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Science 20 May 1994:
Vol. 264. no. 5162, pp. 1145 - 1148
DOI: 10.1126/science.8178174

Articles

Science, Vol 264, Issue 5162, 1145-1148
Copyright © 1994 by American Association for the Advancement of Science


articles

Long-distance neuronal migration in the adult mammalian brain

C Lois and A Alvarez-Buylla

Rockefeller University, New York, NY 10021.

During the development of the mammalian brain, neuronal precursors migrate to their final destination from their site of birth in the ventricular and subventricular zones (VZ and SVZ, respectively). SVZ cells in the walls of the lateral ventricle continue to proliferate in the brain of adult mice and can generate neurons in vitro, but their fate in vivo is unknown. Here SVZ cells from adult mice that carry a neuronal-specific transgene were grafted into the brain of adult recipients. In addition, the fate of endogenous SVZ cells was examined by microinjection of tritiated thymidine or a vital dye that labeled a discrete population of SVZ cells. Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.


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From the Cover: Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors.
A. Consiglio, A. Gritti, D. Dolcetta, A. Follenzi, C. Bordignon, F. H. Gage, A. L. Vescovi, and L. Naldini (2004)
PNAS 101, 14835-14840
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Preferential Origin and Layer Destination of GAD65-GFP Cortical Interneurons.
G. Lopez-Bendito, K. Sturgess, F. Erdelyi, G. Szabo, Z. Molnar, and O. Paulsen (2004)
Cereb Cortex 14, 1122-1133
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Aging Results in Reduced Epidermal Growth Factor Receptor Signaling, Diminished Olfactory Neurogenesis, and Deficits in Fine Olfactory Discrimination.
E. Enwere, T. Shingo, C. Gregg, H. Fujikawa, S. Ohta, and S. Weiss (2004)
J. Neurosci. 24, 8354-8365
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p107 regulates neural precursor cells in the mammalian brain.
J. L. Vanderluit, K. L. Ferguson, V. Nikoletopoulou, M. Parker, V. Ruzhynsky, T. Alexson, S. M. McNamara, D. S. Park, M. Rudnicki, and R. S. Slack (2004)
J. Cell Biol. 166, 853-863
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