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Science 22 April 1994:
Vol. 264. no. 5158, pp. 572 - 575
DOI: 10.1126/science.8160014
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Articles

Science, Vol 264, Issue 5158, 572-575
Copyright © 1994 by American Association for the Advancement of Science

articles

Bacillus subtilis spoIIIE protein required for DNA segregation during asymmetric cell division

LJ Wu and J Errington

Sir William Dunn School of Pathology, University of Oxford, UK.

Sporulation in Bacillus subtilis begins with an asymmetric cell division, producing a smaller prespore and a larger mother cell, both of which contain intact copies of the chromosome. The spoIIIE gene is required for chromosome segregation into the prespore compartment. The effects of the spoIIIE36 mutation on sigma F-dependent transcription are an indirect consequence of the failure of certain genes to enter the cellular compartment in which their transcription factor has become active. SpoIIIE may also be required to prevent sigma F from becoming active in the mother cell.


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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »


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