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Science 10 June 1994:
Vol. 264. no. 5165, pp. 1551 - 1557
DOI: 10.1126/science.8202709
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Articles
Science, Vol 264, Issue 5165, 1551-1557
Copyright © 1994 by American Association for the Advancement of Science
How nature builds the pigments of life: the conquest of vitamin B12
AR Battersby
University Chemical Laboratory, Cambridge, UK.
In part because humans cannot synthesize vitamin B12 and must obtain it from organisms that produce it and because B12 deficiency leads to pernicious anemia, it has been important to understand how microorganisms build this quite complex substance. As shown here, an interdisciplinary attack was needed, which combined the strengths of genetics, molecular biology, enzymology, chemistry, and spectroscopy. This allowed the step-by-step synthetic pathway of B12 to be elucidated, and this approach has acted as a model for future research on the synthesis of substances in living organisms. One practical outcome of such an approach has been the improved availability of B12 for animal feedstuffs and human health.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Demonstration That CobG, the Monooxygenase Associated with the Ring Contraction Process of the Aerobic Cobalamin (Vitamin B12) Biosynthetic Pathway, Contains an Fe-S Center and a Mononuclear Non-heme Iron Center.
- S. Schroeder, A. D. Lawrence, R. Biedendieck, R.-S. Rose, E. Deery, R. M. Graham, K. J. McLean, A. W. Munro, S. E. J. Rigby, and M. J. Warren (2009)
J. Biol. Chem.
284, 4796-4805
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- The PduX Enzyme of Salmonella enterica Is an L-Threonine Kinase Used for Coenzyme B12 Synthesis.
- C. Fan and T. A. Bobik (2008)
J. Biol. Chem.
283, 11322-11329
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- The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098.
- F. Santos, J. L. Vera, R. van der Heijden, G. Valdez, W. M. de Vos, F. Sesma, and J. Hugenholtz (2008)
Microbiology
154, 81-93
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- Finding the final pieces of the vitamin B12 biosynthetic jigsaw.
- M. J. Warren (2006)
PNAS
103, 4799-4800
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- The Yeast Iron Regulon Is Induced upon Cobalt Stress and Crucial for Cobalt Tolerance.
- J. A. Stadler and R. J. Schweyen (2002)
J. Biol. Chem.
277, 39649-39654
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- Identification of an Alternative Nucleoside Triphosphate: 5'-Deoxyadenosylcobinamide Phosphate Nucleotidyltransferase in Methanobacterium thermoautotrophicum Delta H.
- M. G. Thomas and J. C. Escalante-Semerena (2000)
J. Bacteriol.
182, 4227-4233
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- A primitive pathway of porphyrin biosynthesis and enzymology in Desulfovibrio vulgaris.
- T. Ishida, L. Yu, H. Akutsu, K. Ozawa, S. Kawanishi, A. Seto, T. Inubushi, and S. Sano (1998)
PNAS
95, 4853-4858
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- CobD, a Novel Enzyme with L-Threonine-O-3-phosphate Decarboxylase Activity, Is Responsible for the Synthesis of (R)-1-Amino-2-propanol O-2-Phosphate, a Proposed New Intermediate in Cobalamin Biosynthesis in Salmonella typhimurium LT2.
- K. R. Brushaber, G. A. O'Toole, and J. C. Escalante-Semerena (1998)
J. Biol. Chem.
273, 2684-2691
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- Sequence of a 189-kb segment of the chromosome of Rhodobacter capsulatus SB1003.
- C. Vlcek, V. Paces, N. Maltsev, R. Haselkorn, and M. Fonstein (1997)
PNAS
94, 9384-9388
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- Binding site revealed of nature's most beautiful cofactor.
- J Stubbe (1994)
Science
266, 1663-1664
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- An in Vitro Reducing System for the Enzymic Conversion of Cobalamin to Adenosylcobalamin.
- M. V. Fonseca and J. C. Escalante-Semerena (2001)
J. Biol. Chem.
276, 32101-32108
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