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Science 1 July 1994:
Vol. 265. no. 5168, pp. 118 - 120
DOI: 10.1126/science.8016645
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Articles

Science, Vol 265, Issue 5168, 118-120
Copyright © 1994 by American Association for the Advancement of Science

articles

Suppression of odorant responses by odorants in olfactory receptor cells

T Kurahashi, G Lowe, and GH Gold

Monell Chemical Senses Center, Philadelphia, PA 19104.

Odorants activate an inward current in vertebrate olfactory receptor cells. Here it is shown, in receptor cells from the newt, that odorants can also suppress this current, by a mechanism that is distinct from inhibition and adaptation. Suppression provides a simple explanation for two seemingly unrelated phenomena: the anomalously long latency of olfactory transduction and the existence of an "off response" at the end of a prolonged stimulus. Suppression may influence the perception of odorants by masking odorant responses and by sharpening the odorant specificities of single cells.


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