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Science 24 June 1994:
Vol. 264. no. 5167, pp. 1878 - 1883
DOI: 10.1126/science.8009217
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Articles

Science, Vol 264, Issue 5167, 1878-1883
Copyright © 1994 by American Association for the Advancement of Science

articles

Malaria pathogenesis

LH Miller, MF Good, and G Milon

Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Malaria is a disease caused by repeated cycles of growth of the parasite Plasmodium in the erythrocyte. Various cellular and molecular strategies allow the parasite to evade the human immune response for many cycles of parasite multiplication. Under certain circumstances Plasmodium infection causes severe anemia or cerebral malaria; the expression of disease is influenced by both parasite and host factors, as exemplified by the exacerbation of disease during pregnancy. This article provides an overview of malaria pathogenesis, synthesizing the recent field, laboratory, and epidemiological data that will lead to the development of strategies to reduce mortality and morbidity.


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Am. J. Pathol. 158, 163-172
   Abstract »    Full Text »    PDF »
Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance.
I. D. McGilvray, L. Serghides, A. Kapus, O. D. Rotstein, and K. C. Kain (2000)
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Molecular Aspects of Severe Malaria.
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Q. Chen, A. Heddini, A. Barragan, V. Fernandez, S. F. A. Pearce, and M. Wahlgren (2000)
J. Exp. Med. 192, 1-10
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The Duffy-binding-like domain 1 of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a heparan sulfate ligand that requires 12 mers for binding.
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Blood 95, 3594-3599
   Abstract »    Full Text »    PDF »
Macrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia.
J. A. Martiney, B. Sherry, C. N. Metz, M. Espinoza, A. S. Ferrer, T. Calandra, H. E. Broxmeyer, and R. Bucala (2000)
Infect. Immun. 68, 2259-2267
   Abstract »    Full Text »    PDF »
Multiple human serum components act as bridging molecules in rosette formation by Plasmodium falciparum-infected erythrocytes.
E. A. Somner, J. Black, and G. Pasvol (2000)
Blood 95, 674-682
   Abstract »    Full Text »    PDF »
Small, Clonally Variant Antigens Expressed on the Surface of the Plasmodium falciparum-infected Erythrocyte Are Encoded by the rif Gene Family and Are the Target of Human Immune Responses.
V. Fernandez, M. Hommel, Q. Chen, P. Hagblom, and M. Wahlgren (1999)
J. Exp. Med. 190, 1393-1404
   Abstract »    Full Text »    PDF »
CD36 Peptides That Block Cytoadherence Define the CD36 Binding Region for Plasmodium falciparum-Infected Erythrocytes.
D. I. Baruch, X. C. Ma, B. Pasloske, R. J. Howard, and L. H. Miller (1999)
Blood 94, 2121-2127
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T cell response in malaria pathogenesis: selective increase in T cells carrying the TCR V{beta}8 during experimental cerebral malaria.
M. I. Boubou, A. Collette, D. Voegtle, D. Mazier, P.-A. Cazenave, and S. Pied (1999)
Int. Immunol. 11, 1553-1562
   Abstract »    Full Text »    PDF »
DNA and a CpG Oligonucleotide Derived from Babesia bovis Are Mitogenic for Bovine B Cells.
W. C. Brown, D. M. Estes, S. E. Chantler, K. A. Kegerreis, and C. E. Suarez (1998)
Infect. Immun. 66, 5423-5432
   Abstract »    Full Text »    PDF »
The evolution of primate malaria parasites based on the gene encoding cytochrome b from the linear mitochondrial genome.
A. A. Escalante, D. E. Freeland, W. E. Collins, and A. A. Lal (1998)
PNAS 95, 8124-8129
   Abstract »    Full Text »    PDF »
Multiple Adhesive Phenotypes Linked to Rosetting Binding of Erythrocytes in Plasmodium falciparum Malaria.
V. Fernandez, C. J. Treutiger, G. B. Nash, and M. Wahlgren (1998)
Infect. Immun. 66, 2969-2975
   Abstract »    Full Text »    PDF »
Identification of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) as the Rosetting Ligand of the Malaria Parasite P. falciparum.
Q. Chen, A. Barragan, V. Fernandez, A. Sundstrom, M. Schlichtherle, A. Sahlen, J. Carlson, S. Datta, and M. Wahlgren (1998)
J. Exp. Med. 187, 15-23
   Abstract »    Full Text »    PDF »
Identification of a Region of PfEMP1 That Mediates Adherence of Plasmodium falciparum Infected Erythrocytes to CD36: Conserved Function With Variant Sequence.
D. I. Baruch, X. C. Ma, H. B. Singh, X. Bi, B. L. Pasloske, and R. J. Howard (1997)
Blood 90, 3766-3775
   Abstract »    Full Text »    PDF »
From Malaria to Chemokine Receptor: The Emerging Physiologic Role of the Duffy Blood Group Antigen.
T. J. Hadley and S. C. Peiper (1997)
Blood 89, 3077-3091
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Artemether in Severe Malaria -- Still Too Many Deaths.
S. L. Hoffman (1996)
N. Engl. J. Med. 335, 124-126
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Malarial Circumsporozoite Protein Is a Novel Gene Delivery Vehicle to Primary Hepatocyte Cultures and Cultured Cells.
Z.-M. Ding, R. J. Cristiano, J. A. Roth, B. Takacs, and M. T. Kuo (1995)
J. Biol. Chem. 270, 3667-3676
   Abstract »    Full Text »    PDF »
Characterization of Proteoglycans of Human Placenta and Identification of Unique Chondroitin Sulfate Proteoglycans of the Intervillous Spaces That Mediate the Adherence of Plasmodium falciparum-infected Erythrocytes to the Placenta.
R. N. Achur, M. Valiyaveettil, A. Alkhalil, C. F. Ockenhouse, and D. C. Gowda (2000)
J. Biol. Chem. 275, 40344-40356
   Abstract »    Full Text »    PDF »
Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malaria.
J. D. Smith, A. G. Craig, N. Kriek, D. Hudson-Taylor, S. Kyes, T. Fagan, R. Pinches, D. I. Baruch, C. I. Newbold, and L. H. Miller (2000)
PNAS 97, 1766-1771
   Abstract »    Full Text »    PDF »
A role for CD36 in the regulation of dendritic cell function.
B. C. Urban, N. Willcox, and D. J. Roberts (2001)
PNAS 98, 8750-8755
   Abstract »    Full Text »    PDF »


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