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Science 24 June 1994:
Vol. 264. no. 5167, pp. 1948 - 1951
DOI: 10.1126/science.7516582
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Articles

Science, Vol 264, Issue 5167, 1948-1951
Copyright © 1994 by American Association for the Advancement of Science

articles

Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking

S Mayor, KG Rothberg, and FR Maxfield

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

Glycosyl-phosphatidylinositol (GPI)-anchored proteins have been reported to reside in clusters collected over small membrane invaginations called caveolae. The detection of different GPI-anchored proteins with fluorescently labeled monoclonal antibodies showed that these proteins are not constitutively concentrated in caveolae; they enter these structures independently after cross-linking with polyclonal secondary antibodies. Analysis of the cell surface distribution of the GPI-anchored folate receptor by electron microscopy confirms these observations. Thus, multimerization of GPI-anchored proteins regulates their sequestration in caveolae, but in the absence of agents that promote clustering they are diffusely distributed over the plasma membrane.


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   Abstract »    Full Text »    PDF »
Ligand-stimulated beta 2-adrenergic receptor internalization via the constitutive endocytic pathway into rab5-containing endosomes.
R. Moore, N Sadovnikoff, S Hoffenberg, S Liu, P Woodford, K Angelides, J. Trial, N. Carsrud, B. Dickey, and B. Knoll (1995)
J. Cell Sci. 108, 2983-2991
   Abstract »    PDF »
The glycophosphatidylinositol anchor affects the conformation of Thy-1 protein.
E Barboni, B. Rivero, A. George, S. Martin, D. Renoup, E. Hounsell, P. Barber, and R. Morris (1995)
J. Cell Sci. 108, 487-497
   Abstract »    PDF »
Inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae is linked to actin filaments.
T Fujimoto, A Miyawaki, and K Mikoshiba (1995)
J. Cell Sci. 108, 7-15
   Abstract »    PDF »
Lazarillo, a new GPI-linked surface lipocalin, is restricted to a subset of neurons in the grasshopper embryo.
M. Ganfornina, D Sanchez, and M. Bastiani (1995)
Development 121, 123-134
   Abstract »    PDF »
Lipid Rafts Exist as Stable Cholesterol-independent Microdomains in the Brush Border Membrane of Enterocytes.
G. H. Hansen, L. Immerdal, E. Thorsen, L.-L. Niels-Christiansen, B. T. Nystrom, E. J. F. Demant, and E. M. Danielsen (2001)
J. Biol. Chem. 276, 32338-32344
   Abstract »    Full Text »    PDF »
Palmitoylation of Caveolin-1 at a Single Site (Cys-156) Controls Its Coupling to the c-Src Tyrosine Kinase. TARGETING OF DUALLY ACYLATED MOLECULES (GPI-LINKED, TRANSMEMBRANE, OR CYTOPLASMIC) TO CAVEOLAE EFFECTIVELY UNCOUPLES c-Src AND CAVEOLIN-1 (TYR-14).
H. Lee, S. E. Woodman, J. A. Engelman, D. Volonte', F. Galbiati, H. L. Kaufman, D. M. Lublin, and M. P. Lisanti (2001)
J. Biol. Chem. 276, 35150-35158
   Abstract »    Full Text »    PDF »
Lipid rafts are required for GLUT4 internalization in adipose cells.
A. Ros-Baro, C. Lopez-Iglesias, S. Peiro, D. Bellido, M. Palacin, A. Zorzano, and M. Camps (2001)
PNAS 98, 12050-12055
   Abstract »    Full Text »    PDF »
Heterologous desensitization of EGF receptors and PDGF receptors by sequestration in caveolae.
S. V. Matveev and E. J. Smart (2002)
Am J Physiol Cell Physiol 282, C935-C946
   Abstract »    Full Text »    PDF »


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