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Science 25 March 1994:
Vol. 263. no. 5154, pp. 1756 - 1759
DOI: 10.1126/science.8134837
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Articles

Science, Vol 263, Issue 5154, 1756-1759
Copyright © 1994 by American Association for the Advancement of Science

articles

The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-beta superfamily

T Xie, AL Finelli, and RW Padgett

Waksman Institute, Rutgers University, Piscataway, NJ 08855-0759.

The Drosophila decapentaplegic (dpp) gene encodes a transforming growth factor-beta (TGF-beta)-like protein that plays a key role in several aspects of development. Transduction of the DPP signal was investigated by cloning of serine-threonine kinase transmembrane receptors from Drosophila because this type of receptor is specific for the TGF-beta-like ligands. Here evidence is provided demonstrating that the Drosophila saxophone (sax) gene, a previously identified female sterile locus, encodes a TGF-beta-like type I receptor. Embryos from sax mothers and dpp embryos exhibit similar mutant phenotypes during early gastrulation, and these two loci exhibit genetic interactions, which suggest that they are utilized in the same pathway. These data suggest that sax encodes a receptor for dpp.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Genetic Analysis of the Bone Morphogenetic Protein-Related Gene, gbb, Identifies Multiple Requirements During Drosophila Development.
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Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
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Interplay of Signal Mediators of Decapentaplegic (Dpp): Molecular Characterization of Mothers against dpp, Medea, and Daughters against dpp.
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Interaction of Drosophila Inhibitors of Apoptosis with Thick Veins, a Type I Serine/Threonine Kinase Receptor for Decapentaplegic.
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decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc.
D. Hazelett, M Bourouis, U Walldorf, and J. Treisman (1998)
Development 125, 3741-3751
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TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing.
O Khalsa, J. Yoon, S Torres-Schumann, and K. Wharton (1998)
Development 125, 2723-2734
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A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A.
Y Chen, M. Riese, M. Killinger, and F. Hoffmann (1998)
Development 125, 1759-1768
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The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.
J. Hudson, S. Podos, K Keith, S. Simpson, and E. Ferguson (1998)
Development 125, 1407-1420
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The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling.
P Das, L. Maduzia, H Wang, A. Finelli, S. Cho, M. Smith, and R. Padgett (1998)
Development 125, 1519-1528
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The Type II Transforming Growth Factor-beta Receptor Autophosphorylates Not Only on Serine and Threonine but Also on Tyrosine Residues.
S. Lawler, X.-H. Feng, R.-H. Chen, E. M. Maruoka, C. W. Turck, I. Griswold-Prenner, and R. Derynck (1997)
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Biosynthesis of the Type I and Type II TGF-beta Receptors. IMPLICATIONS FOR COMPLEX FORMATION.
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J. Biol. Chem. 272, 11444-11451
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Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade.
S. Newfeld, A Mehra, M. Singer, J. Wrana, L Attisano, and W. Gelbart (1997)
Development 124, 3167-3176
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Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing.
J. de Celis (1997)
Development 124, 1007-1018
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Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing.
M. Singer, A Penton, V Twombly, F. Hoffmann, and W. Gelbart (1997)
Development 124, 79-89
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Regulation of a dpp target gene in the Drosophila embryo.
J Rusch and M Levine (1997)
Development 124, 303-311
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Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina.
F Chanut and U Heberlein (1997)
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Transcriptional Regulation by Transforming Growth Factorbeta of the Expression of Retinoic Acid and Retinoid X Receptor Genes in Osteoblastic Cells Is Mediated through AP-1.
Y. Chen, A. Takeshita, K. Ozaki, S. Kitano, and S. Hanazawa (1996)
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Purification, Characterization, and cDNA Cloning of a Novel Growth Factor from the Conditioned Medium of NIH-Sape-4, an Embryonic Cell Line of Sarcophaga peregrina (Flesh Fly).
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Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells.
S. Newfeld, E. Chartoff, J. Graff, D. Melton, and W. Gelbart (1996)
Development 122, 2099-2108
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Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis..
Y Mishina, A Suzuki, N Ueno, and R R Behringer (1995)
Genes & Dev. 9, 3027-3037
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GH3 Pituitary Tumor Cells Contain Heteromeric Type I and Type II Receptor Complexes for Transforming Growth Factor beta and Activin-A.
A. Moustakas, T. Takumi, H. Y. Lin, and H. F. Lodish (1995)
J. Biol. Chem. 270, 765-769
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A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.
K Staehling-Hampton, A. Laughon, and F. Hoffmann (1995)
Development 121, 3393-3403
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Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene.
J. Treisman, Z. Lai, and G. Rubin (1995)
Development 121, 2835-2845
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Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene..
V Francois, M Solloway, J W O'Neill, J Emery, and E Bier (1994)
Genes & Dev. 8, 2602-2616
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