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Science 20 May 1994:
Vol. 264. no. 5162, pp. 1141 - 1145
DOI: 10.1126/science.8178173
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Articles

Science, Vol 264, Issue 5162, 1141-1145
Copyright © 1994 by American Association for the Advancement of Science

articles

Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

J Tomfohrde, A Silverman, R Barnes, MA Fernandez-Vina, M Young, D Lory, L Morris, KD Wuepper, P Stastny, A Menter, and al. et

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-8591.

A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.


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