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Science 13 May 1994:
Vol. 264. no. 5161, pp. 974 - 977
DOI: 10.1126/science.8178157
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Articles

Science, Vol 264, Issue 5161, 974-977
Copyright © 1994 by American Association for the Advancement of Science

articles

Activity-dependent changes in the intrinsic properties of cultured neurons

G Turrigiano, LF Abbott, and E Marder

Department of Biology, Brandeis University, Waltham, MA 02254.

Learning and memory arise through activity-dependent modifications of neural circuits. Although the activity dependence of synaptic efficacy has been studied extensively, less is known about how activity shapes the intrinsic electrical properties of neurons. Lobster stomatogastric ganglion neurons fire in bursts when receiving synaptic and modulatory input but fire tonically when pharmacologically isolated. Long-term isolation in culture changed their intrinsic activity from tonic firing to burst firing. Rhythmic stimulation reversed this transition through a mechanism that was mediated by a rise in intracellular calcium concentration. These data suggest that neurons regulate their conductances to maintain stable activity patterns and that the intrinsic properties of a neuron depend on its recent history of activation.


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Activity-Dependent Regulation of Potassium Currents in an Identified Neuron of the Stomatogastric Ganglion of the Crab Cancer borealis.
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