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Science 15 April 1994:
Vol. 264. no. 5157, pp. 436 - 440
DOI: 10.1126/science.8153634
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Articles

Science, Vol 264, Issue 5157, 436-440
Copyright © 1994 by American Association for the Advancement of Science

articles

A cell cycle regulator potentially involved in genesis of many tumor types

A Kamb, NA Gruis, J Weaver-Feldhaus, Q Liu, K Harshman, SV Tavtigian, E Stockert, RS Day 3rd, BE Johnson, and MH Skolnick

Myriad Genetics, Inc., Salt Lake City, UT 84108.

A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (p16) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.


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   Abstract »    Full Text »    PDF »
Haplotypes of Two Variants in p16 (CDKN2/MTS-1/INK4a) Exon 3 and Risk of Squamous Cell Carcinoma of the Head and Neck: A Case-Control Study.
Y. Zheng, H. Shen, E. M. Sturgis, L.-E Wang, S. Shete, M. R. Spitz, and Q. Wei (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 640-645
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Replicative Senescence Revisited.
R. Marcotte and E. Wang (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B257-269
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Significant Impact of Promoter Hypermethylation and the 540 C>T Polymorphism of CDKN2A in Cutaneous Melanoma of the Vertical Growth Phase.
O. Straume, J. Smeds, R. Kumar, K. Hemminki, and L. A. Akslen (2002)
Am. J. Pathol. 161, 229-237
   Abstract »    Full Text »    PDF »
Molecular Aspects of Melanocytic Dysplastic Nevi.
M. R. A.-E. Hussein and G. S. Wood (2002)
J. Mol. Diagn. 4, 71-80
   Abstract »    Full Text »    PDF »
ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc.
J. L. Russell, J. T. Powers, R. J. Rounbehler, P. M. Rogers, C. J. Conti, and D. G. Johnson (2002)
Mol. Cell. Biol. 22, 1360-1368
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A Possible Role for Insulin-like Growth Factor-binding Protein-3 Autocrine/Paracrine Loops in Controlling Hepatocellular Carcinoma Cell Proliferation.
H. Huynh, P. K. H. Chow, L. L. P. Ooi, and K.-C. Soo (2002)
Cell Growth Differ. 13, 115-122
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DNA Damage Is Able to Induce Senescence in Tumor Cells in Vitro and in Vivo.
R. H. te Poele, A. L. Okorokov, L. Jardine, J. Cummings, and S. P. Joel (2002)
Cancer Res. 62, 1876-1883
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p14ARF nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways.
A. Sanchez-Aguilera, M. Sanchez-Beato, J. F. Garcia, I. Prieto, M. Pollan, and M. A. Piris (2002)
Blood 99, 1411-1418
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Specific Allelic Loss of p16 INK4A Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis.
M. Hiroyasu, M. Ozeki, H. Kohda, M. Echizenya, T. Tanaka, H. Hiai, and S. Toyokuni (2002)
Am. J. Pathol. 160, 419-424
   Abstract »    Full Text »    PDF »
Obligate Roles for p16Ink4a and p19Arf-p53 in the Suppression of Murine Pancreatic Neoplasia.
N. Bardeesy, J. Morgan, M. Sinha, S. Signoretti, S. Srivastava, M. Loda, G. Merlino, and R. A. DePinho (2002)
Mol. Cell. Biol. 22, 635-643
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Germ Line Transmission of the Cdk4R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence.
S. G. Rane, S. C. Cosenza, R. V. Mettus, and E. P. Reddy (2002)
Mol. Cell. Biol. 22, 644-656
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Cooperative Role of Telomerase Activity and p16 Expression in the Prognosis of Non-Small-Cell Lung Cancer.
R. Gonzalez-Quevedo, P. Iniesta, A. Moran, C. de Juan, A. Sanchez-Pernaute, C. Fernandez, A. Torres, E. Diaz-Rubio, J.-L. Balibrea, and M. Benito (2002)
J. Clin. Oncol. 20, 254-262
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Identification of Frequent G2 Checkpoint Impairment and a Homozygous Deletion of 14-3-3{epsilon} at 17p13.3 in Small Cell Lung Cancers.
H. Konishi, T. Nakagawa, T. Harano, K. Mizuno, H. Saito, A. Masuda, H. Matsuda, H. Osada, and T. Takahashi (2002)
Cancer Res. 62, 271-276
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Head and Neck Cancer.
A. Forastiere, W. Koch, A. Trotti, and D. Sidransky (2001)
N. Engl. J. Med. 345, 1890-1900
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Down-regulation of Integrin alpha vbeta 3 Expression and Integrin-mediated Signaling in Glioma Cells by Adenovirus-mediated Transfer of Antisense Urokinase-type Plasminogen Activator Receptor (uPAR) and Sense p16 Genes.
Y. Adachi, S. S. Lakka, N. Chandrasekar, N. Yanamandra, C. S. Gondi, S. Mohanam, D. H. Dinh, W. C. Olivero, M. Gujrati, T. Tamiya, et al. (2001)
J. Biol. Chem. 276, 47171-47177
   Abstract »    Full Text »    PDF »
Selected Novel Anticancer Treatments Targeting Cell Signaling Proteins.
Y. A. Elsayed and E. A. Sausville (2001)
Oncologist 6, 517-537
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Validation of Denaturing High Performance Liquid Chromatography as a Rapid Detection Method for the Identification of Human INK4A Gene Mutations.
I. Orlow, P. Roy, A. Barz, R. Canchola, Y. Song, and M. Berwick (2001)
J. Mol. Diagn. 3, 158-163
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Induction of Melanoma in Murine Macrophage Inflammatory Protein 2 Transgenic Mice Heterozygous for Inhibitor of Kinase/Alternate Reading Frame.
J. Yang, J. Luan, Y. Yu, C. Li, R. A. DePinho, L. Chin, and A. Richmond (2001)
Cancer Res. 61, 8150-8157
   Abstract »    Full Text »    PDF »
Genetic Epidemiology of Cutaneous Melanoma: A Global Perspective.
A. M. Goldstein and M. A. Tucker (2001)
Arch Dermatol 137, 1493-1496
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Functional Impairment of Melanoma-associated p16INK4a Mutants in Melanoma Cells despite Retention of Cyclin-dependent Kinase 4 Binding.
T. M. Becker, H. Rizos, R. F. Kefford, and G. J. Mann (2001)
Clin. Cancer Res. 7, 3282-3288
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