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Science 29 April 1994:
Vol. 264. no. 5159, pp. 671 - 677
DOI: 10.1126/science.8171318

Articles

Science, Vol 264, Issue 5159, 671-677
Copyright © 1994 by American Association for the Advancement of Science


articles

Application and accuracy of molecular phylogenies

DM Hillis, JP Huelsenbeck, and CW Cunningham

Department of Zoology, University of Texas, Austin 78712.

Molecular investigations of evolutionary history are being used to study subjects as diverse as the epidemiology of acquired immune deficiency syndrome and the origin of life. These studies depend on accurate estimates of phylogeny. The performance of methods of phylogenetic analysis can be assessed by numerical simulation studies and by the experimental evolution of organisms in controlled laboratory situations. Both kinds of assessment indicate that existing methods are effective at estimating phylogenies over a wide range of evolutionary conditions, especially if information about substitution bias is used to provide differential weightings for character transformations.


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