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Science 25 March 1994:
Vol. 263. no. 5154, pp. 1759 - 1762
DOI: 10.1126/science.7510905

Articles

Science, Vol 263, Issue 5154, 1759-1762
Copyright © 1994 by American Association for the Advancement of Science


articles

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule

J Cheng, T Zhou, C Liu, JP Shapiro, MJ Brauer, MC Kiefer, PJ Barr, and JD Mountz

University of Alabama at Birmingham.

Fas is an apoptosis-signaling receptor molecule on the surface of a number of cell types. Molecular cloning and nucleotide sequence analysis revealed a human Fas messenger RNA variant capable of encoding a soluble Fas molecule lacking the transmembrane domain because of the deletion of an exon encoding this region. The expression of soluble Fas was confirmed by flow cytometry and immunocytochemical analysis. Supernatants from cells transfected with the variant messenger RNA blocked apoptosis induced by the antibody to Fas. Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features.


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Lupus 10, 866-872
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Clinical significance of CD38 expression in chronic lymphocytic leukemia.
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Soluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis.
S. Sugita, C. Taguchi, H. Takase, K. Sagawa, J. Sueda, K. Fukushi, N. Hikita, T. Watanabe, K. Itoh, and M. Mochizuki (2000)
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Chest 118, 451-458
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TNF-{alpha} and IFN-{gamma} Regulate Expression and Function of the Fas System in the Seminiferous Epithelium.
A. Riccioli, D. Starace, A. D'Alessio, G. Starace, F. Padula, P. De Cesaris, A. Filippini, and E. Ziparo (2000)
J. Immunol. 165, 743-749
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D WENDLING, F MICHEL, E TOUSSIROT, and E RACADOT (2000)
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CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway.
M. Tateyama, N. Oyaizu, T. W. McCloskey, S. Than, and S. Pahwa (2000)
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Production and Pro-Apoptotic Activity of Soluble CD95 Ligand in Pancreatic Carcinoma.
G. Bellone, C. Smirne, A. Carbone, K. Mareschi, L. Dughera, E. C. Farina, O. Alabiso, G. Valente, G. Emanuelli, and U. Rodeck (2000)
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M. K. Oaks and K. M. Hallett (2000)
J. Immunol. 164, 5015-5018
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Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury.
K. Fukuzuka, C. K. Edwards III, M. Clare-Salzler, E. M. Copeland III, L. L. Moldawer, and D. W. Mozingo (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R1005-R1018
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A Membrane-bound Fas Decoy Receptor Expressed by Human Thymocytes.
M. Jenkins, M. Keir, and J. M. McCune (2000)
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Fas and Fas ligand in gut and liver.
M. J. Pinkoski, T. Brunner, D. R. Green, and T. Lin (2000)
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Serum levels of soluble Fas correlate with indices of organ damage in systemic lupus erythematosus.
M. H Al-Maini, J. D Mountz, H. A Al-Mohri, E. M El-Ageb, B. M Al-Riyami, K. L G Svenson, T. Zhou, and E. R Richens (2000)
Lupus 9, 132-139
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Systemic lupus erythematosus--messages from experimental models.
M. L. Stoll and J. Gavalchin (2000)
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Serum levels of soluble Fas in patients with Graves' ophthalmopathy.
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Clin. Cancer Res. 5, 3529-3533
   Abstract »    Full Text »    PDF »
LFG: An anti-apoptotic gene that provides protection from Fas-mediated cell death.
N. V. Somia, M. J. Schmitt, D. E. Vetter, D. Van Antwerp, S. F. Heinemann, and I. M. Verma (1999)
PNAS 96, 12667-12672
   Abstract »    Full Text »    PDF »
Lymphocyte apoptosis in systemic lupus erythematosus: relationships with Fas expression, serum soluble Fas and disease activity.
P A Courtney, A D Crockard, K Williamson, J McConnell, R J Kennedy, and A L Bell (1999)
Lupus 8, 508-513
   Abstract »    PDF »
Involvement of Soluble CD95 in Churg-Strauss Syndrome.
M. Muschen, U. Warskulat, A. Perniok, J. Even, C. Moers, B. Kismet, N. Temizkan, D. Simon, M. Schneider, and D. Haussinger (1999)
Am. J. Pathol. 155, 915-925
   Abstract »    Full Text »    PDF »
Fas Is Expressed Early in Human Thymocyte Development But Does Not Transmit an Apoptotic Signal.
M. Jenkins, M. Keir, and J. M. McCune (1999)
J. Immunol. 163, 1195-1204
   Abstract »    Full Text »    PDF »
Inhibition of caspase activity prevents CD95-mediated hepatic microvascular perfusion failure and restores Kupffer cell clearance capacity.
G. A. WANNER, L. MICA, E. WANNER-SCHMID, S. A. KOLB, H. HENTZE, O. TRENTZ, and W. ERTEL (1999)
FASEB J 13, 1239-1248
   Abstract »    Full Text »
Apoptosis and Tumorigenesis in Human Cholangiocarcinoma Cells : Involvement of Fas/APO-1 (CD95) and Calmodulin.
G. Pan, S. M. Vickers, A. Pickens, J. O. Phillips, W. Ying, J. A. Thompson, G. P. Siegal, and J. M. McDonald (1999)
Am. J. Pathol. 155, 193-203
   Abstract »    Full Text »    PDF »
Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia.
P A Courtney, A D Crockard, K Williamson, A E Irvine, R J Kennedy, and A L Bell (1999)
Ann Rheum Dis 58, 309-314
   Abstract »    Full Text »
Fas Gene Mutation in the Progression of Adult T Cell Leukemia.
T. Maeda, Y. Yamada, R. Moriuchi, K. Sugahara, K. Tsuruda, T. Joh, S. Atogami, K. Tsukasaki, M. Tomonaga, and S. Kamihira (1999)
J. Exp. Med. 189, 1063-1071
   Abstract »    Full Text »    PDF »
Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases : A Mechanism of Hepatocyte Destruction to Facilitate Local Tumor Invasion.
K. F. Yoong, S. C. Afford, S. Randhawa, S. G. Hubscher, and D. H. Adams (1999)
Am. J. Pathol. 154, 693-703
   Abstract »    Full Text »    PDF »



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