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Science 17 June 1994:
Vol. 264. no. 5166, pp. 1724 - 1733
DOI: 10.1126/science.8209253
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Articles

Science, Vol 264, Issue 5166, 1724-1733
Copyright © 1994 by American Association for the Advancement of Science

articles

Forward and reverse genetic approaches to behavior in the mouse

JS Takahashi, LH Pinto, and MH Vitaterna

Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.

Modern molecular genetic and genomic approaches are revolutionizing the study of behavior in the mouse. "Reverse genetics" (from gene to phenotype) with targeted gene transfer provides a powerful tool to dissect behavior and has been used successfully to study the effects of null mutations in genes implicated in the regulation of long-term potentiation and spatial learning in mice. In addition, "forward genetics" (from phenotype to gene) with high-efficiency mutagenesis in the mouse can uncover unknown genes and has been used to isolate a behavioral mutant of the circadian system. With the recent availability of high-density genetic maps and physical mapping resources, positional cloning of virtually any mutation is now feasible in the mouse. Together, these approaches permit a molecular analysis of both known and previously unknown genes regulating behavior.


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