Science 15 April 1994: Vol. 264. no. 5157, pp. 436 - 440 DOI: 10.1126/science.8153634

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Articles

Sample Type Bias in the Analysis of Cancer Genomes.

D. A. Solomon, J.-S. Kim, H. W. Ressom, Z. Sibenaller, T. Ryken, W. Jean, D. Bigner, H. Yan, and T. Waldman (2009)
Cancer Res. 69, 5630-5633
 |  Abstract »  |  Full Text »  |  PDF »

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.

S. Sulong, A. V. Moorman, J. A. E. Irving, J. C. Strefford, Z. J. Konn, M. C. Case, L. Minto, K. E. Barber, H. Parker, S. L. Wright, et al. (2009)
Blood 113, 100-107
 |  Abstract »  |  Full Text »  |  PDF »

Interaction Between Poor Glycemic Control and 9p21 Locus on Risk of Coronary Artery Disease in Type 2 Diabetes.

A. Doria, J. Wojcik, R. Xu, E. V. Gervino, T. H. Hauser, M. T. Johnstone, D. Nolan, F. B. Hu, and J. H. Warram (2008)
JAMA 300, 2389-2397
 |  Abstract »  |  Full Text »  |  PDF »

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.

R. J. Leary, J. C. Lin, J. Cummins, S. Boca, L. D. Wood, D. W. Parsons, S. Jones, T. Sjoblom, B.-H. Park, R. Parsons, et al. (2008)
PNAS 105, 16224-16229
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer.

R. Kikuchi, H. Tsuda, K.-i. Kozaki, Y. Kanai, T. Kasamatsu, K. Sengoku, S. Hirohashi, J. Inazawa, and I. Imoto (2008)
Cancer Res. 68, 5067-5075
 |  Abstract »  |  Full Text »  |  PDF »

Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape.

A. Sekulic, P. Haluska Jr, A. J. Miller, J. G. De Lamo, S. Ejadi, J. S. Pulido, D. R. Salomao, E. C. Thorland, R. G. Vile, D. L. Swanson, et al. (2008)
Mayo Clin. Proc. 83, 825-846
 |  Abstract »  |  Full Text »  |  PDF »

Frequent p16-Independent Inactivation of p14ARF in Human Melanoma.

D. E. Freedberg, S. H. Rigas, J. Russak, W. Gai, M. Kaplow, I. Osman, F. Turner, J. A. Randerson-Moor, A. Houghton, K. Busam, et al. (2008)
J Natl Cancer Inst 100, 784-795
 |  Abstract »  |  Full Text »  |  PDF »

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.

T. Terzian, Y.-A. Suh, T. Iwakuma, S. M. Post, M. Neumann, G. A. Lang, C. S. Van Pelt, and G. Lozano (2008)
Genes & Dev. 22, 1337-1344
 |  Abstract »  |  Full Text »  |  PDF »

Differential Roles of p16INK4A and p14ARF Genes in Prognosis of Oral Carcinoma.

R. Sailasree, A. Abhilash, K.M. Sathyan, K.R. Nalinakumari, S. Thomas, and S. Kannan (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 414-420
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy.

S. Choi and J.N. Myers (2008)
Journal of Dental Research 87, 14-32
 |  Abstract »  |  Full Text »  |  PDF »

S-Adenosylmethionine as a Biomarker for the Early Detection of Lung Cancer.

A. K. Greenberg, B. Rimal, K. Felner, S. Zafar, J. Hung, E. Eylers, B. Phalan, M. Zhang, J. D. Goldberg, B. Crawford, et al. (2007)
Chest 132, 1247-1252
 |  Abstract »  |  Full Text »  |  PDF »

Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer.

R. Kikuchi, H. Tsuda, Y. Kanai, T. Kasamatsu, K. Sengoku, S. Hirohashi, J. Inazawa, and I. Imoto (2007)
Cancer Res. 67, 7095-7105
 |  Abstract »  |  Full Text »  |  PDF »

Monitoring of Kindreds With Hereditary Predisposition for Cutaneous Melanoma and Dysplastic Nevus Syndrome: Results of a Swedish Preventive Program.

J. Hansson, M. Bergenmar, P.-A. Hofer, G. Lundell, E. Mansson-Brahme, U. Ringborg, I. Synnerstad, A. T. Bratel, A.-M. Wennberg, and I. Rosdahl (2007)
J. Clin. Oncol. 25, 2819-2824
 |  Abstract »  |  Full Text »  |  PDF »

Phenotypic Variation in Familial Melanoma: Consequences for Predictive DNA Testing.

W. Bergman and N. A. Gruis (2007)
Arch Dermatol 143, 525-526
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Ovarian clear cell adenocarcinoma: a continuing enigma.

D. S P Tan and S. Kaye (2007)
J. Clin. Pathol. 60, 355-360
 |  Abstract »  |  Full Text »  |  PDF »

The Role of EXT1 in Nonhereditary Osteochondroma: Identification of Homozygous Deletions.

L. Hameetman, K. Szuhai, A. Yavas, J. Knijnenburg, M. van Duin, H. van Dekken, A. H. M. Taminiau, A.-M. Cleton-Jansen, J. V. M. G. Bovee, and P. C. W. Hogendoorn (2007)
J Natl Cancer Inst 99, 396-406
 |  Abstract »  |  Full Text »  |  PDF »

The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light.

M. A. Al-Mohanna, H. H. Al-Khalaf, N. Al-Yousef, and A. Aboussekhra (2007)
Nucleic Acids Res. 35, 223-233
 |  Abstract »  |  Full Text »  |  PDF »

Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort.

M. Falchi, T. D. Spector, U. Perks, B. S. Kato, and V. Bataille (2006)
Hum. Mol. Genet. 15, 2975-2979
 |  Abstract »  |  Full Text »  |  PDF »

Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma.

P. Ghiorzo, S. Gargiulo, L. Pastorino, S. Nasti, R. Cusano, W. Bruno, S. Gliori, M. R. Sertoli, A. Burroni, V. Savarino, et al. (2006)
Hum. Mol. Genet. 15, 2682-2689
 |  Abstract »  |  Full Text »  |  PDF »

Oncogene-induced cell senescence--halting on the road to cancer..

W.J. Mooi and D.S. Peeper (2006)
N. Engl. J. Med. 355, 1037-1046
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Malignant melanoma: genetics and therapeutics in the genomic era..

L. Chin, L. A. Garraway, and D. E. Fisher (2006)
Genes & Dev. 20, 2149-2182
 |  Abstract »  |  Full Text »  |  PDF »

Melanoma..

A. J. Miller and M. C. Mihm Jr. (2006)
N. Engl. J. Med. 355, 51-65
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Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion.

K-T Kuo, H-C Chang, C-H Hsiao, and M-C Lin (2006)
Br J Ophthalmol 90, 894-899
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Silencing of the Candidate Tumor Suppressor PCDH20 by Epigenetic Mechanism in Non-Small-Cell Lung Cancers..

I. Imoto, H. Izumi, S. Yokoi, H. Hosoda, T. Shibata, F. Hosoda, M. Ohki, S. Hirohashi, and J. Inazawa (2006)
Cancer Res. 66, 4617-4626
 |  Abstract »  |  Full Text »  |  PDF »

Cohypermethylation of p16 and FHIT Promoters as a Prognostic Factor of Recurrence in Surgically Resected Stage I Non-Small Cell Lung Cancer..

J. S. Kim, J. W. Kim, J. Han, Y. M. Shim, J. Park, and D.-H. Kim (2006)
Cancer Res. 66, 4049-4054
 |  Abstract »  |  Full Text »  |  PDF »

The Retinoblastoma Protein Is Required for Ras-Induced Oncogenic Transformation.

J. P. Williams, T. Stewart, B. Li, R. Mulloy, D. Dimova, and M. Classon (2006)
Mol. Cell. Biol. 26, 1170-1182
 |  Abstract »  |  Full Text »  |  PDF »

Melanocortin-1 Receptor (MC1R) Gene Variants and Dysplastic Nevi Modify Penetrance of CDKN2A Mutations in French Melanoma-Prone Pedigrees.

V. Chaudru, K. Laud, M.-F. Avril, A. Miniere, A. Chompret, B. Bressac-de Paillerets, F. Demenais, and The French Familial Melanoma Study Group (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 2384-2390
 |  Abstract »  |  Full Text »  |  PDF »

Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer.

S. A. Belinsky (2005)
Carcinogenesis 26, 1481-1487
 |  Abstract »  |  Full Text »  |  PDF »

Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis.

X. Zhao, B. A. Weir, T. LaFramboise, M. Lin, R. Beroukhim, L. Garraway, J. Beheshti, J. C. Lee, K. Naoki, W. G. Richards, et al. (2005)
Cancer Res. 65, 5561-5570
 |  Abstract »  |  Full Text »  |  PDF »

Biallelic Deletions in INK4 in Cutaneous Melanoma Are Common and Associated with Decreased Survival.

E. Grafstrom, S. Egyhazi, U. Ringborg, J. Hansson, and A. Platz (2005)
Clin. Cancer Res. 11, 2991-2997
 |  Abstract »  |  Full Text »  |  PDF »

A survey of homozygous deletions in human cancer genomes.

C. Cox, G. Bignell, C. Greenman, A. Stabenau, W. Warren, P. Stephens, H. Davies, S. Watt, J. Teague, S. Edkins, et al. (2005)
PNAS 102, 4542-4547
 |  Abstract »  |  Full Text »  |  PDF »

Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity.

R. Ghosh, N. Nadiminty, J. E. Fitzpatrick, W. L. Alworth, T. J. Slaga, and A. P. Kumar (2005)
J. Biol. Chem. 280, 5812-5819
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Networks in Cutaneous Melanoma Metastasis Identified by Complementary DNA Microarrays.

S. Nambiar, A. Mirmohammadsadegh, R. Doroudi, A. Gustrau, A. Marini, G. Roeder, T. Ruzicka, and U. R. Hengge (2005)
Arch Dermatol 141, 165-173
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Heterozygosity on Chromosome 1 and 9 and Hormone Receptor Analysis of Metastatic Malignant Melanoma Presenting in Breast.

M. W. Beaty, M. Quezado, M. E. Sobel, P. Duray, and M. J. Merino (2005)
International Journal of Surgical Pathology 13, 9-18
 |  Abstract »  |  PDF »

Epigenetic Changes in Cancer and Preneoplasia.

J.G. HERMAN (2005)
Cold Spring Harb Symp Quant Biol 70, 329-333
 |  Abstract »  |  PDF »

Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines.

A. H. Box and D. J. Demetrick (2004)
Carcinogenesis 25, 2325-2335
 |  Abstract »  |  Full Text »  |  PDF »

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.

J. S. Aveyard and M. A. Knowles (2004)
J. Mol. Diagn. 6, 356-365
 |  Abstract »  |  Full Text »  |  PDF »

Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas.

K. Hoek, D. L. Rimm, K. R. Williams, H. Zhao, S. Ariyan, A. Lin, H. M. Kluger, A. J. Berger, E. Cheng, E. S. Trombetta, et al. (2004)
Cancer Res. 64, 5270-5282
 |  Abstract »  |  Full Text »  |  PDF »

Does Percutaneous Liver Biopsy of Hepatocellular Carcinoma Cause Hematogenous Dissemination? An In Vivo Study with Quantitative Assay of Circulating Tumor DNA Using Methylation-Specific Real-Time Polymerase Chain Reaction.

S. C. H. Yu, D. Y. M. Lo, C. B. Ip, C. T. Liew, T. W. T. Leung, and W. Y. Lau (2004)
Am. J. Roentgenol. 183, 383-385
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of tumour suppressor retinoblastoma 2 protein (pRb2/p130) in hepatocellular carcinoma.

H. Huynh (2004)
Carcinogenesis 25, 1485-1494
 |  Abstract »  |  Full Text »  |  PDF »

The Clinical Application of Targeting Cancer through Histone Acetylation and Hypomethylation.

J. Gilbert, S. D. Gore, J. G. Herman, and M. A. Carducci (2004)
Clin. Cancer Res. 10, 4589-4596
 |  Abstract »  |  Full Text »  |  PDF »

Isolation and Characterization of a Novel Pituitary Tumor Apoptosis Gene.

A. Bahar, D. J. Simpson, S. J. Cutty, J. E. Bicknell, P. R. Hoban, S. Holley, M. Mourtada-Maarabouni, G. T. Williams, R. N. Clayton, and W. E. Farrell (2004)
Mol. Endocrinol. 18, 1827-1839
 |  Abstract »  |  Full Text »  |  PDF »

Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression.

B. G. Masayesva, P. Ha, E. Garrett-Mayer, T. Pilkington, R. Mao, J. Pevsner, T. Speed, N. Benoit, C.-S. Moon, D. Sidransky, et al. (2004)
PNAS 101, 8715-8720
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Silencing of Low Density Lipoprotein Receptor-Related Protein 1B (LRP1B) Expression by Genetic and Epigenetic Mechanisms in Esophageal Squamous Cell Carcinoma.

I. Sonoda, I. Imoto, J. Inoue, T. Shibata, Y. Shimada, K. Chin, M. Imamura, T. Amagasa, J. W. Gray, S. Hirohashi, et al. (2004)
Cancer Res. 64, 3741-3747
 |  Abstract »  |  Full Text »  |  PDF »

An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays.

X. Zhao, C. Li, J. G. Paez, K. Chin, P. A. Janne, T.-H. Chen, L. Girard, J. Minna, D. Christiani, C. Leo, et al. (2004)
Cancer Res. 64, 3060-3071
 |  Abstract »  |  Full Text »  |  PDF »

Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells.

M.-J. Boucher, D. Jean, A. Vezina, and N. Rivard (2004)
Am J Physiol Gastrointest Liver Physiol 286, G736-G746
 |  Abstract »  |  Full Text »  |  PDF »

Alterations of p16 and Prognosis in Biliary Tract Cancers from a Population-Based Study in China.

T. Ueki, A. W. Hsing, Y.-T. Gao, B.-S. Wang, M.-C. Shen, J. Cheng, J. Deng, J. F. Fraumeni Jr., and A. Rashid (2004)
Clin. Cancer Res. 10, 1717-1725
 |  Abstract »  |  Full Text »  |  PDF »

Case 7-2004 - A 48-Year-Old Woman with Multiple Pigmented Lesions and a Personal and Family History of Melanoma.

H. Tsao, A. J. Sober, K. B. Niendorf, and A. Zembowicz (2004)
N. Engl. J. Med. 350, 924-932
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NC381, a Novel Anticancer Agent, Arrests the Cell Cycle in G0-G1 and Inhibits Lung Tumor Cell Growth in Vitro and in Vivo.

M.-Y. Cao, Y. Lee, N.-P. Feng, R. A. Al-Qawasmeh, S. Viau, X.-P. Gu, L. Lau, H. Jin, M. Wang, A. Vassilakos, et al. (2004)
J. Pharmacol. Exp. Ther. 308, 538-546
 |  Abstract »  |  Full Text »  |  PDF »

Short Hairpin RNA System to Inhibit Human p16 in Squamous Cell Carcinoma.

J. J. Shin, T. Katayama, W. A. Michaud, and J. W. Rocco (2004)
Arch Otolaryngol Head Neck Surg 130, 68-73
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression Profiling in Clinically Localized Prostate Cancer: A Four-Gene Expression Model Predicts Clinical Behavior.

A. Latil, I. Bieche, L. Chene, I. Laurendeau, P. Berthon, O. Cussenot, and M. Vidaud (2003)
Clin. Cancer Res. 9, 5477-5485
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic Exploitation of the Physiological and Molecular Genetic Alterations in Head and Neck Cancer.

Q.-T. Le and A. J. Giaccia (2003)
Clin. Cancer Res. 9, 4287-4295
 |  Abstract »  |  Full Text »  |  PDF »

Mice with Alterations in Both p53 and Ink4a/Arf Display a Striking Increase in Lung Tumor Multiplicity and Progression: Differential Chemopreventive Effect of Budesonide in Wild-type and Mutant A/J Mice.

Y. Wang, Z. Zhang, E. Kastens, R. A. Lubet, and M. You (2003)
Cancer Res. 63, 4389-4395
 |  Abstract »  |  Full Text »  |  PDF »

Co-Expression of p16INK4A and Laminin 5 {gamma}2 by Microinvasive and Superficial Squamous Cell Carcinomas in Vivo and by Migrating Wound and Senescent Keratinocytes in Culture.

E. Natarajan, M. Saeb, C. P. Crum, S. B. Woo, P. H. McKee, and J. G. Rheinwald (2003)
Am. J. Pathol. 163, 477-491
 |  Abstract »  |  Full Text »  |  PDF »

Expression of a MYCN-interacting Isoform of the Tumor Suppressor BIN1 Is Reduced in Neuroblastomas with Unfavorable Biological Features.

T. Tajiri, X. Liu, P. M. Thompson, S. Tanaka, S. Suita, H. Zhao, J. M. Maris, G. C. Prendergast, and M. D. Hogarty (2003)
Clin. Cancer Res. 9, 3345-3355
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Ink4a/Arf in ErbB2 Mammary Gland Tumorigenesis.

M. D'Amico, K. Wu, D. Di Vizio, A. T. Reutens, M. Stahl, M. Fu, C. Albanese, R. G. Russell, W. J. Muller, M. White, et al. (2003)
Cancer Res. 63, 3395-3402
 |  Abstract »  |  Full Text »  |  PDF »

Loss of PTEN Promotes Tumor Development in Malignant Melanoma.

J. M. Stahl, M. Cheung, A. Sharma, N. R. Trivedi, S. Shanmugam, and G. P. Robertson (2003)
Cancer Res. 63, 2881-2890
 |  Abstract »  |  Full Text »  |  PDF »

Homozygous Deletion of CDKN2A and Codeletion of the Methylthioadenosine Phosphorylase Gene in the Majority of Pleural Mesotheliomas.

P. B. Illei, V. W. Rusch, M. F. Zakowski, and M. Ladanyi (2003)
Clin. Cancer Res. 9, 2108-2113
 |  Abstract »  |  Full Text »  |  PDF »

Hypoxia-Inducible Erythropoietin Signaling in Squamous Dysplasia and Squamous Cell Carcinoma of the Uterine Cervix and Its Potential Role in Cervical Carcinogenesis and Tumor Progression.

G. Acs, P. J. Zhang, C. M. McGrath, P. Acs, J. McBroom, A. Mohyeldin, S. Liu, H. Lu, and A. Verma (2003)
Am. J. Pathol. 162, 1789-1806
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Models in Applied Physiology: Invited Review: Effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest.

R. M. Douglas and G. G. Haddad (2003)
J Appl Physiol 94, 2068-2083
 |  Abstract »  |  Full Text »  |  PDF »

High Prognostic Value of p16INK4 Alterations in Gastrointestinal Stromal Tumors.

R. Schneider-Stock, C. Boltze, J. Lasota, M. Miettinen, B. Peters, M. Pross, A. Roessner, and T. Gunther (2003)
J. Clin. Oncol. 21, 1688-1697
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms of Myelodysplastic Syndrome.

H. Hirai (2003)
Jpn. J. Clin. Oncol. 33, 153-160
 |  Abstract »  |  Full Text »  |  PDF »

Malignant Transformation of Melanocytes to Melanoma by Constitutive Activation of Mitogen-activated Protein Kinase Kinase (MAPKK) Signaling.

B. Govindarajan, X. Bai, C. Cohen, H. Zhong, S. Kilroy, G. Louis, M. Moses, and J. L Arbiser (2003)
J. Biol. Chem. 278, 9790-9795
 |  Abstract »  |  Full Text »  |  PDF »

Expression of p16 Protein Identifies a Distinct Entity of Tonsillar Carcinomas Associated with Human Papillomavirus.

J. P. Klussmann, E. Gultekin, S. J. Weissenborn, U. Wieland, V. Dries, H. P. Dienes, H. E. Eckel, H. J. Pfister, and P. G. Fuchs (2003)
Am. J. Pathol. 162, 747-753
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency of p18INK4c Sensitizes Mice to Carcinogen-Induced Tumorigenesis.

F. Bai, X.-H. Pei, V. L. Godfrey, and Y. Xiong (2003)
Mol. Cell. Biol. 23, 1269-1277
 |  Abstract »  |  Full Text »  |  PDF »

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.

K. Kannan, N. E. Sharpless, J. Xu, R. C. O'Hagan, M. Bosenberg, and L. Chin (2003)
PNAS 100, 1221-1225
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of Germline Mutations in BRCA2, P16INK4A, P14ARF and P15 to Uveal Melanoma.

N. Hearle, B. E. Damato, J. Humphreys, J. Wixey, H. Green, J. Stone, D. F. Easton, and R. S. Houlston (2003)
Invest. Ophthalmol. Vis. Sci. 44, 458-462
 |  Abstract »  |  Full Text »  |  PDF »

The E6 and E7 Proteins of the Cutaneous Human Papillomavirus Type 38 Display Transforming Properties.

S. Caldeira, I. Zehbe, R. Accardi, I. Malanchi, W. Dong, M. Giarre, E.-M. de Villiers, R. Filotico, P. Boukamp, and M. Tommasino (2003)
J. Virol. 77, 2195-2206
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cytogenetic Aberrations in Autosomal Dominant Polycystic Kidney Disease Tissue.

J. Gogusev, I. Murakami, M. Doussau, L. Telvi, A. Stojkoski, P. Lesavre, and D. Droz (2003)
J. Am. Soc. Nephrol. 14, 359-366
 |  Abstract »  |  Full Text »  |  PDF »

Gadd45a Protects against UV Irradiation-induced Skin Tumors, and Promotes Apoptosis and Stress Signaling via MAPK and p53.

J. Hildesheim, D. V. Bulavin, M. R. Anver, W. G. Alvord, M. C. Hollander, L. Vardanian, and A. J. Fornace Jr. (2002)
Cancer Res. 62, 7305-7315
 |  Abstract »  |  Full Text »  |  PDF »

Structure-based Design of p18INK4c Proteins with Increased Thermodynamic Stability and Cell Cycle Inhibitory Activity.

R. N. Venkataramani, T. K. MacLachlan, X. Chai, W. S. El-Deiry, and R. Marmorstein (2002)
J. Biol. Chem. 277, 48827-48833
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-actived Protein Kinase Activation Is an Early Event in Melanoma Progression.

C. Cohen, A. Zavala-Pompa, J. H. Sequeira, M. Shoji, D. G. Sexton, G. Cotsonis, F. Cerimele, B. Govindarajan, N. Macaron, and J. L. Arbiser (2002)
Clin. Cancer Res. 8, 3728-3733
 |  Abstract »  |  Full Text »  |  PDF »

Methylthioadenosine Phosphorylase, a Gene Frequently Codeleted with p16cdkN2a/ARF, Acts as a Tumor Suppressor in a Breast Cancer Cell Line.

S. A. Christopher, P. Diegelman, C. W. Porter, and W. D. Kruger (2002)
Cancer Res. 62, 6639-6644
 |  Abstract »  |  Full Text »  |  PDF »

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.

X. Zou, D. Ray, A. Aziyu, K. Christov, A. D. Boiko, A. V. Gudkov, and H. Kiyokawa (2002)
Genes & Dev. 16, 2923-2934
 |  Abstract »  |  Full Text »  |  PDF »

Lung cancer * 1: Prevention of lung cancer.

G E Goodman (2002)
Thorax 57, 994-999
 |  Abstract »  |  Full Text »  |  PDF »

Association of Genetic Defects in Primary Resected Lung Adenocarcinoma Revealed by Targeted Allelic Imbalance Analysis.

F. Cave-Riant, B. Cuillerier, M. Beau-Faller, N. Martinet, F. Alla, C. Bronner, A. Schneider, P. Oudet, and M. P. Gaub (2002)
Am. J. Respir. Cell Mol. Biol. 27, 495-502
 |  Abstract »  |  Full Text »  |  PDF »

Mutational Analysis of Selected Genes in the TGF{beta}, Wnt, pRb, and p53 Pathways in Primary Uveal Melanoma.

S. C. Edmunds, D. P. Kelsell, J. L. Hungerford, and I. A. Cree (2002)
Invest. Ophthalmol. Vis. Sci. 43, 2845-2851
 |  Abstract »  |  Full Text »  |  PDF »

Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation.

Q N Vo, J Geradts, M L Gulley, D A Boudreau, J C Bravo, and B G Schneider (2002)
J. Clin. Pathol. 55, 669-675
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Haplotypes of Two Variants in p16 (CDKN2/MTS-1/INK4a) Exon 3 and Risk of Squamous Cell Carcinoma of the Head and Neck: A Case-Control Study.

Y. Zheng, H. Shen, E. M. Sturgis, L.-E Wang, S. Shete, M. R. Spitz, and Q. Wei (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 640-645
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Replicative Senescence Revisited.

R. Marcotte and E. Wang (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B257-269
 |  Abstract »  |  Full Text »

Significant Impact of Promoter Hypermethylation and the 540 C>T Polymorphism of CDKN2A in Cutaneous Melanoma of the Vertical Growth Phase.

O. Straume, J. Smeds, R. Kumar, K. Hemminki, and L. A. Akslen (2002)
Am. J. Pathol. 161, 229-237
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Molecular Aspects of Melanocytic Dysplastic Nevi.

M. R. A.-E. Hussein and G. S. Wood (2002)
J. Mol. Diagn. 4, 71-80
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ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc.

J. L. Russell, J. T. Powers, R. J. Rounbehler, P. M. Rogers, C. J. Conti, and D. G. Johnson (2002)
Mol. Cell. Biol. 22, 1360-1368
 |  Abstract »  |  Full Text »  |  PDF »

A Possible Role for Insulin-like Growth Factor-binding Protein-3 Autocrine/Paracrine Loops in Controlling Hepatocellular Carcinoma Cell Proliferation.

H. Huynh, P. K. H. Chow, L. L. P. Ooi, and K.-C. Soo (2002)
Cell Growth Differ. 13, 115-122
 |  Abstract »  |  Full Text »  |  PDF »

DNA Damage Is Able to Induce Senescence in Tumor Cells in Vitro and in Vivo.

R. H. te Poele, A. L. Okorokov, L. Jardine, J. Cummings, and S. P. Joel (2002)
Cancer Res. 62, 1876-1883
 |  Abstract »  |  Full Text »  |  PDF »

p14ARF nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways.

A. Sanchez-Aguilera, M. Sanchez-Beato, J. F. Garcia, I. Prieto, M. Pollan, and M. A. Piris (2002)
Blood 99, 1411-1418
 |  Abstract »  |  Full Text »  |  PDF »

Specific Allelic Loss of p16 INK4A Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis.

M. Hiroyasu, M. Ozeki, H. Kohda, M. Echizenya, T. Tanaka, H. Hiai, and S. Toyokuni (2002)
Am. J. Pathol. 160, 419-424
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Obligate Roles for p16Ink4a and p19Arf-p53 in the Suppression of Murine Pancreatic Neoplasia.

N. Bardeesy, J. Morgan, M. Sinha, S. Signoretti, S. Srivastava, M. Loda, G. Merlino, and R. A. DePinho (2002)
Mol. Cell. Biol. 22, 635-643
 |  Abstract »  |  Full Text »  |  PDF »

Germ Line Transmission of the Cdk4R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence.

S. G. Rane, S. C. Cosenza, R. V. Mettus, and E. P. Reddy (2002)
Mol. Cell. Biol. 22, 644-656
 |  Abstract »  |  Full Text »  |  PDF »

Cooperative Role of Telomerase Activity and p16 Expression in the Prognosis of Non-Small-Cell Lung Cancer.

R. Gonzalez-Quevedo, P. Iniesta, A. Moran, C. de Juan, A. Sanchez-Pernaute, C. Fernandez, A. Torres, E. Diaz-Rubio, J.-L. Balibrea, and M. Benito (2002)
J. Clin. Oncol. 20, 254-262
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Frequent G2 Checkpoint Impairment and a Homozygous Deletion of 14-3-3{epsilon} at 17p13.3 in Small Cell Lung Cancers.

H. Konishi, T. Nakagawa, T. Harano, K. Mizuno, H. Saito, A. Masuda, H. Matsuda, H. Osada, and T. Takahashi (2002)
Cancer Res. 62, 271-276
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Head and Neck Cancer.

A. Forastiere, W. Koch, A. Trotti, and D. Sidransky (2001)
N. Engl. J. Med. 345, 1890-1900
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Down-regulation of Integrin alpha vbeta 3 Expression and Integrin-mediated Signaling in Glioma Cells by Adenovirus-mediated Transfer of Antisense Urokinase-type Plasminogen Activator Receptor (uPAR) and Sense p16 Genes.

Y. Adachi, S. S. Lakka, N. Chandrasekar, N. Yanamandra, C. S. Gondi, S. Mohanam, D. H. Dinh, W. C. Olivero, M. Gujrati, T. Tamiya, et al. (2001)
J. Biol. Chem. 276, 47171-47177
 |  Abstract »  |  Full Text »  |  PDF »

Selected Novel Anticancer Treatments Targeting Cell Signaling Proteins.

Y. A. Elsayed and E. A. Sausville (2001)
Oncologist 6, 517-537
 |  Abstract »  |  Full Text »  |  PDF »

Validation of Denaturing High Performance Liquid Chromatography as a Rapid Detection Method for the Identification of Human INK4A Gene Mutations.

I. Orlow, P. Roy, A. Barz, R. Canchola, Y. Song, and M. Berwick (2001)
J. Mol. Diagn. 3, 158-163
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Melanoma in Murine Macrophage Inflammatory Protein 2 Transgenic Mice Heterozygous for Inhibitor of Kinase/Alternate Reading Frame.

J. Yang, J. Luan, Y. Yu, C. Li, R. A. DePinho, L. Chin, and A. Richmond (2001)
Cancer Res. 61, 8150-8157
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Epidemiology of Cutaneous Melanoma: A Global Perspective.

A. M. Goldstein and M. A. Tucker (2001)
Arch Dermatol 137, 1493-1496
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Functional Impairment of Melanoma-associated p16INK4a Mutants in Melanoma Cells despite Retention of Cyclin-dependent Kinase 4 Binding.

T. M. Becker, H. Rizos, R. F. Kefford, and G. J. Mann (2001)
Clin. Cancer Res. 7, 3282-3288
 |  Abstract »  |  Full Text »  |  PDF »

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