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Science 17 June 1994:
Vol. 264. no. 5166, pp. 1715 - 1723
DOI: 10.1126/science.8209252
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Articles

Science, Vol 264, Issue 5166, 1715-1723
Copyright © 1994 by American Association for the Advancement of Science

articles

Genetic animal models of alcohol and drug abuse

JC Crabbe, JK Belknap, and KJ Buck

Research Service, Veterans Administration (VA) Medical Center, Portland, OR 97201.

Behavioral and pharmacological responses of selectively bred and inbred rodent lines have been analyzed to elucidate many features of drug sensitivity and the adverse effects of drugs, the underlying mechanisms of drug tolerance and dependence, and the motivational states underlying drug reward and aversion. Genetic mapping of quantitative trait loci (QTLs) has been used to identify provisional chromosomal locations of genes influencing such pharmacological responses. Recent advances in transgenic technology, representational difference analysis, and other molecular methods now make feasible the positional cloning of QTLs that influence sensitivity to drugs of abuse. This marks a new period of synthesis in pharmacogenetic research, in which networks of drug-related behaviors, their underlying pharmacological, physiological, and biochemical mechanisms, and particular genomic regions of interest are being identified.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Ferment in the Family Tree: Does a Frugivorous Dietary Heritage Influence Contemporary Patterns of Human Ethanol Use?.
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Genetic analyses of complex behavioral disorders.
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Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice..
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Common Quantitative Trait Loci for Alcohol-Related Behaviors and Central Nervous System Neurotensin Measures: Hypnotic and Hypothermic Effects.
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M A Bedell, D A Largaespada, N A Jenkins, and N G Copeland (1997)
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Quantitative Trait Loci Mapping in Mouse Models of Complex Behavior.
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Molecular dissection of quantitative traits: progress and prospects..
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Genome Res. 5, 321-333
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Convergent Domestication of Cereal Crops by Independent Mutations at Corresponding Genetic Loci.
A. H. Paterson, Y.-R. Lin, Z. Li, K. F. Schertz, J. F. Doebley, S. R. M. Pinson, S.-C. Liu, J. W. Stansel, and J. E. Irvine (1995)
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Quantitative trait loci that modify the severity of spotting in piebald mice..
W J Pavan, S Mac, M Cheng, and S M Tilghman (1995)
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P. M. Marzuk and J. D. Barchas (1995)
JAMA 273, 1715-1716
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The D2 receptor gene.
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Genetic dissection of complex traits.
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