Science 27 May 1994: Vol. 264. no. 5163, pp. 1336 - 1340 DOI: 10.1126/science.8191290

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Articles

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.

K. Usui, J. D. Hulleman, J. F. Paulsson, S. J. Siegel, E. T. Powers, and J. W. Kelly (2009)
PNAS 106, 18563-18568
 |  Abstract »  |  Full Text »  |  PDF »

Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease.

S. Peng, D. J. Garzon, M. Marchese, W. Klein, S. D. Ginsberg, B. M. Francis, H. T. J. Mount, E. J. Mufson, A. Salehi, and M. Fahnestock (2009)
J. Neurosci. 29, 9321-9329
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Deletion of the {alpha}7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease.

G. Dziewczapolski, C. M. Glogowski, E. Masliah, and S. F. Heinemann (2009)
J. Neurosci. 29, 8805-8815
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Amyloid {beta}-Protein Toxicity and the Pathogenesis of Alzheimer Disease.

B. A. Yankner and T. Lu (2009)
J. Biol. Chem. 284, 4755-4759
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The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid {beta} Peptides in an in Vitro Model of the Blood-Brain Barrier Cells.

K. Yamada, T. Hashimoto, C. Yabuki, Y. Nagae, M. Tachikawa, D. K. Strickland, Q. Liu, G. Bu, J. M. Basak, D. M. Holtzman, et al. (2008)
J. Biol. Chem. 283, 34554-34562
 |  Abstract »  |  Full Text »  |  PDF »

Retinoic Acid Attenuates {beta}-Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model.

Y. Ding, A. Qiao, Z. Wang, J. S. Goodwin, E.-S. Lee, M. L. Block, M. Allsbrook, M. P. McDonald, and G.-H. Fan (2008)
J. Neurosci. 28, 11622-11634
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Phosphoinositides Suppress {gamma}-Secretase in Both the Detergent-soluble and -insoluble States.

S. Osawa, S. Funamoto, M. Nobuhara, S. Wada-Kakuda, M. Shimojo, S. Yagishita, and Y. Ihara (2008)
J. Biol. Chem. 283, 19283-19292
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of {gamma}-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes.

R. A. Sharples, L. J. Vella, R. M. Nisbet, R. Naylor, K. Perez, K. J. Barnham, C. L. Masters, and A. F. Hill (2008)
FASEB J 22, 1469-1478
 |  Abstract »  |  Full Text »  |  PDF »

5-Lipoxygenase gene disruption reduces amyloid-{beta} pathology in a mouse model of Alzheimer's disease.

O. Firuzi, J. Zhuo, C. M. Chinnici, T. Wisniewski, and D. Pratico (2008)
FASEB J 22, 1169-1178
 |  Abstract »  |  Full Text »  |  PDF »

Plasma amyloid {beta} protein is elevated in late-onset Alzheimer disease families.

N. Ertekin-Taner, L. H. Younkin, D. M. Yager, F. Parfitt, M. C. Baker, S. Asthana, M. L. Hutton, S. G. Younkin, and N. R. Graff-Radford (2008)
Neurology 70, 596-606
 |  Abstract »  |  Full Text »  |  PDF »

Genetic association of CTNNA3 with late-onset Alzheimer's disease in females.

A. Miyashita, H. Arai, T. Asada, M. Imagawa, E. Matsubara, M. Shoji, S. Higuchi, K. Urakami, A. Kakita, H. Takahashi, et al. (2007)
Hum. Mol. Genet. 16, 2854-2869
 |  Abstract »  |  Full Text »  |  PDF »

Rodent Abeta Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice.

J. L. Jankowsky, L. H. Younkin, V. Gonzales, D. J. Fadale, H. H. Slunt, H. A. Lester, S. G. Younkin, and D. R. Borchelt (2007)
J. Biol. Chem. 282, 22707-22720
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated A{beta} Deposition in APPswe/PS1{Delta}E9 Mice with Hemizygous Deletions of TTR (Transthyretin).

S. H. Choi, S. N. Leight, V. M.-Y. Lee, T. Li, P. C. Wong, J. A. Johnson, M. J. Saraiva, and S. S. Sisodia (2007)
J. Neurosci. 27, 7006-7010
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of -site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

H. Ma, S. Lesne, L. Kotilinek, J. V. Steidl-Nichols, M. Sherman, L. Younkin, S. Younkin, C. Forster, N. Sergeant, A. Delacourte, et al. (2007)
PNAS 104, 8167-8172
 |  Abstract »  |  Full Text »  |  PDF »

Cortical biochemistry in MCI and Alzheimer disease: Lack of correlation with clinical diagnosis.

M. S. Forman, E. J. Mufson, S. Leurgans, D. Pratico, S. Joyce, S. Leight, V. M.-Y. Lee, and J. Q. Trojanowski (2007)
Neurology 68, 757-763
 |  Abstract »  |  Full Text »  |  PDF »

The Tottori (D7N) and English (H6R) Familial Alzheimer Disease Mutations Accelerate Abeta Fibril Formation without Increasing Protofibril Formation.

Y. Hori, T. Hashimoto, Y. Wakutani, K. Urakami, K. Nakashima, M. M. Condron, S. Tsubuki, T. C. Saido, D. B. Teplow, and T. Iwatsubo (2007)
J. Biol. Chem. 282, 4916-4923
 |  Abstract »  |  Full Text »  |  PDF »

A review of genome mutation and Alzheimer's disease.

P. Thomas and M. Fenech (2007)
Mutagenesis 22, 15-33
 |  Abstract »  |  Full Text »  |  PDF »

A Century of Alzheimer's Disease.

M. Goedert and M. G. Spillantini (2006)
Science 314, 777-781
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic approaches to Alzheimer's disease.

H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang (2006)
Brain 129, 2840-2855
 |  Abstract »  |  Full Text »  |  PDF »

Acceleration of Amyloid beta-Peptide Aggregation by Physiological Concentrations of Calcium.

A. M. Isaacs, D. B. Senn, M. Yuan, J. P. Shine, and B. A. Yankner (2006)
J. Biol. Chem. 281, 27916-27923
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Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-beta Peptides Abeta40 and Abeta42: STABLE TRIMER OR TETRAMER FORMATION BY Abeta42.

Y.-R. Chen and C. G. Glabe (2006)
J. Biol. Chem. 281, 24414-24422
 |  Abstract »  |  Full Text »  |  PDF »

Age and Apolipoprotein E*4 Allele Effects on Cerebrospinal Fluid beta-Amyloid 42 in Adults With Normal Cognition..

E. R. Peskind, G. Li, J. Shofer, J. F. Quinn, J. A. Kaye, C. M. Clark, M. R. Farlow, C. DeCarli, M. A. Raskind, G. D. Schellenberg, et al. (2006)
Arch Neurol 63, 936-939
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Amyloid Precursor Protein (APP) at Thr668 Regulates the Nuclear Translocation of the APP Intracellular Domain and Induces Neurodegeneration..

K.-A Chang, H.-S. Kim, T.-Y. Ha, J.-W. Ha, K. Y. Shin, Y. H. Jeong, J.-P. Lee, C.-H. Park, S. Kim, T.-K. Baik, et al. (2006)
Mol. Cell. Biol. 26, 4327-4338
 |  Abstract »  |  Full Text »  |  PDF »

Reductions in levels of the Alzheimer's amyloid {beta} peptide after oral administration of ginsenosides.

F. Chen, E. A. Eckman, and C. B. Eckman (2006)
FASEB J 20, 1269-1271
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Amyloid Mediated Nitration of Manganese Superoxide Dismutase: Implication for Oxidative Stress in a APPNLh/NLh X PS-1P264L/P264L Double Knock-In Mouse Model of Alzheimer's Disease.

M. Anantharaman, J. Tangpong, J. N. Keller, M. P. Murphy, W. R. Markesbery, K. K. Kiningham, and D. K. St. Clair (2006)
Am. J. Pathol. 168, 1608-1618
 |  Abstract »  |  Full Text »  |  PDF »

Inclusion-body myositis and Alzheimer disease: Two sides of the same coin, or different currencies altogether?.

M. P. Murphy and T. E. Golde (2006)
Neurology 66, S65-S68
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The Solvent Protection of Alzheimer Amyloid-{beta}-(1-42) Fibrils as Determined by Solution NMR Spectroscopy.

A. Olofsson, A. E. Sauer-Eriksson, and A. Ohman (2006)
J. Biol. Chem. 281, 477-483
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Defective Tumor Necrosis Factor-{alpha}-dependent Control of Astrocyte Glutamate Release in a Transgenic Mouse Model of Alzheimer Disease.

D. Rossi, L. Brambilla, C. F. Valori, A. Crugnola, G. Giaccone, R. Capobianco, M. Mangieri, A. E. Kingston, A. Bloc, P. Bezzi, et al. (2005)
J. Biol. Chem. 280, 42088-42096
 |  Abstract »  |  Full Text »  |  PDF »

Choroid Plexus Megalin Is Involved in Neuroprotection by Serum Insulin-Like Growth Factor I.

E. Carro, C. Spuch, J. L. Trejo, D. Antequera, and I. Torres-Aleman (2005)
J. Neurosci. 25, 10884-10893
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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer {beta}-amyloid peptide in rodent.

N. H. Greig, T. Utsuki, D. K. Ingram, Y. Wang, G. Pepeu, C. Scali, Q.-S. Yu, J. Mamczarz, H. W. Holloway, T. Giordano, et al. (2005)
PNAS 102, 17213-17218
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta}2 Is a Neuronal Death-Inducing Ligand for Amyloid-{beta} Precursor Protein.

Y. Hashimoto, T. Chiba, M. Yamada, M. Nawa, K. Kanekura, H. Suzuki, K. Terashita, S. Aiso, I. Nishimoto, and M. Matsuoka (2005)
Mol. Cell. Biol. 25, 9304-9317
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen Therapy Fails to Alter Amyloid Deposition in the PDAPP Model of Alzheimer's Disease.

P. S. Green, K. Bales, S. Paul, and G. Bu (2005)
Endocrinology 146, 2774-2781
 |  Abstract »  |  Full Text »  |  PDF »

CLAC Binds to Amyloid {beta} Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils.

Y. Osada, T. Hashimoto, A. Nishimura, Y. Matsuo, T. Wakabayashi, and T. Iwatsubo (2005)
J. Biol. Chem. 280, 8596-8605
 |  Abstract »  |  Full Text »  |  PDF »

Elevated amyloid {beta} protein (A{beta}42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.

N. Ertekin-Taner, J. Ronald, L. Feuk, J. Prince, M. Tucker, L. Younkin, M. Hella, S. Jain, A. Hackett, L. Scanlin, et al. (2005)
Hum. Mol. Genet. 14, 447-460
 |  Abstract »  |  Full Text »  |  PDF »

Longer Forms of Amyloid {beta} Protein: Implications for the Mechanism of Intramembrane Cleavage by {gamma}-Secretase.

Y. Qi-Takahara, M. Morishima-Kawashima, Y. Tanimura, G. Dolios, N. Hirotani, Y. Horikoshi, F. Kametani, M. Maeda, T. C. Saido, R. Wang, et al. (2005)
J. Neurosci. 25, 436-445
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of the safety and immunogenicity of synthetic A{beta}42 (AN1792) in patients with AD.

A. J. Bayer, R. Bullock, R. W. Jones, D. Wilkinson, K. R. Paterson, L. Jenkins, S. B. Millais, and S. Donoghue (2005)
Neurology 64, 94-101
 |  Abstract »  |  Full Text »  |  PDF »

Altered Amyloid-{beta} Metabolism and Deposition in Genomic-based {beta}-Secretase Transgenic Mice.

M. J. Chiocco, L. S. Kulnane, L. Younkin, S. Younkin, G. Evin, and B. T. Lamb (2004)
J. Biol. Chem. 279, 52535-52542
 |  Abstract »  |  Full Text »  |  PDF »

Single Transmembrane Spanning Heterotrimeric G Protein-Coupled Receptors and Their Signaling Cascades.

T. B. Patel (2004)
Pharmacol. Rev. 56, 371-385
 |  Abstract »  |  Full Text »  |  PDF »

Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease.

J. Brown III, C. Theisler, S. Silberman, D. Magnuson, N. Gottardi-Littell, J. M. Lee, D. Yager, J. Crowley, K. Sambamurti, M. M. Rahman, et al. (2004)
J. Biol. Chem. 279, 34674-34681
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Neprilysin Chimeric Proteins Targeted to Subcellular Compartments on Amyloid {beta} Peptide Clearance in Primary Neurons.

E. Hama, K. Shirotani, N. Iwata, and T. C. Saido (2004)
J. Biol. Chem. 279, 30259-30264
 |  Abstract »  |  Full Text »  |  PDF »

Mostly Separate Distributions of CLAC- versus A{beta}40- or Thioflavin S-Reactivities in Senile Plaques Reveal Two Distinct Subpopulations of {beta}-Amyloid Deposits.

H. Kowa, T. Sakakura, Y. Matsuura, T. Wakabayashi, D. M.A. Mann, K. Duff, S. Tsuji, T. Hashimoto, and T. Iwatsubo (2004)
Am. J. Pathol. 165, 273-281
 |  Abstract »  |  Full Text »  |  PDF »

Luteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid-{beta} Precursor Protein and Amyloid-{beta} Deposition.

R. L. Bowen, G. Verdile, T. Liu, A. F. Parlow, G. Perry, M. A. Smith, R. N. Martins, and C. S. Atwood (2004)
J. Biol. Chem. 279, 20539-20545
 |  Abstract »  |  Full Text »  |  PDF »

Dimeric Amyloid {beta} Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease.

T. Kawarabayashi, M. Shoji, L. H. Younkin, L. Wen-Lang, D. W. Dickson, T. Murakami, E. Matsubara, K. Abe, K. H. Ashe, and S. G. Younkin (2004)
J. Neurosci. 24, 3801-3809
 |  Abstract »  |  Full Text »  |  PDF »

Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

Q. Zhang, E. T. Powers, J. Nieva, M. E. Huff, M. A. Dendle, J. Bieschke, C. G. Glabe, A. Eschenmoser, P. Wentworth Jr., R. A. Lerner, et al. (2004)
PNAS 101, 4752-4757
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Secretase Activity Increases with Aging in Human, Monkey, and Mouse Brain.

H. Fukumoto, D. L. Rosene, M. B. Moss, S. Raju, B. T. Hyman, and M. C. Irizarry (2004)
Am. J. Pathol. 164, 719-725
 |  Abstract »  |  Full Text »  |  PDF »

Mutant presenilins specifically elevate the levels of the 42 residue {beta}-amyloid peptide in vivo: evidence for augmentation of a 42-specific {gamma} secretase.

J. L. Jankowsky, D. J. Fadale, J. Anderson, G. M. Xu, V. Gonzales, N. A. Jenkins, N. G. Copeland, M. K. Lee, L. H. Younkin, S. L. Wagner, et al. (2004)
Hum. Mol. Genet. 13, 159-170
 |  Abstract »  |  Full Text »  |  PDF »

Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.

N. Ertekin-Taner, J. Ronald, H. Asahara, L. Younkin, M. Hella, S. Jain, E. Gnida, S. Younkin, D. Fadale, Y. Ohyagi, et al. (2003)
Hum. Mol. Genet. 12, 3133-3143
 |  Abstract »  |  Full Text »  |  PDF »

Cerebrospinal Fluid Tau and {beta}-Amyloid: How Well Do These Biomarkers Reflect Autopsy-Confirmed Dementia Diagnoses?.

C. M. Clark, S. Xie, J. Chittams, D. Ewbank, E. Peskind, D. Galasko, J. C. Morris, D. W. McKeel Jr, M. Farlow, S. L. Weitlauf, et al. (2003)
Arch Neurol 60, 1696-1702
 |  Abstract »  |  Full Text »  |  PDF »

Genetic background regulates {beta}-amyloid precursor protein processing and {beta}-amyloid deposition in the mouse.

E. J.H. Lehman, L. S. Kulnane, Y. Gao, M. C. Petriello, K. M. Pimpis, L. Younkin, G. Dolios, R. Wang, S. G. Younkin, and B. T. Lamb (2003)
Hum. Mol. Genet. 12, 2949-2956
 |  Abstract »  |  Full Text »  |  PDF »

Cu2+-induced modification of the kinetics of A{beta}(1-42) channels.

R. Bahadi, P. V. Farrelly, B. L. Kenna, C. C. Curtain, C. L. Masters, R. Cappai, K. J. Barnham, and J. I. Kourie (2003)
Am J Physiol Cell Physiol 285, C873-C880
 |  Abstract »  |  Full Text »  |  PDF »

The Non-cyclooxygenase Targets of Non-steroidal Anti-inflammatory Drugs, Lipoxygenases, Peroxisome Proliferator-activated Receptor, Inhibitor of {kappa}B Kinase, and NF{kappa}B, Do Not Reduce Amyloid {beta}42 Production.

S. A. Sagi, S. Weggen, J. Eriksen, T. E. Golde, and E. H. Koo (2003)
J. Biol. Chem. 278, 31825-31830
 |  Abstract »  |  Full Text »  |  PDF »

Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid {beta}42 Production by Direct Modulation of {gamma}-Secretase Activity.

S. Weggen, J. L. Eriksen, S. A. Sagi, C. U. Pietrzik, V. Ozols, A. Fauq, Todd. E. Golde, and E. H. Koo (2003)
J. Biol. Chem. 278, 31831-31837
 |  Abstract »  |  Full Text »  |  PDF »

Neurotoxic Mechanisms Caused by the Alzheimer's Disease-linked Swedish Amyloid Precursor Protein Mutation: OXIDATIVE STRESS, CASPASES, AND THE JNK PATHWAY.

C. A. Marques, U. Keil, A. Bonert, B. Steiner, C. Haass, W. E. Muller, and A. Eckert (2003)
J. Biol. Chem. 278, 28294-28302
 |  Abstract »  |  Full Text »  |  PDF »

Glycation of the amyloid {beta}-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease.

T. J. Dickerson and K. D. Janda (2003)
PNAS 100, 8182-8187
 |  Abstract »  |  Full Text »  |  PDF »

Specific Compositions of Amyloid-{beta} Peptides as the Determinant of Toxic {beta}-Aggregation.

Y. Yoshiike, D.-H. Chui, T. Akagi, N. Tanaka, and A. Takashima (2003)
J. Biol. Chem. 278, 23648-23655
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Mutant Amyloid Peptide That Predominantly Forms Neurotoxic Protofibrillar Aggregates.

I. Qahwash, K. L. Weiland, Y. Lu, R. W. Sarver, R. F. Kletzien, and R. Yan (2003)
J. Biol. Chem. 278, 23187-23195
 |  Abstract »  |  Full Text »  |  PDF »

The {gamma}-Secretase Inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl Ester Reduces A{beta} Levels in Vivo in Plasma and Cerebrospinal Fluid in Young (Plaque-Free) and Aged (Plaque-Bearing) Tg2576 Mice.

T. A. Lanz, C. S. Himes, G. Pallante, L. Adams, S. Yamazaki, B. Amore, and K. M. Merchant (2003)
J. Pharmacol. Exp. Ther. 305, 864-871
 |  Abstract »  |  Full Text »  |  PDF »

Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment.

A. L. Guillozet, S. Weintraub, D. C. Mash, and M. M. Mesulam (2003)
Arch Neurol 60, 729-736
 |  Abstract »  |  Full Text »  |  PDF »

gamma -Secretase Cleavage Site Specificity Differs for Intracellular and Secretory Amyloid beta.

H. S. Grimm, D. Beher, S. F. Lichtenthaler, M. S. Shearman, K. Beyreuther, and T. Hartmann (2003)
J. Biol. Chem. 278, 13077-13085
 |  Abstract »  |  Full Text »  |  PDF »

The Transmembrane Domain of the Amyloid Precursor Protein in Microsomal Membranes Is on Both Sides Shorter than Predicted.

B. Grziwa, M. O. W. Grimm, C. L. Masters, K. Beyreuther, T. Hartmann, and S. F. Lichtenthaler (2003)
J. Biol. Chem. 278, 6803-6808
 |  Abstract »  |  Full Text »  |  PDF »

Secretion and Intracellular Generation of Truncated Abeta in beta -Site Amyloid-beta Precursor Protein-cleaving Enzyme Expressing Human Neurons.

E. B. Lee, D. M. Skovronsky, F. Abtahian, R. W. Doms, and V. M.-Y. Lee (2003)
J. Biol. Chem. 278, 4458-4466
 |  Abstract »  |  Full Text »  |  PDF »

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis.

J. M. Redwine, B. Kosofsky, R. E. Jacobs, D. Games, J. F. Reilly, J. H. Morrison, W. G. Young, and F. E. Bloom (2003)
PNAS 100, 1381-1386
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease, Neuropeptides, Neuropeptidase, and Amyloid-{beta} Peptide Metabolism.

T. Saito, Y. Takaki, N. Iwata, J. Trojanowski, and T. C. Saido (2003)
Sci. Aging Knowl. Environ. 2003, pe1-1
 |  Abstract »  |  Full Text »

Amyloid beta -protein (Abeta ) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.

G. Bitan, M. D. Kirkitadze, A. Lomakin, S. S. Vollers, G. B. Benedek, and D. B. Teplow (2003)
PNAS 100, 330-335
 |  Abstract »  |  Full Text »  |  PDF »

Metalloenzyme-like Activity of Alzheimer's Disease beta -Amyloid. Cu-DEPENDENT CATALYTIC CONVERSION OF DOPAMINE, CHOLESTEROL, AND BIOLOGICAL REDUCING AGENTS TO NEUROTOXIC H2O2.

C. Opazo, X. Huang, R. A. Cherny, R. D. Moir, A. E. Roher, A. R. White, R. Cappai, C. L. Masters, R. E. Tanzi, N. C. Inestrosa, et al. (2002)
J. Biol. Chem. 277, 40302-40308
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.

Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev. 54, 469-525
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease.

H. Fukumoto, B. S. Cheung, B. T. Hyman, and M. C. Irizarry (2002)
Arch Neurol 59, 1381-1389
 |  Abstract »  |  Full Text »  |  PDF »

Dense-Core Senile Plaques in the Flemish Variant of Alzheimer's Disease Are Vasocentric.

S. Kumar-Singh, P. Cras, R. Wang, J. M. Kros, J. van Swieten, U. Lubke, C. Ceuterick, S. Serneels, K.'l Vennekens, J.-P. Timmermans, et al. (2002)
Am. J. Pathol. 161, 507-520
 |  Abstract »  |  Full Text »  |  PDF »

Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein.

K. Niwa, K. Kazama, L. Younkin, S. G. Younkin, G. A. Carlson, and C. Iadecola (2002)
Am J Physiol Heart Circ Physiol 283, H315-H323
 |  Abstract »  |  Full Text »  |  PDF »

beta -Secretase Processing in the Trans-Golgi Network Preferentially Generates Truncated Amyloid Species That Accumulate in Alzheimer's Disease Brain.

J. T. Huse, K. Liu, D. S. Pijak, D. Carlin, V. M.-Y. Lee, and R. W. Doms (2002)
J. Biol. Chem. 277, 16278-16284
 |  Abstract »  |  Full Text »  |  PDF »

Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.

M. C. Sugarman, T. R. Yamasaki, S. Oddo, J. C. Echegoyen, M. P. Murphy, T. E. Golde, M. Jannatipour, M. A. Leissring, and F. M. LaFerla (2002)
PNAS 99, 6334-6339
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning and Characterization of CALP/KChIP4, a Novel EF-hand Protein Interacting with Presenilin 2 and Voltage-gated Potassium Channel Subunit Kv4.

Y. Morohashi, N. Hatano, S. Ohya, R. Takikawa, T. Watabiki, N. Takasugi, Y. Imaizumi, T. Tomita, and T. Iwatsubo (2002)
J. Biol. Chem. 277, 14965-14975
 |  Abstract »  |  Full Text »  |  PDF »

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

M. A. Leissring, M. P. Murphy, T. R. Mead, Y. Akbari, M. C. Sugarman, M. Jannatipour, B. Anliker, U. Muller, P. Saftig, B. De Strooper, et al. (2002)
PNAS
 |  Abstract »  |  Full Text »  |  PDF »

The Relationship between Abeta and Memory in the Tg2576 Mouse Model of Alzheimer's Disease.

M. A. Westerman, D. Cooper-Blacketer, A. Mariash, L. Kotilinek, T. Kawarabayashi, L. H. Younkin, G. A. Carlson, S. G. Younkin, and K. H. Ashe (2002)
J. Neurosci. 22, 1858-1867
 |  Abstract »  |  Full Text »  |  PDF »

Stable {beta}-Secretase Activity and Presynaptic Cholinergic Markers During Progressive Central Nervous System Amyloidogenesis in Tg2576 Mice.

J.-T. Gau, M. L. Steinhilb, T.-C. Kao, C. J. D'Amato, J. R. Gaut, K. A. Frey, and R. S. Turner (2002)
Am. J. Pathol. 160, 731-738
 |  Abstract »  |  Full Text »  |  PDF »

Repetitive Mild Brain Trauma Accelerates Abeta Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis.

K. Uryu, H. Laurer, T. McIntosh, D. Pratico, D. Martinez, S. Leight, V. M.-Y. Lee, and J. Q. Trojanowski (2002)
J. Neurosci. 22, 446-454
 |  Abstract »  |  Full Text »  |  PDF »

Correlation Between A{beta}x-40-, A{beta}x-42-, and A{beta}x-43-Containing Amyloid Plaques and Cognitive Decline.

S. Parvathy, P. Davies, V. Haroutunian, D. P. Purohit, K. L. Davis, R. C. Mohs, H. Park, T. M. Moran, J. Y. Chan, and J. D. Buxbaum (2001)
Arch Neurol 58, 2025-2031
 |  Abstract »  |  Full Text »  |  PDF »

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

C. Lesuisse, G. Xu, J. Anderson, M. Wong, J. Jankowsky, G. Holtz, V. Gonzalez, P. C. Y. Wong, D. L. Price, F. Tang, et al. (2001)
Hum. Mol. Genet. 10, 2525-2537
 |  Abstract »  |  Full Text »  |  PDF »

A Portrait of Alzheimer Secretases--New Features and Familiar Faces.

W. P. Esler and M. S. Wolfe (2001)
Science 293, 1449-1454
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenic APP mutations near the {gamma}-secretase cleavage site differentially affect A{beta} secretion and APP C-terminal fragment stability.

C. De Jonghe, C. Esselens, S. Kumar-Singh, K. Craessaerts, S. Serneels, F. Checler, W. Annaert, C. Van Broeckhoven, and B. De Strooper (2001)
Hum. Mol. Genet. 10, 1665-1671
 |  Abstract »  |  Full Text »  |  PDF »

BACE knockout mice are healthy despite lacking the primary {beta}-secretase activity in brain: implications for Alzheimer's disease therapeutics.

S. L. Roberds, J. Anderson, G. Basi, M. J. Bienkowski, D. G. Branstetter, K. S. Chen, S. Freedman, N. L. Frigon, D. Games, K. Hu, et al. (2001)
Hum. Mol. Genet. 10, 1317-1324
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-Like Growth Factor I (IGF-I) Protects Cells from Apoptosis by Alzheimer's V642I Mutant Amyloid Precursor Protein through IGF-I Receptor in an IGF-Binding Protein-Sensitive Manner.

T. Niikura, Y. Hashimoto, T. Okamoto, Y. Abe, T. Yasukawa, M. Kawasumi, T. Hiraki, Y. Kita, K. Terashita, K. Kouyama, et al. (2001)
J. Neurosci. 21, 1902-1910
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Recombinant, Soluble {beta}-Secretase from an Insect Cell Expression System.

W. D. Mallender, D. Yager, L. Onstead, M. R. Nichols, C. Eckman, K. Sambamurti, L. M. Kopcho, J. Marcinkeviciene, R. A. Copeland, and T. L. Rosenberry (2001)
Mol. Pharmacol. 59, 619-626
 |  Abstract »  |  Full Text »

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid {beta} Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease.

T. Kawarabayashi, L. H. Younkin, T. C. Saido, M. Shoji, K. H. Ashe, and S. G. Younkin (2001)
J. Neurosci. 21, 372-381
 |  Abstract »  |  Full Text »  |  PDF »

Linkage of Plasma A{beta}42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees.

N. Ertekin-Taner, N. Graff-Radford, L. H. Younkin, C. Eckman, M. Baker, J. Adamson, J. Ronald, J. Blangero, M. Hutton, and S. G. Younkin (2000)
Science 290, 2303-2304
 |  Abstract »  |  Full Text »

Presenilin-1 P264L Knock-In Mutation: Differential Effects on Abeta Production, Amyloid Deposition, and Neuronal Vulnerability.

R. Siman, A. G. Reaume, M. J. Savage, S. Trusko, Y.-G. Lin, R. W. Scott, and D. G. Flood (2000)
J. Neurosci. 20, 8717-8726
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Apolipoprotein E Allele {{epsilon}}4 on the Initial Phase of Amyloid {beta}-Protein Accumulation in the Human Brain.

M. Morishima-Kawashima, N. Oshima, H. Ogata, H. Yamaguchi, M. Yoshimura, S. Sugihara, and Y. Ihara (2000)
Am. J. Pathol. 157, 2093-2099
 |  Abstract »  |  Full Text »  |  PDF »

Nonfibrillar diffuse amyloid deposition due to a {gamma}42-secretase site mutation points to an essential role for N-truncated A{beta}42 in Alzheimer's disease.

S. Kumar-Singh, C. De Jonghe, M. Cruts, R. Kleinert, R. Wang, M. Mercken, B. De Strooper, H. Vanderstichele, A. Lofgren, I. Vanderhoeven, et al. (2000)
Hum. Mol. Genet. 9, 2589-2598
 |  Abstract »  |  Full Text »  |  PDF »

Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation.

K. Niwa, L. Younkin, C. Ebeling, S. K. Turner, D. Westaway, S. Younkin, K. H. Ashe, G. A. Carlson, and C. Iadecola (2000)
PNAS 97, 9735-9740
 |  Abstract »  |  Full Text »  |  PDF »

Age-Related Amyloid {beta} Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid {beta} Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss.

A. Takeuchi, M. C. Irizarry, K. Duff, T. C. Saido, K. Hsiao Ashe, M. Hasegawa, D. M. A. Mann, B. T. Hyman, and T. Iwatsubo (2000)
Am. J. Pathol. 157, 331-339
 |  Abstract »  |  Full Text »  |  PDF »

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.

D. M. Skovronsky, B. Zhang, M.-P. Kung, H. F. Kung, J. Q. Trojanowski, and V. M.-Y. Lee (2000)
PNAS 97, 7609-7614
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Neurodegenerative Disorders: Part 1: Protein Aggregates.

B. Wolozin and C. Behl (2000)
Arch Neurol 57, 793-796
 |  Full Text »  |  PDF »

Early-Onset Alzheimer Disease Caused by a New Mutation (V717L) in the Amyloid Precursor Protein Gene.

J. R. Murrell, A. M. Hake, K. A. Quaid, M. R. Farlow, and B. Ghetti (2000)
Arch Neurol 57, 885-887
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease, {beta}-Amyloid Protein and Zinc.

X. Huang, M. P. Cuajungco, C. S. Atwood, R. D. Moir, R. E. Tanzi, and A. I. Bush (2000)
J. Nutr. 130, 1488S-1492
 |  Abstract »  |  Full Text »

Mutational Analysis of Intrinsic Regions of Presenilin 2 That Determine Its Endoproteolytic Cleavage and Pathological Function.

K. Shirotani, K. Takahashi, W. Araki, K. Maruyama, and T. Tabira (2000)
J. Biol. Chem. 275, 3681-3686
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C-dependent alpha -Secretase Competes with beta -Secretase for Cleavage of Amyloid-beta Precursor Protein in the Trans-Golgi Network.

D. M. Skovronsky, D. B. Moore, M. E. Milla, R. W. Doms, and V. M.-Y. Lee (2000)
J. Biol. Chem. 275, 2568-2575
 |  Abstract »  |  Full Text »  |  PDF »

AMY plaques in familial AD: Comparison with sporadic Alzheimer's disease.

C. F. Lippa, M. L. Schmidt, L. E. Nee, T. Bird, D. Nochlin, C. Hulette, H. Mori, V. M.- Y. Lee, and J. Q. Trojanowski (2000)
Neurology 54, 100
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Amyloid Precursor Protein Processing by Presenilin 1 (PS1) and PS2 in PS1 Knockout Cells.

J. J. Palacino, B. E. Berechid, P. Alexander, C. Eckman, S. Younkin, J. S. Nye, and B. Wolozin (2000)
J. Biol. Chem. 275, 215-222
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic processing and cell biological functions of the amyloid precursor protein.

B De Strooper and W Annaert (2000)
J. Cell Sci. 113, 1857-1870
 |  Abstract »  |  PDF »

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