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Science 29 April 1994: Vol. 264. no. 5159, pp. 719 - 725 DOI: 10.1126/science.8171325
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Articles
Science, Vol 264, Issue 5159, 719-725
Copyright © 1994 by American Association for the Advancement of Science
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior
MH Vitaterna,
DP King,
AM Chang,
JM Kornhauser,
PL Lowrey,
JD McDonald,
WF Dove,
LH Pinto,
FW Turek,
and
JS Takahashi
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.
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- S. Pitts, E. Perone, and R. Silver (2003)
Am J Physiol Regulatory Integrative Comp Physiol
285, R57-R67
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- Melatonin and activity rhythm responses to light pulses in mice with the Clock mutation.
- D. J. Kennaway, A. Voultsios, T. J. Varcoe, and R. W. Moyer (2003)
Am J Physiol Regulatory Integrative Comp Physiol
284, R1231-R1240
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- The Genes and Brains of Mice and Men.
- L. H. Tecott (2003)
Am J Psychiatry
160, 646-656
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- Genetic Models in Applied Physiology: Invited Review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms.
- J. C. Hendricks (2003)
J Appl Physiol
94, 1660-1672
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- Light-Induced Phase Shifts in Mice Lacking mPER1 or mPER2.
- K. Bae and D. R. Weaver (2003)
J Biol Rhythms
18, 123-133
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- Aging Alters Circadian and Light-Induced Expression of Clock Genes in Golden Hamsters.
- D. E. Kolker, H. Fukuyama, D. S. Huang, J. S. Takahashi, T. H. Horton, and F. W. Turek (2003)
J Biol Rhythms
18, 159-169
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- One Hundred Years of Mouse Genetics: An Intellectual History. II. The Molecular Revolution (1981-2002).
- K. Paigen (2003)
Genetics
163, 1227-1235
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- No Circadian Rhythms in Testis: Period1 Expression Is Clock Independent and Developmentally Regulated in the Mouse.
- D. Morse, N. Cermakian, S. Brancorsini, M. Parvinen, and P. Sassone-Corsi (2003)
Mol. Endocrinol.
17, 141-151
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