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Science 25 March 1994: Vol. 263. no. 5154, pp. 1759 - 1762 DOI: 10.1126/science.7510905
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Articles
Science, Vol 263, Issue 5154, 1759-1762
Copyright © 1994 by American Association for the Advancement of Science
Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule
J Cheng,
T Zhou,
C Liu,
JP Shapiro,
MJ Brauer,
MC Kiefer,
PJ Barr,
and
JD Mountz
University of Alabama at Birmingham.
Fas is an apoptosis-signaling receptor molecule on the surface of a number of cell types. Molecular cloning and nucleotide sequence analysis revealed a human Fas messenger RNA variant capable of encoding a soluble Fas molecule lacking the transmembrane domain because of the deletion of an exon encoding this region. The expression of soluble Fas was confirmed by flow cytometry and immunocytochemical analysis. Supernatants from cells transfected with the variant messenger RNA blocked apoptosis induced by the antibody to Fas. Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features.
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- Serum levels of soluble Fas in patients with Graves' ophthalmopathy.
- K. Ohtsuka and M. Hashimoto (2000)
Br J Ophthalmol
84, 103-106
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- Identification and Characterization of a Ligand-independent Oligomerization Domain in the Extracellular Region of the CD95 Death Receptor.
- G. Papoff, P. Hausler, A. Eramo, M. G. Pagano, G. Di Leve, A. Signore, and G. Ruberti (1999)
J. Biol. Chem.
274, 38241-38250
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- Soluble Fas and Fas ligand in human tear fluid after photorefractive keratectomy.
- I. Tuominen, M. Vesaluoma, A.-M. Teppo, C. Gronhagen-Riska, and T. Tervo (1999)
Br J Ophthalmol
83, 1360-1363
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- Cloning and Expression of a Short Fas Ligand: A New Alternatively Spliced Product of the Mouse Fas Ligand Gene.
- E. Ayroldi, F. D'Adamio, O. Zollo, M. Agostini, R. Moraca, L. Cannarile, G. Migliorati, D. V. Delfino, and C. Riccardi (1999)
Blood
94, 3456-3467
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- Quantitative Changes In T-Cell Populations After Left Ventricular Assist Device Implantation : Relationship to T-Cell Apoptosis and Soluble CD95.
- H.-J. Ankersmit, N. M. Edwards, M. Schuster, R. John, A. Kocher, E. A. Rose, M. Oz, and S. Itescu (1999)
Circulation
100
, II-211-II-215
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- Circulating Soluble Fas Concentration in Breast Cancer Patients.
- T. Ueno, M. Toi, and T. Tominaga (1999)
Clin. Cancer Res.
5, 3529-3533
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- LFG: An anti-apoptotic gene that provides protection from Fas-mediated cell death.
- N. V. Somia, M. J. Schmitt, D. E. Vetter, D. Van Antwerp, S. F. Heinemann, and I. M. Verma (1999)
PNAS
96, 12667-12672
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- Lymphocyte apoptosis in systemic lupus erythematosus: relationships with Fas expression, serum soluble Fas and disease activity.
- P A Courtney, A D Crockard, K Williamson, J McConnell, R J Kennedy, and A L Bell (1999)
Lupus
8, 508-513
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- Involvement of Soluble CD95 in Churg-Strauss Syndrome.
- M. Muschen, U. Warskulat, A. Perniok, J. Even, C. Moers, B. Kismet, N. Temizkan, D. Simon, M. Schneider, and D. Haussinger (1999)
Am. J. Pathol.
155, 915-925
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- Fas Is Expressed Early in Human Thymocyte Development But Does Not Transmit an Apoptotic Signal.
- M. Jenkins, M. Keir, and J. M. McCune (1999)
J. Immunol.
163, 1195-1204
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- Inhibition of caspase activity prevents CD95-mediated hepatic microvascular perfusion failure and restores Kupffer cell clearance capacity.
- G. A. WANNER, L. MICA, E. WANNER-SCHMID, S. A. KOLB, H. HENTZE, O. TRENTZ, and W. ERTEL (1999)
FASEB J
13, 1239-1248
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- Apoptosis and Tumorigenesis in Human Cholangiocarcinoma Cells : Involvement of Fas/APO-1 (CD95) and Calmodulin.
- G. Pan, S. M. Vickers, A. Pickens, J. O. Phillips, W. Ying, J. A. Thompson, G. P. Siegal, and J. M. McDonald (1999)
Am. J. Pathol.
155, 193-203
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- Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia.
- P A Courtney, A D Crockard, K Williamson, A E Irvine, R J Kennedy, and A L Bell (1999)
Ann Rheum Dis
58, 309-314
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- Fas Gene Mutation in the Progression of Adult T Cell Leukemia.
- T. Maeda, Y. Yamada, R. Moriuchi, K. Sugahara, K. Tsuruda, T. Joh, S. Atogami, K. Tsukasaki, M. Tomonaga, and S. Kamihira (1999)
J. Exp. Med.
189, 1063-1071
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- Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases : A Mechanism of Hepatocyte Destruction to Facilitate Local Tumor Invasion.
- K. F. Yoong, S. C. Afford, S. Randhawa, S. G. Hubscher, and D. H. Adams (1999)
Am. J. Pathol.
154, 693-703
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