Science 18 March 1994: Vol. 263. no. 5153, pp. 1625 - 1629 DOI: 10.1126/science.8128251

Prev | Table of Contents | Next

Articles

MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.

A. Ruzov, B. Shorning, O. Mortusewicz, D. S. Dunican, H. Leonhardt, and R. R. Meehan (2009)
Development 136, 2277-2286
 |  Abstract »  |  Full Text »  |  PDF »

Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing.

K. E. Varley, D. G. Mutch, T. B. Edmonston, P. J. Goodfellow, and R. D. Mitra (2009)
Nucleic Acids Res.
 |  Abstract »  |  Full Text »  |  PDF »

Deficient DNA Mismatch Repair Is Common in Lynch Syndrome-Associated Colorectal Adenomas.

M. S. Pino, M. Mino-Kenudson, B. M. Wildemore, A. Ganguly, J. Batten, I. Sperduti, A. J. Iafrate, and D. C. Chung (2009)
J. Mol. Diagn. 11, 238-247
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B.

S.-i. Asaka, Y. Arai, Y. Nishimura, K. Yamaguchi, T. Ishikubo, T. Yatsuoka, Y. Tanaka, and K. Akagi (2009)
Carcinogenesis 30, 494-499
 |  Abstract »  |  Full Text »  |  PDF »

Perforin-mediated suppression of B-cell lymphoma.

P. Bolitho, S. E. A. Street, J. A. Westwood, W. Edelmann, D. MacGregor, P. Waring, W. K. Murray, D. I. Godfrey, J. A. Trapani, R. W. Johnstone, et al. (2009)
PNAS 106, 2723-2728
 |  Abstract »  |  Full Text »  |  PDF »

Systematic Review and Meta-analysis of Ovarian Cancers: Estimation of Microsatellite-High Frequency and Characterization of Mismatch Repair Deficient Tumor Histology.

T. Pal, J. Permuth-Wey, A. Kumar, and T. A. Sellers (2008)
Clin. Cancer Res. 14, 6847-6854
 |  Abstract »  |  Full Text »  |  PDF »

Genome-wide association studies in cancer.

D. F. Easton and R. A. Eeles (2008)
Hum. Mol. Genet. 17, R109-R115
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of predictive models, clinical criteria and molecular tumour screening for the identification of patients with Lynch syndrome in a population-based cohort of colorectal cancer patients.

J Balmana, F Balaguer, S Castellvi-Bel, E W Steyerberg, M Andreu, X Llor, R Jover, A Castells, S Syngal, and for the Gastrointestinal Oncology Group of the Spa (2008)
J. Med. Genet. 45, 557-563
 |  Abstract »  |  Full Text »  |  PDF »

Role of c-Abl Kinase in DNA Mismatch Repair-dependent G2 Cell Cycle Checkpoint Arrest Responses.

M. W. Wagner, L. S. Li, J. C. Morales, C. L. Galindo, H. R. Garner, W. G. Bornmann, and D. A. Boothman (2008)
J. Biol. Chem. 283, 21382-21393
 |  Abstract »  |  Full Text »  |  PDF »

AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition.

S. Caporali, L. Levati, G. Starace, G. Ragone, E. Bonmassar, E. Alvino, and S. D'Atri (2008)
Mol. Pharmacol. 74, 173-183
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Target of Rapamycin and S6 Kinase 1 Positively Regulate 6-thioguanine-Induced Autophagy.

X. Zeng and T. J. Kinsella (2008)
Cancer Res. 68, 2384-2390
 |  Abstract »  |  Full Text »  |  PDF »

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

T. D. Barber, K. McManus, K. W. Y. Yuen, M. Reis, G. Parmigiani, D. Shen, I. Barrett, Y. Nouhi, F. Spencer, S. Markowitz, et al. (2008)
PNAS 105, 3443-3448
 |  Abstract »  |  Full Text »  |  PDF »

Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility?.

C. Paul, D. W. Melton, and P. T.K. Saunders (2008)
Mol. Hum. Reprod. 14, 1-8
 |  Abstract »  |  Full Text »  |  PDF »

Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres.

I. Siegl-Cachedenier, P. Munoz, J. M. Flores, P. Klatt, and M. A. Blasco (2007)
Genes & Dev. 21, 2234-2247
 |  Abstract »  |  Full Text »  |  PDF »

Exposure to the Tobacco Smoke Constituent 4-Aminobiphenyl Induces Chromosomal Instability in Human Cancer Cells.

F. Saletta, G. Matullo, M. Manuguerra, S. Arena, A. Bardelli, and P. Vineis (2007)
Cancer Res. 67, 7088-7094
 |  Abstract »  |  Full Text »  |  PDF »

Background Mutation Frequency in Microsatellite-Unstable Colorectal Cancer.

H. Sammalkorpi, P. Alhopuro, R. Lehtonen, J. Tuimala, J.-P. Mecklin, H. J. Jarvinen, J. Jiricny, A. Karhu, and L. A. Aaltonen (2007)
Cancer Res. 67, 5691-5698
 |  Abstract »  |  Full Text »  |  PDF »

Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2.

P. Pitsikas, D. Lee, and A. J. Rainbow (2007)
Mutagenesis 22, 235-243
 |  Abstract »  |  Full Text »  |  PDF »

Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players.

N. Rahman and R. H. Scott (2007)
Hum. Mol. Genet. 16, R60-R66
 |  Abstract »  |  Full Text »  |  PDF »

Replication Fork Stalling at Natural Impediments.

E. V. Mirkin and S. M. Mirkin (2007)
Microbiol. Mol. Biol. Rev. 71, 13-35
 |  Abstract »  |  Full Text »  |  PDF »

Toward a Consensus in Molecular Diagnosis of Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome).

H. T. Lynch, J. F. Lynch, and P. M. Lynch (2007)
J Natl Cancer Inst 99, 261-263
 |  Full Text »  |  PDF »

DNA Mismatch Repair Initiates 6-Thioguanine-Induced Autophagy through p53 Activation in Human Tumor Cells.

X. Zeng, T. Yan, J. E. Schupp, Y. Seo, and T. J. Kinsella (2007)
Clin. Cancer Res. 13, 1315-1321
 |  Abstract »  |  Full Text »  |  PDF »

Performance of Different Microsatellite Marker Panels for Detection of Mismatch Repair-Deficient Colorectal Tumors.

R. M. Xicola, X. Llor, E. Pons, A. Castells, C. Alenda, V. Pinol, M. Andreu, S. Castellvi-Bel, A. Paya, R. Jover, et al. (2007)
J Natl Cancer Inst 99, 244-252
 |  Abstract »  |  Full Text »  |  PDF »

Prediction of germline mutations and cancer risk in the Lynch syndrome..

S. Chen, W. Wang, S. Lee, K. Nafa, J. Lee, K. Romans, P. Watson, S. B. Gruber, D. Euhus, K. W. Kinzler, et al. (2006)
JAMA 296, 1479-1487
 |  Abstract »  |  Full Text »  |  PDF »

MDM2 Promoter Polymorphism Is Associated With Both an Increased Susceptibility to Gastric Carcinoma and Poor Prognosis.

N. Ohmiya, A. Taguchi, N. Mabuchi, A. Itoh, Y. Hirooka, Y. Niwa, and H. Goto (2006)
J. Clin. Oncol. 24, 4434-4440
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.

L. Tentori, C. Leonetti, M. Scarsella, A. Muzi, E. Mazzon, M. Vergati, O. Forini, R. Lapidus, W. Xu, A. S. Dorio, et al. (2006)
FASEB J 20, 1709-1711
 |  Abstract »  |  Full Text »  |  PDF »

Disparities in Genetic Testing: Thinking Outside the BRCA Box.

M. J. Hall and O. I. Olopade (2006)
J. Clin. Oncol. 24, 2197-2203
 |  Abstract »  |  Full Text »  |  PDF »

Detection of microsatellite instability in endometrial cancer: advantages of a panel of five mononucleotide repeats over the National Cancer Institute panel of markers.

Y. F. Wong, T. H. Cheung, K. W. K. Lo, S. F. Yim, L. K. Y. Chan, O. Buhard, A. Duval, T. K. H. Chung, and R. Hamelin (2006)
Carcinogenesis 27, 951-955
 |  Abstract »  |  Full Text »  |  PDF »

Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.

E. C. Chao and S. M. Lipkin (2006)
Nucleic Acids Res. 34, 840-852
 |  Abstract »  |  Full Text »  |  PDF »

Prophylactic Surgery to Reduce the Risk of Gynecologic Cancers in the Lynch Syndrome.

K. M. Schmeler, H. T. Lynch, L.-m. Chen, M. F. Munsell, P. T. Soliman, M. B. Clark, M. S. Daniels, K. G. White, S. G. Boyd-Rogers, P. G. Conrad, et al. (2006)
N. Engl. J. Med. 354, 261-269
 |  Abstract »  |  Full Text »  |  PDF »

Multipopulation Analysis of Polymorphisms in Five Mononucleotide Repeats Used to Determine the Microsatellite Instability Status of Human Tumors.

O. Buhard, F. Cattaneo, Y. F. Wong, S. F. Yim, E. Friedman, J.-F. Flejou, A. Duval, and R. Hamelin (2006)
J. Clin. Oncol. 24, 241-251
 |  Abstract »  |  Full Text »  |  PDF »

The Interaction between Two Radiosensitizers: 5-Iododeoxyuridine and Caffeine.

Y. Seo, T. Yan, J. E. Schupp, K. Yamane, T. Radivoyevitch, and T. J. Kinsella (2006)
Cancer Res. 66, 490-498
 |  Abstract »  |  Full Text »  |  PDF »

The Relationship between Global Methylation Level, Loss of Heterozygosity, and Microsatellite Instability in Sporadic Colorectal Cancer.

K. Matsuzaki, G. Deng, H. Tanaka, S. Kakar, S. Miura, and Y. S. Kim (2005)
Clin. Cancer Res. 11, 8564-8569
 |  Abstract »  |  Full Text »  |  PDF »

Molecular basis for subdividing hereditary colon cancer?.

W M Grady (2005)
Gut 54, 1676-1678
 |  Full Text »  |  PDF »

Tumor suppressor genetics.

S. R. Payne and C. J. Kemp (2005)
Carcinogenesis 26, 2031-2045
 |  Abstract »  |  Full Text »  |  PDF »

Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter.

K. Koinuma, R. Kaneda, M. Toyota, Y. Yamashita, S. Takada, Y. L. Choi, T. Wada, M. Okada, F. Konishi, H. Nagai, et al. (2005)
Carcinogenesis 26, 2078-2085
 |  Abstract »  |  Full Text »  |  PDF »

History and Molecular Genetics of Lynch Syndrome in Family G: A Century Later.

J. A. Douglas, S. B. Gruber, K. A. Meister, J. Bonner, P. Watson, A. J. Krush, and H. T. Lynch (2005)
JAMA 294, 2195-2202
 |  Abstract »  |  Full Text »  |  PDF »

Novel PMS1 Alleles Preferentially Affect the Repair of Primer Strand Loops during DNA Replication.

N. Erdeniz, S. Dudley, R. Gealy, S. Jinks-Robertson, and R. M. Liskay (2005)
Mol. Cell. Biol. 25, 9221-9231
 |  Abstract »  |  Full Text »  |  PDF »

Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma.

C. Tzao, H.-S. Hsu, G.-H. Sun, H.-L. Lai, Y.-C. Wang, H.-J. Tung, C.-P. Yu, Y.-L. Cheng, and S.-C. Lee (2005)
J. Thorac. Cardiovasc. Surg. 130, 1371
 |  Abstract »  |  Full Text »  |  PDF »

Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway.

X. Llor, E. Pons, R. M. Xicola, A. Castells, C. Alenda, V. Pinol, M. Andreu, S. Castellvi-Bel, A. Paya, R. Jover, et al. (2005)
Clin. Cancer Res. 11, 7304-7310
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Microsatellite Instability in Early Onset Gastric Cancer.

J. Bacani, R. Zwingerman, N. Di Nicola, S. Spencer, T. Wegrynowski, K. Mitchell, K. Hay, M. Redston, E. Holowaty, D. Huntsman, et al. (2005)
J. Mol. Diagn. 7, 465-477
 |  Abstract »  |  Full Text »  |  PDF »

Assay Validation for Identification of Hereditary Nonpolyposis Colon Cancer-Causing Mutations in Mismatch Repair Genes MLH1, MSH2, and MSH6.

M. Hegde, M. Blazo, B. Chong, T. Prior, and C. Richards (2005)
J. Mol. Diagn. 7, 525-534
 |  Abstract »  |  Full Text »  |  PDF »

High Frequency of Hereditary Colorectal Cancer in Newfoundland Likely Involves Novel Susceptibility Genes.

M. O. Woods, A. J. Hyde, F. K. Curtis, S. Stuckless, J. S. Green, A. F. Pollett, J. D. Robb, R. C. Green, M. E. Croitoru, A. Careen, et al. (2005)
Clin. Cancer Res. 11, 6853-6861
 |  Abstract »  |  Full Text »  |  PDF »

Isolated Loss of PMS2 Expression in Colorectal Cancers: Frequency, Patient Age, and Familial Aggregation.

S. Gill, N. M. Lindor, L. J. Burgart, R. Smalley, O. Leontovich, A. J. French, R. M. Goldberg, D. J. Sargent, J. R. Jass, J. L. Hopper, et al. (2005)
Clin. Cancer Res. 11, 6466-6471
 |  Abstract »  |  Full Text »  |  PDF »

Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability.

I.-Y. Chang, S.-H. Kim, H.-J. Cho, D. Y. Lee, M.-H. Kim, M.-H. Chung, and H. J. You (2005)
Nucleic Acids Res. 33, 5073-5081
 |  Abstract »  |  Full Text »  |  PDF »

Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers.

J. El-Bchiri, O. Buhard, V. Penard-Lacronique, G. Thomas, R. Hamelin, and A. Duval (2005)
Hum. Mol. Genet. 14, 2435-2442
 |  Abstract »  |  Full Text »  |  PDF »

Immunohistochemistry Identifies Carriers of Mismatch Repair Gene Defects Causing Hereditary Nonpolyposis Colorectal Cancer.

A. T. Stormorken, I. M. Bowitz-Lothe, T. Noren, E. Kure, S. Aase, J. Wijnen, J. Apold, K. Heimdal, and P. Moller (2005)
J. Clin. Oncol. 23, 4705-4712
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in Two Short Noncoding Mononucleotide Repeats in Most Microsatellite-Unstable Colorectal Cancers.

T. Hienonen, H. Sammalkorpi, S. Enholm, P. Alhopuro, T. D. Barber, R. Lehtonen, N. N. Nupponen, H. Lehtonen, R. Salovaara, J.-P. Mecklin, et al. (2005)
Cancer Res. 65, 4607-4613
 |  Abstract »  |  Full Text »  |  PDF »

Association between family history and mismatch repair in colorectal cancer.

R P Coggins, L Cawkwell, S M Bell, G P Crockford, P Quirke, P J Finan, and D T Bishop (2005)
Gut 54, 636-642
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite Analysis of Hereditary Nonpolyposis Colorectal Cancer-Associated Colorectal Adenomas by Laser-Assisted Microdissection: Correlation with Mismatch Repair Protein Expression Provides New Insights in Early Steps of Tumorigenesis.

G. Giuffre, A. Muller, T. Brodegger, T. Bocker-Edmonston, J. Gebert, M. Kloor, W. Dietmaier, F. Kullmann, R. Buttner, G. Tuccari, et al. (2005)
J. Mol. Diagn. 7, 160-170
 |  Abstract »  |  Full Text »  |  PDF »

Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the Identification of Patients With Hereditary Nonpolyposis Colorectal Cancer.

V. Pinol, A. Castells, M. Andreu, S. Castellvi-Bel, C. Alenda, X. Llor, R. M. Xicola, F. Rodriguez-Moranta, A. Paya, R. Jover, et al. (2005)
JAMA 293, 1986-1994
 |  Abstract »  |  Full Text »  |  PDF »

Psychological Impact of Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer.

E. R. Gritz, S. K. Peterson, S. W. Vernon, S. K. Marani, W. F. Baile, B. G. Watts, C. I. Amos, M. L. Frazier, and P. M. Lynch (2005)
J. Clin. Oncol. 23, 1902-1910
 |  Abstract »  |  Full Text »  |  PDF »

Methylator-induced, Mismatch Repair-dependent G2 Arrest Is Activated through Chk1 and Chk2.

A. W. Adamson, D. I. Beardsley, W.-J. Kim, Y. Gao, R. Baskaran, and K. D. Brown (2005)
Mol. Biol. Cell 16, 1513-1526
 |  Abstract »  |  Full Text »  |  PDF »

Mutants with Temperature-Sensitive Defects in the Escherichia coli Mismatch Repair System: Sensitivity to Mispairs Generated In Vivo.

E. S. Hong, A. Yeung, P. Funchain, M. M. Slupska, and J. H. Miller (2005)
J. Bacteriol. 187, 840-846
 |  Abstract »  |  Full Text »  |  PDF »

Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain.

A. R. Ellison, J. Lofing, and G. A. Bitter (2004)
Nucleic Acids Res. 32, 5321-5338
 |  Abstract »  |  Full Text »  |  PDF »

Is hEXO1 a Cancer Predisposing Gene?.

S. E. Liberti and L. J. Rasmussen (2004)
Mol. Cancer Res. 2, 427-432
 |  Full Text »  |  PDF »

Measurement of DNA mismatch repair activity in live cells.

X. Lei, Y. Zhu, A. Tomkinson, and L. Sun (2004)
Nucleic Acids Res. 32, e100
 |  Abstract »  |  Full Text »  |  PDF »

A genotype-phenotype correlation in HNPCC: strong predominance of msh2 mutations in 41 patients with Muir-Torre syndrome.

E Mangold, C Pagenstecher, M Leister, M Mathiak, A Rutten, W Friedl, P Propping, T Ruzicka, and R Kruse (2004)
J. Med. Genet. 41, 567-572
 |  Full Text »  |  PDF »

Proteolysis of the Mismatch Repair Protein MLH1 by Caspase-3 Promotes DNA Damage-induced Apoptosis.

F. Chen, O. K. Arseven, and V. L. Cryns (2004)
J. Biol. Chem. 279, 27542-27548
 |  Abstract »  |  Full Text »  |  PDF »

Site directed mutagenesis of hMLH1 exonic splicing enhancers does not correlate with splicing disruption.

P Lastella, N Resta, I Miccolis, A Quagliarella, G Guanti, and A Stella (2004)
J. Med. Genet. 41, e72
 |  Full Text »  |  PDF »

Molecular Differences between Sporadic Serrated and Conventional Colorectal Adenomas.

K. Konishi, T. Yamochi, R. Makino, K. Kaneko, T. Yamamoto, H. Nozawa, A. Katagiri, H. Ito, K. Nakayama, H. Ota, et al. (2004)
Clin. Cancer Res. 10, 3082-3090
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirement for Proliferating Cell Nuclear Antigen in 5' and 3' Nick-directed Excision in Human Mismatch Repair.

S. Guo, S. R. Presnell, F. Yuan, Y. Zhang, L. Gu, and G.-M. Li (2004)
J. Biol. Chem. 279, 16912-16917
 |  Abstract »  |  Full Text »  |  PDF »

The mutator pathway is a feature of immunodeficiency-related lymphomas.

A. Duval, M. Raphael, C. Brennetot, H. Poirel, O. Buhard, A. Aubry, A. Martin, A. Krimi, V. Leblond, J. Gabarre, et al. (2004)
PNAS 101, 5002-5007
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Pathogenic Human MSH2 Missense Mutations Using Yeast as a Model System: A Laboratory Course in Molecular Biology.

A. E. Gammie and N. Erdeniz (2004)
CBE Life Sci Educ 3, 31-48
 |  Abstract »  |  Full Text »  |  PDF »

A founder MLH1 mutation in families from the districts of Modena and Reggio-Emilia in northern Italy with hereditary non-polyposis colorectal cancer associated with protein elongation and instability.

O Caluseriu, C Di Gregorio, E Lucci-Cordisco, M Santarosa, J Trojan, A Brieger, P Benatti, M Pedroni, T Colibazzi, A Bellacosa, et al. (2004)
J. Med. Genet. 41, e34-34
 |  Full Text »  |  PDF »

The Correlation of Microsatellite Instability and Tumor-infiltrating Lymphocytes in Hereditary Non-polyposis Colorectal Cancer (HNPCC) and Sporadic Colorectal Cancers: the Significance of Different Types of Lymphocyte Infiltration.

N. Takemoto, F. Konishi, K. Yamashita, M. Kojima, T. Furukawa, Y. Miyakura, K. Shitoh, and H. Nagai (2004)
Jpn. J. Clin. Oncol. 34, 90-98
 |  Abstract »  |  Full Text »  |  PDF »

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.

Y. Wang and J. Qin (2003)
PNAS 100, 15387-15392
 |  Abstract »  |  Full Text »  |  PDF »

Differential deletions of chromosome 3p are associated with the development of uterine cervical carcinoma in Indian patients.

S Dasgupta, S B Chakraborty, A Roy, S Roychowdhury, and C K Panda (2003)
Mol. Pathol. 56, 263-269
 |  Abstract »  |  Full Text »  |  PDF »

Proportion and Phenotype of MYH-Associated Colorectal Neoplasia in a Population-Based Series of Finnish Colorectal Cancer Patients.

S. Enholm, T. Hienonen, A. Suomalainen, L. Lipton, I. Tomlinson, V. Karja, M. Eskelinen, J.-P. Mecklin, A. Karhu, H. J. Jarvinen, et al. (2003)
Am. J. Pathol. 163, 827-832
 |  Abstract »  |  Full Text »  |  PDF »

The Impact of Microsatellite Instability on the Molecular Phenotype of Colorectal Tumors.

Y. Mori, F. M. Selaru, F. Sato, J. Yin, L. A. Simms, Y. Xu, A. Olaru, E. Deacu, S. Wang, J. M. Taylor, et al. (2003)
Cancer Res. 63, 4577-4582
 |  Abstract »  |  Full Text »  |  PDF »

An Intron Splice Acceptor Polymorphism in hMSH2 and Risk of Leukemia after Treatment with Chemotherapeutic Alkylating Agents.

L. J. Worrillow, L. B. Travis, A. G. Smith, S. Rollinson, A. J. Smith, C. P. Wild, E. J. Holowaty, B. A. Kohler, T. Wiklund, E. Pukkala, et al. (2003)
Clin. Cancer Res. 9, 3012-3020
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer.

C. M. Ribic, D. J. Sargent, M. J. Moore, S. N. Thibodeau, A. J. French, R. M. Goldberg, S. R. Hamilton, P. Laurent-Puig, R. Gryfe, L. E. Shepherd, et al. (2003)
N. Engl. J. Med. 349, 247-257
 |  Abstract »  |  Full Text »  |  PDF »

A Specific Genetic Alteration on Chromosome 6 in Ulcerative Colitis-associated Colorectal Cancers.

T. Ezaki, M. Watanabe, N. Inoue, T. Kanai, H. Ogata, Y. Iwao, H. Ishii, and T. Hibi (2003)
Cancer Res. 63, 3747-3749
 |  Abstract »  |  Full Text »  |  PDF »

A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome.

A. R. Meetei, S. Sechi, M. Wallisch, D. Yang, M. K. Young, H. Joenje, M. E. Hoatlin, and W. Wang (2003)
Mol. Cell. Biol. 23, 3417-3426
 |  Abstract »  |  Full Text »  |  PDF »

Dimerization of MLH1 and PMS2 Limits Nuclear Localization of MutL{alpha}.

X. Wu, J. L. Platt, and M. Cascalho (2003)
Mol. Cell. Biol. 23, 3320-3328
 |  Abstract »  |  Full Text »  |  PDF »

Variation in the extent of microsatellite instability in human cell lines with defects in different mismatch repair genes.

N.A. Yamada, A. Castro, and R.A. Farber (2003)
Mutagenesis 18, 277-282
 |  Abstract »  |  Full Text »  |  PDF »

The Role of hMLH3 in Familial Colorectal Cancer.

H.-X. Liu, X.-L. Zhou, T. Liu, B. Werelius, G. Lindmark, N. Dahl, and A. Lindblom (2003)
Cancer Res. 63, 1894-1899
 |  Abstract »  |  Full Text »  |  PDF »

DNA Ploidy and Markovian Analysis of Neoplastic Progression in Experimental Pancreatic Cancer.

R. G. Postier, M. R. Lerner, S. A. Lightfoot, R. Vannarath, M. M. Lane, J. S. Hanas, and D. J. Brackett (2003)
J. Histochem. Cytochem. 51, 303-309
 |  Abstract »  |  Full Text »  |  PDF »

Identification of frame-shift intermediate mutant cells.

C. Gasche, C. L. Chang, L. Natarajan, A. Goel, J. Rhees, D. J. Young, C. N. Arnold, and C. R. Boland (2003)
PNAS 100, 1914-1919
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis.

S.-H. Lee, D. K. Chang, A. Goel, C. R. Boland, W. Bugbee, D. L. Boyle, and G. S. Firestein (2003)
J. Immunol. 170, 2214-2220
 |  Abstract »  |  Full Text »  |  PDF »

A novel algorithm for computational identification of contaminated EST libraries.

R. Sorek and H. M. Safer (2003)
Nucleic Acids Res. 31, 1067-1074
 |  Abstract »  |  Full Text »  |  PDF »

Mismatch Repair Genes hMLH1 and hMSH2 and Colorectal Cancer: A HuGE Review.

R. J. Mitchell, S. M. Farrington, M. G. Dunlop, and H. Campbell (2002)
Am. J. Epidemiol. 156, 885-902
 |  Abstract »  |  Full Text »  |  PDF »

Screening for microsatellite instability target genes in colorectal cancers.

S Vilkki, V Launonen, A Karhu, P Sistonen, I Vastrik, and L A Aaltonen (2002)
J. Med. Genet. 39, 785-789
 |  Abstract »  |  Full Text »  |  PDF »

The Genetics of Colorectal Cancer.

P. M. Calvert and H. Frucht (2002)
Ann Intern Med 137, 603-612
 |  Abstract »  |  Full Text »  |  PDF »

Germline MSH2 and MLH1 mutational spectrum in HNPCC families from Poland and the Baltic States.

G Kurzawski, J Suchy, J Kladny, K Safranow, A Jakubowska, P Elsakov, V Kucinskas, J Gardovski, A Irmejs, H Sibul, et al. (2002)
J. Med. Genet. 39, e65-65
 |  Full Text »  |  PDF »

Microsatellite Instability in Japanese vs European American Patients With Gastric Cancer.

C. P. Theuer, B. S. Campbell, D. J. Peel, F. Lin, P. Carpenter, A. Ziogas, and J. A. Butler (2002)
Arch Surg 137, 960-966
 |  Abstract »  |  Full Text »  |  PDF »

hMLH1 and hMSH2 Gene Mutation in Brazilian Families With Suspected Hereditary Nonpolyposis Colorectal Cancer.

B. M. Rossi, A. Lopes, F. Oliveira Ferreira, W. T. Nakagawa, C. C. Napoli Ferreira, J. C. Casali da Rocha, C. C. Simpson, and A. J. G. Simpson (2002)
Ann. Surg. Oncol. 9, 555-561
 |  Abstract »  |  Full Text »  |  PDF »

Management of women with a family history of breast cancer in the North West Region of England: training for implementing a vision of the future.

M McAllister, K O'Malley, P Hopwood, B Kerr, A Howell, and D G R Evans (2002)
J. Med. Genet. 39, 531-535
 |  Full Text »  |  PDF »

Mutations within the hMLH1 and hPMS2 Subunits of the Human MutLalpha Mismatch Repair Factor Affect Its ATPase Activity, but Not Its Ability to Interact with hMutSalpha.

M. Raschle, P. Dufner, G. Marra, and J. Jiricny (2002)
J. Biol. Chem. 277, 21810-21820
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Germline Mutations and Somatic Repeat Instability in DNA Mismatch-Repair-Deficient Caenorhabditis elegans.

M. Tijsterman, J. Pothof, and R. H. A. Plasterk (2002)
Genetics 161, 651-660
 |  Abstract »  |  Full Text »  |  PDF »

Mutations at Coding Repeat Sequences in Mismatch Repair-deficient Human Cancers: Toward a New Concept of Target Genes for Instability.

A. Duval and R. Hamelin (2002)
Cancer Res. 62, 2447-2454
 |  Abstract »  |  Full Text »  |  PDF »

An MLH1 haplotype is over-represented on chromosomes carrying an HNPCC predisposing mutation in MLH1.

P Hutter, J Wijnen, C Rey-Berthod, I Thiffault, P Verkuijlen, D Farber, N Hamel, B Bapat, S N Thibodeau, J Burn, et al. (2002)
J. Med. Genet. 39, 323-327
 |  Abstract »  |  Full Text »  |  PDF »

Human Exonuclease I Is Required for 5' and 3' Mismatch Repair.

J. Genschel, L. R. Bazemore, and P. Modrich (2002)
J. Biol. Chem. 277, 13302-13311
 |  Abstract »  |  Full Text »  |  PDF »

A new mutator phenotype in breast cancer?.

J. G. de Boer (2002)
PNAS 99, 3368-3369
 |  Full Text »  |  PDF »

Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis.

S. Liu, W. Liu, J. L. Jakubczak, G. L. Erexson, K. R. Tindall, R. Chan, W. J. Muller, S. Adhya, S. Garges, and G. Merlino (2002)
PNAS 99, 3770-3775
 |  Abstract »  |  Full Text »  |  PDF »

Sequence dependent instability of mononucleotide microsatellites in cultured mismatch repair proficient and deficient mammalian cells.

J. C. Boyer, N. A. Yamada, C. N. Roques, S. B. Hatch, K. Riess, and R. A. Farber (2002)
Hum. Mol. Genet. 11, 707-713
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenicity of missense and splice site mutations in hMSH2 and hMLH1 mismatch repair genes: implications for genetic testing.

M Cravo, A J Afonso, P Lage, C Albuquerque, L Maia, C Lacerda, P Fidalgo, P Chaves, C Cruz, and C Nobre-Leitao (2002)
Gut 50, 405-412
 |  Abstract »  |  Full Text »  |  PDF »

Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors.

X.-P. Zhou, S. Kuismanen, M. Nystrom-Lahti, P. Peltomaki, and C. Eng (2002)
Hum. Mol. Genet. 11, 445-450
 |  Abstract »  |  Full Text »  |  PDF »

MSH2 in Contrast to MLH1 and MSH6 Is Frequently Inactivated by Exonic and Promoter Rearrangements in Hereditary Nonpolyposis Colorectal Cancer.

F. Charbonnier, S. Olschwang, Q. Wang, C. Boisson, C. Martin, M.-P. Buisine, A. Puisieux, and T. Frebourg (2002)
Cancer Res. 62, 848-853
 |  Abstract »  |  Full Text »  |  PDF »

An insight into the genetic pathway of adenocarcinoma of the small intestine.

J M D Wheeler, B F Warren, N J McC Mortensen, H C Kim, S C Biddolph, G Elia, N E Beck, G T Williams, N A Shepherd, A C Bateman, et al. (2002)
Gut 50, 218-223
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products