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Science 3 June 1994:
Vol. 264. no. 5164, pp. 1467 - 1471
DOI: 10.1126/science.8197461
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Articles

Science, Vol 264, Issue 5164, 1467-1471
Copyright © 1994 by American Association for the Advancement of Science

articles

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells

JW Schneider, W Gu, L Zhu, V Mahdavi, and B Nadal-Ginard

Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.

The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to re-enter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes.


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