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Science 18 March 1994: Vol. 263. no. 5153, pp. 1629 - 1631 DOI: 10.1126/science.8128252
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Articles
Science, Vol 263, Issue 5153, 1629-1631
Copyright © 1994 by American Association for the Advancement of Science
Coatomer interaction with di-lysine endoplasmic reticulum retention motifs
P Cosson
and
F Letourneur
Basel Institute for Immunology, Switzerland.
Although signals for retention in the endoplasmic reticulum (ER) have been identified in the cytoplasmic domain of various ER-resident type I transmembrane proteins, the mechanisms responsible for ER retention are still unknown. Yeast and mammalian ER retention motifs interacted specifically in cell lysates with the coatomer, a polypeptide complex implicated in membrane traffic. Mutations that affect the ER retention capacity of the motifs also abolished binding of the coatomer. These results suggest a role for the coatomer in the retrieval of transmembrane proteins to the ER in both yeast and mammals.
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- Mannose-dependent Endoplasmic Reticulum (ER)-Golgi Intermediate Compartment-53-mediated ER to Golgi Trafficking of Coagulation Factors V and VIII.
- M. Moussalli, S. W. Pipe, H.-P. Hauri, W. C. Nichols, D. Ginsburg, and R. J. Kaufman (1999)
J. Biol. Chem.
274, 32539-32542
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- Saturation of the Endoplasmic Reticulum Retention Machinery Reveals Anterograde Bulk Flow.
- A. J. Crofts, N. Leborgne-Castel, S. Hillmer, D. G. Robinson, B. Phillipson, L. E. Carlsson, D. A. Ashford, and J. Denecke (1999)
PLANT CELL
11, 2233-2248
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- Presenilin 1 Controls {gamma}-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons.
- W. G. Annaert, L. Levesque, K. Craessaerts, I. Dierinck, G. Snellings, D. Westaway, P. St. George-Hyslop, B. Cordell, P. Fraser, and B. De Strooper (1999)
J. Cell Biol.
147, 277-294
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- An Endoplasmic Reticulum Retrieval Signal Partitions Human Foamy Virus Maturation to Intracytoplasmic Membranes.
- P. A. Goepfert, K. Shaw, G. Wang, A. Bansal, B. H. Edwards, and M. J. Mulligan (1999)
J. Virol.
73, 7210-7217
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- Erg30, a Vap-33-Related Protein, Functions in Protein Transport Mediated by Copi Vesicles.
- L. Soussan, D. Burakov, M. P. Daniels, M. Toister-Achituv, A. Porat, Y. Yarden, and Z. Elazar (1999)
J. Cell Biol.
146, 301-312
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- The KDEL Receptor Regulates a GTPase-activating Protein for ADP-ribosylation Factor 1 by Interacting with Its Non-catalytic Domain.
- T. Aoe, I. Huber, C. Vasudevan, S. C. Watkins, G. Romero, D. Cassel, and V. W. Hsu (1999)
J. Biol. Chem.
274, 20545-20549
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- Protein Sorting by Directed Maturation of Golgi Compartments.
- B. B. Allan and W. E. Balch (1999)
Science
285, 63-66
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- A Rab2 Mutant with Impaired GTPase Activity Stimulates Vesicle Formation from Pre-Golgi Intermediates.
- E. J. Tisdale (1999)
Mol. Biol. Cell
10, 1837-1849
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- Erp1p and Erp2p, Partners for Emp24p and Erv25p in a Yeast p24 Complex.
- M. Marzioch, D. C. Henthorn, J. M. Herrmann, R. Wilson, D. Y. Thomas, J. J. M. Bergeron, R. C. E. Solari, and A. Rowley (1999)
Mol. Biol. Cell
10, 1923-1938
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- Protein Targeting to Endoplasmic Reticulum by Dilysine Signals Involves Direct Retention in Addition to Retrieval.
- H. Andersson, F. Kappeler, and H.-P. Hauri (1999)
J. Biol. Chem.
274, 15080-15084
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- GTP-dependent Binding of ADP-ribosylation Factor to Coatomer in Close Proximity to the Binding Site for Dilysine Retrieval Motifs and p23.
- L. Zhao, J. B. Helms, J. Brunner, and F. T. Wieland (1999)
J. Biol. Chem.
274, 14198-14203
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- A Different Intracellular Distribution of a Single Reporter Protein Is Determined at Steady State by KKXX or KDEL Retrieval Signals.
- L. V. Lotti, G. Mottola, M. R. Torrisi, and S. Bonatti (1999)
J. Biol. Chem.
274, 10413-10420
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- The Endoplasmic Reticulum—Gateway of the Secretory Pathway.
- A. Vitale and J. Denecke (1999)
PLANT CELL
11, 615-628
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- Inhibition of Secretion by 1,3-Cyclohexanebis(methylamine), a Dibasic Compound That Interferes with Coatomer Function.
- T. Hu, C.-Y. Kao, R. T. Hudson, A. Chen, and R. K. Draper (1999)
Mol. Biol. Cell
10, 921-933
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- Two Endoplasmic Reticulum () Membrane Proteins That Facilitate ER-to-Golgi Transport of Glycosylphosphatidylinositol-anchored Proteins.
- W. P. Barz and P. Walter (1999)
Mol. Biol. Cell
10, 1043-1059
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- Receptor-induced polymerization of coatomer.
- C. Reinhard, C. Harter, M. Bremser, B. Brugger, K. Sohn, J. B. Helms, and F. Wieland (1999)
PNAS
96, 1224-1228
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- The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.
- J. Greenfield and S High (1999)
J. Cell Sci.
112, 1477-1486
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