Science 1 April 1994: Vol. 264. no. 5155, pp. 104 - 107 DOI: 10.1126/science.7908145

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Articles

Novel Cross-Talk between Three Cardiovascular Regulators: Thrombin Cleavage Fragment of Jagged1 Induces Fibroblast Growth Factor 1 Expression and Release.

M. Duarte, V. Kolev, D. Kacer, C. Mouta-Bellum, R. Soldi, I. Graziani, A. Kirov, R. Friesel, L. Liaw, D. Small, et al. (2008)
Mol. Biol. Cell 19, 4863-4874
 |  Abstract »  |  Full Text »  |  PDF »

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development.

D. ten Berge, S. A. Brugmann, J. A. Helms, and R. Nusse (2008)
Development 135, 3247-3257
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Classic limb patterning models and the work of Dennis Summerbell.

J. L. Galloway and C. J. Tabin (2008)
Development 135, 2683-2687
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FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.

K. Yu and D. M. Ornitz (2008)
Development 135, 483-491
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BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling.

S. Pajni-Underwood, C. P. Wilson, C. Elder, Y. Mishina, and M. Lewandoski (2007)
Development 134, 2359-2368
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Activities of N-Myc in the developing limb link control of skeletal size with digit separation.

S. Ota, Z.-Q. Zhou, D. R. Keene, P. Knoepfler, and P. J. Hurlin (2007)
Development 134, 1583-1592
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Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function.

P. Lu, G. Minowada, and G. R. Martin (2006)
Development 133, 33-42
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Biological Approaches to Bone Regeneration by Gene Therapy.

R.T. Franceschi (2005)
Journal of Dental Research 84, 1093-1103
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FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.

C. Li, X. Xu, D. K. Nelson, T. Williams, M. R. Kuehn, and C.-X. Deng (2005)
Development 132, 4755-4764
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Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.

J. M. Verheyden, M. Lewandoski, C. Deng, B. D. Harfe, and X. Sun (2005)
Development 132, 4235-4245
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The Limb Bud Shh-Fgf Feedback Loop Is Terminated by Expansion of Former ZPA Cells.

P. J. Scherz, B. D. Harfe, A. P. McMahon, and C. J. Tabin (2004)
Science 305, 396-399
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Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration.

A H Reddi (2003)
Ann Rheum Dis 62, ii73-78
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Tbx5 is required for forelimb bud formation and continued outgrowth.

C. Rallis, B. G. Bruneau, J. Del Buono, C. E. Seidman, J. G. Seidman, S. Nissim, C. J. Tabin, and M. P. O. Logan (2003)
Development 130, 2741-2751
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Pitx1 and Pitx2 are required for development of hindlimb buds.

A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin (2003)
Development 130, 45-55
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FGFR4 signaling is a necessary step in limb muscle differentiation.

I. Marics, F. Padilla, J.-F. Guillemot, M. Scaal, and C. Marcelle (2002)
Development 129, 4559-4569
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BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb.

S. Pizette, C. Abate-Shen, and L. Niswander (2001)
Development 128, 4463-4474
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Mechanisms of Fibroblast Growth Factor-2 Modulation of Vascular Endothelial Growth Factor Expression by Osteoblastic Cells.

P. B. Saadeh, B. J. Mehrara, D. S. Steinbrech, J. A. Spector, J. A. Greenwald, G. S. Chin, H. Ueno, G. K. Gittes, and M. T. Longaker (2000)
Endocrinology 141, 2075-2083
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Fate and function of the ventral ectodermal ridge during mouse tail development.

D. C. Goldman, G. R. Martin, and P. P. Tam (2000)
Development 127, 2113-2123
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Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway.

M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros (2000)
Development 127, 2133-2142
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Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development.

A. Tavares, T Tsukui, and J. Izpisua Belmonte (2000)
Development 127, 5133-5144
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dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling.

H Grandel, B. Draper, and S Schulte-Merker (2000)
Development 127, 4169-4178
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Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes.

N Mercader, E Leonardo, M. Piedra, C Martinez-A, M. Ros, and M Torres (2000)
Development 127, 3961-3970
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The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.

J Charite, D. McFadden, and E. Olson (2000)
Development 127, 2461-2470
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Normal limb development in conditional mutants of Fgf4.

A. Moon, A. Boulet, and M. Capecchi (2000)
Development 127, 989-996
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Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity.

C. Neumann, H Grandel, W Gaffield, S Schulte-Merker, and C Nusslein-Volhard (1999)
Development 126, 4817-4826
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Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

G Minowada, L. Jarvis, C. Chi, A Neubuser, X Sun, N Hacohen, M. Krasnow, and G. Martin (1999)
Development 126, 4465-4475
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Wnt-7a in feather morphogenesis: involvement of anterior-posterior asymmetry and proximal-distal elongation demonstrated with an in vitro reconstitution model.

R. Widelitz, T. Jiang, C. Chen, N. Stott, and C. Chuong (1999)
Development 126, 2577-2587
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BMPs negatively regulate structure and function of the limb apical ectodermal ridge.

S Pizette and L Niswander (1999)
Development 126, 883-894
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Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development.

I Munoz-Sanjuan, B. Simandl, J. Fallon, and J Nathans (1999)
Development 126, 409-421
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The roles of FGFs in the early development of vertebrate limbs.

G. R. Martin (1998)
Genes & Dev. 12, 1571-1586
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Notochord repression of endodermal Sonic hedgehog permits pancreas development.

M. Hebrok, S. K. Kim, and D. A. Melton (1998)
Genes & Dev. 12, 1705-1713
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Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2.

S. Ortega, M. Ittmann, S. H. Tsang, M. Ehrlich, and C. Basilico (1998)
PNAS 95, 5672-5677
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Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.

R. Jiang, Y. Lan, H. D. Chapman, C. Shawber, C. R. Norton, D. V. Serreze, G. Weinmaster, and T. Gridley (1998)
Genes & Dev. 12, 1046-1057
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A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth.

L. Sherman, D. Wainwright, H. Ponta, and P. Herrlich (1998)
Genes & Dev. 12, 1058-1071
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The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development.

M Takahashi, K Tamura, D Buscher, H Masuya, S Yonei-Tamura, K Matsumoto, M Naitoh-Matsuo, J Takeuchi, K Ogura, T Shiroishi, et al. (1998)
Development 125, 4417-4425
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Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.

Y Yang, P Guillot, Y Boyd, M. Lyon, and A. McMahon (1998)
Development 125, 3123-3132
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Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary.

J Ericson, S Norlin, T. Jessell, and T Edlund (1998)
Development 125, 1005-1015
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Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.

X Xu, M Weinstein, C Li, M Naski, R. Cohen, D. Ornitz, P Leder, and C Deng (1998)
Development 125, 753-765
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Fibroblast Growth Factor 4 Directs Gap Junction Expression in the Mesenchyme of the Vertebrate Limb Bud.

H. Makarenkova, D.L. Becker, C. Tickle, and A.E. Warner (1997)
J. Cell Biol. 138, 1125-1137
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A Minimal Murine Msx-1 Gene Promoter. ORGANIZATION OF ITS cis-REGULATORY MOTIFS AND THEIR ROLE IN TRANSCRIPTIONAL ACTIVATION IN CELLS IN CULTURE AND IN TRANSGENIC MICE.

T. Takahashi, C. Guron, S. Shetty, H. Matsui, and R. Raghow (1997)
J. Biol. Chem. 272, 22667-22678
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Identification and Characterization of a Fibroblast Growth Factor (FGF) Binding Domain in the Cysteine-rich FGF Receptor.

Z. Zhou, M. E. Zuber, L. W. Burrus, and B. B. Olwin (1997)
J. Biol. Chem. 272, 5167-5174
 |  Abstract »  |  Full Text »  |  PDF »

Biological Roles of Fibroblast Growth Factor-2.

A. Bikfalvi, S. Klein, G. Pintucci, and D. B. Rifkin (1997)
Endocr. Rev. 18, 26-45
 |  Abstract »  |  Full Text »

Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb.

T. Stratford, K Kostakopoulou, and M Maden (1997)
Development 124, 4225-4234
 |  Abstract »  |  PDF »

Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb.

M Altabef, J. Clarke, and C Tickle (1997)
Development 124, 4547-4556
 |  Abstract »  |  PDF »

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice.

S Qu, K. Niswender, Q Ji, R van der Meer, D Keeney, M. Magnuson, and R Wisdom (1997)
Development 124, 3999-4008
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The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.

H Ohuchi, T Nakagawa, A Yamamoto, A Araga, T Ohata, Y Ishimaru, H Yoshioka, T Kuwana, T Nohno, M Yamasaki, et al. (1997)
Development 124, 2235-2244
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The role of Engrailed in establishing the dorsoventral axis of the chick limb.

C Logan, A Hornbruch, I Campbell, and A Lumsden (1997)
Development 124, 2317-2324
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Cell fate in the chick limb bud and relationship to gene expression.

N Vargesson, J. Clarke, K Vincent, C Coles, L Wolpert, and C Tickle (1997)
Development 124, 1909-1918
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Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos.

C Pittack, G. Grunwald, and T. Reh (1997)
Development 124, 805-816
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Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge.

J Kuhlman and L Niswander (1997)
Development 124, 133-139
 |  Abstract »  |  PDF »

BMP-2/-4 mediate programmed cell death in chicken limb buds.

Y Yokouchi, J Sakiyama, T Kameda, H Iba, A Suzuki, N Ueno, and A Kuroiwa (1996)
Development 122, 3725-3734
 |  Abstract »  |  PDF »

The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation.

U Grieshammer, G Minowada, J. Pisenti, U. Abbott, and G. Martin (1996)
Development 122, 3851-3861
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The distal limb environment regulates MyoD accumulation and muscle differentiation in mouse-chick chimaeric limbs.

L. Robson and S. Hughes (1996)
Development 122, 3899-3910
 |  Abstract »  |  PDF »

Nerve dependency of regeneration: the role of Distal-less and FGF signaling in amphibian limb regeneration.

L. Mullen, S. Bryant, M. Torok, B Blumberg, and D. Gardiner (1996)
Development 122, 3487-3497
 |  Abstract »  |  PDF »

The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions.

M. Ros, A Lopez-Martinez, B. Simandl, C Rodriguez, J. Izpisua Belmonte, R Dahn, and J. Fallon (1996)
Development 122, 2319-2330
 |  Abstract »  |  PDF »

Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod.

Y Ganan, D Macias, M Duterque-Coquillaud, M. Ros, and J. Hurle (1996)
Development 122, 2349-2357
 |  Abstract »  |  PDF »

Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.

A Vogel, C Rodriguez, and J. Izpisua-Belmonte (1996)
Development 122, 1737-1750
 |  Abstract »  |  PDF »

Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds.

K Patel, R Nittenberg, D D'Souza, C Irving, D Burt, D. Wilkinson, and C Tickle (1996)
Development 122, 1147-1155
 |  Abstract »  |  PDF »

A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse.

A. Davis and M. Capecchi (1996)
Development 122, 1175-1185
 |  Abstract »  |  PDF »

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb.

V Marigo, M. Scott, R. Johnson, L. Goodrich, and C. Tabin, (1996)
Development 122, 1225-1233
 |  Abstract »  |  PDF »

IGF-I, insulin and FGFs induce outgrowth of the limb buds of amelic mutant chick embryos.

C. Dealy and R. Kosher (1996)
Development 122, 1323-1330
 |  Abstract »  |  PDF »

Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle.

N Itoh, T Mima, and T Mikawa (1996)
Development 122, 291-300
 |  Abstract »  |  PDF »

A duplicated zone of polarizing activity in polydactylous mouse mutants..

H Masuya, T Sagai, S Wakana, K Moriwaki, and T Shiroishi (1995)
Genes & Dev. 9, 1645-1653
 |  Abstract »  |  PDF »

FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development.

C. MacArthur, A Lawshe, J Xu, S Santos-Ocampo, M Heikinheimo, A. Chellaiah, and D. Ornitz (1995)
Development 121, 3603-3613
 |  Abstract »  |  PDF »

Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud.

D. Chan, A Wynshaw-Boris, and P Leder (1995)
Development 121, 3151-3162
 |  Abstract »  |  PDF »

Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice.

A. Reginelli, Y. Wang, D Sassoon, and K Muneoka (1995)
Development 121, 1065-1076
 |  Abstract »  |  PDF »

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.

P. Crossley and G. Martin (1995)
Development 121, 439-451
 |  Abstract »  |  PDF »

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