Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 April 1994:
Vol. 264. no. 5156, pp. 267 - 270
DOI: 10.1126/science.8146660

Articles

Science, Vol 264, Issue 5156, 267-270
Copyright © 1994 by American Association for the Advancement of Science


articles

Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands

P Constant, F Davodeau, MA Peyrat, Y Poquet, G Puzo, M Bonneville, and JJ Fournie

Department III, Laboratoire de Pharmacologie et de Toxicologie Fondamentales du CNRS, Toulouse, France.

Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation of {gamma}{delta} T Cells by Borrelia burgdorferi Is Indirect via a TLR- and Caspase-Dependent Pathway.
C. Collins, C. Shi, J. Q. Russell, K. A. Fortner, and R. C. Budd (2008)
J. Immunol. 181, 2392-2398
   Abstract »    Full Text »    PDF »
Central Memory V{gamma}9V{delta}2 T Lymphocytes Primed and Expanded by Bacillus Calmette-Guerin-Infected Dendritic Cells Kill Mycobacterial-Infected Monocytes.
A. Martino, R. Casetti, A. Sacchi, and F. Poccia (2007)
J. Immunol. 179, 3057-3064
   Abstract »    Full Text »    PDF »
Targeting Human {gamma}{delta} T Cells with Zoledronate and Interleukin-2 for Immunotherapy of Hormone-Refractory Prostate Cancer.
F. Dieli, D. Vermijlen, F. Fulfaro, N. Caccamo, S. Meraviglia, G. Cicero, A. Roberts, S. Buccheri, M. D'Asaro, N. Gebbia, et al. (2007)
Cancer Res. 67, 7450-7457
   Abstract »    Full Text »    PDF »
Preferential recognition of a microbial metabolite by human V{gamma}2V{delta}2 T cells.
K.-J. Puan, C. Jin, H. Wang, G. Sarikonda, A. M. Raker, H. K. Lee, M. I. Samuelson, E. Marker-Hermann, L. Pasa-Tolic, E. Nieves, et al. (2007)
Int. Immunol. 19, 657-673
   Abstract »    Full Text »    PDF »
CXCR5 Identifies a Subset of V{gamma}9V{delta}2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production.
N. Caccamo, L. Battistini, M. Bonneville, F. Poccia, J. J. Fournie, S. Meraviglia, G. Borsellino, R. A. Kroczek, C. La Mendola, E. Scotet, et al. (2006)
J. Immunol. 177, 5290-5295
   Abstract »    Full Text »    PDF »
Immunological alterations during the clinical and recovery phases of experimental swine dysentery..
R. Jonasson, M. Andersson, T. Rasback, A. Johannisson, and M. Jensen-Waern (2006)
J. Med. Microbiol. 55, 845-855
   Abstract »    Full Text »    PDF »
Contribution of NK, NK T, {gamma}{delta} T, and {alpha}{beta} T Cells to the Gamma Interferon Response Required for Liver Protection against Trypanosoma cruzi.
L. R. Sardinha, R. M. Elias, T. Mosca, K. R. B. Bastos, C. R. F. Marinho, M. R. D'Imperio Lima, and J. M. Alvarez (2006)
Infect. Immun. 74, 2031-2042
   Abstract »    Full Text »    PDF »
Direct Costimulatory Effect of TLR3 Ligand Poly(I:C) on Human {gamma}{delta} T Lymphocytes.
D. Wesch, S. Beetz, H.-H. Oberg, M. Marget, K. Krengel, and D. Kabelitz (2006)
J. Immunol. 176, 1348-1354
   Abstract »    Full Text »    PDF »
Potentiation of Antigen-Stimulated V{gamma}9V{delta}2 T Cell Cytokine Production by Immature Dendritic Cells (DC) and Reciprocal Effect on DC Maturation.
M.-C. Devilder, S. Maillet, I. Bouyge-Moreau, E. Donnadieu, M. Bonneville, and E. Scotet (2006)
J. Immunol. 176, 1386-1393
   Abstract »    Full Text »    PDF »
Activation of V{gamma}9V{delta}2 T cells by non-peptidic antigens induces the inhibition of subgenomic HCV replication.
C. Agrati, T. Alonzi, R. De Santis, C. Castilletti, I. Abbate, M. R. Capobianchi, G. D'Offizi, F. Siepi, G. M. Fimia, M. Tripodi, et al. (2006)
Int. Immunol. 18, 11-18
   Abstract »    Full Text »    PDF »
In Vivo Immunomanipulation of V{gamma}9V{delta}2 T Cells with a Synthetic Phosphoantigen in a Preclinical Nonhuman Primate Model.
H. Sicard, S. Ingoure, B. Luciani, C. Serraz, J.-J. Fournie, M. Bonneville, J. Tiollier, and F. Romagne (2005)
J. Immunol. 175, 5471-5480
   Abstract »    Full Text »    PDF »
V{gamma}9V{delta}2 T Cell Response to Colon Carcinoma Cells.
M. Corvaisier, A. Moreau-Aubry, E. Diez, J. Bennouna, J.-F. Mosnier, E. Scotet, M. Bonneville, and F. Jotereau (2005)
J. Immunol. 175, 5481-5488
   Abstract »    Full Text »    PDF »
MICA Expressed by Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance Plasma Cells Costimulates Pamidronate-Activated {gamma}{delta} Lymphocytes.
S. Girlanda, C. Fortis, D. Belloni, E. Ferrero, P. Ticozzi, C. Sciorati, M. Tresoldi, A. Vicari, T. Spies, V. Groh, et al. (2005)
Cancer Res. 65, 7502-7508
   Abstract »    Full Text »    PDF »
Drug-Induced Expansion and Differentiation of V{gamma}9V{delta}2 T Cells In Vivo: The Role of Exogenous IL-2.
R. Casetti, G. Perretta, A. Taglioni, M. Mattei, V. Colizzi, F. Dieli, G. D'Offizi, M. Malkovsky, and F. Poccia (2005)
J. Immunol. 175, 1593-1598
   Abstract »    Full Text »    PDF »
Shared reactivity of V{delta}2neg {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells.
F. Halary, V. Pitard, D. Dlubek, R. Krzysiek, H. de la Salle, P. Merville, C. Dromer, D. Emilie, J.-F. Moreau, and J. Dechanet-Merville (2005)
J. Exp. Med. 201, 1567-1578
   Abstract »    Full Text »    PDF »
{gamma}{delta} T Cells Respond Directly to Pathogen-Associated Molecular Patterns.
J. F. Hedges, K. J. Lubick, and M. A. Jutila (2005)
J. Immunol. 174, 6045-6053
   Abstract »    Full Text »    PDF »
Beyond the 12/23 Rule of VDJ Recombination Independent of the Rag Proteins.
A. Olaru, H. T. Petrie, and F. Livak (2005)
J. Immunol. 174, 6220-6226
   Abstract »    Full Text »    PDF »
V{delta}1 T Lymphocytes from B-CLL Patients Recognize ULBP3 Expressed on Leukemic B Cells and Up-Regulated by Trans-Retinoic Acid.
A. Poggi, C. Venturino, S. Catellani, M. Clavio, M. Miglino, M. Gobbi, A. Steinle, P. Ghia, S. Stella, F. Caligaris-Cappio, et al. (2004)
Cancer Res. 64, 9172-9179
   Abstract »    Full Text »    PDF »
Characterization of Tumor Reactivity of Human V{gamma}9V{delta}2 {gamma}{delta} T Cells In Vitro and in SCID Mice In Vivo.
D. Kabelitz, D. Wesch, E. Pitters, and M. Zoller (2004)
J. Immunol. 173, 6767-6776
   Abstract »    Full Text »    PDF »
V{delta}1+ {gamma}{delta} T Cells Producing CC Chemokines May Bridge a Gap between Neutrophils and Macrophages in Innate Immunity during Escherichia coli Infection in Mice.
T. Tagawa, H. Nishimura, T. Yajima, H. Hara, K. Kishihara, G. Matsuzaki, I. Yoshino, Y. Maehara, and Y. Yoshikai (2004)
J. Immunol. 173, 5156-5164
   Abstract »    Full Text »    PDF »
Ontogeny of {gamma}{delta} T Cells in Humans.
S. C. De Rosa, J. P. Andrus, S. P. Perfetto, J. J. Mantovani, L. A. Herzenberg, L. A. Herzenberg, and M. Roederer (2004)
J. Immunol. 172, 1637-1645
   Abstract »    Full Text »    PDF »
Transcriptional Profiling of {gamma}{delta} T Cells.
J. F. Hedges, J. C. Graff, and M. A. Jutila (2003)
J. Immunol. 171, 4959-4964
   Full Text »    PDF »
Specific Signaling Pathways Triggered by IL-2 in Human V{gamma}9V{delta}2 T Cells: An Amalgamation of NK and {alpha}{beta} T Cell Signaling.
V. Lafont, S. Loisel, J. Liautard, S. Dudal, M. Sable-teychene, J.-P. Liautard, and J. Favero (2003)
J. Immunol. 171, 5225-5232
   Abstract »    Full Text »    PDF »
Recognition mechanism of non-peptide antigens by human {gamma}{delta} T cells.
S. Yamashita, Y. Tanaka, M. Harazaki, B. Mikami, and N. Minato (2003)
Int. Immunol. 15, 1301-1307
   Abstract »    Full Text »    PDF »
Differentiation of Effector/Memory V{delta}2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites.
F. Dieli, F. Poccia, M. Lipp, G. Sireci, N. Caccamo, C. Di Sano, and A. Salerno (2003)
J. Exp. Med. 198, 391-397
   Abstract »    Full Text »    PDF »
Leptospira interrogans Activation of Human Peripheral Blood Mononuclear Cells: Preferential Expansion of TCR{gamma}{delta}+ T Cells vs TCR{alpha}{beta}+ T Cells.
G. R. Klimpel, M. A. Matthias, and J. M. Vinetz (2003)
J. Immunol. 171, 1447-1455
   Abstract »    Full Text »    PDF »
Infection with Mycobacterium bovis BCG Diverts Traffic of Myelin Oligodendroglial Glycoprotein Autoantigen-Specific T Cells Away from the Central Nervous System and Ameliorates Experimental Autoimmune Encephalomyelitis.
D. L. Sewell, E. K. Reinke, D. O. Co, L. H. Hogan, R. B. Fritz, M. Sandor, and Z. Fabry (2003)
Clin. Vaccine Immunol. 10, 564-572
   Abstract »    Full Text »    PDF »
{gamma}{delta} T cells for immune therapy of patients with lymphoid malignancies.
M. Wilhelm, V. Kunzmann, S. Eckstein, P. Reimer, F. Weissinger, T. Ruediger, and H.-P. Tony (2003)
Blood 102, 200-206
   Abstract »    Full Text »    PDF »
Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses.
A. B. Kamath, L. Wang, H. Das, L. Li, V. N. Reinhold, and J. F. Bukowski (2003)
PNAS 100, 6009-6014
   Abstract »    Full Text »    PDF »
Requirement of Species-Specific Interactions for the Activation of Human {gamma}{delta} T Cells by Pamidronate.
Y. Kato, Y. Tanaka, H. Tanaka, S. Yamashita, and N. Minato (2003)
J. Immunol. 170, 3608-3613
   Abstract »    Full Text »    PDF »
Conservation of Nonpeptide Antigen Recognition by Rhesus Monkey V{gamma}2V{delta}2 T Cells.
H. Wang, H. K. Lee, J. F. Bukowski, H. Li, R. A. Mariuzza, Z. W. Chen, K.-H. Nam, and C. T. Morita (2003)
J. Immunol. 170, 3696-3706
   Abstract »    Full Text »    PDF »
Inhibition of Adaptive V{gamma}2V{delta}2+ T-Cell Responses during Active Mycobacterial Coinfection of Simian Immunodeficiency Virus SIVmac-Infected Monkeys.
D. Zhou, X. Lai, Y. Shen, P. Sehgal, L. Shen, M. Simon, L. Qiu, D. Huang, G. Z. Du, Q. Wang, et al. (2003)
J. Virol. 77, 2998-3006
   Abstract »    Full Text »    PDF »
Expansion of human {gamma}{delta} T cells after in vitro stimulation with Campylobacter jejuni.
I. Van Rhijn, L. H. Van den Berg, C. W. Ang, J. Admiraal, and T. Logtenberg (2003)
Int. Immunol. 15, 373-382
   Abstract »    Full Text »    PDF »
High Expression of Fas Ligand by Synovial Fluid-Derived {gamma}{delta} T Cells in Lyme Arthritis.
K. Roessner, J. Wolfe, C. Shi, L. H. Sigal, S. Huber, and R. C. Budd (2003)
J. Immunol. 170, 2702-2710
   Abstract »    Full Text »    PDF »
Human T Cell Receptor {gamma}{delta} Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells.
H.-J. Gober, M. Kistowska, L. Angman, P. Jeno, L. Mori, and G. De Libero (2003)
J. Exp. Med. 197, 163-168
   Abstract »    Full Text »    PDF »
Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies.
H. Hebart, C. Bollinger, P. Fisch, J. Sarfati, C. Meisner, M. Baur, J. Loeffler, M. Monod, J.-P. Latge, and H. Einsele (2002)
Blood 100, 4521-4528
   Abstract »    Full Text »    PDF »
Responses of Bovine WC1+{gamma}{delta} T Cells to Protein and Nonprotein Antigens of Mycobacterium bovis.
M. D. Welsh, H. E. Kennedy, A. J. Smyth, R. M. Girvin, P. Andersen, and J. M. Pollock (2002)
Infect. Immun. 70, 6114-6120
   Abstract »    Full Text »    PDF »
Phosphoantigen Presentation by Macrophages to Mycobacterium tuberculosis-Reactive V{gamma}9V{delta}2+ T Cells: Modulation by Chloroquine.
R. E. Rojas, M. Torres, J.-J. Fournie, C. V. Harding, and W. H. Boom (2002)
Infect. Immun. 70, 4019-4027
   Abstract »    Full Text »    PDF »
T Cell Antigen Receptor Engagement and Specificity in the Recognition of Stress-Inducible MHC Class I-Related Chains by Human Epithelial {gamma}{delta} T Cells.
J. Wu, V. Groh, and T. Spies (2002)
J. Immunol. 169, 1236-1240
   Abstract »    Full Text »    PDF »
Numerical and functional alterations of circulating {gamma}{delta} T lymphocytes in aged people and centenarians.
K. Argentati, F. Re, A. Donnini, M. G. Tucci, C. Franceschi, B. Bartozzi, G. Bernardini, and M. Provinciali (2002)
J. Leukoc. Biol. 72, 65-71
   Abstract »    Full Text »    PDF »
Patterns of Chemokine Receptor Expression on Peripheral Blood {gamma}{delta} T Lymphocytes: Strong Expression of CCR5 Is a Selective Feature of V{delta}2/V{gamma}9 {gamma}{delta} T Cells.
A. Glatzel, D. Wesch, F. Schiemann, E. Brandt, O. Janssen, and D. Kabelitz (2002)
J. Immunol. 168, 4920-4929
   Abstract »    Full Text »    PDF »
{gamma}{delta} T cell subsets in patients with arthritis and chronic neutropenia.
I Bank, L Cohen, M Mouallem, Z Farfel, E Grossman, and A Ben-Nun (2002)
Ann Rheum Dis 61, 438-443
   Abstract »    Full Text »    PDF »
The Danger Model: A Renewed Sense of Self.
P. Matzinger (2002)
Science 296, 301-305
   Abstract »    Full Text »    PDF »
Innate Immunity to Mycobacterium tuberculosis.
R. van Crevel, T. H. M. Ottenhoff, and J. W. M. van der Meer (2002)
Clin. Microbiol. Rev. 15, 294-309
   Abstract »    Full Text »    PDF »
Recognition of Nonclassical HLA Class I Antigens by {gamma}{delta} T Cells During Pregnancy.
A. Barakonyi, K. T. Kovacs, E. Miko, L. Szereday, P. Varga, and J. Szekeres-Bartho (2002)
J. Immunol. 168, 2683-2688
   Abstract »    Full Text »    PDF »
Lack of CD27-CD45RA-V{gamma}9V{delta}2+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis.
C. Gioia, C. Agrati, R. Casetti, C. Cairo, G. Borsellino, L. Battistini, G. Mancino, D. Goletti, V. Colizzi, L. P. Pucillo, et al. (2002)
J. Immunol. 168, 1484-1489
   Abstract »    Full Text »    PDF »
Escherichia coli Produces Phosphoantigens Activating Human gamma delta T Cells.
J. Feurle, E. Espinosa, S. Eckstein, F. Pont, V. Kunzmann, J.-J. Fournie, M. Herderich, and M. Wilhelm (2002)
J. Biol. Chem. 277, 148-154
   Abstract »    Full Text »
Essential Contribution of Germline-Encoded Lysine Residues in J{gamma}1.2 Segment to the Recognition of Nonpeptide Antigens by Human {gamma}{delta} T Cells.
F. Miyagawa, Y. Tanaka, S. Yamashita, B. Mikami, K. Danno, M. Uehara, and N. Minato (2001)
J. Immunol. 167, 6773-6779
   Abstract »    Full Text »    PDF »
Functional and Structural Similarity of V{gamma}9V{delta}2 T Cells in Humans and Aotus Monkeys, a Primate Infection Model for Plasmodium falciparum Malaria.
C. A. Daubenberger, M. Salomon, W. Vecino, B. Hubner, H. Troll, R. Rodriques, M. E. Patarroyo, and G. Pluschke (2001)
J. Immunol. 167, 6421-6430
   Abstract »    Full Text »    PDF »
Targeting of Tumor Cells for Human {gamma}{delta} T Cells by Nonpeptide Antigens.
Y. Kato, Y. Tanaka, F. Miyagawa, S. Yamashita, and N. Minato (2001)
J. Immunol. 167, 5092-5098
   Abstract »    Full Text »    PDF »
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens.
N. Kadowaki, S. Ho, S. Antonenko, R. de Waal Malefyt, R. A. Kastelein, F. Bazan, and Y.-J. Liu (2001)
J. Exp. Med. 194, 863-870
   Abstract »    Full Text »    PDF »
V{gamma}9V{delta}2 T Cells in Human Legionellosis.
M. Kroca, A. Johansson, A. Sjostedt, and A. Tarnvik (2001)
Clin. Vaccine Immunol. 8, 949-954
   Abstract »    Full Text »    PDF »
The search for new vaccines against tuberculosis.
I. M. Orme (2001)
J. Leukoc. Biol. 70, 1-10
   Abstract »    Full Text »    PDF »
Structural Features of Nonpeptide Prenyl Pyrophosphates That Determine Their Antigenicity for Human {{gamma}}{{delta}} T Cells.
C. T. Morita, H. K. Lee, H. Wang, H. Li, R. A. Mariuzza, and Y. Tanaka (2001)
J. Immunol. 167, 36-41
   Abstract »    Full Text »    PDF »
Perturbation and Proinflammatory Type Activation of V{delta}1+ {gamma}{delta} T Cells in African Children with Plasmodium falciparum Malaria.
L. Hviid, J. A. L. Kurtzhals, V. Adabayeri, S. Loizon, K. Kemp, B. Q. Goka, A. Lim, O. Mercereau-Puijalon, B. D. Akanmori, and C. Behr (2001)
Infect. Immun. 69, 3190-3196
   Abstract »    Full Text »    PDF »
Essential Requirement of Antigen Presentation by Monocyte Lineage Cells for the Activation of Primary Human {{gamma}}{{delta}} T Cells by Aminobisphosphonate Antigen.
F. Miyagawa, Y. Tanaka, S. Yamashita, and N. Minato (2001)
J. Immunol. 166, 5508-5514
   Abstract »    Full Text »    PDF »
Antigen Recognition and Immunomodulation by {{gamma}}{{delta}} T Cells in Bovine Tuberculosis.
S. G. Rhodes, R. G. Hewinson, and H. M. Vordermeier (2001)
J. Immunol. 166, 5604-5610
   Abstract »    Full Text »    PDF »
Leishmaniasis: Current Status of Vaccine Development.
E. Handman (2001)
Clin. Microbiol. Rev. 14, 229-243
   Abstract »    Full Text »    PDF »
Cutting Edge: Human {{gamma}}{{delta}} T Cells Are Activated by Intermediates of the 2-C-methyl-D-erythritol 4-phosphate Pathway of Isoprenoid Biosynthesis.
B. Altincicek, J. Moll, N. Campos, G. Foerster, E. Beck, J.-F. Hoeffler, C. Grosdemange-Billiard, M. Rodriguez-Concepcion, M. Rohmer, A. Boronat, et al. (2001)
J. Immunol. 166, 3655-3658
   Abstract »    Full Text »    PDF »
V{{gamma}}2 TCR Repertoire Overlap in Different Anatomical Compartments of Healthy, Unrelated Rhesus Macaques.
A. V. MacDougall, P. Enders, G. Hatfield, D. C. Pauza, and E. Rakasz (2001)
J. Immunol. 166, 2296-2302
   Abstract »    Full Text »    PDF »
V{gamma}9V{delta}2 T Cells Impair Intracellular Multiplication of Brucella suis in Autologous Monocytes Through Soluble Factor Release and Contact-Dependent Cytotoxic Effect.
F. Ottones, J. Dornand, A. Naroeni, J.-P. Liautard, and J. Favero (2000)
J. Immunol. 165, 7133-7139
   Abstract »    Full Text »    PDF »
gamma delta Cells and the Regulation of Mucosal Immune Responses.
A. C. HAYDAY, S. ROBERTS, and E. RAMSBURG (2000)
Am. J. Respir. Crit. Care Med. 162, S161-163
   Abstract »    Full Text »    PDF »
Response of Murine {gamma}{delta} T Cells to the Synthetic Polypeptide Poly-Glu50Tyr50 1.
C. T. Cady, M. Lahn, M. Vollmer, M. Tsuji, S. J. Seo, C. L. Reardon, R. L. O'Brien, and W. K. Born (2000)
J. Immunol. 165, 1790-1798
   Abstract »    Full Text »    PDF »
Metabolic Routes as Targets for Immunological Discrimination of Host and Parasite.
H. Sicard and J.-J. Fournie (2000)
Infect. Immun. 68, 4375-4377
   Full Text »    PDF »
A Novel Nonclassic beta 2-Microglobulin-Restricted Mechanism Influencing Early Lymphocyte Accumulation and Subsequent Resistance to Tuberculosis in the Lung.
C. D. D'Souza, A. M. Cooper, A. A. Frank, S. Ehlers, J. Turner, A. Bendelac, and I. M. Orme (2000)
Am. J. Respir. Cell Mol. Biol. 23, 188-193
   Abstract »    Full Text »
Comparison of the T Cell Patterns in Leprous and Cutaneous Sarcoid Granulomas : Presence of V{alpha}24-Invariant Natural Killer T Cells in T-Cell-Reactive Leprosy Together with a Highly Biased T Cell Receptor V{alpha} Repertoire.
M. Mempel, B. Flageul, F. Suarez, C. Ronet, L. Dubertret, P. Kourilsky, G. Gachelin, and P. Musette (2000)
Am. J. Pathol. 157, 509-523
   Abstract »    Full Text »    PDF »
Stimulation of gamma delta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma.
V. Kunzmann, E. Bauer, J. Feurle, F. W.{b.}i. H.-P. Tony, and M. Wilhelm (2000)
Blood 96, 384-392
   Abstract »    Full Text »    PDF »
High frequency of circulating {gamma}{delta} T cells with dominance of the V{delta}1 subset in a healthy population.
L. Hviid, B. D. Akanmori, S. Loizon, J. A. L. Kurtzhals, C. H. Ricke, A. Lim, K. A. Koram, F. K. Nkrumah, O. Mercereau-Puijalon, and C. Behr (2000)
Int. Immunol. 12, 797-805
   Abstract »    Full Text »    PDF »
T Cells Activated by Zwitterionic Molecules Prevent Abscesses Induced by Pathogenic Bacteria.
A. O. Tzianabos, R. W. Finberg, Y. Wang, M. Chan, A. B. Onderdonk, H. J. Jennings, and D. L. Kasper (2000)
J. Biol. Chem. 275, 6733-6740
   Abstract »    Full Text »    PDF »
CD1, Tuberculosis, and the Evolution of Major Histocompatibility Complex Molecules.
K. Shinkai and R. M. Locksley (2000)
J. Exp. Med. 191, 907-914
   Full Text »    PDF »
Activation of C-C beta -chemokines in human peripheral blood gamma delta T cells by isopentenyl pyrophosphate and regulation by cytokines.
B. Cipriani, G. Borsellino, F. Poccia, R. Placido, D. Tramonti, S. Bach, L. Battistini, and C. F. Brosnan (2000)
Blood 95, 39-47
   Abstract »    Full Text »    PDF »
Regulation of Human CD4+ alpha beta T-Cell-Receptor-Positive (TCR+) and gamma delta TCR+ T-Cell Responses to Mycobacterium tuberculosis by Interleukin-10 and Transforming Growth Factor beta.
R. E. Rojas, K. N. Balaji, A. Subramanian, and W. H. Boom (1999)
Infect. Immun. 67, 6461-6472
   Abstract »    Full Text »    PDF »
3-Formyl-1-butyl Pyrophosphate A Novel Mycobacterial Metabolite-activating Human gamma delta T Cells.
C. Belmant, E. Espinosa, R. Poupot, M.-A. Peyrat, M. Guiraud, Y. Poquet, M. Bonneville, and J.-J. Fournie (1999)
J. Biol. Chem. 274, 32079-32084
   Abstract »    Full Text »    PDF »
{gamma}{delta}T cells increase with Mycobacterium avium complex infection but not with tuberculosis in AIDS patients.
J.-L. Pellegrin, J.-L. Taupin, M. Dupon, J.-M. Ragnaud, J. Maugein, M. Bonneville, and J.-F. Moreau (1999)
Int. Immunol. 11, 1475-1478
   Abstract »    Full Text »    PDF »
Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls.
I. Apostolou, Y. Takahama, C. Belmant, T. Kawano, M. Huerre, G. Marchal, J. Cui, M. Taniguchi, H. Nakauchi, J.-J. Fournie, et al. (1999)
PNAS 96, 5141-5146
   Abstract »    Full Text »    PDF »
Role of Heat Shock Proteins in Protection from and Pathogenesis of Infectious Diseases.
U. Zugel and S. H. E. Kaufmann (1999)
Clin. Microbiol. Rev. 12, 19-39
   Abstract »    Full Text »    PDF »
Murine gamma delta T Lymphocytes Elicited during Plasmodium yoelii Infection Respond to Plasmodium Heat Shock Proteins.
J. Kopacz and N. Kumar (1999)
Infect. Immun. 67, 57-63
   Abstract »    Full Text »    PDF »
Apoptosis in Coxsackievirus B3-induced Myocarditis and Dilated Cardiomyopathy.
S. A. HUBER, R. C. BUDD, K. ROSSNER, and M. K. NEWELL (1999)
Ann. N.Y. Acad. Sci. 887, 181-190
   Abstract »    Full Text »    PDF »
HSV-1 Glycoprotein I-Reactive TCR{gamma}{delta} Cells Directly Recognize the Peptide Backbone in a Conformationally Dependent Manner.
R. Sciammas and J. A. Bluestone (1998)
J. Immunol. 161, 5187-5192
   Abstract »    Full Text »    PDF »
Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules.
A. Steinle, V. Groh, and T. Spies (1998)
PNAS 95, 12510-12515
   Abstract »    Full Text »    PDF »
Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection.
E. Y. Denkers and R. T. Gazzinelli (1998)
Clin. Microbiol. Rev. 11, 569-588
   Abstract »    Full Text »    PDF »
Protective Roles of gamma delta T Cells and Interleukin-15 in Escherichia coli Infection in Mice.
M. Takano, H. Nishimura, Y. Kimura, Y. Mokuno, J. Washizu, S. Itohara, Y. Nimura, and Y. Yoshikai (1998)
Infect. Immun. 66, 3270-3278
   Abstract »    Full Text »    PDF »
Crucial Role of TCR{gamma} Chain Junctional Region in Prenyl Pyrophosphate Antigen Recognition by {gamma}{delta} T Cells.
J. F. Bukowski, C. T. Morita, H. Band, and M. B. Brenner (1998)
J. Immunol. 161, 286-293
   Abstract »    Full Text »    PDF »
Expansion of Vgamma 9Vdelta 2 T Cells Is Triggered by Francisella tularensis-Derived Phosphoantigens in Tularemia but Not after Tularemia Vaccination.
Y. Poquet, M. Kroca, F. Halary, S. Stenmark, M.-A. Peyrat, M. Bonneville, J. J. Fournie, and A. Sjostedt (1998)
Infect. Immun. 66, 2107-2114
   Abstract »    Full Text »    PDF »
Lifespan of gamma /delta T Cells.
D. F. Tough and J. Sprent (1998)
J. Exp. Med. 187, 357-365
   Abstract »    Full Text »    PDF »