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Science 24 June 1994: Vol. 264. no. 5167, pp. 1918 - 1921 DOI: 10.1126/science.8009221
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Articles
Science, Vol 264, Issue 5167, 1918-1921
Copyright © 1994 by American Association for the Advancement of Science
Functional role of type I and type II interferons in antiviral defense
U Muller,
U Steinhoff,
LF Reis,
S Hemmi,
J Pavlovic,
RM Zinkernagel,
and
M Aguet
Institute of Molecular Biology I, University of Zurich, Switzerland.
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
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- Virulence of a mouse-adapted Semliki Forest virus strain is associated with reduced susceptibility to interferon.
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- Stat2-Dependent Regulation of MHC Class II Expression.
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J. Immunol.
179, 463-471
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- Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.
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Blood
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- Type I IFN Contributes to NK Cell Homeostasis, Activation, and Antitumor Function.
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- TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help.
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Blood
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- Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus.
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- Murine Dendritic Cell Type I IFN Production Induced by Human IgG-RNA Immune Complexes Is IFN Regulatory Factor (IRF)5 and IRF7 Dependent and Is Required for IL-6 Production.
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- La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts.
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- Type I Interferon Signaling and B Cells Maintain Hemopoiesis during Pneumocystis Infection of the Lung.
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- Vesicular Stomatitis Virus Glycoprotein Displaying Retrovirus-Like Particles Induce a Type I IFN Receptor-Dependent Switch to Neutralizing IgG Antibodies.
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- NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.
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- Oligoadenylate Synthetase/Protein Kinase R Pathways and {alpha}beta TCR+ T Cells Are Required for Adenovirus Vector: IFN-{gamma} Inhibition of Herpes Simplex Virus-1 in Cornea.
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- Role of MyD88 in Route-Dependent Susceptibility to Vesicular Stomatitis Virus Infection.
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- In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein.
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- Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways.
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- Functional Polymorphism in the Suppressor of Cytokine Signaling 1 Gene Associated with Adult Asthma.
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- CpG-B ODNs potently induce low levels of IFN-{alpha}{beta} and induce IFN-{alpha}{beta}-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNs.
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- Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System.
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- IL-12 and Type-I IFN Synergize for IFN-{gamma} Production by CD4 T Cells, Whereas Neither Are Required for IFN-{gamma} Production by CD8 T Cells after Listeria monocytogenes Infection.
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- Oncolytic Vesicular Stomatitis Virus Induces Apoptosis via Signaling through PKR, Fas, and Daxx.
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