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Science 6 May 1994: Vol. 264. no. 5160, pp. 835 - 839 DOI: 10.1126/science.7513443
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Articles
Science, Vol 264, Issue 5160, 835-839
Copyright © 1994 by American Association for the Advancement of Science
Control of cell behavior during vertebrate development by Slug, a zinc finger gene
MA Nieto,
MG Sargent,
DG Wilkinson,
and
J Cooke
Instituto Cajal, Madrid, Spain.
Slug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in the neural crest and in mesodermal cells emigrating from the primitive streak. Early chick embryos were incubated with antisense oligonucleotides to chick Slug. These oligonucleotides specifically inhibit the normal change in cell behavior that occurs at the two sites in the emerging body plan in which the gene is expressed. This change, which is the transition from epithelial to mesenchymal character, occurs at the formation of mesoderm during gastrulation and on emigration of the neutral crest from the neural tube.
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