Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 April 1994:
Vol. 264. no. 5156, pp. 258 - 260
DOI: 10.1126/science.8146657
Prev | Table of Contents | Next

Articles

Science, Vol 264, Issue 5156, 258-260
Copyright © 1994 by American Association for the Advancement of Science

articles

Recombination in adaptive mutation

RS Harris, S Longerich, and SM Rosenberg

Department of Genetics, University of Alberta, Edmonton, Canada.

The genetic requirements for adaptive mutation in Escherichia coli parallel those for homologous recombination in the RecBCD pathway. Recombination-deficient recA and recB null mutant strains are deficient in adaptive reversion. A hyper-recombinagenic recD strain is hypermutable, and its hypermutation depends on functional recA and recB genes. Genes of subsidiary recombination systems are not required. These results indicate that the molecular mechanism by which adaptive mutation occurs includes recombination. No such association is seen for spontaneous mutation in growing cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DinB Upregulation Is the Sole Role of the SOS Response in Stress-Induced Mutagenesis in Escherichia coli.
R. S. Galhardo, R. Do, M. Yamada, E. C. Friedberg, P. J. Hastings, T. Nohmi, and S. M. Rosenberg (2009)
Genetics 182, 55-68
   Abstract »    Full Text »    PDF »
Defects in the Error Prevention Oxidized Guanine System Potentiate Stationary-Phase Mutagenesis in Bacillus subtilis.
L. E. Vidales, L. C. Cardenas, E. Robleto, R. E. Yasbin, and M. Pedraza-Reyes (2009)
J. Bacteriol. 191, 506-513
   Abstract »    Full Text »    PDF »
A Novel Mutator of Escherichia coli Carrying a Defect in the dgt Gene, Encoding a dGTP Triphosphohydrolase.
D. Gawel, M. D. Hamilton, and R. M. Schaaper (2008)
J. Bacteriol. 190, 6931-6939
   Abstract »    Full Text »    PDF »
Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae.
C. Y. Chan, M. Kiechle, P. Manivasakam, and R. H. Schiestl (2007)
Nucleic Acids Res. 35, 5051-5059
   Abstract »    Full Text »    PDF »
Single-Strand-Specific Exonucleases Prevent Frameshift Mutagenesis by Suppressing SOS Induction and the Action of DinB/DNA Polymerase IV in Growing Cells..
M. N. Hersh, L. D. Morales, K. J. Ross, and S. M. Rosenberg (2006)
J. Bacteriol. 188, 2336-2342
   Abstract »    Full Text »    PDF »
NinR- and Red-Mediated Phage-Prophage Marker Rescue Recombination in Escherichia coli: Recovery of a Nonhomologous imm{lambda} DNA Segment by Infecting {lambda}imm434 Phages.
S. Hayes, K. Asai, A. M. Chu, and C. Hayes (2005)
Genetics 170, 1485-1499
   Abstract »    Full Text »    PDF »
Error-Prone DNA Polymerase IV Is Regulated by the Heat Shock Chaperone GroE in Escherichia coli.
J. C. Layton and P. L. Foster (2005)
J. Bacteriol. 187, 449-457
   Abstract »    Full Text »    PDF »
Contribution of the Mismatch DNA Repair System to the Generation of Stationary-Phase-Induced Mutants of Bacillus subtilis.
M. Pedraza-Reyes and R. E. Yasbin (2004)
J. Bacteriol. 186, 6485-6491
   Abstract »    Full Text »    PDF »
Adaptive Point Mutation and Adaptive Amplification Pathways in the Escherichia coli Lac System: Stress Responses Producing Genetic Change.
S. M. Rosenberg and P. J. Hastings (2004)
J. Bacteriol. 186, 4838-4843
   Full Text »    PDF »
Adaptive Mutation in Escherichia coli.
P. L. Foster (2004)
J. Bacteriol. 186, 4846-4852
   Full Text »    PDF »
Adaptive Mutation: How Growth under Selection Stimulates Lac+ Reversion by Increasing Target Copy Number.
J. R. Roth and D. I. Andersson (2004)
J. Bacteriol. 186, 4855-4860
   Full Text »    PDF »
Rebuttal: Growth under Selection Stimulates Lac+ Reversion (Roth and Andersson).
S. M. Rosenberg and P. J. Hastings (2004)
J. Bacteriol. 186, 4862-4863
   Full Text »    PDF »
Involvement of Error-Prone DNA Polymerase IV in Stationary-Phase Mutagenesis in Pseudomonas putida.
R. Tegova, A. Tover, K. Tarassova, M. Tark, and M. Kivisaar (2004)
J. Bacteriol. 186, 2735-2744
   Abstract »    Full Text »    PDF »
General Stress Response Regulator RpoS in Adaptive Mutation and Amplification in Escherichia coli.
M.-J. Lombardo, I. Aponyi, and S. M. Rosenberg (2004)
Genetics 166, 669-680
   Abstract »    Full Text »    PDF »
Error-Prone Polymerase, DNA Polymerase IV, Is Responsible for Transient Hypermutation during Adaptive Mutation in Escherichia coli.
J. D. Tompkins, J. L. Nelson, J. C. Hazel, S. L. Leugers, J. D. Stumpf, and P. L. Foster (2003)
J. Bacteriol. 185, 3469-3472
   Abstract »    Full Text »    PDF »
Stress-Induced Mutagenesis in Bacteria.
I. Bjedov, O. Tenaillon, B. Gerard, V. Souza, E. Denamur, M. Radman, F. Taddei, and I. Matic (2003)
Science 300, 1404-1409
   Abstract »    Full Text »    PDF »
Roles of YqjH and YqjW, Homologs of the Escherichiacoli UmuC/DinB or Y Superfamily of DNA Polymerases, in Stationary-Phase Mutagenesis and UV-Induced Mutagenesis of Bacillussubtilis.
H.-M. Sung, G. Yeamans, C. A. Ross, and R. E. Yasbin (2003)
J. Bacteriol. 185, 2153-2160
   Abstract »    Full Text »    PDF »
Induction of a DNA Nickase in the Presence of Its Target Site Stimulates Adaptive Mutation in Escherichia coli.
C. Rodriguez, J. Tompkin, J. Hazel, and P. L. Foster (2002)
J. Bacteriol. 184, 5599-5608
   Abstract »    Full Text »    PDF »
Adaptive, or Stationary-Phase, Mutagenesis, a Component of Bacterial Differentiation in Bacillus subtilis.
H.-M. Sung and R. E. Yasbin (2002)
J. Bacteriol. 184, 5641-5653
   Abstract »    Full Text »    PDF »
Phage {lambda} Red-Mediated Adaptive Mutation.
A. R. Poteete, H. R. Wang, and P. L. Foster (2002)
J. Bacteriol. 184, 3753-3755
   Abstract »    Full Text »    PDF »
Stationary-phase mutation in the bacterial chromosome: Recombination protein and DNA polymerase IV dependence.
H. J. Bull, M.-J. Lombardo, and S. M. Rosenberg (2001)
PNAS 98, 8334-8341
   Abstract »    Full Text »    PDF »
radC102 of Escherichia coli Is an Allele of recG.
M.-J. Lombardo and S. M. Rosenberg (2000)
J. Bacteriol. 182, 6287-6291
   Abstract »    Full Text »
Evidence That Stationary-Phase Hypermutation in the Escherichia coli Chromosome Is Promoted by Recombination.
H. J. Bull, G. J. McKenzie, P. J. Hastings, and S. M. Rosenberg (2000)
Genetics 154, 1427-1437
   Abstract »    Full Text »
DNA Repair Systems and Bacterial Evolution.
M. RADMAN, F. TADDEI, and I. MATIC (2000)
Cold Spring Harb Symp Quant Biol 65, 11-20
   Abstract »    PDF »
Adaptive Mutation in Escherichia coli.
P.L. FOSTER (2000)
Cold Spring Harb Symp Quant Biol 65, 21-30
   Abstract »    PDF »
Some Features of the Mutability of Bacteria During Nonlethal Selection.
V. G. Godoy, F. S. Gizatullin, and M. S. Fox (2000)
Genetics 154, 49-59
   Abstract »    Full Text »
Double-strand-break repair recombination in Escherichia coli: physical evidence for a DNA replication mechanism in vivo.
M. R. Motamedi, S. K. Szigety, and S. M. Rosenberg (1999)
Genes & Dev. 13, 2889-2903
   Abstract »    Full Text »
Increased Episomal Replication Accounts for the High Rate of Adaptive Mutation in recD Mutants of Escherichia coli.
P. L. Foster and W. A. Rosche (1999)
Genetics 152, 15-30
   Abstract »    Full Text »
Evidence That Gene Amplification Underlies Adaptive Mutability of the Bacterial lac Operon.
D. I. Andersson, E. S. Slechta, and J. R. Roth (1998)
Science 282, 1133-1135
   Abstract »    Full Text »
Adaptive Mutagenesis at ebgR Is Regulated by PhoPQ.
B. G. Hall (1998)
J. Bacteriol. 180, 2862-2865
   Abstract »    Full Text »
Adaptive Mutation: Has the Unicorn Landed?.
P. L. Foster (1998)
Genetics 148, 1453-1459
   Abstract »    Full Text »    PDF »
Transient and Heritable Mutators in Adaptive Evolution in the Lab and in Nature.
S. M. Rosenberg, C. Thulin, and R. S. Harris (1998)
Genetics 148, 1559-1566
   Abstract »    Full Text »    PDF »
Topical Reversion at the HIS1 Locus of Saccharomyces cerevisiae {bullet} A Tale of Three Mutants.
R. C. von Borstel, E. A. Savage, Q. Wang, U. G. G. Hennig, R. G. Ritzel, G. S.-F. Lee, M. D. Hamilton, M. A. Chrenek, R. W. Tomaszewski, J. A. Higgins, et al. (1998)
Genetics 148, 1647-1654
   Abstract »    Full Text »    PDF »
Mismatch Repair in Escherichia coli Cells Lacking Single-Strand Exonucleases ExoI, ExoVII, and RecJ.
R. S. Harris, K. J. Ross, M.-J. Lombardo, and S. M. Rosenberg (1998)
J. Bacteriol. 180, 989-993
   Abstract »    Full Text »
Mismatch repair protein MutL becomes limiting during stationary-phase mutation.
R. S. Harris, G. Feng, K. J. Ross, R. Sidhu, C. Thulin, S. Longerich, S. K. Szigety, M. E. Winkler, and S. M. Rosenberg (1997)
Genes & Dev. 11, 2426-2437
   Abstract »    Full Text »    PDF »
Promoter-creating mutations in Pseudomonas putida: A model system for the study of mutation in starving bacteria.
L. Kasak, R. Horak, and M. Kivisaar (1997)
PNAS 94, 3134-3139
   Abstract »    Full Text »    PDF »
Adaptive mutation: who's really in the garden?.
J. Shapiro (1995)
Science 268, 373-374
   PDF »
Adaptive mutation in Escherichia coli: a role for conjugation.
J. Radicella, P. Park, and M. Fox (1995)
Science 268, 418-420
   Abstract »    PDF »
Evidence that F plasmid transfer replication underlies apparent adaptive mutation.
T Galitski and Roth JR (1995)
Science 268, 421-423
   Abstract »    PDF »
Adaptive mutation.
J. Shapiro (1994)
Science 265, 1994-1995
   PDF »
Adaptive mutation by deletions in small mononucleotide repeats.
S. Rosenberg, S Longerich, P Gee, and R. Harris (1994)
Science 265, 405-407
   Abstract »    PDF »
Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs.
P. Foster and J. Trimarchi (1994)
Science 265, 407-409
   Abstract »    PDF »
The evolution of genetic intelligence.
D. Thaler (1994)
Science 264, 224-225
   PDF »
Amplification-mutagenesis: Evidence that "directed" adaptive mutation and general hypermutability result from growth with a selected gene amplification.
H. Hendrickson, E. S. Slechta, U. Bergthorsson, D. I. Andersson, and J. R. Roth (2002)
PNAS 99, 2164-2169
   Abstract »    Full Text »    PDF »
The SOS response regulates adaptive mutation.
G. J. McKenzie, R. S. Harris, P. L. Lee, and S. M. Rosenberg (2000)
PNAS 97, 6646-6651
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)