Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 29 April 1994:
Vol. 264. no. 5159, pp. 699 - 703
DOI: 10.1126/science.8171321

Articles

Science, Vol 264, Issue 5159, 699-703
Copyright © 1994 by American Association for the Advancement of Science


articles

A genetic linkage map for the zebrafish

JH Postlethwait, SL Johnson, CN Midson, WS Talbot, M Gates, EW Ballinger, D Africa, R Andrews, T Carl, JS Eisen, and al. et

Institute of Neurosciences, University of Oregon, Eugene 97403.

To facilitate molecular genetic analysis of vertebrate development, haploid genetics was used to construct a recombination map for the zebrafish Danio (Brachydanio) rerio. The map consists of 401 random amplified polymorphic DNAs (RAPDs) and 13 simple sequence repeats spaced at an average interval of 5.8 centimorgans. Strategies that exploit the advantages of haploid genetics and RAPD markers were developed that quickly mapped lethal and visible mutations and that placed cloned genes on the map. This map is useful for the position-based cloning of mutant genes, the characterization of chromosome rearrangements, and the investigation of evolution in vertebrate genomes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The C. savignyi genetic map and its integration with the reference sequence facilitates insights into chordate genome evolution.
M. M. Hill, K. W. Broman, E. Stupka, W. C. Smith, D. Jiang, and A. Sidow (2008)
Genome Res. 18, 1369-1379
   Abstract »    Full Text »    PDF »
A Microsatellite Genetic Map of the Turbot (Scophthalmus maximus).
C. Bouza, M. Hermida, B. G. Pardo, C. Fernandez, G. G. Fortes, J. Castro, L. Sanchez, P. Presa, M. Perez, A. Sanjuan, et al. (2007)
Genetics 177, 2457-2467
   Abstract »    Full Text »    PDF »
Genetic variation in the zebrafish.
V. Guryev, M. J. Koudijs, E. Berezikov, S. L. Johnson, R. H.A. Plasterk, F. J.M. van Eeden, and E. Cuppen (2006)
Genome Res. 16, 491-497
   Abstract »    Full Text »    PDF »
A Microsatellite Linkage Map of the European Sea Bass Dicentrarchus labrax L..
D. A. Chistiakov, B. Hellemans, C. S. Haley, A. S. Law, C. S. Tsigenopoulos, G. Kotoulas, D. Bertotto, A. Libertini, and F. A. M. Volckaert (2005)
Genetics 170, 1821-1826
   Abstract »    Full Text »    PDF »
Intraocular Pressure in Zebrafish: Comparison of Inbred Strains and Identification of a Reduced Melanin Mutant with Raised IOP.
B. A. Link, M. P. Gray, R. S. Smith, and S. W. M. John (2004)
Invest. Ophthalmol. Vis. Sci. 45, 4415-4422
   Abstract »    Full Text »    PDF »
The Zebrafish nrc Mutant Reveals a Role for the Polyphosphoinositide Phosphatase Synaptojanin 1 in Cone Photoreceptor Ribbon Anchoring.
H. A. Van Epps, M. Hayashi, L. Lucast, G. W. Stearns, J. B. Hurley, P. De Camilli, and S. E. Brockerhoff (2004)
J. Neurosci. 24, 8641-8650
   Abstract »    Full Text »    PDF »
Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations.
W. A. Cresko, A. Amores, C. Wilson, J. Murphy, M. Currey, P. Phillips, M. A. Bell, C. B. Kimmel, and J. H. Postlethwait (2004)
PNAS 101, 6050-6055
   Abstract »    Full Text »    PDF »
The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate.
S. L. Amacher, B. W. Draper, B. R. Summers, and C. B. Kimmel (2003)
Development 129, 3311-3323
   Abstract »    Full Text »    PDF »
Coupled Mutagenesis Screens and Genetic Mapping in Zebrafish.
J. F. Rawls, M. R. Frieda, A. R. McAdow, J. P. Gross, C. M. Clayton, C. K. Heyen, and S. L. Johnson (2003)
Genetics 163, 997-1009
   Abstract »    Full Text »    PDF »
The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1).
A. Donovan, A. Brownlie, M. O. Dorschner, Y. Zhou, S. J. Pratt, B. H. Paw, R. B. Phillips, C. Thisse, B. Thisse, and L. I. Zon (2002)
Blood 100, 4655-4659
   Abstract »    Full Text »    PDF »
Rapid Mapping of Zebrafish Mutations With SNPs and Oligonucleotide Microarrays.
H. L. Stickney, J. Schmutz, I. G. Woods, C. C. Holtzer, M. C. Dickson, P. D. Kelly, R. M. Myers, and W. S. Talbot (2002)
Genome Res. 12, 1929-1934
   Abstract »    Full Text »    PDF »
Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries.
C. A. Henry, M. K. Urban, K. K. Dill, J. P. Merlie, M. F. Page, C. B. Kimmel, and S. L. Amacher (2002)
Development 129, 3693-3704
   Abstract »    Full Text »    PDF »
Sex-Specific Recombination Rates in Zebrafish (Danio rerio).
A. Singer, H. Perlman, Y. Yan, C. Walker, G. Corley-Smith, B. Brandhorst, and J. Postlethwait (2002)
Genetics 160, 649-657
   Abstract »    Full Text »    PDF »
A zebrafish sox9 gene required for cartilage morphogenesis.
Y.-L. Yan, C. T. Miller, R. Nissen, A. Singer, D. Liu, A. Kirn, B. Draper, J. Willoughby, P. A. Morcos, A. Amsterdam, et al. (2002)
Development 129, 5065-5079
   Abstract »    Full Text »    PDF »
Mapping a Cave Fish Genome: Polygenic Systems and Regressive Evolution.
R. Borowsky and H. Wilkens (2002)
J. Hered. 93, 19-21
   Abstract »    Full Text »    PDF »
Hedgehog signaling is required for primary motoneuron induction in zebrafish.
K. E. Lewis and J. S. Eisen (2001)
Development 128, 3485-3495
   Abstract »    Full Text »    PDF »
Zebrafish Comparative Genomics and the Origins of Vertebrate Chromosomes.
J. H. Postlethwait, I. G. Woods, P. Ngo-Hazelett, Y.-L. Yan, P. D. Kelly, F. Chu, H. Huang, A. Hill-Force, and W. S. Talbot (2000)
Genome Res. 10, 1890-1902
   Abstract »    Full Text »
Toward a Physical Map of Drosophila buzzatii: Use of Randomly Amplified Polymorphic DNA Polymorphisms and Sequence-Tagged Site Landmarks.
H. Laayouni, M. Santos, and A. Fontdevila (2000)
Genetics 156, 1797-1816
   Abstract »    Full Text »
A Microsatellite Linkage Map of Rainbow Trout (Oncorhynchus mykiss) Characterized by Large Sex-Specific Differences in Recombination Rates.
T. Sakamoto, R. G. Danzmann, K. Gharbi, P. Howard, A. Ozaki, S. K. Khoo, R. A. Woram, N. Okamoto, M. M. Ferguson, L.-E. Holm, et al. (2000)
Genetics 155, 1331-1345
   Abstract »    Full Text »
Evidence for Recent Invasion of the Medaka Fish Genome by the Tol2 Transposable Element.
A. Koga, A. Shimada, A. Shima, M. Sakaizumi, H. Tachida, and H. Hori (2000)
Genetics 155, 273-281
   Abstract »    Full Text »
Genetic Linkage Mapping of Zebrafish Genes and ESTs.
P. D. Kelly, F. Chu, I. G. Woods, P. Ngo-Hazelett, T. Cardozo, H. Huang, F. Kimm, L. Liao, Y.-L. Yan, Y. Zhou, et al. (2000)
Genome Res. 10, 558-567
   Abstract »    Full Text »
Zebrafish mutations and functional analysis of the vertebrate genome.
W. S. Talbot and N. Hopkins (2000)
Genes & Dev. 14, 755-762
   Full Text »
A Detailed Linkage Map of Medaka, Oryzias latipes: Comparative Genomics and Genome Evolution.
K. Naruse, S. Fukamachi, H. Mitani, M. Kondo, T. Matsuoka, S. Kondo, N. Hanamura, Y. Morita, K. Hasegawa, R. Nishigaki, et al. (2000)
Genetics 154, 1773-1784
   Abstract »    Full Text »
Reverse genetics in zebrafish.
A. C. LEKVEN, K. A. HELDE, C. J. THORPE, R. ROOKE, and R. T. MOON (2000)
Physiol Genomics 2, 37-48
   Abstract »    Full Text »    PDF »
gridlock, an HLH Gene Required for Assembly of the Aorta in Zebrafish.
T. P. Zhong, M. Rosenberg, M. P. Mohideen, B. Weinstein, and M. C. Fishman (2000)
Science 287, 1820-1824
   Abstract »    Full Text »
Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish.
W Liao, C. Ho, Y. Yan, J Postlethwait, and D. Stainier (2000)
Development 127, 4303-4313
   Abstract »    PDF »
Mutations in the stumpy gene reveal intermediate targets for zebrafish motor axons.
C. Beattie, E Melancon, and J. Eisen (2000)
Development 127, 2653-2662
   Abstract »    PDF »
Assessment of Polymorphism in Zebrafish Mapping Strains.
A. Nechiporuk, J. E. Finney, M. T. Keating, and S. L. Johnson (1999)
Genome Res. 9, 1231-1238
   Abstract »    Full Text »
Construction of a Linkage Map of the Medaka (Oryzias latipes) and Mapping of the Da Mutant Locus Defective in Dorsoventral Patterning.
M. Ohtsuka, S. Makino, K. Yoda, H. Wada, K. Naruse, H. Mitani, A. Shima, K. Ozato, M. Kimura, and H. Inoko (1999)
Genome Res. 9, 1277-1287
   Abstract »    Full Text »
RAPD-Based Genetic Linkage Maps of Tribolium castaneum.
R. W. Beeman and S. J. Brown (1999)
Genetics 153, 333-338
   Abstract »    Full Text »
Radiation hybrid mapping of the zebrafish genome.
N. A. Hukriede, L. Joly, M. Tsang, J. Miles, P. Tellis, J. A. Epstein, W. B. Barbazuk, F. N. Li, B. Paw, J. H. Postlethwait, et al. (1999)
PNAS 96, 9745-9750
   Abstract »    Full Text »    PDF »
A Genetic Linkage Map for Zebrafish: Comparative Analysis and Localization of Genes and Expressed Sequences.
M. A. Gates, L. Kim, E. S. Egan, T. Cardozo, H. I. Sirotkin, S. T. Dougan, D. Lashkari, R. Abagyan, A. F. Schier, and W. S. Talbot (1999)
Genome Res. 9, 334-347
   Abstract »    Full Text »
Isolation of Zebrafish gdf7 and Comparative Genetic Mapping of Genes Belonging to the Growth/Differentiation Factor 5, 6, 7 Subgroup of the TGF-beta Superfamily.
A. J. Davidson, J. H. Postlethwait, Y.-L. Yan, D. R. Beier, C. van Doren, D. Foernzler, A. J. Celeste, K. E. Crosier, and P. S. Crosier (1999)
Genome Res. 9, 121-129
   Abstract »    Full Text »
The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures.
K Fekany, Y Yamanaka, T Leung, H. Sirotkin, J Topczewski, M. Gates, M Hibi, A Renucci, D Stemple, A Radbill, et al. (1999)
Development 126, 1427-1438
   Abstract »    PDF »
A High-Resolution Microsatellite Map of the Mouse Genome.
M. Rhodes, R. Straw, S. Fernando, A. Evans, T. Lacey, A. Dearlove, J. Greystrong, J. Walker, P. Watson, P. Weston, et al. (1998)
Genome Res. 8, 531-542
   Abstract »    Full Text »
A Detailed Linkage Map of Rainbow Trout Produced Using Doubled Haploids.
W. P. Young, P. A. Wheeler, V. H. Coryell, P. Keim, and G. H. Thorgaard (1998)
Genetics 148, 839-850
   Abstract »    Full Text »    PDF »
Promoting notochord fate and repressing muscle development in zebrafish axial mesoderm.
S. Amacher and C. Kimmel (1998)
Development 125, 1397-1406
   Abstract »    PDF »
Equivalence in the genetic control of hindbrain segmentation in fish and mouse.
C. Moens, S. Cordes, M. Giorgianni, G. Barsh, and C. Kimmel (1998)
Development 125, 381-391
   Abstract »    PDF »
Zebrafish: Genomics on the Fast Track.
D. R. Beier (1998)
Genome Res. 8, 9-17
   Full Text »    PDF »
An Altered Intron Inhibits Synthesis of the Acetylcholine Receptor {alpha}-Subunit in the Paralyzed Zebrafish Mutant nic1.
(1998)
Genetics 148, 361-372
Genetic Analysis of Chromosomal Rearrangements in the cyclops Region of the Zebrafish Genome.
(1998)
Genetics 148, 373-380
Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate.
K. Baker, K. S. Warren, G. Yellen, and M. C. Fishman (1997)
PNAS 94, 4554-4559
   Abstract »    Full Text »    PDF »
Loss of cerebum function ventralizes the zebrafish embryo.
S Fisher, S. Amacher, and M. Halpern (1997)
Development 124, 1301-1311
   Abstract »    PDF »
Genetic Analysis of Pattern Formation in the Zebrafish Neural Plate.
W. Driever, L. Solnica-Krezel, S. Abdelilah, D. Meyer, and D. Stemple (1997)
Cold Spring Harb Symp Quant Biol 62, 523-534
   Abstract »    PDF »
High-throughput microsatellite analysis using fluorescent dUTPs for high-resolution genetic mapping of the mouse genome..
M Rhodes, A Dearlove, R Straw, S Fernando, A Evans, M Greener, T Lacey, M Kelly, K Gibson, S D Brown, et al. (1997)
Genome Res. 7, 81-86
   Abstract »    PDF »
The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail.
A. Schier, S. Neuhauss, K. Helde, W. Talbot, and W Driever (1997)
Development 124, 327-342
   Abstract »    PDF »
From screens to genes: prospects for insertional mutagenesis in zebrafish..
A F Schier, A L Joyner, R Lehmann, and W S Talbot (1996)
Genes & Dev. 10, 3077-3080
   PDF »
Genetic mapping in Xiphophorus hybrid fish: assignment of 43 AP-PCR/RAPD and isozyme markers to multipoint linkage groups..
S Kazianis, D C Morizot, B B McEntire, R S Nairn, and R L Borowsky (1996)
Genome Res. 6, 280-289
   Abstract »    PDF »
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.
P Haffter, M Granato, M Brand, M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, F. van Eeden, Y. Jiang, C. Heisenberg, et al. (1996)
Development 123, 1-36
   Abstract »    PDF »
A genetic screen for mutations affecting embryogenesis in zebrafish.
W Driever, L Solnica-Krezel, A. Schier, S. Neuhauss, J Malicki, D. Stemple, D. Stainier, F Zwartkruis, S Abdelilah, Z Rangini, et al. (1996)
Development 123, 37-46
   Abstract »    PDF »
Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes.
M. Mullins, M Hammerschmidt, D. Kane, J Odenthal, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, P Haffter, C. Heisenberg, et al. (1996)
Development 123, 81-93
   Abstract »    PDF »
Mutations affecting development of the zebrafish ear.
J Malicki, A. Schier, L Solnica-Krezel, D. Stemple, S. Neuhauss, D. Stainier, S Abdelilah, Z Rangini, F Zwartkruis, and W Driever (1996)
Development 123, 275-283
   Abstract »    PDF »
Mutations affecting craniofacial development in zebrafish.
S. Neuhauss, L Solnica-Krezel, A. Schier, F Zwartkruis, D. Stemple, J Malicki, S Abdelilah, D. Stainier, and W Driever (1996)
Development 123, 357-367
   Abstract »    PDF »
Zebrafish pigmentation mutations and the processes of neural crest development.
R. Kelsh, M Brand, Y. Jiang, C. Heisenberg, S Lin, P Haffter, J Odenthal, M. Mullins, F. van Eeden, M Furutani-Seiki, et al. (1996)
Development 123, 369-389
   Abstract »    PDF »
A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms.
E. Knapik, A Goodman, O. Atkinson, C. Roberts, M Shiozawa, C. Sim, S Weksler-Zangen, M. Trolliet, C Futrell, B. Innes, et al. (1996)
Development 123, 451-460
   Abstract »    PDF »
valentino: a zebrafish gene required for normal hindbrain segmentation.
C. Moens, Y. Yan, B Appel, A. Force, and C. Kimmel (1996)
Development 122, 3981-3990
   Abstract »    PDF »
Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype.
D Alexandre, J. Clarke, E Oxtoby, Y. Yan, T Jowett, and N Holder (1996)
Development 122, 735-746
   Abstract »    PDF »
Generation of DNA-based markers in specific genome regions by two-primer RAPD reactions..
J Hu, J van Eysden, and C F Quiros (1995)
Genome Res. 4, 346-351
   Abstract »    PDF »
Of flies and fishes.
C Nusslein-Volhard (1994)
Science 266, 572-574
   PDF »
Zebrafish hit the big time.
P Kahn (1994)
Science 264, 904-905
   PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)