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Science 3 June 1994:
Vol. 264. no. 5164, pp. 1455 - 1458
DOI: 10.1126/science.8197458

Articles

Science, Vol 264, Issue 5164, 1455-1458
Copyright © 1994 by American Association for the Advancement of Science


articles

Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription

S Halachmi, E Marden, G Martin, H MacKay, C Abbondanza, and M Brown

Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA.

The estrogen receptor is a transcription factor which, when bound to estradiol, binds DNA and regulates expression of estrogen-responsive genes. A 160-kilodalton estrogen receptor-associated protein, ERAP160, was identified that exhibits estradiol-dependent binding to the receptor. Mutational analysis of the receptor shows that its ability to activate transcription parallels its ability to bind ERAP160. Antiestrogens are unable to promote ERAP160 binding and can block the estrogen-dependent interaction of the receptor and ERAP160 in a dose-dependent manner. This evidence suggests that ERAP160 may mediate estradiol-dependent transcriptional activation by the estrogen receptor. Furthermore, the ability of antiestrogens to block estrogen receptor-ERAP160 complex formation could account for their therapeutic effects in breast cancer.


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   Abstract »    Full Text »    PDF »
Competition between Thyroid Hormone Receptor-associated Protein (TRAP) 220 and Transcriptional Intermediary Factor (TIF) 2 for Binding to Nuclear Receptors. IMPLICATIONS FOR THE RECRUITMENT OF TRAP AND p160 COACTIVATOR COMPLEXES.
E. Treuter, L. Johansson, J. S. Thomsen, A. Warnmark, J. Leers, M. Pelto-Huikko, M. Sjoberg, A. P. H. Wright, G. Spyrou, and J.-A. Gustafsson (1999)
J. Biol. Chem. 274, 6667-6677
   Abstract »    Full Text »    PDF »
Clinical Effects of Raloxifene Hydrochloride in Women.
W. Khovidhunkit and D. M. Shoback (1999)
Ann Intern Med 130, 431-439
   Abstract »    Full Text »    PDF »
Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog.
K.-I. Takeyama, Y. Masuhiro, H. Fuse, H. Endoh, A. Murayama, S. Kitanaka, M. Suzawa, J. Yanagisawa, and S. Kato (1999)
Mol. Cell. Biol. 19, 1049-1055
   Abstract »    Full Text »    PDF »
Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER{alpha} and ER{beta} Expressed in Chinese Hamster Ovary Cells.
M. Razandi, A. Pedram, G. L. Greene, and E. R. Levin (1999)
Mol. Endocrinol. 13, 307-319
   Abstract »    Full Text »
Transcriptional Regulation by a Naturally Occurring Truncated Rat Estrogen Receptor (ER), Truncated ER Product-1 (TERP-1).
D. A. Schreihofer, E. M. Resnick, A. Y. Soh, and M. A. Shupnik (1999)
Mol. Endocrinol. 13, 320-329
   Abstract »    Full Text »
Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium.
W.-S. Shim, J. DiRenzo, J. A. DeCaprio, R. J. Santen, M. Brown, and M.-H. Jeng (1999)
PNAS 96, 208-213
   Abstract »    Full Text »    PDF »
Functional Analysis of a Novel Estrogen Receptor-{beta} Isoform.
B. Hanstein, H. Liu, M. C. Yancisin, and M. Brown (1999)
Mol. Endocrinol. 13, 129-137
   Abstract »    Full Text »
Calmodulin Is Essential for Estrogen Receptor Interaction with Its Motif and Activation of Responsive Promoter.
D. K. Biswas, P. V. Reddy, M. Pickard, B. Makkad, N. Pettit, and A. B. Pardee (1998)
J. Biol. Chem. 273, 33817-33824
   Abstract »    Full Text »    PDF »
A Potent Antidiabetic Thiazolidinedione with Unique Peroxisome Proliferator-activated Receptor gamma -activating Properties.
M. J. Reginato, S. T. Bailey, S. L. Krakow, C. Minami, S. Ishii, H. Tanaka, and M. A. Lazar (1998)
J. Biol. Chem. 273, 32679-32684
   Abstract »    Full Text »    PDF »
Bcl3, an Ikappa B Protein, as a Novel Transcription Coactivator of the Retinoid X Receptor.
S.-Y. Na, H.-S. Choi, J. W. Kim, D. S. Na, and J. W. Lee (1998)
J. Biol. Chem. 273, 30933-30938
   Abstract »    Full Text »    PDF »
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation.
E. M. McInerney, D. W. Rose, S. E. Flynn, S. Westin, T.-M. Mullen, A. Krones, J. Inostroza, J. Torchia, R. T. Nolte, N. Assa-Munt, et al. (1998)
Genes & Dev. 12, 3357-3368
   Abstract »    Full Text »
Coactivator TIF1beta Interacts with Transcription Factor C/EBPbeta and Glucocorticoid Receptor To Induce alpha 1-Acid Glycoprotein Gene Expression.
C.-J. Chang, Y.-L. Chen, and S.-C. Lee (1998)
Mol. Cell. Biol. 18, 5880-5887
   Abstract »    Full Text »
Distinct steady-state nuclear receptor coregulator complexes exist in vivo.
N. J. McKenna, Z. Nawaz, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley (1998)
PNAS 95, 11697-11702
   Abstract »    Full Text »    PDF »
Identification of a Novel RING Finger Protein as a Coregulator in Steroid Receptor-Mediated Gene Transcription.
A.-M. Moilanen, H. Poukka, U. Karvonen, M. Häkli, O. A. Jänne, and J. J. Palvimo (1998)
Mol. Cell. Biol. 18, 5128-5139
   Abstract »    Full Text »
Tuberous Sclerosis Gene 2 Product Modulates Transcription Mediated by Steroid Hormone Receptor Family Members.
K. W. Henry, X. Yuan, N. J. Koszewski, H. Onda, D. J. Kwiatkowski, and D. J. Noonan (1998)
J. Biol. Chem. 273, 20535-20539
   Abstract »    Full Text »    PDF »



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