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Science 6 May 1994:
Vol. 264. no. 5160, pp. 835 - 839
DOI: 10.1126/science.7513443

Articles

Science, Vol 264, Issue 5160, 835-839
Copyright © 1994 by American Association for the Advancement of Science


articles

Control of cell behavior during vertebrate development by Slug, a zinc finger gene

MA Nieto, MG Sargent, DG Wilkinson, and J Cooke

Instituto Cajal, Madrid, Spain.

Slug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in the neural crest and in mesodermal cells emigrating from the primitive streak. Early chick embryos were incubated with antisense oligonucleotides to chick Slug. These oligonucleotides specifically inhibit the normal change in cell behavior that occurs at the two sites in the emerging body plan in which the gene is expressed. This change, which is the transition from epithelial to mesenchymal character, occurs at the formation of mesoderm during gastrulation and on emigration of the neutral crest from the neural tube.


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Neural crest emigration from the neural tube depends on regulated cadherin expression.
S Nakagawa and M Takeichi (1998)
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   Abstract »    PDF »
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A Subclass of bHLH Proteins Required for Cardiac Morphogenesis.
D. Srivastava, P. Cserjesi, and E. N. Olson (1995)
Science 270, 1995-1999
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M Roark, M A Sturtevant, J Emery, H Vaessin, E Grell, and E Bier (1995)
Genes & Dev. 9, 2384-2398
   Abstract »    PDF »
twist is required in head mesenchyme for cranial neural tube morphogenesis..
Z F Chen and R R Behringer (1995)
Genes & Dev. 9, 686-699
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Regulative response of the cranial neural tube after neural fold ablation: spatiotemporal nature of neural crest regeneration and up-regulation of Slug.
J Sechrist, M. Nieto, R. Zamanian, and M Bronner-Fraser (1995)
Development 121, 4103-4115
   Abstract »    PDF »
Induction of avian cardiac myogenesis by anterior endoderm.
T. Schultheiss, S Xydas, and A. Lassar (1995)
Development 121, 4203-4214
   Abstract »    PDF »
Dorsalization of the neural tube by the non-neural ectoderm.
M. Dickinson, M. Selleck, A. McMahon, and M Bronner-Fraser (1995)
Development 121, 2099-2106
   Abstract »    PDF »
Multiple roles for FGF-3 during cranial neural development in the chicken.
R Mahmood, P Kiefer, S Guthrie, C Dickson, and I Mason (1995)
Development 121, 1399-1410
   Abstract »    PDF »
Induction of the prospective neural crest of Xenopus.
R Mayor, R Morgan, and M. Sargent (1995)
Development 121, 767-777
   Abstract »    PDF »
Origins of the avian neural crest: the role of neural plate-epidermal interactions.
M. Selleck and M Bronner-Fraser (1995)
Development 121, 525-538
   Abstract »    PDF »
Short-range repression permits multiple enhancers to function autonomously within a complex promoter..
S Gray, P Szymanski, and M Levine (1994)
Genes & Dev. 8, 1829-1838
   Abstract »    PDF »
Cloning and Characterization of Three Xenopus Slug Promoters Reveal Direct Regulation by Lef/beta -Catenin Signaling.
J. Vallin, R. Thuret, E. Giacomello, M. M. Faraldo, J. P. Thiery, and F. Broders (2001)
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   Abstract »    Full Text »    PDF »
Mammalian Scratch: A neural-specific Snail family transcriptional repressor.
E. K. Nakakura, D. N. Watkins, K. E. Schuebel, V. Sriuranpong, M. W. Borges, B. D. Nelkin, and D. W. Ball (2001)
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