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Science 1 April 1994:
Vol. 264. no. 5155, pp. 92 - 95
DOI: 10.1126/science.8140421

Articles

Science, Vol 264, Issue 5155, 92-95
Copyright © 1994 by American Association for the Advancement of Science


articles

Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine

PM Deen, MA Verdijk, NV Knoers, B Wieringa, LA Monnens, CH van Os, and BA van Oost

Department of Cell Physiology, University of Nijmegen, Netherlands.

Concentration of urine in mammals is regulated by the antidiuretic hormone vasopressin. Binding of vasopressin to its V2 receptor leads to the insertion of water channels in apical membranes of principal cells in collecting ducts. In nephrogenic diabetes insipidus (NDI), the kidney fails to concentrate urine in response to vasopressin. A male patient with an autosomal recessive form of NDI was found to be a compound heterozygote for two mutations in the gene encoding aquaporin-2, a water channel. Functional expression studies in Xenopus oocytes revealed that each mutation resulted in nonfunctional water channel proteins. Thus, aquaporin-2 is essential for vasopressin-dependent concentration of urine.


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   Abstract »    Full Text »
Dissociation between urine osmolality and urinary excretion of aquaporin-2 in healthy volunteers.
R. Baumgarten, M. H. J. van de Pol, P. M. T. Deen, C. H. van Os, and J. F. M. Wetzels (2000)
Nephrol. Dial. Transplant. 15, 1155-1161
   Abstract »    Full Text »    PDF »
Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice.
Y. Song, N. Fukuda, C. Bai, T. Ma, M. A Matthay, and A S Verkman (2000)
J. Physiol. 525, 771-779
   Abstract »    Full Text »    PDF »
Key Roles of Renal Aquaporins in Water Balance and Water-Balance Disorders.
S. Nielsen, T.-H. Kwon, J. Frokiar, and M. A. Knepper (2000)
Physiology 15, 136-143
   Abstract »    Full Text »    PDF »
Skeletal muscle function and water permeability in aquaporin-4 deficient mice.
B. Yang, J.-M. Verbavatz, Y. Song, L. Vetrivel, G. Manley, W.-M. Kao, T. Ma, and A. S. Verkman (2000)
Am J Physiol Cell Physiol 278, C1108-C1115
   Abstract »    Full Text »    PDF »
Functional Characterization of the Molecular Defects Causing Nephrogenic Diabetes Insipidus in Eight Families.
K. Pasel, A. Schulz, K. Timmermann, K. Linnemann, M. Hoeltzenbein, J. Jääskeläinen, A. Grüters, G. Filler, and T. Schöneberg (2000)
J. Clin. Endocrinol. Metab. 85, 1703-1710
   Abstract »    Full Text »
Aquaporin Water Channels in Kidney.
P. AGRE (2000)
J. Am. Soc. Nephrol. 11, 764-777
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Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens.
A. L. Stevens, S. Breton, C. E. Gustafson, R. Bouley, R. D. Nelson, D. E. Kohan, and D. Brown (2000)
Am J Physiol Cell Physiol 278, C791-C802
   Abstract »    Full Text »    PDF »
Hypertonic Induction of Aquaporin-5 Expression through an ERK-dependent Pathway.
J. D. Hoffert, V. Leitch, P. Agre, and L. S. King (2000)
J. Biol. Chem. 275, 9070-9077
   Abstract »    Full Text »    PDF »
Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade.
T. E. N. Jonassen, D. Promeneur, S. Christensen, J. S. Petersen, and S. Nielsen (2000)
Am J Physiol Renal Physiol 278, F246-F256
   Abstract »    Full Text »    PDF »
Respiratory Aquaporins in Lung Inflammation . The Night Is Young.
L. S. King, S. Nielsen, and P. Agre (2000)
Am. J. Respir. Cell Mol. Biol. 22, 8-10
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Structure and function of aquaporin water channels.
A. S. Verkman and A. K. Mitra (2000)
Am J Physiol Renal Physiol 278, F13-F28
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Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus.
B. K. Tamarappoo, B. Yang, and A. S. Verkman (1999)
J. Biol. Chem. 274, 34825-34831
   Abstract »    Full Text »    PDF »
Regulation of Aquaporin-2 Expression by the alpha 2-Adrenoceptor Agonist Clonidine in the Rat.
A. Junaid, L. Cui, S. B. Penner, and D. D. Smyth (1999)
J. Pharmacol. Exp. Ther. 291, 920-923
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Functional analysis of aquaporin-2 mutants associated with nephrogenic diabetes insipidus by yeast expression.
I. Shinbo, K. Fushimi, M. Kasahara, K. Yamauchi, S. Sasaki, and F. Marumo (1999)
Am J Physiol Renal Physiol 277, F734-F741
   Abstract »    Full Text »    PDF »
At Physiological Expression Levels the Kidd Blood Group/Urea Transporter Protein Is Not a Water Channel.
F. Sidoux-Walter, N. Lucien, B. Olives, R. Gobin, G. Rousselet, E.-J. Kamsteeg, P. Ripoche, P. M. T. Deen, J.-P. Cartron, and P. Bailly (1999)
J. Biol. Chem. 274, 30228-30235
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Clinical Presentation and Follow-Up of 30 Patients with Congenital Nephrogenic Diabetes Insipidus.
A. F. VAN LIEBURG, N. V. A. M. KNOERS, and L. A. H. MONNENS (1999)
J. Am. Soc. Nephrol. 10, 1958-1964
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Decreased Abundance of Collecting Duct Aquaporins in Post-Ischemic Renal Failure in Rats.
P. FERNÁNDEZ-LLAMA, P. ANDREWS, R. TURNER, S. SAGGI, J. DIMARI, T.-H. KWON, S. NIELSEN, R. SAFIRSTEIN, and M. A. KNEPPER (1999)
J. Am. Soc. Nephrol. 10, 1658-1668
   Abstract »    Full Text »



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