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Science 18 March 1994:
Vol. 263. no. 5153, pp. 1629 - 1631
DOI: 10.1126/science.8128252

Articles

Science, Vol 263, Issue 5153, 1629-1631
Copyright © 1994 by American Association for the Advancement of Science


articles

Coatomer interaction with di-lysine endoplasmic reticulum retention motifs

P Cosson and F Letourneur

Basel Institute for Immunology, Switzerland.

Although signals for retention in the endoplasmic reticulum (ER) have been identified in the cytoplasmic domain of various ER-resident type I transmembrane proteins, the mechanisms responsible for ER retention are still unknown. Yeast and mammalian ER retention motifs interacted specifically in cell lysates with the coatomer, a polypeptide complex implicated in membrane traffic. Mutations that affect the ER retention capacity of the motifs also abolished binding of the coatomer. These results suggest a role for the coatomer in the retrieval of transmembrane proteins to the ER in both yeast and mammals.


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J. Biol. Chem. 274, 20545-20549
   Abstract »    Full Text »    PDF »
Protein Sorting by Directed Maturation of Golgi Compartments.
B. B. Allan and W. E. Balch (1999)
Science 285, 63-66
   Abstract »    Full Text »
A Rab2 Mutant with Impaired GTPase Activity Stimulates Vesicle Formation from Pre-Golgi Intermediates.
E. J. Tisdale (1999)
Mol. Biol. Cell 10, 1837-1849
   Abstract »    Full Text »
Erp1p and Erp2p, Partners for Emp24p and Erv25p in a Yeast p24 Complex.
M. Marzioch, D. C. Henthorn, J. M. Herrmann, R. Wilson, D. Y. Thomas, J. J. M. Bergeron, R. C. E. Solari, and A. Rowley (1999)
Mol. Biol. Cell 10, 1923-1938
   Abstract »    Full Text »
Protein Targeting to Endoplasmic Reticulum by Dilysine Signals Involves Direct Retention in Addition to Retrieval.
H. Andersson, F. Kappeler, and H.-P. Hauri (1999)
J. Biol. Chem. 274, 15080-15084
   Abstract »    Full Text »    PDF »
GTP-dependent Binding of ADP-ribosylation Factor to Coatomer in Close Proximity to the Binding Site for Dilysine Retrieval Motifs and p23.
L. Zhao, J. B. Helms, J. Brunner, and F. T. Wieland (1999)
J. Biol. Chem. 274, 14198-14203
   Abstract »    Full Text »    PDF »
A Different Intracellular Distribution of a Single Reporter Protein Is Determined at Steady State by KKXX or KDEL Retrieval Signals.
L. V. Lotti, G. Mottola, M. R. Torrisi, and S. Bonatti (1999)
J. Biol. Chem. 274, 10413-10420
   Abstract »    Full Text »    PDF »
The Endoplasmic Reticulum—Gateway of the Secretory Pathway.
A. Vitale and J. Denecke (1999)
PLANT CELL 11, 615-628
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Inhibition of Secretion by 1,3-Cyclohexanebis(methylamine), a Dibasic Compound That Interferes with Coatomer Function.
T. Hu, C.-Y. Kao, R. T. Hudson, A. Chen, and R. K. Draper (1999)
Mol. Biol. Cell 10, 921-933
   Abstract »    Full Text »
Two Endoplasmic Reticulum () Membrane Proteins That Facilitate ER-to-Golgi Transport of Glycosylphosphatidylinositol-anchored Proteins.
W. P. Barz and P. Walter (1999)
Mol. Biol. Cell 10, 1043-1059
   Abstract »    Full Text »
Receptor-induced polymerization of coatomer.
C. Reinhard, C. Harter, M. Bremser, B. Brugger, K. Sohn, J. B. Helms, and F. Wieland (1999)
PNAS 96, 1224-1228
   Abstract »    Full Text »    PDF »
The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.
J. Greenfield and S High (1999)
J. Cell Sci. 112, 1477-1486
   Abstract »    PDF »



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