194
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Human cytomegalovirus immediate-early over protein 2 (IE2)-mediated activation of cyclin E is cell-cycle-independent and forces S-phase entry in IE2-arrested cells.
L. Wiebusch, J. Asmar, R. Uecker, and C. Hagemeier (2003)
J. Gen. Virol. 84, 51-60
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Synergistic induction of intercellular adhesion molecule-1 by the human cytomegalovirus transactivators IE2p86 and pp71 is mediated via an Sp1-binding site.
M. Kronschnabl and T. Stamminger (2003)
J. Gen. Virol. 84, 61-73
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Overexpression of p73 causes apoptosis in vascular smooth muscle cells.
B. B. Davis, Y. Dong, and R. H. Weiss (2003)
Am J Physiol Cell Physiol 284, C16-C23
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The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms.
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J. Virol. 76, 12503-12512
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T. Maisch, B. Kropff, C. Sinzger, and M. Mach (2002)
J. Virol. 76, 12803-12812
   Abstract »    Full Text »    PDF »
Cell Cycle Arrest by Human Cytomegalovirus 86-kDa IE2 Protein Resembles Premature Senescence.
E. Noris, C. Zannetti, A. Demurtas, J. Sinclair, M. De Andrea, M. Gariglio, and S. Landolfo (2002)
J. Virol. 76, 12135-12148
   Abstract »    Full Text »    PDF »
Human Cytomegalovirus-Caused Damage to Placental Trophoblasts Mediated by Immediate-Early Gene-Induced Tumor Necrosis Factor-{alpha}.
G. Chan, D. G. Hemmings, A. D. Yurochko, and L. J. Guilbert (2002)
Am. J. Pathol. 161, 1371-1381
   Abstract »    Full Text »    PDF »
Human Cytomegalovirus Immediate-Early Protein IE2-86, but not IE1-72, Causes Graft Coronary Arteriopathy in the Transplanted Rat Heart.
K. Suzuki, B. Murtuza, N. Suzuki, M. Khan, Y. Kaneda, and M. H. Yacoub (2002)
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J. C. Fanzo, S. K. Reaves, L. Cui, L. Zhu, and K. Y. Lei (2002)
Am J Physiol Cell Physiol 283, C631-C638
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Human Cytomegalovirus Infection and Expression in Human Malignant Glioma.
C. S. Cobbs, L. Harkins, M. Samanta, G. Y. Gillespie, S. Bharara, P. H. King, L. B. Nabors, C. G. Cobbs, and W. J. Britt (2002)
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Role of Regulatory Elements and the MAPK/ERK or p38 MAPK Pathways for Activation of Human Cytomegalovirus Gene Expression.
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Human Vascular Smooth Muscle Cells From Restenosis or In-Stent Stenosis Sites Demonstrate Enhanced Responses to p53: Implications for Brachytherapy and Drug Treatment for Restenosis.
S. Scott, M. O'Sullivan, S. Hafizi, L. M. Shapiro, and M. R. Bennett (2002)
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Viable Human Cytomegalovirus Recombinant Virus with an Internal Deletion of the IE2 86 Gene Affects Late Stages of Viral Replication.
V. Sanchez, C. L. Clark, J. Y. Yen, R. Dwarakanath, and D. H. Spector (2002)
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W. R. P. Agema, J. W. Jukema, S. N. Pimstone, and J. J. P. Kastelein (2001)
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Previous Cytomegalovirus Infection and Restenosis After Coronary Stent Placement.
F.-J. Neumann, A. Kastrati, T. Miethke, J. Mehilli, G. Pogatsa-Murray, W. Koch, M. Seyfarth, and A. Schomig (2001)
Circulation 104, 1135-1139
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The growth suppressor p27Kip1 protects against diet-induced atherosclerosis.
A. DIEZ-JUAN and V. ANDRES (2001)
FASEB J 15, 1989-1995
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Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor.
H. Nakamura, M. Li, J. Zarycki, and J. U. Jung (2001)
J. Virol. 75, 7572-7582
   Abstract »    Full Text »    PDF »
Prevention of Cytomegalovirus Infection-enhanced Experimental Obliterative Bronchiolitis by Antiviral Prophylaxis or Immunosuppression in Rat Tracheal Allografts.
J. M. TIKKANEN, E. A. KALLIO, C. A. BRUGGEMAN, P. K. KOSKINEN, and K. B. LEMSTROM (2001)
Am. J. Respir. Crit. Care Med. 164, 672-679
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Identification of a Novel Transcriptional Repressor Encoded by Human Cytomegalovirus.
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J. Virol. 75, 6062-6069
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Renal Arterial Stenosis in Renal Allografts: Retrospective Study of Predisposing Factors and Outcome after Percutaneous Transluminal Angioplasty.
N. H. Patel, R. M. Jindal, T. Wilkin, S. Rose, M. S. Johnson, H. Shah, J. Namyslowski, K. P. Moresco, and S. O. Trerotola (2001)
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Herpesvirus Lytic Replication and the Cell Cycle: Arresting New Developments.
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Cytomegalovirus in Renal Transplantation.
D. C. BRENNAN (2001)
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F Schiele, M K Batur, M F Seronde, N Meneveau, P Sewoke, A Bassignot, G Couetdic, F Caulfield, and J-P Bassand (2001)
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Cardiovasc Res 49, 440-448
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Antioxidant Effect of Estrogen on Cytomegalovirus-Induced Gene Expression in Coronary Artery Smooth Muscle Cells.
E. Speir, Z.-X. Yu, K. Takeda, V. J. Ferrans, and R. O. Cannon III (2000)
Circulation 102, 2990-2996
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Competition for p300 Regulates Transcription by Estrogen Receptors and Nuclear Factor-{kappa}B in Human Coronary Smooth Muscle Cells.
E. Speir, Z.-X. Yu, K. Takeda, V. J. Ferrans, and R. O. Cannon III (2000)
Circ. Res. 87, 1006-1011
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Activation of Transcription of the Human Cytomegalovirus Early UL4 Promoter by the Ets Transcription Factor Binding Element.
J. Chen and M. F. Stinski (2000)
J. Virol. 74, 9845-9857
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Valganciclovir Results in Improved Oral Absorption of Ganciclovir in Liver Transplant Recipients.
M. D. Pescovitz, J. Rabkin, R. M. Merion, C. V. Paya, J. Pirsch, R. B. Freeman, J. O'Grady, C. Robinson, Z. To, K. Wren, et al. (2000)
Antimicrob. Agents Chemother. 44, 2811-2815
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Role of Human Cytomegalovirus Immediate-Early Proteins in Cell Growth Control.
J. P. Castillo, A. D. Yurochko, and T. F. Kowalik (2000)
J. Virol. 74, 8028-8037
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The Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein Interacts