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Science 15 April 1994:
Vol. 264. no. 5157, pp. 433 - 436
DOI: 10.1126/science.8153633
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Articles

Science, Vol 264, Issue 5157, 433-436
Copyright © 1994 by American Association for the Advancement of Science

articles

Association of poly(CA).poly(TG) DNA fragments into four-stranded complexes bound by HMG1 and 2

C Gaillard and F Strauss

Institut Jacques Monod, Paris, France.

The tandemly repeated DNA sequence poly(CA).poly(TG) is found in tracts up to 60 base pairs long, dispersed at thousands of sites throughout the genomes of eukaryotes. Double-stranded DNA fragments containing such sequences associated spontaneously with each other in vitro, in the absence of protein, forming stable four-stranded structures that were detected by gel electrophoresis and electron microscopy. These structures were recognized specifically by the nuclear nonhistone high mobility group (HMG) proteins 1 and 2 as evidenced by gel retardation. Such sequence-specific complexes might be involved in vivo in recombination or other processes requiring specific association of two double-stranded DNA molecules.


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