Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 29 April 1994:
Vol. 264. no. 5159, pp. 719 - 725
DOI: 10.1126/science.8171325

Articles

Science, Vol 264, Issue 5159, 719-725
Copyright © 1994 by American Association for the Advancement of Science


articles

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

MH Vitaterna, DP King, AM Chang, JM Kornhauser, PL Lowrey, JD McDonald, WF Dove, LH Pinto, FW Turek, and JS Takahashi

Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.

In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Clock genes and metabolic disease.
B. Marcheva, K. M. Ramsey, A. Affinati, and J. Bass (2009)
J Appl Physiol 107, 1638-1646
   Abstract »    Full Text »    PDF »
Working around the clock: circadian rhythms and skeletal muscle.
X. Zhang, T. J. Dube, and K. A. Esser (2009)
J Appl Physiol 107, 1647-1654
   Abstract »    Full Text »    PDF »
Time Is of the Essence: Vascular Implications of the Circadian Clock.
R. D. Rudic (2009)
Circulation 120, 1714-1721
   Full Text »    PDF »
Anticipating anticipation: pursuing identification of cardiomyocyte circadian clock function.
M. E. Young (2009)
J Appl Physiol 107, 1339-1347
   Abstract »    Full Text »    PDF »
Clock is important for food and circadian regulation of macronutrient absorption in mice.
X. Pan and M. M. Hussain (2009)
J. Lipid Res. 50, 1800-1813
   Abstract »    Full Text »    PDF »
Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription.
H. Yoshitane, T. Takao, Y. Satomi, N.-H. Du, T. Okano, and Y. Fukada (2009)
Mol. Cell. Biol. 29, 3675-3686
   Abstract »    Full Text »    PDF »
The Role of mPer2 Clock Gene in Glucocorticoid and Feeding Rhythms.
S. Yang, A. Liu, A. Weidenhammer, R. C. Cooksey, D. McClain, M. K. Kim, G. Aguilera, E. D. Abel, and J. H. Chung (2009)
Endocrinology 150, 2153-2160
   Abstract »    Full Text »    PDF »
Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock.
K.-F. Storch and C. J. Weitz (2009)
PNAS 106, 6808-6813
   Abstract »    Full Text »    PDF »
Impaired Steroidogenesis and Implantation Failure in Bmal1-/- Mice.
C. K. Ratajczak, K. L. Boehle, and L. J. Muglia (2009)
Endocrinology 150, 1879-1885
   Abstract »    Full Text »    PDF »
Vascular Disease in Mice With a Dysfunctional Circadian Clock.
C. B. Anea, M. Zhang, D. W. Stepp, G. B. Simkins, G. Reed, D. J. Fulton, and R. D. Rudic (2009)
Circulation 119, 1510-1517
   Abstract »    Full Text »    PDF »
Vascular Rhythms and Adaptation: Do Your Arteries Know What Time It Is?.
J. F. Keaney Jr and D. R. Weaver (2009)
Circulation 119, 1463-1466
   Full Text »    PDF »
The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes.
J. A. Mohawk, M. L. Baer, and M. Menaker (2009)
PNAS 106, 3519-3524
   Abstract »    Full Text »    PDF »
Sleep and Wake Neuroscience.
P. C. Zee (2009)
ACCP Sleep Med Brd Rev 4, 153-162
   Full Text »    PDF »
Genetic and Immunologic Aspects of Sleep Disorders.
J. M. Parish (2009)
ACCP Sleep Med Brd Rev 4, 271-286
   Full Text »    PDF »
Clock-dependent and independent transcriptional control of the two isoforms from the mouse Rorgammagene..
V. Mongrain, X. Ruan, H. Dardente, E. E. Fortier, and N. Cermakian (2008)
Genes Cells 13, 1197-1210
   Abstract »    Full Text »    PDF »
Searching for Genes Underlying Behavior: Lessons from Circadian Rhythms.
J. S. Takahashi, K. Shimomura, and V. Kumar (2008)
Science 322, 909-912
   Abstract »    Full Text »    PDF »
A new mouse mutant for the LDL receptor identified using ENU mutagenesis.
K. L. Svenson, N. Ahituv, R. S. Durgin, H. Savage, P. A. Magnani, O. Foreman, B. Paigen, and L. L. Peters (2008)
J. Lipid Res. 49, 2452-2462
   Abstract »    Full Text »    PDF »
The Circadian Gene NPAS2, a Putative Tumor Suppressor, Is Involved in DNA Damage Response.
A. E. Hoffman, T. Zheng, Y. Ba, and Y. Zhu (2008)
Mol. Cancer Res. 6, 1461-1468
   Abstract »    Full Text »    PDF »
Genetic Differences in Human Circadian Clock Genes among Worldwide Populations.
C. M. Ciarleglio, K. K. Ryckman, S. V. Servick, A. Hida, S. Robbins, N. Wells, J. Hicks, S. A. Larson, J. P. Wiedermann, K. Carver, et al. (2008)
J Biol Rhythms 23, 330-340
   Abstract »    PDF »
The expanding role of mouse genetics for understanding human biology and disease.
D. Nguyen and T. Xu (2008)
Dis. Model. Mech. 1, 56-66
   Abstract »    Full Text »    PDF »
Diurnal Amplitudes of Arterial Pressure and Heart Rate Are Dampened in Clock Mutant Mice and Adrenalectomized Mice.
H. Sei, K. Oishi, S. Chikahisa, K. Kitaoka, E. Takeda, and N. Ishida (2008)
Endocrinology 149, 3576-3580
   Abstract »    Full Text »    PDF »
Evidence for an Overlapping Role of CLOCK and NPAS2 Transcription Factors in Liver Circadian Oscillators.
C. Bertolucci, N. Cavallari, I. Colognesi, J. Aguzzi, Z. Chen, P. Caruso, A. Foa, G. Tosini, F. Bernardi, and M. Pinotti (2008)
Mol. Cell. Biol. 28, 3070-3075
   Abstract »    Full Text »    PDF »
Low reproductive success in Per1 and Per2 mutant mouse females due to accelerated ageing?.
V. Pilorz and S. Steinlechner (2008)
Reproduction 135, 559-568
   Abstract »    Full Text »    PDF »
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.
M. S. Bray, C. A. Shaw, M. W. S. Moore, R. A. P. Garcia, M. M. Zanquetta, D. J. Durgan, W. J. Jeong, J.-Y. Tsai, H. Bugger, D. Zhang, et al. (2008)
Am J Physiol Heart Circ Physiol 294, H1036-H1047
   Abstract »    Full Text »    PDF »
Thrombomodulin Is a Clock-controlled Gene in Vascular Endothelial Cells.
N. Takeda, K. Maemura, S. Horie, K. Oishi, Y. Imai, T. Harada, T. Saito, T. Shiga, E. Amiya, I. Manabe, et al. (2007)
J. Biol. Chem. 282, 32561-32567
   Abstract »    Full Text »    PDF »
Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues.
D. J. Kennaway, J. A. Owens, A. Voultsios, M. J. Boden, and T. J. Varcoe (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R1528-R1537
   Abstract »    Full Text »    PDF »
Identification of the circadian transcriptome in adult mouse skeletal muscle.
J. J. McCarthy, J. L. Andrews, E. L. McDearmon, K. S. Campbell, B. K. Barber, B. H. Miller, J. R. Walker, J. B. Hogenesch, J. S. Takahashi, and K. A. Esser (2007)
Physiol Genomics 31, 86-95
   Abstract »    Full Text »    PDF »
Tumor Suppression and Circadian Function.
M. Chen-Goodspeed and Cheng Chi Lee (2007)
J Biol Rhythms 22, 291-298
   Abstract »    PDF »
Peripheral Circadian Clocks in the Vasculature.
D. F. Reilly, E. J. Westgate, and G. A. FitzGerald (2007)
Arterioscler Thromb Vasc Biol 27, 1694-1705
   Abstract »    Full Text »    PDF »
Beyond Intuitive Modeling: Combining Biophysical Models with Innovative Experiments to Move the Circadian Clock Field Forward.
D. Forger, D. Gonze, D. Virshup, and D. K. Welsh (2007)
J Biol Rhythms 22, 200-210
   Abstract »    PDF »
Light-Inducible and Clock-Controlled Expression of MAP Kinase Phosphatase 1 in Mouse Central Pacemaker Neurons.
M. Doi, S. Cho, I. Yujnovsky, J. Hirayama, N. Cermakian, A. C. B. Cato, and P. Sassone-Corsi (2007)
J Biol Rhythms 22, 127-139
   Abstract »    PDF »
Prokineticin 2 Is a Target Gene of Proneural Basic Helix-Loop-Helix Factors for Olfactory Bulb Neurogenesis.
C. Zhang, K. L. Ng, J.-D. Li, F. He, D. J. Anderson, Y. E. Sun, and Q.-Y. Zhou (2007)
J. Biol. Chem. 282, 6917-6921
   Abstract »    Full Text »    PDF »
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
B. H. Miller, E. L. McDearmon, S. Panda, K. R. Hayes, J. Zhang, J. L. Andrews, M. P. Antoch, J. R. Walker, K. A. Esser, J. B. Hogenesch, et al. (2007)
PNAS 104, 3342-3347
   Abstract »    Full Text »    PDF »
Novel method for high-throughput phenotyping of sleep in mice.
A. I. Pack, R. J. Galante, G. Maislin, J. Cater, D. Metaxas, S. Lu, L. Zhang, R. V. Smith, T. Kay, J. Lian, et al. (2007)
Physiol Genomics 28, 232-238
   Abstract »    Full Text »    PDF »
Biological Rhythms Workshop I: Introduction to Chronobiology.
S. J. Kuhlman, S. R. Mackey, and J. F. Duffy (2007)
Cold Spring Harb Symp Quant Biol 72, 1-6
   Abstract »    PDF »
Biological Rhythms Workshop IB: Neurophysiology of SCN Pacemaker Function.
S. J. Kuhlman (2007)
Cold Spring Harb Symp Quant Biol 72, 21-33
   Abstract »    PDF »
Chromatin Remodeling and Circadian Control: Master Regulator CLOCK Is an Enzyme.
B. Grimaldi, Y. Nakahata, S. Sahar, M. Kaluzova, D. Gauthier, K. Pham, N. Patel, J. Hirayama, and P. Sassone-Corsi (2007)
Cold Spring Harb Symp Quant Biol 72, 105-112
   Abstract »    PDF »
Principles and Problems Revolving Round Rhythm-related Genetic Variants.
J. C. Hall, D. C. Chang, and E. Dolezelova (2007)
Cold Spring Harb Symp Quant Biol 72, 215-232
   Abstract »    PDF »
Genetics and Neurobiology of Circadian Clocks in Mammals.
S. M. Siepka, S.-H. Yoo, J. Park, C. Lee, and J. S. Takahashi (2007)
Cold Spring Harb Symp Quant Biol 72, 251-259
   Abstract »    PDF »
The Clock Proteins, Aging, and Tumorigenesis.
R. V. Kondratov and M. P. Antoch (2007)
Cold Spring Harb Symp Quant Biol 72, 477-482
   Abstract »    PDF »
Role for the Clock Gene in Bipolar Disorder.
C. A. McClung (2007)
Cold Spring Harb Symp Quant Biol 72, 637-644
   Abstract »    PDF »
The Prokineticins: A NOVEL PAIR OF REGULATORY PEPTIDES.
Q.-Y. Zhou (2006)
Mol. Interv. 6, 330-338
   Abstract »    Full Text »    PDF »
Encoding the Ins and Outs of Circadian Pacemaking.
S. J. Kuhlman and D. G. McMahon (2006)
J Biol Rhythms 21, 470-481
   Abstract »    PDF »
Regulating a Circadian Clock's Period, Phase and Amplitude by Phosphorylation: Insights from Drosophila.
K. Bae and I. Edery (2006)
J. Biochem. 140, 609-617
   Abstract »    Full Text »    PDF »
Long-lived {alpha}MUPA transgenic mice exhibit pronounced circadian rhythms.
O. Froy, N. Chapnik, and R. Miskin (2006)
Am J Physiol Endocrinol Metab 291, E1017-E1024
   Abstract »    Full Text »    PDF »
Molecular components of the mammalian circadian clock.
C. H. Ko and J. S. Takahashi (2006)
Hum. Mol. Genet. 15, R271-R277
   Abstract »    Full Text »    PDF »
Functional central rhythmicity and light entrainment, but not liver and muscle rhythmicity, are Clock independent.
D. J. Kennaway, J. A. Owens, A. Voultsios, and T. J. Varcoe (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R1172-R1180
   Abstract »    Full Text »    PDF »
Circadian rhythms and reproduction..
M. J Boden and D. J Kennaway (2006)
Reproduction 132, 379-392
   Abstract »    Full Text »    PDF »
Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index..
P. A. Wood, J. Du-Quiton, S. You, and W. J.M. Hrushesky (2006)
Mol. Cancer Ther. 5, 2023-2033
   Abstract »    Full Text »    PDF »
Essential Role of 3'-Untranslated Region-mediated mRNA Decay in Circadian Oscillations of Mouse Period3 mRNA.
E. Kwak, T.-D. Kim, and K.-T. Kim (2006)
J. Biol. Chem. 281, 19100-19106
   Abstract »    Full Text »    PDF »
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.
M. H. Vitaterna, C. H. Ko, A.-M. Chang, E. D. Buhr, E. M. Fruechte, A. Schook, M. P. Antoch, F. W. Turek, and J. S. Takahashi (2006)
PNAS 103, 9327-9332
   Abstract »    Full Text »    PDF »
Restoration of Circadian Rhythmicity in Circadian Clock-Deficient Mice in Constant Light.
D. Abraham, R. Dallmann, S. Steinlechner, U. Albrecht, G. Eichele, and H. Oster (2006)
J Biol Rhythms 21, 169-176
   Abstract »    PDF »
Search for the feeding-entrainable circadian oscillator: a complex proposition.
A. J. Davidson (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R1524-R1526
   Full Text »    PDF »
Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1.
I. Yujnovsky, J. Hirayama, M. Doi, E. Borrelli, and P. Sassone-Corsi (2006)
PNAS 103, 6386-6391
   Abstract »    Full Text »    PDF »
Transcriptional Feedback Oscillators: Maybe, Maybe Not....
P. L. Lakin-Thomas (2006)
J Biol Rhythms 21, 83-92
   Abstract »    PDF »
Circadian Clock Mutation in Dams Disrupts Nursing Behavior and Growth of Pups.
K. Hoshino, Y. Wakatsuki, M. Iigo, and S. Shibata (2006)
Endocrinology 147, 1916-1923
   Abstract »    Full Text »    PDF »
A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen..
L. G. Reijmers, J. K. Coats, M. T. Pletcher, T. Wiltshire, L. M. Tarantino, and M. Mayford (2006)
Learn. Mem. 13, 143-149
   Abstract »    Full Text »    PDF »
The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function.
M. E. Young (2006)
Am J Physiol Heart Circ Physiol 290, H1-H16
   Abstract »    Full Text »    PDF »
Developmental and reproductive performance in circadian mutant mice.
H. Dolatshad, E.A. Campbell, L. O'Hara, E.S. Maywood, M.H. Hastings, and M.H. Johnson (2006)
Hum. Reprod. 21, 68-79
   Abstract »    Full Text »    PDF »
The Candidate Gene, Clock, Localizes to a Strong Spawning Time Quantitative Trait Locus Region in Rainbow Trout.
E. H. Leder, R. G. Danzmann, and M. M. Ferguson (2006)
J. Hered. 97, 74-80
   Abstract »    Full Text »    PDF »
Clock Gene Expression in the Submandibular Glands.
M. Furukawa, T. Kawamoto, M. Noshiro, K.K. Honda, M. Sakai, K. Fujimoto, S. Honma, K. Honma, T. Hamada, and Y. Kato (2005)
Journal of Dental Research 84, 1193-1197
   Abstract »    Full Text »    PDF »
Shared genetic risk factors for obstructive sleep apnea and obesity.
S. R. Patel (2005)
J Appl Physiol 99, 1600-1606
   Abstract »    Full Text »    PDF »
Tissue-Specific Disruption of Rhythmic Expression of Dec1 and Dec2 in Clock Mutant Mice.
M. Noshiro, M. Furukawa, S. Honma, T. Kawamoto, T. Hamada, K.-i. Honma, and Y. Kato (2005)
J Biol Rhythms 20, 404-418
   Abstract »    PDF »
The intrinsic circadian clock within the cardiomyocyte.
D. J. Durgan, M. A. Hotze, T. M. Tomlin, O. Egbejimi, C. Graveleau, E. D. Abel, C. A. Shaw, M. S. Bray, P. E. Hardin, and M. E. Young (2005)
Am J Physiol Heart Circ Physiol 289, H1530-H1541
   Abstract »    Full Text »    PDF »
N-Ethyl-N-Nitrosourea Mutagenesis: Boarding the Mouse Mutant Express.
S. P. Cordes (2005)
Microbiol. Mol. Biol. Rev. 69, 426-439
   Abstract »    Full Text »    PDF »
CO-dependent Activity-controlling Mechanism of Heme-containing CO-sensor Protein, Neuronal PAS Domain Protein 2.
T. Uchida, E. Sato, A. Sato, I. Sagami, T. Shimizu, and T. Kitagawa (2005)
J. Biol. Chem. 280, 21358-21368
   Abstract »    Full Text »    PDF »
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice.
F. W. Turek, C. Joshu, A. Kohsaka, E. Lin, G. Ivanova, E. McDearmon, A. Laposky, S. Losee-Olson, A. Easton, D. R. Jensen, et al. (2005)
Science 308, 1043-1045
   Abstract »    Full Text »    PDF »
Keep Time, Stay Healthy.
G. Block (2005)
Sci. Aging Knowl. Environ. 2005, pe13
   Abstract »    Full Text »
Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide.
C. B. Green (2005)
PNAS 102, 3529-3530
   Full Text »    PDF »
Role of Cyclic mPer2 Expression in the Mammalian Cellular Clock.
Y. Yamamoto, K. Yagita, and H. Okamura (2005)
Mol. Cell. Biol. 25, 1912-1921
   Abstract »    Full Text »    PDF »
From The Cover: Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.
V. Y. Gorbacheva, R. V. Kondratov, R. Zhang, S. Cherukuri, A. V. Gudkov, J. S. Takahashi, and M. P. Antoch (2005)
PNAS 102, 3407-3412
   Abstract »    Full Text »    PDF »
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo.
S.-H. Yoo, C. H. Ko, P. L. Lowrey, E. D. Buhr, E.-j. Song, S. Chang, O. J. Yoo, S. Yamazaki, C. Lee, and J. S. Takahashi (2005)
PNAS 102, 2608-2613
   Abstract »    Full Text »    PDF »
Stochastic simulation of the mammalian circadian clock.
D. B. Forger and C. S. Peskin (2005)
PNAS 102, 321-324
   Abstract »    Full Text »    PDF »
The role of circadian rhythmicity in reproduction.
D. J. Kennaway (2005)
Hum. Reprod. Update 11, 91-101
   Abstract »    Full Text »    PDF »
The involvement of Cry1 and Cry2 genes in the regulation of the circadian body temperature rhythm in mice.
K. Nagashima, K. Matsue, M. Konishi, C. Iidaka, K. Miyazaki, N. Ishida, and K. Kanosue (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R329-R335
   Abstract »    Full Text »    PDF »
ENU induced mutations causing congenital cardiovascular anomalies.
Q. Yu, Y. Shen, B. Chatterjee, B. H. Siegfried, L. Leatherbury, J. Rosenthal, J. F. Lucas, A. Wessels, C. F. Spurney, Y.-J. Wu, et al. (2004)
Development 131, 6211-6223
   Abstract »    Full Text »    PDF »
The orphan receptor Rev-erb{alpha} gene is a target of the circadian clock pacemaker.
G. Triqueneaux, S. Thenot, T. Kakizawa, M. P Antoch, R. Safi, J. S Takahashi, F. Delaunay, and V. Laudet (2004)
J. Mol. Endocrinol. 33, 585-608
   Abstract »    Full Text »    PDF »
Phase Responses to Light Pulses in Mice Lacking Functional per or cry Genes.
K. Spoelstra, U. Albrecht, G. T. J. van der Horst, V. Brauer, and S. Daan (2004)
J Biol Rhythms 19, 518-529
   Abstract »    PDF »
Finding New Clock Components: Past and Future.
J. S. Takahashi (2004)
J Biol Rhythms 19, 339-347
   Abstract »    PDF »
Identification of mPer1 Phosphorylation Sites Responsible for the Nuclear Entry.
A. Takano, Y. Isojima, and K. Nagai (2004)
J. Biol. Chem. 279, 32578-32585
   Abstract »    Full Text »    PDF »
Circadian Organization of a Subarctic Rodent, the Northern Red-Backed Vole (Clethrionomys Rutilus).
R. J. Tavernier, A. L. Largen, and A. Bult-Ito (2004)
J Biol Rhythms 19, 238-247
   Abstract »    PDF »
Inaugural Article: Biography of Joseph S. Takahashi.
M. Marino (2004)
PNAS 101, 5336-5338
   Full Text »    PDF »
Inaugural Article: PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.
S.-H. Yoo, S. Yamazaki, P. L. Lowrey, K. Shimomura, C. H. Ko, E. D. Buhr, S. M. Siepka, H.-K. Hong, W. J. Oh, O. J. Yoo, et al. (2004)
PNAS 101, 5339-5346
   Abstract »    Full Text »    PDF »
Dec1 and Dec2 Expression is Disrupted in the Suprachiasmatic Nuclei of Clock Mutant Mice.
M. P. Butler, S. Honma, T. Fukumoto, T. Kawamoto, K. Fujimoto, M. Noshiro, Y. Kato, and K.-I. Honma (2004)
J Biol Rhythms 19, 126-134
   Abstract »    PDF »
Restricted Expression and Photic Induction of a Novel Mouse Regulatory Factor X4 Transcript in the Suprachiasmatic Nucleus.
R. Araki, H. Takahashi, R. Fukumura, F. Sun, N. Umeda, M. Sujino, S.-I. T. Inouye, T. Saito, and M. Abe (2004)
J. Biol. Chem. 279, 10237-10242
   Abstract »    Full Text »    PDF »
Clean Thoughts about Dirty Genes.
R. N. van Gelder and J. B. Hogenesch (2004)
J Biol Rhythms 19, 3-9
   Abstract »    PDF »
Molecular Mechanism of Mammalian Circadian Clock.
Y. Isojima, N. Okumura, and K. Nagai (2003)
J. Biochem. 134, 777-784
   Abstract »    Full Text »    PDF »
The Days and Nights of Cancer Cells.
L. Canaple, T. Kakizawa, and V. Laudet (2003)
Cancer Res. 63, 7545-7552
   Abstract »    Full Text »    PDF »
Toward the Genetics of Mammalian Reproduction: Induction and Mapping of Gametogenesis Mutants in Mice.
J. O. Ward, L. G. Reinholdt, S. A. Hartford, L. A. Wilson, R. J. Munroe, K. J. Schimenti, B. J. Libby, M. O'Brien, J. K. Pendola, J. Eppig, et al. (2003)
Biol Reprod 69, 1615-1625
   Abstract »    Full Text »    PDF »
Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes.
K. Oishi, K. Miyazaki, K. Kadota, R. Kikuno, T. Nagase, G.-i. Atsumi, N. Ohkura, T. Azama, M. Mesaki, S. Yukimasa, et al. (2003)
J. Biol. Chem. 278, 41519-41527
   Abstract »    Full Text »    PDF »
Clocks, genes and sleep.
M. von Schantz and S. N Archer (2003)
J R Soc Med 96, 486-489
   Full Text »    PDF »
Altered Patterns of Sleep and Behavioral Adaptability in NPAS2-Deficient Mice.
C. A. Dudley, C. Erbel-Sieler, S. J. Estill, M. Reick, P. Franken, S. Pitts, and S. L. McKnight (2003)
Science 301, 379-383
   Abstract »    Full Text »    PDF »
Food-entrained circadian rhythms are sustained in arrhythmic Clk/Clk mutant mice.
S. Pitts, E. Perone, and R. Silver (2003)
Am J Physiol Regulatory Integrative Comp Physiol 285, R57-R67
   Abstract »    Full Text »    PDF »
Melatonin and activity rhythm responses to light pulses in mice with the Clock mutation.
D. J. Kennaway, A. Voultsios, T. J. Varcoe, and R. W. Moyer (2003)
Am J Physiol Regulatory Integrative Comp Physiol 284, R1231-R1240
   Abstract »    Full Text »    PDF »
The Genes and Brains of Mice and Men.
L. H. Tecott (2003)
Am J Psychiatry 160, 646-656
   Abstract »    Full Text »    PDF »
Genetic Models in Applied Physiology: Invited Review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms.
J. C. Hendricks (2003)
J Appl Physiol 94, 1660-1672
   Abstract »    Full Text »    PDF »
Light-Induced Phase Shifts in Mice Lacking mPER1 or mPER2.
K. Bae and D. R. Weaver (2003)
J Biol Rhythms 18, 123-133
   Abstract »    PDF »
Aging Alters Circadian and Light-Induced Expression of Clock Genes in Golden Hamsters.
D. E. Kolker, H. Fukuyama, D. S. Huang, J. S. Takahashi, T. H. Horton, and F. W. Turek (2003)
J Biol Rhythms 18, 159-169
   Abstract »    PDF »
One Hundred Years of Mouse Genetics: An Intellectual History. II. The Molecular Revolution (1981-2002).
K. Paigen (2003)
Genetics 163, 1227-1235
   Full Text »    PDF »
No Circadian Rhythms in Testis: Period1 Expression Is Clock Independent and Developmentally Regulated in the Mouse.
D. Morse, N. Cermakian, S. Brancorsini, M. Parvinen, and P. Sassone-Corsi (2003)
Mol. Endocrinol. 17, 141-151
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)