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Science 25 March 1994:
Vol. 263. no. 5154, pp. 1774 - 1778
DOI: 10.1126/science.7907820
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Articles

Science, Vol 263, Issue 5154, 1774-1778
Copyright © 1994 by American Association for the Advancement of Science

articles

A subset of CD4+ thymocytes selected by MHC class I molecules

A Bendelac, N Killeen, DR Littman, and RH Schwartz

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

To complete their maturation, most immature thymocytes depend on the simultaneous engagement of their antigen receptor [alpha beta T cell receptor (TCR)] and their CD4 or CD8 coreceptors with major histocompatibility complex class II or I ligands, respectively. However, a normal subset of mature alpha beta TCR+ thymocytes did not follow these rules. These thymocytes expressed NK1.1 and a restricted set of alpha beta TCRs that are intrinsically class I-reactive because their positive selection was class I-dependent but CD8-independent. These cells were CD4+ and CD4-8- but never CD8+, because the presence of CD8 caused negative selection. Thus, neither CD4 nor CD8 contributes signals that direct their maturation into the CD4+ and CD4-8- lineages.


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   Abstract »    Full Text »    PDF »
IL-7 Up-Regulates IL-4 Production by Splenic NK1.1+ and NK1.1- MHC Class I-Like/CD1-Dependent CD4+ T Cells.
A. Hameg, C. Gouarin, J.-M. Gombert, S. Hong, L. Van Kaer, J.-F. Bach, and A. Herbelin (1999)
J. Immunol. 162, 7067-7074
   Abstract »    Full Text »    PDF »
Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells.
G. Eberl, R. Lees, S. T. Smiley, M. Taniguchi, M. J. Grusby, and H. R. MacDonald (1999)
J. Immunol. 162, 6410-6419
   Abstract »    Full Text »    PDF »
Critical Role of Leukocyte Function-Associated Antigen-1 in Liver Accumulation of CD4+NKT Cells.
M. Emoto, H.-W. Mittrucker, R. Schmits, T. W. Mak, and S. H. E. Kaufmann (1999)
J. Immunol. 162, 5094-5098
   Abstract »    Full Text »    PDF »
Splenic NK1.1-Negative, TCR{alpha}{beta} Intermediate CD4+ T Cells Exist in Naive NK1.1 Allelic Positive and Negative Mice, with the Capacity to Rapidly Secrete Large Amounts of IL-4 and IFN-{gamma} Upon Primary TCR Stimulation.
A. M. Moodycliffe, S. Maiti, and S. E. Ullrich (1999)
J. Immunol. 162, 5156-5163
   Abstract »    Full Text »    PDF »
Cutting Edge: LFA-1 Is Required for Liver NK1.1+TCR{alpha}{beta}+ Cell Development: Evidence That Liver NK1.1+TCR{alpha}{beta}+ Cells Originate from Multiple Pathways.
T. Ohteki, C. Maki, S. Koyasu, T. W. Mak, and P. S. Ohashi (1999)
J. Immunol. 162, 3753-3756
   Abstract »    Full Text »    PDF »
CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells.
L. Schofield, M. J. McConville, D. Hansen, A. S. Campbell, B. Fraser-Reid, M. J. Grusby, and S. D. Tachado (1999)
Science 283, 225-229
   Abstract »    Full Text »
Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments.
Y.-H. Chiu, J. Jayawardena, A. Weiss, D. Lee, S.-H. Park, A. Dautry-Varsat, and A. Bendelac (1999)
J. Exp. Med. 189, 103-110
   Abstract »    Full Text »    PDF »
CD161 (NKR-P1A) Costimulation of CD1d-dependent Activation of Human T Cells Expressing Invariant V{alpha}24J{alpha}Q T Cell Receptor {alpha} Chains.
M. Exley, S. Porcelli, M. Furman, J. Garcia, and S. Balk (1998)
J. Exp. Med. 188, 867-876
   Abstract »    Full Text »    PDF »
Highly Restricted T Cell Repertoire Shaped by a Single Major Histocompatibility Complex-Peptide Ligand in the Presence of a Single Rearranged T Cell Receptor {beta} Chain.
Y. Fukui, O. Hashimoto, A. Inayoshi, T. Gyotoku, T. Sano, T. Koga, T. Gushima, and T. Sasazuki (1998)
J. Exp. Med. 188, 897-907
   Abstract »    Full Text »    PDF »
Effective and Long-Lasting Immunity against the Parasite Leishmania major in CD8-Deficient Mice.
M. Huber, E. Timms, T. W. Mak, M. Rollinghoff, and M. Lohoff (1998)
Infect. Immun. 66, 3968-3970
   Abstract »    Full Text »    PDF »
Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma.
M. Bagot, H. Echchakir, F. Mami-Chouaib, M.-H. Delfau-Larue, D. Charue, A. Bernheim, S. Chouaib, L. Boumsell, and A. Bensussan (1998)
Blood 91, 4331-4341
   Abstract »    Full Text »    PDF »
Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha 14 NKT cells.
T. Kawano, J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, H. Sato, E. Kondo, M. Harada, H. Koseki, T. Nakayama, et al. (1998)
PNAS 95, 5690-5693
   Abstract »    Full Text »    PDF »
In Vivo IL-4 Responses to Anti-IgD Antibody Are MHC Class II Dependent and {beta}2-Microglobulin Independent and Develop Normally in the Absence of IL-4 Priming of T Cells.
S. C. Morris, R. L. Coffman, and F. D. Finkelman (1998)
J. Immunol. 160, 3299-3304
   Abstract »    Full Text »    PDF »
Involvement of NK1+ T Cells and Their IFN-{gamma} Production in the Generalized Shwartzman Reaction.
K. Ogasawara, K. Takeda, W. Hashimoto, M. Satoh, R. Okuyama, N. Yanai, M. Obinata, K. Kumagai, H. Takada, H. Hiraide, et al. (1998)
J. Immunol. 160, 3522-3527
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The Transcription Factor Interferon Regulatory Factor 1 (IRF-1) Is Important during the Maturation of Natural Killer 1.1+ T Cell Receptor-{alpha}/{beta}+ (NK1+ T) Cells, Natural Killer Cells, and Intestinal Intraepithelial T Cells.
T. Ohteki, H. Yoshida, T. Matsuyama, G. S. Duncan, T. W. Mak, and P. S. Ohashi (1998)
J. Exp. Med. 187, 967-972
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Age-Dependent Appearance of NK1.1+ T Cells in the Livers of {beta}2-Microglobulin Knockout and SJL Mice.
M. Murakami and W. E. Paul (1998)
J. Immunol. 160, 2649-2654
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Requirement for Valpha 14 NKT Cells in IL-12-Mediated Rejection of Tumors.
J. Cui, T. Shin, T. Kawano, H. Sato, E. Kondo, I. Toura, Y. Kaneko, H. Koseki, M. Kanno, and M. Taniguchi (1997)
Science 278, 1623-1626
   Abstract »    Full Text »
Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells.
B.-n. Zhang, T. Yamamura, T. Kondo, M. Fujiwara, and T. Tabira (1997)
J. Exp. Med. 186, 1677-1687
   Abstract »    Full Text »    PDF »
Distinct Roles for Signals Relayed through the Common Cytokine Receptor {gamma} Chain and Interleukin 7 Receptor {alpha} Chain in Natural T Cell Development.
A. Boesteanu, A. D. D. Silva, H. Nakajima, W. J. Leonard, J. J. Peschon, and S. Joyce (1997)
J. Exp. Med. 186, 331-336
   Abstract »    Full Text »    PDF »


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