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Science 24 June 1994:
Vol. 264. no. 5167, pp. 1918 - 1921
DOI: 10.1126/science.8009221

Articles

Science, Vol 264, Issue 5167, 1918-1921
Copyright © 1994 by American Association for the Advancement of Science


articles

Functional role of type I and type II interferons in antiviral defense

U Muller, U Steinhoff, LF Reis, S Hemmi, J Pavlovic, RM Zinkernagel, and M Aguet

Institute of Molecular Biology I, University of Zurich, Switzerland.

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.


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   Abstract »    Full Text »    PDF »
Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus.
C. Johansson, J. D. Wetzel, J. He, C. Mikacenic, T. S. Dermody, and B. L. Kelsall (2007)
J. Exp. Med. 204, 1349-1358
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Murine Dendritic Cell Type I IFN Production Induced by Human IgG-RNA Immune Complexes Is IFN Regulatory Factor (IRF)5 and IRF7 Dependent and Is Required for IL-6 Production.
K. Yasuda, C. Richez, J. W. Maciaszek, N. Agrawal, S. Akira, A. Marshak-Rothstein, and I. R. Rifkin (2007)
J. Immunol. 178, 6876-6885
   Abstract »    Full Text »    PDF »
La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts.
G. Blakqori, S. Delhaye, M. Habjan, C. D. Blair, I. Sanchez-Vargas, K. E. Olson, G. Attarzadeh-Yazdi, R. Fragkoudis, A. Kohl, U. Kalinke, et al. (2007)
J. Virol. 81, 4991-4999
   Abstract »    Full Text »    PDF »
Type I Interferon Signaling and B Cells Maintain Hemopoiesis during Pneumocystis Infection of the Lung.
N. Meissner, M. Rutkowski, A. L. Harmsen, S. Han, and A. G. Harmsen (2007)
J. Immunol. 178, 6604-6615
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Vesicular Stomatitis Virus Glycoprotein Displaying Retrovirus-Like Particles Induce a Type I IFN Receptor-Dependent Switch to Neutralizing IgG Antibodies.
P. Bach, E. Kamphuis, B. Odermatt, G. Sutter, C. J. Buchholz, and U. Kalinke (2007)
J. Immunol. 178, 5839-5847
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NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.
U. Schleicher, J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J. A.A. Fischer, S. Weiss, U. Kalinke, S. Kunz, et al. (2007)
J. Exp. Med. 204, 893-906
   Abstract »    Full Text »    PDF »
Oligoadenylate Synthetase/Protein Kinase R Pathways and {alpha}beta TCR+ T Cells Are Required for Adenovirus Vector: IFN-{gamma} Inhibition of Herpes Simplex Virus-1 in Cornea.
B. A. Austin, W. P. Halford, B. R. G. Williams, and D. J. J. Carr (2007)
J. Immunol. 178, 5166-5172
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Role of MyD88 in Route-Dependent Susceptibility to Vesicular Stomatitis Virus Infection.
S. Zhou, E. A. Kurt-Jones, K. A. Fitzgerald, J. P. Wang, A. M. Cerny, M. Chan, and R. W. Finberg (2007)
J. Immunol. 178, 5173-5181
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In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein.
D. C. Clark, M. Lobigs, E. Lee, M. J. Howard, K. Clark, B. J. Blitvich, and R. A. Hall (2007)
J. Gen. Virol. 88, 1175-1183
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Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways.
J. Zhu, X. Huang, and Y. Yang (2007)
J. Virol. 81, 3170-3180
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Functional Polymorphism in the Suppressor of Cytokine Signaling 1 Gene Associated with Adult Asthma.
M. Harada, K. Nakashima, T. Hirota, M. Shimizu, S. Doi, K. Fujita, T. Shirakawa, T. Enomoto, M. Yoshikawa, H. Moriyama, et al. (2007)
Am. J. Respir. Cell Mol. Biol. 36, 491-496
   Abstract »    Full Text »    PDF »
CpG-B ODNs potently induce low levels of IFN-{alpha}{beta} and induce IFN-{alpha}{beta}-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNs.
R. C. Gray, J. Kuchtey, and C. V. Harding (2007)
J. Leukoc. Biol. 81, 1075-1085
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Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System.
J.-P. Levraud, P. Boudinot, I. Colin, A. Benmansour, N. Peyrieras, P. Herbomel, and G. Lutfalla (2007)
J. Immunol. 178, 4385-4394
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IL-12 and Type-I IFN Synergize for IFN-{gamma} Production by CD4 T Cells, Whereas Neither Are Required for IFN-{gamma} Production by CD8 T Cells after Listeria monocytogenes Infection.
S. S. Way, C. Havenar-Daughton, G. A. Kolumam, N. N. Orgun, and K. Murali-Krishna (2007)
J. Immunol. 178, 4498-4505
   Abstract »    Full Text »    PDF »
Oncolytic Vesicular Stomatitis Virus Induces Apoptosis via Signaling through PKR, Fas, and Daxx.
D. F. Gaddy and D. S. Lyles (2007)
J. Virol. 81, 2792-2804
   Abstract »    Full Text »    PDF »



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