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Science 1 July 1994:
Vol. 265. no. 5168, pp. 92 - 95
DOI: 10.1126/science.8016657

Articles

Science, Vol 265, Issue 5168, 92-95
Copyright © 1994 by American Association for the Advancement of Science


articles

Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa

T Henkel, PD Ling, SD Hayward, and MG Peterson

Tularik Inc, South San Francisco, CA 94080.

The Epstein-Barr virus (EBV) transactivator protein, termed Epstein-Barr virus nuclear antigen 2 (EBNA2), plays a critical role in the regulation of latent viral transcription and in the immortalization of EBV-infected B cells. Unlike most transcription factors, EBNA2 does not bind directly to its cis-responsive DNA element but requires a cellular factor, termed C-promoter binding factor 1 (CBF1). Here, CBF1 was purified and was found to directly interact with EBNA2. CBF1 is identical to a protein thought to be involved in immunoglobulin gene rearrangement, RBPJ kappa. Contrary to previous reports, CBF1-RBPJ kappa did not bind to the recombination signal sequences but instead bound to sites in the EBV C-promoter and in the CD23 promoter.


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Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2.
L. J. Strobl, H. Höfelmayr, G. Marschall, M. Brielmeier, G. W. Bornkamm, and U. Zimber-Strobl (2000)
J. Virol. 74, 1727-1735
   Abstract »    Full Text »
A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters.
S. Zhou, M. Fujimuro, J. J.-D. Hsieh, L. Chen, and S. D. Hayward (2000)
J. Virol. 74, 1939-1947
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Intracellular Forms of Human NOTCH1 Functionally Activate Essential Epstein-Barr Virus Major Latent Promoters in the Burkitt's Lymphoma BJAB Cell Line but Repress These Promoters in Jurkat Cells.
M. Cotter, J. Callahan, J. Aster, and E. Robertson (2000)
J. Virol. 74, 1486-1494
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Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.
V. Morel and F. Schweisguth (2000)
Genes & Dev. 14, 377-388
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Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter.
L. Wang, S. R. Grossman, and E. Kieff (2000)
PNAS 97, 430-435
   Abstract »    Full Text »    PDF »
Sequence and Functional Analysis of EBNA-LP and EBNA2 Proteins from Nonhuman Primate Lymphocryptoviruses.
R. Peng, A. V. Gordadze, E. M. Fuentes Pananá, F. Wang, J. Zong, G. S. Hayward, J. Tan, and P. D. Ling (2000)
J. Virol. 74, 379-389
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Genetic Dissection of Cell Growth Arrest Functions Mediated by the Epstein-Barr Virus Lytic Gene Product, Zta.
A. Rodriguez, M. Armstrong, D. Dwyer, and E. Flemington (1999)
J. Virol. 73, 9029-9038
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Strong Selective Pressure for Evolution of an Epstein-Barr Virus LMP2B Homologue in the Rhesus Lymphocryptovirus.
P. Rivailler, C. Quink, and F. Wang (1999)
J. Virol. 73, 8867-8872
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Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors.
S. Jayachandra, K. G. Low, A.-E. Thlick, J. Yu, P. D. Ling, Y. Chang, and P. S. Moore (1999)
PNAS 96, 11566-11571
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Characterization of DP103, a Novel DEAD Box Protein That Binds to the Epstein-Barr Virus Nuclear Proteins EBNA2 and EBNA3C.
A. T. Grundhoff, E. Kremmer, O. Tureci, A. Glieden, C. Gindorf, J. Atz, N. Mueller-Lantzsch, W. H. Schubach, and F. A. Grasser (1999)
J. Biol. Chem. 274, 19136-19144
   Abstract »    Full Text »    PDF »
Epstein-Barr Virus Nuclear Antigen 3C Interacts with Histone Deacetylase To Repress Transcription.
S. A. Radkov, R. Touitou, A. Brehm, M. Rowe, M. West, T. Kouzarides, and M. J. Allday (1999)
J. Virol. 73, 5688-5697
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Epstein-Barr Virus (EBV) Nuclear Protein 2-Induced Disruption of EBV Latency in the Burkitt's Lymphoma Cell Line Akata: Analysis by Tetracycline-Regulated Expression.
S. Fujiwara, Y. Nitadori, H. Nakamura, T. Nagaishi, and Y. Ono (1999)
J. Virol. 73, 5214-5219
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The Proto-Oncogene c-myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2.
C. Kaiser, G. Laux, D. Eick, N. Jochner, G. W. Bornkamm, and B. Kempkes (1999)
J. Virol. 73, 4481-4484
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Activated Mouse Notch1 Transactivates Epstein-Barr Virus Nuclear Antigen 2-Regulated Viral Promoters.
H. Höfelmayr, L. J. Strobl, C. Stein, G. Laux, G. Marschall, G. W. Bornkamm, and U. Zimber-Strobl (1999)
J. Virol. 73, 2770-2780
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CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
J. J.-D. Hsieh, S. Zhou, L. Chen, D. B. Young, and S. D. Hayward (1999)
PNAS 96, 23-28
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Mta Has Properties of an RNA Export Protein and Increases Cytoplasmic Accumulation of Epstein-Barr Virus Replication Gene mRNA.
O. J. Semmes, L. Chen, R. T. Sarisky, Z. Gao, L. Zhong, and S. D. Hayward (1998)
J. Virol. 72, 9526-9534
   Abstract »    Full Text »    PDF »
Residues 231 to 280 of the Epstein-Barr Virus Nuclear Protein 2 Are Not Essential for Primary B-Lymphocyte Growth Transformation.
S. Harada, R. Yalamanchili, and E. Kieff (1998)
J. Virol. 72, 9948-9954
   Abstract »    Full Text »    PDF »



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