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Science 29 April 1994:
Vol. 264. no. 5159, pp. 707 - 710
DOI: 10.1126/science.8171323

Articles

Science, Vol 264, Issue 5159, 707-710
Copyright © 1994 by American Association for the Advancement of Science


articles

A lymphotoxin-beta-specific receptor

PD Crowe, TL VanArsdale, BN Walter, CF Ware, C Hession, B Ehrenfels, JL Browning, WS Din, RG Goodwin, and CA Smith

Division of Biomedical Sciences, University of California, Riverside 92521.

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.


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