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Science 13 May 1994:
Vol. 264. no. 5161, pp. 977 - 979
DOI: 10.1126/science.8178158
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Articles

Science, Vol 264, Issue 5161, 977-979
Copyright © 1994 by American Association for the Advancement of Science

articles

Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons

A Ferreira, KS Kosik, P Greengard, and HQ Han

Center for Neurological Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

Synapsin I and synapsin II are neuron-specific phosphoproteins that have a role in the regulation of neurotransmitter release and in the formation of nerve terminals. After depletion of synapsin II by antisense oligonucleotides, rat hippocampal neurons in culture were unable to consolidate their minor processes and did not elongate axons. These aberrant morphological changes were accompanied by an abnormal distribution of intracellular filamentous actin (F-actin). In addition, synapsin II suppression resulted in a selective decrease in the amounts of several synaptic vesicle-associated proteins. These data suggest that synapsin II participates in cytoskeletal organization during the early stages of nerve cell development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synapsin II and calcium regulate vesicle docking and the cross-talk between vesicle pools at the mouse motor terminals.
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Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment.
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Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.
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Regulation of transmitter release by synapsin II in mouse motor terminals.
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A Role for the Cytoskeleton-associated Protein Palladin in Neurite Outgrowth.
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Inhibition of neuronal maturation in primary hippocampal neurons from &tgr; deficient mice.
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Synapsin III: Developmental Expression, Subcellular Localization, and Role in Axon Formation.
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Transient suppression of cortactin ectopically induces large telencephalic neurons towards a GABAergic phenotype.
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A third member of the synapsin gene family.
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Amphiphysin I Antisense Oligonucleotides Inhibit Neurite Outgrowth in Cultured Hippocampal Neurons.
O. Mundigl, G.-C. Ochoa, C. David, V. I. Slepnev, A. Kabanov, and P. De Camilli (1998)
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Increased Concentrations of Presynaptic Proteins in the Cingulate Cortex of Subjects With Schizophrenia.
S. M. Gabriel, V. Haroutunian, P. Powchih, W. G. Honer, M. Davidson, P. Davies, and K. L. Davis (1997)
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A Transcription-Dependent Switch Controls Competence of Adult Neurons for Distinct Modes of Axon Growth.
D. S. Smith and J. H. Pate Skene (1997)
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