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Science 20 May 1994: Vol. 264. no. 5162, pp. 1145 - 1148 DOI: 10.1126/science.8178174
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Articles
Science, Vol 264, Issue 5162, 1145-1148
Copyright © 1994 by American Association for the Advancement of Science
Long-distance neuronal migration in the adult mammalian brain
C Lois
and
A Alvarez-Buylla
Rockefeller University, New York, NY 10021.
During the development of the mammalian brain, neuronal precursors migrate to their final destination from their site of birth in the ventricular and subventricular zones (VZ and SVZ, respectively). SVZ cells in the walls of the lateral ventricle continue to proliferate in the brain of adult mice and can generate neurons in vitro, but their fate in vivo is unknown. Here SVZ cells from adult mice that carry a neuronal-specific transgene were grafted into the brain of adult recipients. In addition, the fate of endogenous SVZ cells was examined by microinjection of tritiated thymidine or a vital dye that labeled a discrete population of SVZ cells. Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.
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- p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity.
- T. E. Kippin, D. J. Martens, and D. van der Kooy (2005)
Genes & Dev.
19, 756-767
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- Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.
- V. Palma, D. A. Lim, N. Dahmane, P. Sanchez, T. C. Brionne, C. D. Herzberg, Y. Gitton, A. Carleton, A. Alvarez-Buylla, and A. R. i Altaba (2005)
Development
132, 335-344
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- Information Processing in the Mammalian Olfactory System.
- P.-M. Lledo, G. Gheusi, and J.-D. Vincent (2005)
Physiol Rev
85, 281-317
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- The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain.
- M. Tripodi, A. Filosa, M. Armentano, and M. Studer (2004)
Development
131, 6119-6129
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- Radial glia give rise to adult neural stem cells in the subventricular zone.
- F. T. Merkle, A. D. Tramontin, J. M. Garcia-Verdugo, and A. Alvarez-Buylla (2004)
PNAS
101, 17528-17532
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- Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons.
- C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer (2004)
Cereb Cortex
14, 1408-1420
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- From the Cover: Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors.
- A. Consiglio, A. Gritti, D. Dolcetta, A. Follenzi, C. Bordignon, F. H. Gage, A. L. Vescovi, and L. Naldini (2004)
PNAS
101, 14835-14840
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- Preferential Origin and Layer Destination of GAD65-GFP Cortical Interneurons.
- G. Lopez-Bendito, K. Sturgess, F. Erdelyi, G. Szabo, Z. Molnar, and O. Paulsen (2004)
Cereb Cortex
14, 1122-1133
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- Aging Results in Reduced Epidermal Growth Factor Receptor Signaling, Diminished Olfactory Neurogenesis, and Deficits in Fine Olfactory Discrimination.
- E. Enwere, T. Shingo, C. Gregg, H. Fujikawa, S. Ohta, and S. Weiss (2004)
J. Neurosci.
24, 8354-8365
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- p107 regulates neural precursor cells in the mammalian brain.
- J. L. Vanderluit, K. L. Ferguson, V. Nikoletopoulou, M. Parker, V. Ruzhynsky, T. Alexson, S. M. McNamara, D. S. Park, M. Rudnicki, and R. S. Slack (2004)
J. Cell Biol.
166, 853-863
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