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Science 8 July 1994:
Vol. 265. no. 5169, pp. 259 - 262
DOI: 10.1126/science.7517575
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Articles

Science, Vol 265, Issue 5169, 259-262
Copyright © 1994 by American Association for the Advancement of Science

articles

Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium

SP Balk, S Burke, JE Polischuk, ME Frantz, L Yang, S Porcelli, SP Colgan, and RS Blumberg

Hematology-Oncology Division, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215.

A major histocompatibility complex class Ib protein, CD1d, is expressed by human intestinal epithelial cells (IECs) and is a ligand for CD8+ T cells. CD1d was found to be expressed on the surface of human IECs as a 37-kilodalton protein that was beta 2-microglobulin (beta 2M) independent with no N-linked carbohydrate. Transfection into a beta 2M- cell line confirmed that CD1d could be expressed at the cell surface in the absence of beta 2M. These data indicate that IECs use a specialized pathway for CD1d synthesis and that a beta 2M-independent class Ib protein may be the normal ligand for some intestinal T cells.


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