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Science 8 April 1994: Vol. 264. no. 5156, pp. 267 - 270 DOI: 10.1126/science.8146660
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Articles
Science, Vol 264, Issue 5156, 267-270
Copyright © 1994 by American Association for the Advancement of Science
Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands
P Constant,
F Davodeau,
MA Peyrat,
Y Poquet,
G Puzo,
M Bonneville,
and
JJ Fournie
Department III, Laboratoire de Pharmacologie et de Toxicologie Fondamentales du CNRS, Toulouse, France.
Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.
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Blood
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Infect. Immun.
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274, 32079-32084
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PNAS
96, 5141-5146
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PNAS
95, 12510-12515
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66, 98-106
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186, 1769-1774
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185, 91-98
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- Thymus-neuroendocrine interactions in extrathymic T cell development.
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Science
265, 1860-1862
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- Major Histocompatibility Complex-independent Recognition of a Distinctive Pollen Antigen, Most Likely a Carbohydrate, by Human CD8+ alpha /beta T Cells.
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186, 899-908
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- Isopentenyl Pyrophosphate, a Mycobacterial Non-peptidic Antigen, Triggers Delayed and Highly Sustained Signaling in Human gamma delta T Lymphocytes without Inducing Down-modulation of T Cell Antigen Receptor.
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276, 15961-15967
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- Chemical Synthesis and Biological Activity of Bromohydrin Pyrophosphate, a Potent Stimulator of Human gamma delta T Cells.
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276, 18337-18344
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- Tumor Necrosis Factor-alpha Production Is Differently Regulated in gamma delta and alpha beta Human T Lymphocytes.
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- Divergent effect of bacillus Calmette-Guerin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: Implications for primate models in tuberculosis vaccine research.
- J. A. M. Langermans, P. Andersen, D. van Soolingen, R. A. W. Vervenne, P. A. Frost, T. van der Laan, L. A. H. van Pinxteren, J. van den Hombergh, S. Kroon, I. Peekel, et al. (2001)
PNAS
98, 11497-11502
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